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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FANCD2 2177 Fanconi anemia, complementation group D2  3FAD, FA-D2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20339950   2010Cell line : -

Source : Kyushu University at Beppu.

Sample Type : CRC Tumor

No. of Sample : 133

Stage : TNM Stage I-IV

Penalized Canonical Correlation Analysis,LMD and cDNA microarraysUp-regulation-High FANCD2 expression was a significant independent factor for lymph node metastasis.


Gene Details



NC_000003.11 (10068113..10143614)

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Gene Type protein coding
Gene Family Fanconi anemia, complementation groups
Description The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]  
Chromosome 3
Location 3p25.3
Start 10068113  
End 10143614  
Strand +  
Gene Sequence

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Length 75502  
OMIM ID 613984   
HGNC ID HGNC:3585   
Unigene ID Hs.208388   
Ensembl ID ENSG00000144554   
PharmGKB ID PA27999   

mRNA Information


mRNA ID XM_006713023.2
Exon join(1..87,2239..2335,6446..6586,8083..8150,8309..8412, 8787..8847,9901..9953,12893..12971,13335..13459, 15237..15324,16173..16277,16664..16764,17098..17206, 17443..17478,20194..20337,21531..21665,22988..23119, 26001..26111,33908..34017,35765..35825,37406..37525, 37970..38043,38343..38489,39008..39108,39478..39593, 40823..40931,46485..46595,46867..46976,48144..48287, 51695..51811,54714..54842,54960..55078,59426..59536, 60748..60878,62063..62156,62442..62564,63906..63999, 65795..65866,67903..67977,68814..68888,69940..70086, 72334..72898)  
mRNA Sequence

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Length 4831  



CDS Information


   
Location121..4497
CDS Sequence

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CCDS ID CCDS2595.1



Protein Information


      
Protein IDXP_006713086.1
Protein NameFanconi anemia, complementation group D2
Molecular Wt. (Da)164856
Protein Sequence

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Length 1458  
Uniprot IDP35408
Ensembl Protein ID ENSP00000302846  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1412
KUbiquitination561
SPhosphorylation592
SPhosphorylation717
SPhosphorylation1412
KUbiquitination561
SPhosphorylation592
SPhosphorylation717
SPhosphorylation1257
SPhosphorylation222
SPhosphorylation1257
SPhosphorylation222
SPhosphorylation222
SPhosphorylation178;-
SPhosphorylation167;-
SPhosphorylation178;-
SPhosphorylation167;-
SPhosphorylation1418;-
SPhosphorylation1418;-
TPhosphorylation596;-
TPhosphorylation596;-
SPhosphorylation8
SPhosphorylation8
SPhosphorylation330
SPhosphorylation330
SPhosphorylation1435
SPhosphorylation594
SPhosphorylation594
TPhosphorylation691
TPhosphorylation691
SPhosphorylation1401
SPhosphorylation1401
SPhosphorylation720
SPhosphorylation720
SPhosphorylation1423
TPhosphorylation1426

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
672BRCA1218NP_009231.2in vivo11239454   
2176FANCC1967NP_000127.2in vivo11751423   
4683NBN4050NP_002476.2in vivo12447395   
5888RAD511557NP_597994.3in vivo12239151   
7398USP14593NP_003359.3in vivo15694335   


Pathway Information


      
Pathway Name Pathway ID
Fanconi anemia pathway hsa03460


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1172190-1403  FANCD2
cl1701890-1403  FANC superfamily
pfam146311-1424  FancD2
cd11719131-1280  FANC


Ontology Information


   
HPRD ID2599
Molecular ClassCell cycle control protein
Molecular FunctionPeroxidase activity (GO:0004601)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO