Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FANCB | 2187 | Fanconi anemia, complementation group B | X | FAB, FLJ34064, FAAP95 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24301060 | 2014 | Cell line : - Source : - Sample Type : Peripheral blood samples No. of Sample : - Stage : - | real time RT-PCR ,chromosomal analysis | Mutation | - | FANCD1/BRCA2 biallelic mutations and that the presence of such mutations should be considered in families with CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fanconi anemia, complementation groups |
| Description | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] | Chromosome | X |
| Location | Xp22.2 |
| Start | 14861529 |
| End | 14891184 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 29656 |
| OMIM ID | 300515 |
| HGNC ID | HGNC:3583 |
| Unigene ID | Hs.554740 |
| Ensembl ID | ENSG00000181544 |
| PharmGKB ID | PA27996 |
mRNA Information
| mRNA ID | XM_011545470.1 |
|---|---|
| Exon | join(1..332,4275..4395,7738..8758,13984..14136, 15364..15456,20151..20279,22644..22813,28032..28462, 28578..28815,29337..29658,76020..76136,76397..76548, 77018..77165) | mRNA Sequence | Download Select all |
| Length | 3427 |
Protein Information
| Protein ID | XP_011543772.1 |
|---|---|
| Protein Name | Fanconi anemia, complementation group B |
| Molecular Wt. (Da) | 105397 |
| Protein Sequence | Download Select all |
| Length | 929 |
| Uniprot ID | P35354 |
| Ensembl Protein ID | ENSP00000356438 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2152 | F3 | 603 | NP_001984.1 | in vitro | 116 018 481 130 780 000 000 000 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Fanconi anemia pathway | hsa03460 |
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 1347 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.