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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EYA4 | 2070 | EYA transcriptional coactivator and phosphatase 4 | 6 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
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- PPi
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- Structural
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- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23862763 | 2013 | Cell line : - Source : - Sample Type : Serum samples No. of Sample : 26 CRC, 26 controls Stage : TNM Stage I | - | Methylation | - | Serum methylation levels of TAC1. SEPT9 and EYA4 may be useful biomarkers for early detection of CRC though a validation study is necessary. |
| 23867875 | 2013 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 25 UC cases with CRC and 25 UC controls Stage : - | real time methylation specific PCR, Wilcoxon rank-sum test | Methylation | - | CRC-associated field change has important implications to the use of mEYA4 as a potential UC surveillance marker in tissue or stool. |
| 25620232 | 2015 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : - Stage : - | Gene-enrichment and functional annotation analysis | Methylation | - | EYA4 methylation may be identified in stool samples and it serves as a potential stool biomarker for detection of advanced adenoma and CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Asp-based PTPs |
| Description | This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] | Chromosome | 6 |
| Location | 6q23 |
| Start | 133561512 |
| End | 133853258 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 291747 |
| OMIM ID | 603550 |
| HGNC ID | HGNC:3522 |
| Unigene ID | Hs.596680 |
| Ensembl ID | ENSG00000112319 |
| PharmGKB ID | PA27934 |
mRNA Information
| mRNA ID | XM_005266852.3 |
|---|---|
| Exon | join(1..415,33382..33479,141058..141107,205296..205420, 206777..206845,215222..215314,219780..219846, 221001..221143,221287..221430,223445..223524, 227232..227415,240129..240265,241698..241781, 264772..264861,271387..271445,271544..271704, 273987..274101,281722..281843,283681..283781, 284563..284626) | mRNA Sequence | Download Select all |
| Length | 2401 |
Protein Information
| Protein ID | XP_005266909.1 |
|---|---|
| Protein Name | EYA transcriptional coactivator and phosphatase 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 620 |
| Uniprot ID | P52564 |
| Ensembl Protein ID | ENSP00000467213 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 361 |
| S | Phosphorylation | 338 |
| S | Phosphorylation | 361 |
| S | Phosphorylation | 361 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6495 | SIX1 | 3125 | NP_005973.1 | in vivo;yeast 2-hybrid | 15492887 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR01658 | 368-639 | EYA-cons_domain |
| cl11769 | 368-639 | EYA-cons_domain superfamily |
| pfam12533 | 207-318 | Neuro_bHLH |
| cl13910 | 207-318 | Neuro_bHLH superfamily |
| pfam07223 | 131-342 | DUF1421 |
| pfam05109 | 36-321 | Herpes_BLLF1 |
| pfam09786 | 69-182 | CytochromB561_N |
Ontology Information
| HPRD ID | 7180 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Hormone activity (GO:0005179) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.