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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ETV4 2118 Ets variant gene 4 (E1A enhancer binding protein, E1AF)  17E1AF; PEA3; E1A-F; PEAS3 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15695237   2005Cell line : -

Source : -

Sample Type : -

No. of Sample : 90 consisted of 63 adenomas and 27 adenocarcinomas

Stage : TNM Stage I,II

real time RT-PCR, Immunohistochemistry, Northern blottingUp-regulation-The E1AF-MMP1-MMP-7-COX-2-iNOS axis could be a potent therapeutic target in patients with a colorectal tumor.

E1AF overexpression was significantly correlated with histopathology.

16678123   2006Cell line : -

Source : -

Sample Type : -

No. of Sample : 3 normal, 6 adenomatous polyps, and 3 carcinomas

Stage : -

RT-PCR, In vitro invasionUp-regulation-It has demonstrated a novel association between MYEOV cell proliferation and invasion in colon cancer cell lines, and independently confirmed the role of ETV4 in invasion in colon cancer.

ETV4 mRNA levels were significantly increased in colonic neoplasia in comparison to normal colonic tissue.

22930170   2012Cell line : KM12C, KM12SM, HT 29

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Microarray analysis,Real time RT-PCR and Flow cytometryUp-regulation-Gene differentially expressed and analysed bye by Microarray.


Gene Details



Chromosome: 17; NC_000017.10 (41605211..41623800, complement)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 17
Location 17q21
Start 43527843  
End 43546432  
Strand -  
Gene Sequence

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Length 18590  
OMIM ID 600711   
HGNC ID HGNC:3493   
Unigene ID Hs.434059    
Ensembl ID ENSG00000175832   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001261437.1
Exon join(1..248,1066..1159,1411..1458,9954..10007, 12448..12574,13085..13246,13494..13759,16252..16326, 16481..16549,16757..16929,17197..17298,17690..18590)  
mRNA Sequence

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Length 2358  



CDS Information


   
Location join(816..875,1066..1159,1411..1458,9954..10007, 12448..12574,13085..13246,13494..13759,16252..16326, 16481..16549,16757..16929,17197..17298,17690..17914)
CDS Sequence

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CCDS ID CCDS11465.1



Protein Information


      
Protein IDNP_001073143.1
Protein NameEts variant gene 4 (E1A enhancer binding protein, E1AF)
Molecular Wt. (Da)53807
Protein Sequence

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Length 484  
Uniprot IDO75626
Ensembl Protein ID ENSP00000358085  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation140
SPhosphorylation149
SPhosphorylation140
SPhosphorylation149

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2033EP3004078NP_001420.2in vitro14976201   
6722SRF2788NP_003122.1in vitro7796532   


Pathway Information


      
Pathway Name Pathway ID
Transcriptional misregulation in cancer hsa05202


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00178340-423  Ets
cl02599340-423  Ets superfamily
smart00413341-424  ETS
cd09642377-444  Cas8c_I-C
cl12004377-444  Cas8c_I-C superfamily
pfam046218-339  ETS_PEA3_N
pfam0315491-265  Atrophin-1


Ontology Information


   
HPRD ID4572
Molecular ClassTranscription factor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO