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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EXO1 9156 exonuclease 1  1HEX1, hExoI 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25294706   2014Cell line : -

Source : Thomayer Hospital and at the General University Hospital (both located in Prague, Czech Republic).

Sample Type : CRC Tumor and normal tissue

No. of Sample : 53

Stage : TNM Stage I-IV

Genotyping Polymorhpism-�Exo1�gene polymorphism Lys589Glu may be associated with an increased risk ofcolorectal cancer.

24484585   2014Cell line : -

Source : -

Sample Type : CRC Blood sample

No. of Sample : 130 CRC and 135 control

Stage : TNM Stage I-IV

Gene expression profiling,Methylation-specific PCR, real time RT-PCRUp-regulation-Found significantly increased transcription levels in EXO1 gene in tumor tissues (P = 0.05) and significant over-expression of MSH3 gene in colon tumors when compared to adjacent mucosal tissues.


Gene Details



NC_000001.10 (242011491..242053241)

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Gene Type protein coding
Gene Family -
Description This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]  
Chromosome 1
Location 1q42-q43
Start 242011491  
End 242053241  
Strand +  
Gene Sequence

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Length 41751  
OMIM ID 606063   
HGNC ID HGNC:3511   
Unigene ID Hs.498248   
Ensembl ID ENSG00000174371   
PharmGKB ID PA27923   

mRNA Information


mRNA ID ?NM_003686.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS1620.1



Protein Information


      
Protein IDNP_003677.4
Protein Nameexonuclease 1
Molecular Wt. (Da)0
Protein Sequence

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Length 846  
Uniprot IDQ9ULW0
Ensembl Protein ID ENSP00000300403  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation714;-
SPhosphorylation714;-
SPhosphorylation714;-
SPhosphorylation422
SPhosphorylation422
SPhosphorylation422
SPhosphorylation494
SPhosphorylation494
SPhosphorylation494
SPhosphorylation639
SPhosphorylation639
SPhosphorylation639
SPhosphorylation700
SPhosphorylation702
SPhosphorylation700
SPhosphorylation702
SPhosphorylation700
SPhosphorylation702
SPhosphorylation598
SPhosphorylation598
SPhosphorylation598
SPhosphorylation623
SPhosphorylation623
SPhosphorylation623
KAcetylation482
KAcetylation482
KAcetylation482
SPhosphorylation656
SPhosphorylation659
SPhosphorylation656
SPhosphorylation659
SPhosphorylation656
SPhosphorylation659
SPhosphorylation660
SPhosphorylation660
SPhosphorylation660

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4292MLH1390NP_000240.1in vitro;in vivo11   427   529   114   297   000   000   000   000   000   000   
4436MSH2389NP_000242.1in vitro;in vivo;yeast 2-hybrid108   568   339   788   596   000   000   000   000   000   000   000   000   
4437MSH32931AAB47281.1in vitro;in vivo11427529   
5395PMS22598NP_000526.1in vitro;in vivo114   275   291   142   970   000   000   000   


Pathway Information


      
Pathway Name Pathway ID
Mismatch repair hsa03430


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd098571-206  PIN_EXO1
cl148121-206  PIN_SF superfamily
cd09908213-289  H3TH_EXO1
cl22433213-289  H3TH_StructSpec-5'-nucleases superfamily
cd001286-187  PIN_FEN1_EXO1-like
pfam00867138-225  XPG_I
cl22865138-225  XPG_I superfamily
smart00485Jan-86  XPGN
cl02628Jan-86  XPG_N superfamily
cd09901213-289  H3TH_FEN1-like
smart00484138-207  XPGI
cd098681-182  PIN_XPG
cd0985863-187  PIN_MKT1
cd098675-183  PIN_FEN1
cd098701-183  PIN_YEN1
cd09897213-284  H3TH_FEN1-XPG-like
pfam00752Feb-86  XPG_N
cd098691-190  PIN_GEN1
cd098565-183  PIN_FEN1-like
cd0985228-185  PIN_SF
cd09907213-289  H3TH_FEN1-Euk
cd0985327-184  PIN_StructSpec-5'-nucleases
cd00080213-278  H3TH_StructSpec-5'-nucleases
cd09900213-262  H3TH_XPG-like
smart00279213-243  HhH2
TIGR036741-308  fen_arch
PTZ002171-306  PTZ00217
COG025814-243  Exo
PRK0398047-308  PRK03980
TIGR0060097-242  rad2
TIGR00600Jan-79  rad2


Ontology Information


   
HPRD ID10297
Molecular ClassDNA exonuclease
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO