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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EXOC4 | 60412 | Exocyst complex component 4 | 7 | SEC8; Sec8p; SEC8L1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FF E-FASP,SAX fractionation,LC MSMS,Label-free quantitation. | Up-regulation | 4.8 | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7q31 |
| Start | 133253067 |
| End | 134065761 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 812695 |
| OMIM ID | 608185 |
| HGNC ID | HGNC:30389 |
| Unigene ID | Hs.321273 |
| Ensembl ID | ENSG00000131558 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_021807.3 |
|---|---|
| Exon | join(1..121,21916..22105,35856..36050,52811..52995, 64218..64324,103264..103507,121762..121936,222262..222407, 226984..227072,376979..377075,564259..564478, 642533..642669,664517..664672,684825..685003, 744426..744567,751846..752024,754610..754769, 811225..812695) | mRNA Sequence | Download Select all |
| Length | 4203 |
CDS Information
| Location | join(36..121,21916..22105,35856..36050,52811..52995, 64218..64324,103264..103507,121762..121936,222262..222407, 226984..227072,376979..377075,564259..564478, 642533..642669,664517..664672,684825..685003, 744426..744567,751846..752024,754610..754769, 811225..811462) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS5829.1 |
Protein Information
| Protein ID | NP_001032203.1 |
|---|---|
| Protein Name | Exocyst complex component 4 |
| Molecular Wt. (Da) | 53726 |
| Protein Sequence | Download Select all |
| Length | 473 |
| Uniprot ID | Q02790 |
| Ensembl Protein ID | ENSP00000001008 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 237 |
| T | Phosphorylation | 237 |
| K | Acetylation | 9 |
| K | Acetylation | 9 |
| S | Phosphorylation | 226 |
| S | Phosphorylation | 226 |
| T | Phosphorylation | 233 |
| T | Phosphorylation | 233 |
| T | Phosphorylation | 554 |
| S | Phosphorylation | 555 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1741 | DLG3 | 2177 | NP_066943.2 | in vitro;yeast 2-hybrid | 12738960 |
| 2904 | GRIN2B | 697 | NP_000825.2 | in vivo | 12738960 |
| 5898 | RALA | 1549 | NP_005393.2 | in vitro | 11406615 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04048 | 35-144 | Sec8_exocyst |
| cl23539 | 35-144 | Sec8_exocyst superfamily |
Ontology Information
| HPRD ID | 3823 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.