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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18165946 | 2008 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Six distinct FGF9 mutations including one frameshift, four missense, and one nonsense, in 10 (six colorectal and four endometrial) out of 203 tumors and cell lines. |
| 24334956 | 2014 | Cell line : HEK293 Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, ELISA, Immunohistochemistry | Up-regulation | - | FGF9 IRES functions as a cellular switch to turn FGF9 protein synthesis 'on' during hypoxia, a likely mechanism underlying FGF9 overexpression in cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008] | Chromosome | 13 |
| Location | 13q11-q12 |
| Start | 22245215 |
| End | 22278640 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33426 |
| OMIM ID | 600921 |
| HGNC ID | HGNC:3687 |
| Unigene ID | Hs.111 |
| Ensembl ID | ENSG00000102678 |
| PharmGKB ID | PA28126 |
mRNA Information
| mRNA ID | NM_002010.2 |
|---|---|
| Exon | join(1..1114,9967..10070,30115..33426) | mRNA Sequence | Download Select all |
| Length | 4545 |
Protein Information
| Protein ID | NP_002001.1 |
|---|---|
| Protein Name | fibroblast growth factor 9 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 208 |
| Uniprot ID | Q16827 |
| Ensembl Protein ID | ENSP00000281171 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 79 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2261 | FGFR3 | 624 | NP_000133.1 | in vitro;in vivo | 105 749 498 576 175 |
| 2263 | FGFR2 | 1492 | NP_075261.1 | in vivo | 8576175 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 64-191 | FGF |
| cl00060 | 64-191 | FGF superfamily |
| smart00442 | 60-190 | FGF |
| pfam00167 | 62-188 | FGF |
Ontology Information
| HPRD ID | 4169 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.