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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20812987 | 2010 | Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : - No. of Sample : - Stage : - | 2D Gel electrophoresis, and mass spectrometry,Western blotting, Immunohistochemistry | Up-regulation | - | This gene differentially expressed in between normal colorectal tissue and colorectal cancer tissue experiment done by 2-D Gel eclectrophotesis In total, 150 patients were involved in the study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q28 |
| Start | 154562980 |
| End | 154572763 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9784 |
| OMIM ID | 134830 |
| HGNC ID | HGNC:3662 |
| Unigene ID | Hs.300774 |
| Ensembl ID | ENSG00000171564 |
| PharmGKB ID | PA163 |
mRNA Information
| mRNA ID | NM_005141.4 |
|---|---|
| Exon | join(1..153,2829..3020,3510..3693,4614..4841,5402..5515, 6203..6328,6535..6820,7440..9784) | mRNA Sequence | Download Select all |
| Length | 3628 |
CDS Information
| Location | join(40..153,2829..3020,3510..3693,4614..4841,5402..5515, 6203..6328,6535..6820,7440..7671) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS3786.1 |
Protein Information
| Protein ID | NP_001171670.1 |
|---|---|
| Protein Name | Fibrinogen beta chain |
| Molecular Wt. (Da) | 44790 |
| Protein Sequence | Download Select all |
| Length | 432 |
| Uniprot ID | P22004 |
| Ensembl Protein ID | ENSP00000283147 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 394 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 811 | CALR | 169 | NP_004334.1 | in vivo | 7592883 |
| 2243 | FGA | 619 | NP_000499.1 | in vitro | 12356313 |
| 4811 | NID1 | 574 | NP_002499.2 | in vivo | 1680863 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades | hsa04610 |
| Platelet activation | hsa04611 |
Structure Information
| PDB ID | 1FZA |
|---|---|
| Resolution | 2.9 |
| Method | X-RAY DIFFRACTION |
| Chains | A,D |
| Molecule | FIBRINOGEN |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 238-487 | FReD |
| cl00085 | 238-487 | FReD superfamily |
| pfam00147 | 237-487 | Fibrinogen_C |
| smart00186 | 237-487 | FBG |
| pfam08702 | 90-235 | Fib_alpha |
| cl12358 | 90-235 | Fib_alpha superfamily |
| TIGR04523 | 112-221 | Mplasa_alph_rch |
Ontology Information
| HPRD ID | 211 |
|---|---|
| Molecular Class | Coagulation factor |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02675 | DB00364 | Sucralfate | SmallMoleculeDrug |