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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FBXW7 | 55294 | F-box and WD repeat domain containing 7 | 4 | AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19739118 | 2010 | Cell line : - Source : Kyushu University at Beppu and affiliated hospitals. Sample Type : CRC tumor No. of Sample : 93 Stage : - | real time RT-PCR,Immunohistochemistry,cDNA microarray,Array CGH | Down-regulation | - | Genetic alterations in tumors led to the loss of FBXW7 expression and increased cell proliferation. FBXW7 expression provides a prognostic factor for patients with CRC. |
| 26097998 | 2015 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Two-dimensional protein electrophoresis and mass spectrometry assays (2DE-MS),western blotting and immunohistochemical assays. | Down-regulation | - | ENO1 is a novel substrate of FBXW7, and its activity can be negatively regulated by FBXW7 at the posttranslational level. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | WD repeat domain containing |
| Description | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] | Chromosome | 4 |
| Location | 4q31.3 |
| Start | 153242410 |
| End | 153456393 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 213984 |
| OMIM ID | 606278 |
| HGNC ID | HGNC:16712 |
| Unigene ID | Hs.561245 |
| Ensembl ID | ENSG00000109670 |
| PharmGKB ID | PA28054 |
Protein Information
| Protein ID | NP_001013433.1 |
|---|---|
| Protein Name | F-box and WD repeat domain containing 7 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 707 |
| Uniprot ID | Q9NPA2 |
| Ensembl Protein ID | ENSP00000337816 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 26;- |
| S | Phosphorylation | 10;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 898 | CCNE1 | 455 | NP_001229.1 | in vitro;in vivo | 115 650 331 153 344 000 000 000 |
| 3725 | JUN | 1302 | NP_002219.1 | in vitro;in vivo | 16023596 |
| 4609 | MYC | 1818 | NP_002458.2 | in vivo | 1 602 359 617 157 250 |
| 4851 | NOTCH1 | 1827 | NP_060087.3 | in vitro;in vivo | 1 158 592 111 425 850 |
| 4855 | NOTCH4 | 1290 | NP_004548.3 | in vivo | 11585921 |
| 5071 | PARK2 | 3967 | NP_004553.2 | in vitro;in vivo | 12628165 |
| 5663 | PSEN1 | 87 | NP_000012.1 | in vivo | 12354302 |
| 6500 | SKP1 | 3255 | NP_733779.1 | in vitro | 11585921 |
| 8454 | CUL1 | 4389 | NP_003583.2 | in vitro | 14603323 |
| 28996 | HIPK2 | 6039 | NP_073577.3 | in vivo | 18765672 |
| 84894 | LINGO1 | 14322 | NP_116197.4 | yeast 2-hybrid | 16169070 |
| 144347 | FAM101A | 14066 | NP_859060.3 | yeast 2-hybrid | 16169070 |
| 253714 | C6orf167 | 12865 | NP_940870.2 | yeast 2-hybrid | 16169070 |
| 257218 | SHPRH | 10476 | NP_001036148.1 | yeast 2-hybrid | 16169070 |
| 340390 | KIAA1875 | 11168 | NP_115918.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00200 | 374-650 | WD40 |
| cl02567 | 374-650 | WD40 superfamily |
| cd00200 | 453-692 | WD40 |
| cd00200 | 365-447 | WD40 |
| pfam12937 | 281-325 | F-box-like |
| cl02535 | 281-325 | F-box superfamily |
| pfam00646 | 279-326 | F-box |
| pfam00400 | 531-567 | WD40 |
| smart00320 | 610-650 | WD40 |
| smart00320 | 530-567 | WD40 |
| pfam00400 | 451-487 | WD40 |
| pfam00400 | 611-650 | WD40 |
| smart00320 | 450-487 | WD40 |
| smart00256 | 284-324 | FBOX |
| smart00320 | 490-527 | WD40 |
| pfam00400 | 491-527 | WD40 |
| smart00320 | 410-447 | WD40 |
| pfam00400 | 374-407 | WD40 |
| pfam00400 | 411-447 | WD40 |
| smart00320 | 374-407 | WD40 |
| smart00320 | 570-607 | WD40 |
| pfam00400 | 571-607 | WD40 |
| COG2319 | 369-692 | WD40 |
| COG2319 | 367-692 | WD40 |
| COG2319 | 365-610 | WD40 |
| COG2319 | 431-692 | WD40 |
| PLN00181 | 392-561 | PLN00181 |
| PLN00181 | 509-651 | PLN00181 |
| COG2319 | 365-454 | WD40 |
| PTZ00421 | 499-652 | PTZ00421 |
| PTZ00421 | 473-657 | PTZ00421 |
| PLN00181 | 537-662 | PLN00181 |
| PTZ00421 | 372-527 | PTZ00421 |
Ontology Information
| HPRD ID | 13019 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell-cell adhesion (GO:0016337) |
Drug Information
No matching records could be found.