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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21278247 | 2011 | Cell line : - Source : Johns Hopkins (JHU) Training and Validation cohort samples Sample Type : - No. of Sample : - Stage : TNM Stage I-IV | Merging genome-wide genomic and epigenomic alterations, Cox proportional hazard model | Methylation | - | DNA methylation of IGFBP3 and EVL was validated as a prognostic marker in an independent contemporary-matched cohort. |
| 24475022 | 2014 | Cell line : - Source : Shiraz University Hospital, Shiraz, Iran. Sample Type : CRC tumor No. of Sample : Colonic biopsies (n?=?27) were obtained from CRC Caucasian patients Stage : TNM Stage I-IV | Methylation-specific PCR,Comparative genomic hybridization (CGH) experiments. | Methylation | - | Seven markers with moderate to high frequency of methylation (SYNE1, MMP2, CD109, EVL, RET, LGR and PTPRD) had very low levels of chromosomal aberrations. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - | Chromosome | 14 |
| Location | 14q32.2 |
| Start | 100485719 |
| End | 100610573 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 124855 |
| OMIM ID | - |
| HGNC ID | HGNC:20234 |
| Unigene ID | Hs.125867 |
| Ensembl ID | ENSG00000196405 |
| PharmGKB ID | PA134890866 |
Protein Information
| Protein ID | NP_057421.1 |
|---|---|
| Protein Name | Enah/Vasp-like |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 416 |
| Uniprot ID | Q9HD26 |
| Ensembl Protein ID | ENSP00000052569 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 160 |
| S | Phosphorylation | 331 |
| S | Phosphorylation | 333 |
| S | Phosphorylation | 248 |
| S | Phosphorylation | 250 |
| T | Phosphorylation | 252 |
| S | Phosphorylation | 306 |
| S | Phosphorylation | 308 |
| S | Phosphorylation | 347 |
| S | Phosphorylation | 351 |
| S | Phosphorylation | 371 |
| S | Phosphorylation | 261 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 320 |
| S | Phosphorylation | 321 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro | 10945997 |
| 322 | APBB1 | 4087 | NP_001155.1 | in vitro | 10945997 |
| 1399 | CRKL | 3596 | NP_005198.1 | in vitro | 10945997 |
| 2534 | FYN | 655 | NP_002028.1 | in vitro | 10945997 |
| 3055 | HCK | 796 | NP_002101.2 | in vitro | 12029088 |
| 4067 | LYN | 1301 | NP_002341.1 | in vitro | 10945997 |
| 5217 | PFN2 | 1451 | NP_444252.1 | in vitro | 10945997 |
| 6709 | SPTAN1 | 1684 | NP_001123910.1 | in vivo;yeast 2-hybrid | 15656790 |
| 6714 | SRC | 1819 | NP_005408.1 | in vitro | 10945997 |
| 7454 | WAS | 2314 | NP_000368.1 | in vitro;in vivo | 16055720 |
| 8976 | WASL | 5448 | NP_003932.3 | in vitro;in vivo | 16055720 |
| 10006 | ABI1 | 4336 | NP_005461.2 | in vitro;in vivo | 16055720 |
| 23268 | DNMBP | 10918 | NP_056036.1 | in vitro;yeast 2-hybrid | 14506234 |
| 57556 | SEMA6A | 6906 | NP_065847.1 | in vitro;in vivo | 10993894 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01207 | 5-113 | EVH1_Ena_VASP-like |
| cl17171 | 5-113 | PH-like superfamily |
| cd00837 | 5-109 | EVH1_family |
| smart00461 | 1-109 | WH1 |
| pfam00568 | 4-105 | WH1 |
| cd10574 | 5-110 | EVH1_SPRED-like |
| pfam08776 | 376-415 | VASP_tetra |
| cl07401 | 376-415 | VASP_tetra superfamily |
| cd01206 | 3-104 | EVH1_Homer_Vesl |
| cd01205 | 47-106 | EVH1_WASP-like |
| smart00160 | 2-106 | RanBD |
| pfam00638 | 2-104 | Ran_BP1 |
Ontology Information
| HPRD ID | 5836 |
|---|---|
| Molecular Class | Cytoskeletal protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.