CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24158095	2014	Cell line : HCT116, LoVo, HCT15,SW480, HT29 Source : - Sample Type : - No. of Sample : - Stage : -	PCR,Immunohistochemistry,Protein pull-down assay,Luciferase assay	Mutation	-	Relocalization of the EWSR1 protein from nucleus to cytoplasm in MMR-deficient cancers and that the nonprotein-coding MSI target locus itself has a modulatory effect on EWSR1 gene expression through alternative 3' end processing of the EWSR1 gene.

Gene Details

NC_000022.10 (29663998..29696515)
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Gene Type	protein coding
Gene Family	RNA binding motif (RRM) containing
Description	This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Chromosome	22
Location	22q12.2
Start	29663998
End	29696515
Strand	+
Gene Sequence	Download   Select all
Length	32518
OMIM ID	133450
HGNC ID	HGNC:3508
Unigene ID	Hs.374477
Ensembl ID	ENSG00000182944
PharmGKB ID	PA27921

mRNA Information

mRNA ID	XM_006724224.2
Exon	complement(<1..59)
mRNA Sequence	Download   Select all
Length	1496

CDS Information

   

Location	515..1291
CDS Sequence	Download   Select all
CCDS ID	CCDS13851.1

Protein Information

      

Protein ID	XP_006724287.1
Protein Name	EWS RNA-binding protein 1
Molecular Wt. (Da)	26945
Protein Sequence	Download   Select all
Length	258
Uniprot ID	Q13635
Ensembl Protein ID	ENSP00000332353

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
R	Methylation	300
R	Methylation	302
R	Methylation	304
R	Methylation	309
R	Methylation	314
R	Methylation	317
R	Methylation	321
R	Methylation	471
R	Methylation	490
R	Methylation	494
R	Methylation	500
R	Methylation	503
R	Methylation	506
R	Methylation	563
R	Methylation	565
R	Methylation	572
R	Methylation	575
R	Methylation	581
R	Methylation	589
R	Methylation	592
R	Methylation	596
R	Methylation	600
R	Methylation	603
R	Methylation	607
R	Methylation	615
R	Methylation	633
R	Methylation	636
R	Methylation	476
R	Methylation	495
R	Methylation	577
R	Methylation	505
R	Methylation	586
R	Methylation	511
R	Methylation	568
R	Methylation	570
R	Methylation	577
R	Methylation	580
R	Methylation	586
R	Methylation	594
R	Methylation	597
R	Methylation	601
R	Methylation	605
R	Methylation	608
R	Methylation	612
R	Methylation	620
R	Methylation	638
R	Methylation	641
S	Phosphorylation	266
S	Phosphorylation	358;-
S	Phosphorylation	371
S	Phosphorylation	376

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
86	ACTL6A	5389	NP_004292.1	yeast 2-hybrid	16189514
572	BAD	4409	NP_004313.1	yeast 2-hybrid	16189514
665	BNIP3L	7288	NP_004322.1	yeast 2-hybrid	16189514
801	CALM1	241	NP_008819.1	in vitro	9341188
1525	CXADR	11804	NP_001329.1	yeast 2-hybrid	16189514
1676	DFFA	3531	NP_004392.1	yeast 2-hybrid	16189514
1995	ELAVL3	16024	NP_001411.2	yeast 2-hybrid	16189514
1996	ELAVL4	1343	NP_001138247.1	yeast 2-hybrid	16189514
2194	FASN	2567	NP_004095.4	yeast 2-hybrid	16189514
2313	FLI1	1901	NP_002008.2	in vitro	14534527
3159	HMGA1	2829	NP_665906.1	yeast 2-hybrid	16189514
3306	HSPA2	7174	NP_068814.2	yeast 2-hybrid	16713569
3779	KCNMB1	10358	NP_004128.1	yeast 2-hybrid	16189514
4089	SMAD4	2995	NP_005350.1	yeast 2-hybrid	16189514
4110	MAGEA11	2281	NP_005357.2	yeast 2-hybrid	16189514
4145	MATK	2496	NP_002369.2	yeast 2-hybrid	16189514
4188	MDFI	7280	NP_005577.1	yeast 2-hybrid	16189514
4287	ATXN3	6131	NP_004984.2	yeast 2-hybrid	16713569
4515	MTCP1	2122	NP_001018025.1	yeast 2-hybrid	16189514
4542	MYO1F	3282	NP_036467.2	yeast 2-hybrid	16189514
4591	TRIM37	5463	NP_056109.1	yeast 2-hybrid	16189514
4637	MYL6	17618	NP_524149.1	yeast 2-hybrid	16189514
4707	NDUFB1	11952	NP_004536.2	yeast 2-hybrid	16189514
4723	NDUFV1	1191	NP_009034.2	yeast 2-hybrid	16189514
4879	NPPB	8974	NP_002512.1	yeast 2-hybrid	16189514
5093	PCBP1	3128	NP_006187.2	yeast 2-hybrid	16713569
5359	PLSCR1	8855	NP_066928.1	yeast 2-hybrid	16189514
5886	RAD23A	7191	NP_005044.1	yeast 2-hybrid	16189514
6160	RPL31	17994	NP_001092047.1	yeast 2-hybrid	16189514
6210	RPS15A	4723	NP_001010.2	yeast 2-hybrid	16189514
6297	SALL2	3743	NP_005398.1	yeast 2-hybrid	16189514
6505	SLC1A1	597	NP_004161.4	yeast 2-hybrid	16189514
6944	VPS72	2791	NP_005988.1	yeast 2-hybrid	16189514
7288	TULP2	3813	NP_003314.2	yeast 2-hybrid	16189514
7718	ZNF165	2903	NP_003438.1	yeast 2-hybrid	16189514
7874	USP7	3950	NP_003461.2	yeast 2-hybrid	16713569
8050	PDHX	2002	NP_003468.2	yeast 2-hybrid	16189514
9087	TMSB4Y	2458	NP_004193.1	yeast 2-hybrid	16189514
9242	MSC	4694	NP_005089.2	yeast 2-hybrid	16189514
9709	HERPUD1	7456	NP_055500.1	yeast 2-hybrid	16189514
10007	GNPDA1	9048	NP_005462.1	yeast 2-hybrid	16189514
10099	TSPAN3	15512	NP_005715.1	yeast 2-hybrid	16189514
10428	CFDP1	16282	NP_006315.1	yeast 2-hybrid	16189514
11026	LILRA3	10382	NP_006856.2	yeast 2-hybrid	16189514
11030	RBPMS	11870	NP_001008712.1	yeast 2-hybrid	16189514
11052	CPSF6	5401	AAH00714.1	yeast 2-hybrid	16189514
11059	WWP1	3811	NP_008944.1	yeast 2-hybrid	16189514
11060	WWP2	3812	NP_008945.2	yeast 2-hybrid	16189514
11103	KRR1	11027	NP_008974.5	yeast 2-hybrid	16189514
22884	WDR37	15668	NP_054742.2	yeast 2-hybrid	16189514
22981	NINL	11120	NP_079452.3	yeast 2-hybrid	16189514
23635	SSBP2	9577	NP_036578.2	yeast 2-hybrid	16189514
25796	PGLS	12001	NP_036220.1	yeast 2-hybrid	16189514
25941	C18orf10	12684	NP_056291.2	yeast 2-hybrid	16189514
26148	C10orf12	12563	NP_056467.2	yeast 2-hybrid	16189514
26959	HBP1	13634	NP_036389.2	yeast 2-hybrid	16713569
27104	-	9933	BAB15625.1	yeast 2-hybrid	16189514
28973	MRPS18B	14781	NP_054765.1	yeast 2-hybrid	16189514
51304	ZDHHC3	15718	NP_001128652.1	yeast 2-hybrid	16189514
51778	MYOZ2	5724	NP_057683.1	yeast 2-hybrid	16189514
54475	NLE1	16903	NP_060566.2	yeast 2-hybrid	16189514
55249	YY1AP1	8485	NP_620829.1	yeast 2-hybrid	16189514
55297	CCDC91	16905	NP_060788.3	yeast 2-hybrid	16189514
55329	MNS1	10967	NP_060835.1	yeast 2-hybrid	16189514
56302	TRPV5	5981	NP_062815.2	yeast 2-hybrid	16189514
56673	C11orf16	12604	NP_065694.2	yeast 2-hybrid	16189514
56952	PRTFDC1	17917	NP_064585.1	yeast 2-hybrid	16189514
57126	CD177	1222	NP_065139.2	yeast 2-hybrid	16189514
60313	GPBP1L1	15418	NP_067652.1	yeast 2-hybrid	16189514
63948	DMRTB1	16828	NP_149056.1	yeast 2-hybrid	16189514
64777	RMND5B	7985	NP_073599.2	yeast 2-hybrid	16189514
65997	RASL11B	15216	NP_076429.1	yeast 2-hybrid	16189514
66036	MTMR9	9377	NP_056273.2	yeast 2-hybrid	16189514
79004	CUEDC2	13099	NP_076945.2	yeast 2-hybrid	16189514
79036	C19orf50	14526	NP_076974.1	yeast 2-hybrid	16189514
79173	C19orf57	14415	NP_077299.3	yeast 2-hybrid	16189514
79723	SUV39H2	7580	NP_078946.1	yeast 2-hybrid	16189514
79869	CPSF7	16906	NP_079087.3	yeast 2-hybrid	16189514
84224	NBPF3	10633	NP_115640.1	yeast 2-hybrid	16189514
84528	RHOXF2	2345	NP_115887.1	yeast 2-hybrid	16189514
84628	NTNG2	17650	NP_115925.2	yeast 2-hybrid	16189514
85465	-	7616	NP_277040.1	yeast 2-hybrid	16189514
93487	MAPK1IP1L	12647	NP_653179.1	yeast 2-hybrid	16189514
138046	RALYL	11236	NP_001093861.1	yeast 2-hybrid	16189514
138065	RNF183	10082	NP_659488.2	yeast 2-hybrid	16189514
140735	DYNLL2	6489	NP_542408.1	yeast 2-hybrid	16189514
158471	PRUNE2	12970	NP_620173.1	yeast 2-hybrid	16189514
163882	CNST	8718	NP_689822.2	yeast 2-hybrid	16189514
202559	KHDRBS2	13775	NP_689901.2	yeast 2-hybrid	16189514
221016	CCDC7	10812	NP_659460.3	yeast 2-hybrid	16189514
283238	SLC22A24	14591	NP_775857.1	yeast 2-hybrid	16189514
326624	RAB37	6702	NP_001006638.1	yeast 2-hybrid	16189514
348487	FAM131C	8779	NP_872429.2	yeast 2-hybrid	16189514
387338	NSUN4	14842	NP_950245.2	yeast 2-hybrid	16189514
387923	SERP2	16590	NP_001010897.1	yeast 2-hybrid	16189514
414061	DNAJB3	13638	NP_001001394.1	yeast 2-hybrid	16189514

Pathway Information

      

Pathway Name	Pathway ID
Transcriptional misregulation in cancer	hsa05202

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd12533	361-444	RRM_EWS
cl17169	361-444	RRM_SF superfamily
cd12535	359-444	RRM_FUS_TAF15
cd12280	363-444	RRM_FET
cd12534	363-445	RRM_SARFH
cd12281	360-446	RRM1_TatSF1_like
cd12399	363-447	RRM_HP0827_like
cd00590	363-443	RRM_SF
cd12398	363-445	RRM_CSTF2_RNA15_like
cd12324	363-450	RRM_RBM8
cd12316	363-442	RRM3_RBM19_RRM2_MRD1
pfam00076	363-441	RRM_1
cd12387	363-442	RRM3_hnRNPM_like
cd12380	363-448	RRM3_I_PABPs
cd12306	363-443	RRM_II_PABPs
pfam00641	518-547	zf-RanBP
cl02656	518-547	zf-RanBP superfamily
cd12382	363-447	RRM_RBMX_like
cd12392	363-450	RRM2_SART3
cd12413	363-448	RRM1_RBM28_like
cd12372	363-444	RRM_CFIm68_CFIm59
cd12284	363-443	RRM2_RBM23_RBM39
cd12298	363-444	RRM3_Prp24
cd12447	363-445	RRM1_gar2
smart00547	520-546	ZnF_RBZ
cd12411	355-442	RRM_ist3_like
cd12566	359-437	RRM2_MRD1
cd12567	363-442	RRM3_RBM19
cd12674	363-448	RRM1_Nop4p
cd12408	362-446	RRM_eIF3G_like
cd12243	363-438	RRM1_MSSP
cd12260	363-442	RRM2_SREK1
cd12272	362-443	RRM2_PHIP1
cd12328	363-427	RRM2_hnRNPA_like
cd12450	363-448	RRM1_NUCLs
cd12312	361-449	RRM_SRSF10_SRSF12
cd12393	361-445	RRM_ZCRB1
cd12311	365-442	RRM_SRSF2_SRSF8
cd12671	372-445	RRM_CSTF2_CSTF2T
cd12362	376-443	RRM3_CELF1-6
cd12304	367-454	RRM_Set1
cd12401	364-445	RRM_eIF4H
cd12730	363-428	RRM1_GRSF1
cd12373	363-446	RRM_SRSF3_like
cd12236	363-446	RRM_snRNP70
cd12384	363-445	RRM_RBM24_RBM38_like
cd12418	365-444	RRM_Aly_REF_like
cd12550	362-446	RRM_II_PABPN1
cd12579	363-448	RRM2_hnRNPA0
cd12347	363-443	RRM_PPIE
cd12650	365-445	RRM1_Hu
cd12375	368-445	RRM1_Hu_like
cd12599	363-444	RRM1_SF2_plant_like
cd12451	363-442	RRM2_NUCLs
cd12662	363-446	RRM3_MYEF2
cd12551	362-442	RRM_II_PABPN1L
cd12415	363-445	RRM3_RBM28_like
cd12305	363-447	RRM_NELFE
cd12406	363-448	RRM4_NCL
cd12254	363-427	RRM_hnRNPH_ESRPs_RBM12_like
cd12386	363-433	RRM2_hnRNPM_like
cd12246	363-446	RRM1_U1A_like
cd12271	363-442	RRM1_PHIP1
cd12378	362-428	RRM1_I_PABPs
cd12651	363-444	RRM2_SXL
cd12251	362-449	RRM3_hnRNPR_like
cd12771	356-446	RRM1_HuB
cd12325	363-428	RRM1_hnRNPA_hnRNPD_like
cd12661	363-446	RRM3_hnRNPM
cd12230	363-443	RRM1_U2AF65
cd12681	363-444	RRM_SKAR
cd12285	396-433	RRM3_RBM39_like
cd12241	359-442	RRM_SF3B14
cd12449	363-447	RRM_CIRBP_RBM3
cd12597	363-446	RRM1_SRSF1
cd12503	363-428	RRM1_hnRNPH_GRSF1_like
cd12239	360-441	RRM2_RBM40_like
cd12334	363-443	RRM1_SF3B4
cd12409	363-444	RRM1_RRT5
cd12339	365-442	RRM2_SRSF1_4_like
cd12565	361-445	RRM1_MRD1
cd12240	363-432	RRM_NCBP2
cd12580	363-419	RRM2_hnRNPA1
cd12600	363-443	RRM2_SRSF4_like
cd12336	360-443	RRM_RBM7_like
cd12395	362-443	RRM2_RBM34
cd12400	363-442	RRM_Nop6
cd12365	363-443	RRM_RNPS1
cd12327	363-419	RRM2_DAZAP1
cd12359	415-443	RRM2_VICKZ
cd12371	363-445	RRM2_PUF60
cd12223	363-442	RRM_SR140
cd12552	363-442	RRM_Nop15p
cd12381	363-447	RRM4_I_PABPs
cd12330	363-428	RRM2_Hrp1p
cd12338	363-444	RRM1_SRSF1_like
cd12335	363-448	RRM2_SF3B4
cd12446	363-447	RRM_RBM25
cd12355	363-446	RRM_RBM18
cd12454	358-442	RRM2_RIM4_like
smart00360	363-442	RRM
COG0724	350-458	RRM
pfam14259	363-441	RRM_6
TIGR01628	363-448	PABP-1234
PLN03134	360-463	PLN03134
PHA03247	71-206	PHA03247
TIGR01622	363-447	SF-CC1
TIGR01628	363-448	PABP-1234
TIGR01628	119-212	PABP-1234
PRK14949	10-137	PRK14949
TIGR01642	338-451	U2AF_lg
PRK07764	39-202	PRK07764
PHA03369	110-213	PHA03369

Ontology Information

   

HPRD ID	8903
Molecular Class	RNA binding protein
Molecular Function	G-protein coupled receptor activity (GO:0004930)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report