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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 7784081 | 1995 | Cell line : SW613 S Source : - Sample Type : - No. of Sample : - Stage : - | Nuclear run-on analyses. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11q13 |
| Start | 69624736 |
| End | 69634192 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9457 |
| OMIM ID | 164950 |
| HGNC ID | HGNC:3681 |
| Unigene ID | Hs.37092 |
| Ensembl ID | ENSG00000186895 |
| PharmGKB ID | PA28120 |
mRNA Information
| mRNA ID | NM_005247.2 |
|---|---|
| Exon | join(1..711,3002..3105,8725..9457) | mRNA Sequence | Download Select all |
| Length | 1548 |
Protein Information
| Protein ID | NP_005238.1 |
|---|---|
| Protein Name | fibroblast growth factor 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 239 |
| Uniprot ID | P10586 |
| Ensembl Protein ID | ENSP00000353030 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2263 | FGFR2 | 1492 | NP_075261.1 | in vitro | 8663044 |
| 6187 | RPS2 | 4690 | NP_002943.2 | in vivo;yeast 2-hybrid | 16263090 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 46-181 | FGF |
| cl00060 | 46-181 | FGF superfamily |
| smart00442 | 44-181 | FGF |
| pfam00167 | 44-179 | FGF |
Ontology Information
| HPRD ID | 3942 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.