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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22039417 | 2011 | Cell line : HT29, SW480, SW620, HCT116, LoVo and RKO Source : American Type Culture Collection (ATCC, Manassas, Va., USA). Human gastric, colon tumor tissues and normal adult colon tissues were provided by Chinese Medicine Hospital of Zhejiang. Sample Type : CRC tumor No. of Sample : - Stage : - | Real-Time RT-PCR,Methylation-Specific PCR,Bisulfite Genomic Sequencing,Colony Formation Assay. | Hypermethylation | - | Epigenetic inactivation of FBP1 is also common in human liver and colon cancer. FBP1 appears to be a functional tumor suppressor involved in the liver and colon carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008] | Chromosome | 9 |
| Location | 9q22.3 |
| Start | 97365415 |
| End | 97402531 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 37117 |
| OMIM ID | 611570 |
| HGNC ID | HGNC:3606 |
| Unigene ID | Hs.494496 |
| Ensembl ID | ENSG00000165140 |
| PharmGKB ID | PA28018 |
mRNA Information
| mRNA ID | NM_001127628.1 |
|---|---|
| Exon | join(1..206,916..1109,19759..19921,22390..22482, 30189..30329,33298..33435,34674..34793,36678..37117) | mRNA Sequence | Download Select all |
| Length | 1546 |
Protein Information
| Protein ID | NP_001121100.1 |
|---|---|
| Protein Name | fructose-1,6-bisphosphatase 1 |
| Molecular Wt. (Da) | 36711 |
| Protein Sequence | Download Select all |
| Length | 338 |
| Uniprot ID | Q03431 |
| Ensembl Protein ID | ENSP00000321999 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 87 | ACTN1 | 20 | NP_001123476.1 | in vivo | 12507293 |
| 3312 | HSPA8 | 7205 | NP_006588.1 | yeast 2-hybrid | 16169070 |
| 9513 | FXR2 | 5629 | NP_004851.2 | yeast 2-hybrid | 16189514 |
| 9551 | ATP5J2 | 16520 | NP_004880.1 | yeast 2-hybrid | 16169070 |
| 64430 | C14orf135 | 16604 | NP_071940.4 | yeast 2-hybrid | 16189514 |
| 84164 | ASCC2 | 16515 | NP_115580.2 | yeast 2-hybrid | 16169070 |
| 84708 | LNX1 | 17287 | NP_001119800.1 | yeast 2-hybrid | 16189514 |
| 138065 | RNF183 | 10082 | NP_659488.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AMPK signaling pathway | hsa04152 |
| Carbon metabolism | hsa01200 |
| Fructose and mannose metabolism | hsa00051 |
| Glucagon signaling pathway | hsa04922 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| Insulin signaling pathway | hsa04910 |
| Metabolic pathways | hsa01100 |
| Pentose phosphate pathway | hsa00030 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00354 | 18-332 | FBPase |
| cl00289 | 18-332 | FIG superfamily |
| pfam00316 | 12-335 | FBPase |
| PLN02262 | 9-332 | PLN02262 |
| PRK09293 | 13-335 | PRK09293 |
| COG0158 | 13-335 | Fbp |
| PLN02542 | 10-325 | PLN02542 |
| PLN02628 | 8-327 | PLN02628 |
| PLN02462 | 30-328 | PLN02462 |
| cd01636 | 35-299 | FIG |
| cd01637 | 35-320 | IMPase_like |
| PRK12676 | 45-126 | PRK12676 |
| pfam00459 | 30-126 | Inositol_P |
| cd01642 | 34-147 | Arch_FBPase_2 |
| cd01515 | 68-126 | Arch_FBPase_1 |
| COG0483 | 48-126 | SuhB |
| PRK14076 | 68-126 | pnk |
Ontology Information
| HPRD ID | 3534 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09467 | DB00131 | Adenosine monophosphate | SmallMoleculeDrug |