Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22552777 | 2012 | Cell line : - Source : - Sample Type : CRC Tumor and adjecentnormal tissue No. of Sample : 3 Stage : - | MIRA-based microarrays | Hypermethylation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | Chromosome | 3 |
| Location | 3q28 |
| Start | 191857033 |
| End | 192445388 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 588356 |
| OMIM ID | 601513 |
| HGNC ID | HGNC:3668 |
| Unigene ID | Hs.390250 |
| Ensembl ID | ENSG00000114279 |
| PharmGKB ID | PA28108 |
mRNA Information
| mRNA ID | XM_005247227.1 |
|---|---|
| Exon | join(212711..212933,367062..367172,392136..392239, 556944..557142,583473..588356) | mRNA Sequence | Download Select all |
| Length | 5521 |
Protein Information
| Protein ID | XP_005247284.1 |
|---|---|
| Protein Name | fibroblast growth factor 12 |
| Molecular Wt. (Da) | 23118 |
| Protein Sequence | Download Select all |
| Length | 207 |
| Uniprot ID | Q13332 |
| Ensembl Protein ID | ENSP00000269907 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 76-202 | FGF |
| cl00060 | 76-202 | FGF superfamily |
| pfam00167 | 73-198 | FGF |
| smart00442 | 71-201 | FGF |
Ontology Information
| HPRD ID | 1481 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.