CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
15138477	2004	Cell line : - Source : Aberdeen colorectal tumour bank Sample Type : - No. of Sample : - Stage : -	MALDI-TOF MS, 2-D Gel Electrophoresis and Immunohistochemistry	Down-regulation	-	loss of L-FABP (Liver FABP)occurs at the adenoma stage of colorectal tumour development and also indicates that L-FABP is a marker of colorectal cancer differentiation.
16969489	2006	Cell line : - Source : Asan Medical Center, Seoul, Korea Sample Type : - No. of Sample : 2 Stage : -	cDNA microarray analysis	Down-regulation	-	Result show sequential expression change in the normal-adenoma-carcinoma sequence in the colon.
22968445	2012	Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : -	Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.	Down-regulation	-	-
10518104	1999	Cell line : - Source : Niigata University Medical Hospital, Niigata, Japan. Sample Type : - No. of Sample : 68 Stage : -	Immunohistochemistry	Up-regulation	-	Liver fatty acid-binding protein (L-FABP) is reported as a biological marker for enterocytic differentiation. L-FABP expression is suitable for use as a new presurgical prognostic factor for patients undergoing hepatic surgery for colorectal cancer metastases.
15958538	2005	Cell line : - Source : - Sample Type : Blood samples No. of Sample : 74 mCRC and 50 normal donors Stage : TNM Stage IV	real time RT-PCT, Target preparation, microarray hybridization, and microarray	Up-regulation	-	AGR2, S100A14, S100A16, FABP1, and others were found useful for detection of CTCs in peripheral blood of advanced cancer patients. Identified novel CTC-associated genes such as AGR2, FABP1, S100A13, S100A14, S100A16, and others that can be used for CTC monitoring in peripheral blood.
20596680	2010	Cell line : - Source : - Sample Type : Blood samples No. of Sample : 8 CRC and 9 healthy control Stage : -	real time RT-PCR, cDNA digital gene expression displayer (DGED), serial analysis of gene expression (SAGE)	Up-regulation	-	They have selected 7 genes expressed in colon tissue but not in blood and were able to test 6 of them by RT-PCR in peripheral blood of CRC patients and healthy controls.

Gene Details

Chromosome: 2; NC_000002.11 (88422501..88427650, complement)
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Gene Type	protein coding
Gene Family	Fatty acid binding protein family
Description	This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
Chromosome	2
Location	2p11
Start	88122982
End	88128131
Strand	-
Gene Sequence	>gi\|568815596:c88128131-88122982 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly CTGACCTCTGGCCGCTATTCGAAGGGAAGGGAGCCCCCTATAAAACAGCCTACAGTGGACAGTCTGGTCG GCAGAGCCGCAGGTCAGTCGTGAAGAGGGAGCTCTATTGCCACCATGAGTTTCTCCGGCAAGTACCAACT GCAGAGCCAGGAAAACTTTGAAGCCTTCATGAAGGCAATCGGTGAGTGCTGGACTGAAAGGCAAAGCTGT GGGTCACATCAGTGAGGGTCTAGCTCTACCAGCAGTGGCTATTTAGGGTCCAAATGTTGAGATGGGGGGA GAGATTCAGGCTATATACACAAACTAGGGGGCATTTTACTGACTTCTGGAGTTATTTGCAGCAAGTCCTC ACTGCACAAGGCCACCCCATAGGCAAGTGGAAAGAGCACTGAACTAGGGTGTGGTCTGGATTGATGGCCA TGTCATTGGCACTTCGTTGTGTGATCCTATTCCTGCATTTATTCATTCTTCAAACAAACAGTGATTCAAG GCCAACCACACACTGAGCACTGTGCTGGATAGATACCAGGGAGACAGATGATAAAGGCAATAAGGCATTT TCTTATCAGGGAAGAGAAGAGAAGAAATAAAGGTAATAAGGCATTCCCTCAGGTGTATGGAGCGCTGACT GTGCCAGGCGACTGTGCTGACCATGGGATATGCAATACCCCATCTATTCCTTGCCAAAAAACTAAGCTGG GTACCATTATTTTCCCACTTTACAGTTAATGCAACTGAAGCCCAGAAAGGTTTAGTAATCACAAGCAAGG TCATGCAAGTAGGAAGTGTTTAAGTTAGGATTGGAAGCAGGCACTGGTTCTCAGAGACCCTGCTTTAACC CCTGTGCCTCCTAGGGTCATGTACAGGAGGATGTGGCTCACAGAGAGCATGGGGGGATGGCTCAGTGGAG GTAAAGAGAAGGCTCAGGCTGAGCTTTGGAAGACAGGTGTCTAGGGAACTGGGGGCAGGGAGCATGCTCC AGGCAGAGGGAGCCCTATAAGCAAAGGGTGTGGCATGGCAAGGGAGGGTGCCAAGAATGAGAAGGGTGCT GAAGACAGCAGGGGCAGGGAGAGAAGGACCTTCAGTGCTGCCAGAGAAGGATCTTCTGCAGGCAAGCCAT ACCACCTCTGTGTCTCTCATCTCTCCCTCATGCAACAGGACCCTCTGTGCTCACTGTCCACCCACAAAAT TTTTGTGAACCTCAATTTGTATAACAGCATAGACAAGTTCTGAAACTGGTAAAGCTCTATCCCAGGGCAA GGGATTGCTGGTATGTCTTCCTCCAGAGCCTTGACTGCAGAGGTGGACACAGGCTTGCCTGGCACAGTGC CGCTTTGTGTATGTTGGCCTGGCATGATTATCAGCAGCTCCCCTTTCACTTGCAGGAGGGACCTAGCTTG GAAGATCAACTCTCTGGTCACCAGGGGTATGGGGAATGAAATGCTCACACTCCAAGAGCAAAGTCATCAA AGGAGGAGGGAATGAGGAAGGAGAGTGAGCAAGAACCAGGGTGCTTACAAGAGGAACGGTTCTTCAGGCC AGAAGAGTGTCCTTTTTATAAATTGACTGGCAAGATAGCAGCAGGCCAGGCCAGGTCACTGTCCCTTCCT TTCTGAGGCCACAGCCGATGCTGCTGACAAGCCCCCAGTGAGTTTCTGTGGCCCCTTGGGAGACACAGTG CCCTTCTCTGTCCCTCCATGTCATGTCGTTTCTCTCACCTACCTACCACGGTCATGAAACTCCCACCTCT GCCCATATCTAAACCTCAGACGGTTTCCACCAGGTCTGCCGGAAGAGCTCATCCAGAAGGGGAAGGATAT CAAGGGGGTGTCGGAAATCGTGCAGAATGGGAAGCACTTCAAGTTCACCATCACCGCTGGGTCCAAAGTG ATCCAAAACGAATTCACGGTGGGGGAGGAATGTGAGCTGGAGACAATGACAGGGGAGAAAGTCAAGGTAG GAGGGCATCCCTTCTGCTGTCAGAACTTTCCTTGGAACCTGGCCCTGGGACCTCATTCCTCAAGGCTCAA ACCTCACAATTCCACCCACAGATACCATCTCTGAACCCACCTCCCATGTGGGAGAAGCAGAGAGACAAAG GCAGCTCTTAGGGAAGAATCTTATAGAGAAGCTGCTCTCCTCTTCCCAGGGACTGTCTGGGGGGTGTTCC AGCCCCTAAAGTCTGAGCTCTCCCATATGGAGGATATGGGAGAACCAGGCATACAGCAGGATTCTAAGTC TCAGGTTCTCCCAGGCCCAGTGCTCCTAGCACTAAGAGTCCTCTAAGCAGGGCCCAGGAGTGGGGCAAGT GGGAGTTTGTGAAAAACCCTTAACTGAGCCCAAAGTCAACTGGCCTTCACTGAACCTAGAGCTGGTGGTG ATAGGGAGAGACTTCTTGAAGGAGGTGCTAGCAATACCAGAATACCAGGGCCCCAGACAGGTGCTCAGAC CCTGCCTTCAGGGGTGGTCACAAAGTCTCTGGCTTCAGCCACCCCATCTGTAAAATAAGAACAGTCAACC TCCCTAGACTGAAGGCAGTGCAGGGCAGCATCACTTCTGCTGGGCACAACTCATGGTGTGCAATGACAGC TGGGGTGTGGGCTGTGTGAGTGGTTGGCAGATGGTGGCAGGGGGATCCTGGCAATGGGGGTGCCCGTCTC CTCCTCCCTCTGAAACACTCCATGCTCTAGCAGCCCTCTTCTCTCCTCCCCGTGGACAGCTCTGTTCATT GGGCTGGGCGTGTTTGCTTTTTATCTCTTCTGGTCACTCTTTATTTCTGCCTCTCCAATTAGAACATTAC AGGTCAGGATGATTTTAGGAGGATAATATTCTTGATGTGCTCATGGTCAAGGGATTTAACTATGGGCCTT TTCCAAATTTTCTTTTTGGAGGCAAAATGTTTAATGTTGCCCAGGGTCTTTGGCTCCCTGCTGGGTTCCT GTCATCTCTTCCAGGATGTATAAGGGCTTGGAAGGAGGCCACAATATGAAAAGTTAACGCTCTGGGAAGA ATAATACATACCTGGTTGGGCGGGTGGCTCATGCCTACAATCCCAGCACTTTGGGAGGCTGAAGTGAAAG GACTGTTTGAGCCTAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAGACCTCATCTCAATTAAAAAAAA AAAAAAAAGAAGAATACATACCAAAGCAAAATATGTATTCTCTACTGGTCAATATTTGAATTTTGCCACT ACCTCCCTCCATTAGCTTGGGAGAATTGAGATTTTACTTGATTTGATTTTAGCATTTGTATTTGGGGCCA CTTAGGTGTTCCATGCTCATTTCTAGATCACATGCCATGAATTAAAGTTCTGACAAAAGAAGTCGTGACA TTTTATTTAGTTCTTAAATGCACCTCACTTCTATTTGGAGCCAGAGAACTAGAGGCTTGGGATCATAGGA ACCAGAGCATTTTGGTTGTTATGAGCTGAGACCTGTGCAAAGGAAGCAACTTCATTAGCAAGGCTCTTGC CCCCCACCACCCCTTCCTCACAGGTCACCTCTCTGTTCCCTGCAGACAGTGGTTCAGTTGGAAGGTGACA ATAAACTGGTGACAACTTTCAAAAACATCAAGTCTGTGACCGAACTCAACGGCGACATAATCACCAATGT AAGTTGGTGGTGCTCTGAGCGTGTGGCTCCCAGTGCTTGAGGGGAGAGGGGAGGTGAAGCATGGGGAGCG GCTCACATACCCTAATGCCACCCCTCCACCCTCCAACCCCCAAACTTCTTTCCTGTGGTCAGTATCTGCC AGCACTTACTGAGGATCCATCATGTCCCAGGCAGTTTACACACATTATCACTAATCCTTTCTGCTCAGCG CAACCAACCAGCCACAGAGGCCTCCACCTGCCCTGCATGCCCAGGGTGCTTCATAAATGCCTTTGCCCAT TTAGCGTTTATAAAGAGAATCCCATTCATGGTCATATTATGGCAGCTTACAAGCCTGGCACAGTCCAGTT ATGCAGTCAGCCTTGGTGCCTGGCTGCCAGCCACATCCTGTACCCTATTTGGGGGTGAATGGTGCAGTGT TTCTCCTGCAGGTATGTCCCCCTGACTCTTCTTTGCCCCCAGAATATGCTTTAGGGAGTCACAGACAACA GAACACTGCCTCAGGGCGCTGTCATCACTCTATTCAAATGGAAAAATTCTTAAACTAGAGAGAGTGTGAG CATCAACCACCCAATGTGCAGTTTCCACCTCCGCCCCAGCACATTCCCAGGAGAGCAGGGGAGCAGGAGA TGAGCTATCCTGCAGTAAGTCCTGGCCAACGCCCTTTGATAGGTTCCATCTCACCTAATCCTCCTGTCTC CTTCGAGGGAGGCTGGATGAGGGATTCAATAGACAGGTTGACCTGTCCAAGTCATCAGCTAATAAATGTT AAATCCAGGGCTCAAACCCATCAAGCAGCAACTATTGCATTGCTGCTGAAACTGAGGGGCTCCTTTTCAC CCTGATGACATGGTATGTCATTCCAGCAGTCTTATTCAAGAGAACTGGCAGGGGTGGAGGAAACATCCTT AAAAACTCAAAAGCTGATGCATCCACTGTTTTTATATGCTTCACAGCTATAGGAGGACAATTATGCACTA CCCACTGCCTTCCAGGCTGTGTGCCTAGTTGTGTCCATGTACATGTATCCTTGGTGCTCAACATGTATTT GGTGCATAGTAGGTACTCAATGAAATTTTGAGAAATTAGATTGGGCTGGTTTGGATGGTCTTGCTATAAC AGTCATTGATGTAGAAAAGAATTCAGTCAAAGGCAGGAGGACTTTCCAGGTGAGGAGGAGAAGTGACAAA GACTTGGCATAGGATTTTGGAAAACATTGCCAACCTTTCCTCCGGTCCTACAGGAAACCAGACGAATTTT TGAATTGTTTCATATGCCAACATATTTGGTGCTGTTTTTTAAGCTTAATTTTGTTTTTTATGCTTAATTT TGTTTTTTACAATACAACATCAGATGAACACTTCATAATTTCTTTTCTGGCTTTCAGACCATGACATTGG GTGACATTGTCTTCAAGAGAATCAGCAAGAGAATTTAAACAAGTCTGCATTTCATATTATTTTAGTGTGT AAAATTAATGTAATAAAGTGAACTTTGTTTTAAAAAAAAA Download Select all
Length	5150
OMIM ID	134650
HGNC ID	HGNC:3555
Unigene ID	Hs.380135
Ensembl ID	ENSG00000163586
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001443.2
Exon	join(1..181,1784..1956,3546..3638,5028..5150)
mRNA Sequence	>2168 CTGACCTCTGGCCGCTATTCGAAGGGAAGGGAGCCCCCTATAAAACAGCCTACAGTGGACAGTC TGGTCGGCAGAGCCGCAGGTCAGTCGTGAAGAGGGAGCTCTATTGCCACCATGAGTTTCTCCGG CAAGTACCAACTGCAGAGCCAGGAAAACTTTGAAGCCTTCATGAAGGCAATCGGTCTGCCGGAA GAGCTCATCCAGAAGGGGAAGGATATCAAGGGGGTGTCGGAAATCGTGCAGAATGGGAAGCACT TCAAGTTCACCATCACCGCTGGGTCCAAAGTGATCCAAAACGAATTCACGGTGGGGGAGGAATG TGAGCTGGAGACAATGACAGGGGAGAAAGTCAAGACAGTGGTTCAGTTGGAAGGTGACAATAAA CTGGTGACAACTTTCAAAAACATCAAGTCTGTGACCGAACTCAACGGCGACATAATCACCAATA CCATGACATTGGGTGACATTGTCTTCAAGAGAATCAGCAAGAGAATTTAAACAAGTCTGCATTT CATATTATTTTAGTGTGTAAAATTAATGTAATAAAGTGAACTTTGTTTTAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	598

CDS Information

Location	join(115..181,1784..1956,3546..3638,5028..5078)
CDS Sequence	>gi\|325651826:115-498 Homo sapiens fatty acid binding protein 1, liver (FABP1), mRNA ATGAGTTTCTCCGGCAAGTACCAACTGCAGAGCCAGGAAAACTTTGAAGCCTTCATGAAGGCAATCGGTC TGCCGGAAGAGCTCATCCAGAAGGGGAAGGATATCAAGGGGGTGTCGGAAATCGTGCAGAATGGGAAGCA CTTCAAGTTCACCATCACCGCTGGGTCCAAAGTGATCCAAAACGAATTCACGGTGGGGGAGGAATGTGAG CTGGAGACAATGACAGGGGAGAAAGTCAAGACAGTGGTTCAGTTGGAAGGTGACAATAAACTGGTGACAA CTTTCAAAAACATCAAGTCTGTGACCGAACTCAACGGCGACATAATCACCAATACCATGACATTGGGTGA CATTGTCTTCAAGAGAATCAGCAAGAGAATTTAA Download Select all
CCDS ID	CCDS2001.1

Protein Information

Protein ID	NP_001434.1
Protein Name	Fatty acid binding protein 1, liver
Molecular Wt. (Da)	14077
Protein Sequence	>2168 MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFT VGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI Download Select all
Length	127
Uniprot ID	P12643
Ensembl Protein ID	ENSP00000368104

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	11
T	Phosphorylation	53

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Fat digestion and absorption	hsa04975
PPAR signaling pathway	hsa03320

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam14651	3-127	Lipocalin_7
cl21528	3-127	Lipocalin superfamily

Ontology Information

HPRD ID	206
Molecular Class	Transport/cargo protein
Molecular Function	Receptor binding (GO:0005102)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report