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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FBLN1 2192 fibulin 1  22FBLN 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25837757   2015Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : -

Stage : -

 Immunohistochemistry, real time RT-PCR,Methylation-specific PCR and bisulfite sequencing PCR Methylation- Promoter hypermethylation of FBLN1 is an important reason for its downregulation and is also a good predictor of OS for CRC.


Gene Details



NC_000022.10 (45898719..45997014)

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Gene Type protein coding
Gene Family Fibulins
Description Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]  
Chromosome 22
Location 22q13.31
Start 45898719  
End 45997014  
Strand +  
Gene Sequence

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Length 98296  
OMIM ID 135820   
HGNC ID HGNC:3600   
Unigene ID Hs.24601   
Ensembl ID ENSG00000077942   
PharmGKB ID PA28013   

mRNA Information


mRNA ID NM_006486.2
Exon join(1..226,15844..15949,22705..22840,25009..25171, 28427..28486,30225..30326,30923..31060,32362..32499, 38391..38534,39317..39445,40563..40688,44247..44366, 45775..45906,47654..47777,71673..71815,74139..74270, 97469..98296)  
mRNA Sequence

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Length 2947  



CDS Information


   
Location 148..2259
CDS Sequence

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CCDS ID CCDS14067.1



Protein Information


      
Protein ID NP_006477.2
Protein Namefibulin 1
Molecular Wt. (Da)0
Protein Sequence

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Length 703  
Uniprot IDP12272
Ensembl Protein ID ENSP00000201015  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation98
NGlycosylation98
NGlycosylation98
NGlycosylation98
SPhosphorylation147
SPhosphorylation147
SPhosphorylation147
SPhosphorylation147

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
351APP100NP_000475.1in vitro11238726   
1462VCAN340NP_004376.2in vitro10400671   
1839HBEGF526NP_001936.1yeast 2-hybrid11846885   
2006ELN556NP_000492.2in vitro10544250   
2244FGB620NP_005132.2in vitro;in vivo7642629   
2335FN1626NP_997647.1in vitro1400330   
3688ITGB1628NP_391987.1in vivo2527614   
4089SMAD42995NP_005350.1yeast 2-hybrid15231748   
4811NID1574NP_002499.2in vitro929   935   092   784   158   000   000   
8328GFI1B5088NP_004179.3yeast 2-hybrid16713569   
25843MOBKL310165NP_056202.2yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0001730-79  ANATO
cl0003230-79  ANATO superfamily
cd0001797-152  ANATO
cl0003297-152  ANATO superfamily
cd00054356-389  EGF_CA
cl21504356-389  EGF_CA superfamily
cd00054308-347  EGF_CA
cl21504308-347  EGF_CA superfamily
cd00054262-299  EGF_CA
cl21504262-299  EGF_CA superfamily
smart00179356-389  EGF_CA
pfam07645216-259  EGF_CA
cl21504216-259  EGF_CA superfamily
pfam12662504-528  cEGF
cl21504504-528  EGF_CA superfamily
pfam07645525-561  EGF_CA
cl21504525-561  EGF_CA superfamily
cd01475479-522  vWA_Matrilin
cl00057479-522  vWFA superfamily
smart0010436-69  ANATO
smart00179308-355  EGF_CA
pfam12662421-444  cEGF
cl21504421-444  EGF_CA superfamily
pfam07645308-354  EGF_CA
pfam0182136-69  ANATO
smart00179399-440  EGF_CA
pfam12662460-484  cEGF
cl21504460-484  EGF_CA superfamily
pfam07645262-298  EGF_CA
pfam07645356-397  EGF_CA
cd01475354-388  vWA_Matrilin
cl00057354-388  vWFA superfamily
smart00179262-298  EGF_CA
cd01475395-438  vWA_Matrilin
cl00057395-438  vWFA superfamily
smart00179481-524  EGF_CA
cd00054399-440  EGF_CA
cd01475214-258  vWA_Matrilin
cl00057214-258  vWFA superfamily
pfam14670485-523  FXa_inhibition
pfam14670411-439  FXa_inhibition
pfam14670184-214  FXa_inhibition
cl21504184-214  EGF_CA superfamily
pfam07645481-523  EGF_CA
smart00179216-253  EGF_CA


Ontology Information


   
HPRD ID2859
Molecular ClassExtracellular matrix protein
Molecular FunctionProtein-tyrosine kinase activity (GO:0004713)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO