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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
EZH2 2146 Enhancer of zeste homolog 2 (Drosophila)  7WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; KMT6A  







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21926398   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 409

Stage : TNM Stage II,III

Genotyping, RT-PCR.Polymorhpism-rs3757441 C/C SNP associated with significantly higher EZH2 expression so EZH2 SNP may be useful to predict clinical outcome in mCRC patients.

19773751   2009Cell line : -

Source : Beijing People Hospital.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 119

Stage : TNM Stage I-IV

Tissue microarray, immunohistochemistryUp-regulation-Strong EZH2 expression and high proliferation are associated features.

EZH2 is a cell cycle regulator necessary for G2-M transition and is an E2F-regulated gene.

All data were collected at the Regional Research Office and then centralised to the office in Bergen, Norway.

20480530   2010Cell line : CACO2, DLD 1, SW 480, LOVO, SW 48, HT 29, RKO and HCT 116

Source : ATCC

Sample Type : CRC tumor and Normal tissue

No. of Sample : 72

Stage : -

 ImmunohistochemistryUp-regulation-Multivariate analysis revealed that EZH2 expression was an independent prognostic indicator of CRC.

EZH2 and STAT6 expressions have significant values in distinguishing clinical stages of CRC and predicting the prognosis of the patients.

Co-expression of EZH2 and STAT6 showed significantly higher levels in CRC cases of high clinical TNM stages.

20631058   2010Cell line : -

Source : Department of Surgery,Fatebenefratelli Hospital, Benevento, Italy,

Sample Type : -

No. of Sample : -

Stage : -

Immunoblotting, Immunohistochemistry, TMA analysis, RT-PCR, MS-PCR, Chromatin immunoprecepetation and MTT assay.Up-regulation-EZH2 mRNA is upregulated in CRC versus corresponding normal tissue, RUNX3 expression is reduced, raising the possibility of a causative relationship.

21151932   2011Cell line : -

Source : Taipei Veterans General Hospital for CRC.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 140

Stage : -

Western blotting, immunohistochemistry,methylation-specific-PCR, bisulphite sequencing and Chromatin immunoprecepetationUp-regulation-EZH2 high expression was directly related with C-D Duke's tumour stages.

152 patients diagnosed primary sporadic CRC obtained from Department of Surgery, Fatebenefratelli Hospital, Benevento, Italy.

22130667   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

 Chromatin immunoprecipitation Up-regulation-TCF12 is overexpressed in CRC and tightly correlated with cellular expression of Bmi1 and EZH2.

SW620 and LoVo and SW480 cells and CRC tissue sample obtained from Taipei Veterans General Hospital for CRC.

23001792   2012Cell line : -

Source : -

Sample Type : Blood samples

No. of Sample : 110

Stage : TNM Stage IV

-Up-regulation-Ezh2 is a transcriptional repressors of many differentiation-associated genes.


Gene Details



Chromosome: 7; NC_000007.13 (148504464..148581441, complement)

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Gene Type protein coding
Gene Family Chromatin-modifying enzymes / K-methyltransferases
Description This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]  
Chromosome 7
Location 7q35-q36
Start 148807372  
End 148884349  
Strand -  
Gene Sequence

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Length 76978  
OMIM ID 601573   
HGNC ID HGNC:3527   
Unigene ID Hs.444082    
Ensembl ID ENSG00000106462   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001203248.1
Exon join(1..186,37045..37168,37752..37853,51600..51716, 54502..54622,55470..55610,57084..57186,57718..57881, 64663..64754,66233..66473,66959..67128,67572..67666, 68804..68844,69311..69436,70213..70391,72630..72725, 73936..74017,74960..75040,75195..75279,76644..76978)  
mRNA Sequence

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Length 2681  



CDS Information


   
Location join(40..186,51600..51716,54502..54622,55470..55610, 57084..57186,57718..57896,64663..64754,66233..66473, 66959..67128,67572..67666,68804..68844,69311..69436, 70213..70391,72630..72725,73936..74017,74960..75040, 75195..75279,76644..76704)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_004447.2
Protein NameEnhancer of zeste homolog 2 (Drosophila)
Molecular Wt. (Da)85887
Protein Sequence

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Length 751  
Uniprot IDP35226
Ensembl Protein ID ENSP00000365851  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation492
TPhosphorylation448
SPhosphorylation21
SPhosphorylation21
TPhosphorylation492;-
TPhosphorylation448;-
TPhosphorylation344
TPhosphorylation300
SPhosphorylation371
TPhosphorylation372
SPhosphorylation327
TPhosphorylation328
SPhosphorylation385
SPhosphorylation341
SPhosphorylation734
SPhosphorylation690
SPhosphorylation413
SPhosphorylation417
TPhosphorylation421
SPhosphorylation369
SPhosphorylation373
TPhosphorylation377

Enzyme Information


   
EC2.1.1.43
Namehistone-lysine N-methyltransferase
protein methylase III
protein methylase 3
protein (lysine) methyltransferase
protein methyltransferase II
protein-lysine N-methyltransferase
histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase
S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
ClassTransferases; Transferring one-carbon groups; Methyltransferases
SysnameS-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase  
SubstrateS-adenosyl-L-methionine [CPD:C00019]; histone L-lysine  
ProductS-adenosyl-L-homocysteine [CPD:C00021]; histone N6-methyl-L-lysine  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
546ATRX2069NP_000480.2in vitro;yeast 2-hybrid9499421   
2975GTF3C17540NP_001511.2yeast 2-hybrid16169070   
3065HDAC13143NP_004955.2in vivo10581039   
5252PHF14195NP_077084.1yeast 2-hybrid11571280   
5303PIN42219NP_006214.2yeast 2-hybrid16169070   
5694PSMB62630NP_002789.1yeast 2-hybrid16169070   
6185RPN21609NP_002942.2yeast 2-hybrid16169070   
6611SMS2115NP_004586.2yeast 2-hybrid16169070   
7409VAV11284NP_005419.2in vitro;in vivo;yeast 2-hybrid864   941   810   780   782   
11007CCDC85B16101NP_006839.2yeast 2-hybrid16189514   
22981NINL11120NP_079452.3yeast 2-hybrid16169070   
23512SUZ126949NP_056170.2in vivo16224021   
23588KLHDC28824NP_055130.1yeast 2-hybrid16169070   
23649POLA210160NP_002680.2yeast 2-hybrid16169070   
55884WSB218305NP_061109.1yeast 2-hybrid16169070   
80349WDR6115236NP_079510.1yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
MicroRNAs in cancer hsa05206


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00317612-733  SET
cl02566612-733  SET superfamily
pfam00856623-726  SET
pfam1161639-68  EZH2_WD-Binding
cl1312239-68  EZH2_WD-Binding superfamily
COG2940517-726  SET


Ontology Information


   
HPRD ID1277
Molecular ClassTranscription regulatory protein
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO