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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24485021 | 2014 | Cell line : HCT116, HT29, SW480, LIM1215 . Source : Bioserve Biotechnologies Sample Type : CRC Tumor No. of Sample : Non-neoplastic (59), adenoma (13), adenocarcinoma 95 comprising 24 Dukes A, 18 Dukes B 45 Dukes C and 8 Dukes D), Stage : Duke Stage A,B,C,D | Gene expression arrays, methylation specific PCR, Multiplex bisulfite sequencing | Methylation | - | (BCAT1, COL4A2, DLX5, FGF5, FOXF1, FOXI2, GRASP, IKZF1, IRF4, SDC2 and SOX21) have very low methylation in peripheral blood DNA and are suitable for further evaluation as blood-based diagnostic markers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | Chromosome | 4 |
| Location | 4q21 |
| Start | 81187742 |
| End | 81212171 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 24430 |
| OMIM ID | 165190 |
| HGNC ID | HGNC:3683 |
| Unigene ID | Hs.37055 |
| Ensembl ID | ENSG00000138675 |
| PharmGKB ID | PA28122 |
mRNA Information
| mRNA ID | NM_004464.3 |
|---|---|
| Exon | join(1..592,8322..8425,19738..24430) | mRNA Sequence | Download Select all |
| Length | 5399 |
Protein Information
| Protein ID | NP_004455.2 |
|---|---|
| Protein Name | fibroblast growth factor 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 268 |
| Uniprot ID | P23470 |
| Ensembl Protein ID | ENSP00000295874 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 110 |
| N | Glycosylation | 110 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2260 | FGFR1 | 634 | NP_000595.1 | in vivo | 8386828 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 91-219 | FGF |
| cl00060 | 91-219 | FGF superfamily |
| smart00442 | 85-218 | FGF |
| pfam00167 | 87-216 | FGF |
| COG5260 | 116-171 | TRF4 |
Ontology Information
| HPRD ID | 1479 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.