Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ETV4 | 2118 | Ets variant gene 4 (E1A enhancer binding protein, E1AF)  | 17 | E1AF; PEA3; E1A-F; PEAS3  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15695237    | 2005 | Cell line : - Source : - Sample Type : - No. of Sample : 90 consisted of 63 adenomas and 27 adenocarcinomas Stage : TNM Stage I,II | real time RT-PCR, Immunohistochemistry, Northern blotting | Up-regulation | - | The E1AF-MMP1-MMP-7-COX-2-iNOS axis could be a potent therapeutic target in patients with a colorectal tumor. E1AF overexpression was significantly correlated with histopathology. |
| 16678123    | 2006 | Cell line : - Source : - Sample Type : - No. of Sample : 3 normal, 6 adenomatous polyps, and 3 carcinomas Stage : - | RT-PCR, In vitro invasion | Up-regulation | - | It has demonstrated a novel association between MYEOV cell proliferation and invasion in colon cancer cell lines, and independently confirmed the role of ETV4 in invasion in colon cancer. ETV4 mRNA levels were significantly increased in colonic neoplasia in comparison to normal colonic tissue. |
| 22930170    | 2012 | Cell line : KM12C, KM12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Microarray analysis,Real time RT-PCR and Flow cytometry | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | -   | Chromosome | 17 |
| Location | 17q21 |
| Start | 43527843   |
| End | 43546432   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 18590   |
| OMIM ID | 600711    |
| HGNC ID | HGNC:3493    |
| Unigene ID | Hs.434059     |
| Ensembl ID | ENSG00000175832    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001261437.1 |
|---|---|
| Exon | join(1..248,1066..1159,1411..1458,9954..10007, 12448..12574,13085..13246,13494..13759,16252..16326, 16481..16549,16757..16929,17197..17298,17690..18590)   | mRNA Sequence |    Download   Select all |
| Length | 2358   |
CDS Information
| Location | join(816..875,1066..1159,1411..1458,9954..10007, 12448..12574,13085..13246,13494..13759,16252..16326, 16481..16549,16757..16929,17197..17298,17690..17914) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS11465.1 |    
Protein Information
| Protein ID | NP_001073143.1 |
|---|---|
| Protein Name | Ets variant gene 4 (E1A enhancer binding protein, E1AF) |
| Molecular Wt. (Da) | 53807 |
| Protein Sequence |    Download   Select all |
| Length | 484   |
| Uniprot ID | O75626 |    
| Ensembl Protein ID | ENSP00000358085   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 140 |
| S | Phosphorylation | 149 |
| S | Phosphorylation | 140 |
| S | Phosphorylation | 149 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 |    EP300 |    4078 |    NP_001420.2 |    in vitro |    14976201    |
| 6722 |    SRF |    2788 |    NP_003122.1 |    in vitro |    7796532    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer |    hsa05202 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00178 | 340-423  | Ets |
| cl02599 | 340-423  | Ets superfamily |
| smart00413 | 341-424  | ETS |
| cd09642 | 377-444  | Cas8c_I-C |
| cl12004 | 377-444  | Cas8c_I-C superfamily |
| pfam04621 | 8-339  | ETS_PEA3_N |
| pfam03154 | 91-265  | Atrophin-1 |
Ontology Information
| HPRD ID | 4572 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
