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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24135816	2013	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 515 Stage : TNM Stage I-III	FISH, Western blotting and immunohistochemistry	Unknown	-	FGFR1 is a potential therapeutic target in a subset of CRC

Gene Details

Chromosome 8 - NC_000008.11 (38411138..38468834, complement)
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Gene Type	protein coding
Gene Family	CD molecules, "Immunoglobulin superfamily / I-set domain containing"
Description	protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Chromosome	8
Location	8p11.23-p1
Start	38411138
End	38468834
Strand	-
Gene Sequence	>gi|568815590:c38468834-38411138 Homo sapiens chromosome 8, GRCh38.p2 Primary Assembly AGATGCAGGGGCGCAAACGCCAAAGGAGACCAGGCTGTAGGAAGAGAAGGGCAGAGCGCCGGACAGCTCG GCCCGCTCCCCGTCCTTTGGGGCCGCGGCTGGGGAACTACAAGGCCCAGCAGGCAGCTGCAGGGGGCGGA GGCGGAGGAGGGACCAGCGCGGGTGGGAGTGAGAGAGCGAGCCCTCGCGCCCCGCCGGCGCATAGCGCTC GGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGGCAGCTAGCGGGAGCCGGGACGCCG GTGCAGCCGCAGCGCGCGGAGGAACCCGGGTGTGCCGGGAGCTGGGCGGCCACGTCCGGACGGGACCGAG ACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTCCCCGGCCGCGAGCGCGCCGCTGCTTGAAAAGCCGCG GAACCCAAGGACTTTTCTCCGGTCCGAGCTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGTC GGGCACGCCGCGGCGCCGGGGCCTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCC GCTGCGTTCTGGAGGAGGGGGGCACAAGGTCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCC CCGCCTCCGGGGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGCACCGAGCGCCG CCGGGAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGGCG GGCCGGAGCCGGGGACGCGGGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGGCGGAACCT CCACGCCGAGCGAGGTAAGAGCCGCGGCGCCCCCGGATCTGGGGCGGGCTTGGCGTCCCGAGCGGCCCCC GGCGCCGGAGCCTCCCGGCTGCGCGCTTTGCCCGCCGCAGCCCAGCCGGGGCCGGCGCCTCCCTCCGCTC GCCGCCCGCCCCTTTCACCTCCTGGCTCCCTCCCGGGCGATCCGCGCCCCTTGGGTCTCCCCTCCCTTCC CTCCGTCCGCGTCTCCTGCGCCCCCTCCCTGCGCTCGTCCCGCCGCTCTTCCCGCCGCCCAACTTTTCCT CCAACTCGCGCTCGGGAGCTGGCGAGGCGGCGGCGGCTCCTCAGTGAGTCCCGGGAGGGACAGGCCCGGG GCGAAGGCGGCGAGGCCCGCGGTTTCCTGGACTGGGGAGGAGGGCGGGAGTGGGCGGCGAGGTGGGATGC GTTGTGTGTGTTATGTGTGTGTGTTGCATTCCACTCCATGTCTTTTTGGTCCCCTTTTGGGGATTCACCC CCAATTCAGCAGGTAGCTTTGGGCTCAACGCTAAAAATCCGGGGCATTCCTAAGTCCTTTTCCACCCCCG GGAAAGCCTGGGGTGCGGGTTGGGGTCGGATGGGGTGGGAGATGAACTGCGGAGGACGTGGAGGGCTAGG TTAGCTTCTCTTGGAATAGGTTTTAAGGAGGTGTCGTCACCAAATGGCTGAATCTGCTTGAGCTGAGAGC GAAAAACGACTCCCCTTTCCAGAAGGGGTGATCTTATGACTTGGACGGTCTCTGAAAGGGTCGGAAGTTT GGGGAACGGGAGGACAACCCACGGTCGTTAAGCCGAGGTGTGGGATGGGGGCGGAAGGACCGTTCGGTCC CAATCTGGTTCCTAGAGGTGGGGGAAGGGATGAGGGTTTTTGTCCGGTGTGGTTCACTCGGCAGCGATGC GTATGCTTCTCTGGCCCAGACCCCTCTGCACCTCGCTTCCCCTACCGTTATGTTTGGGGTTGGGAGAAAA GTGAGGCTACGACCCATGTTTGCGGAGGAATTTTATGGACCTTGTAGATGGGGGTTCATATAGAACACAC ACCCCCTATGAGGCAGCCAGACACTTTTTTGGTGGTGGTGGGGGGGGGGTGGGGTGTGAAGCCTGTTTCT TGTTCTGAGCCCAGAAGCTATCAACCCTTTTGAAAAACATTACCACGGTGCCTTTCTCCCCCAGCACTCC CCCACCCCCAATTTCCAGATGTAGCAGCCGCATCTGGTTCCGTTTCACCCCACACGGGTACACCGCAGCC GCATTATTAACTTCCCTCTTCCTCCCCTCCCCCTCCCCCAAATTAAAACTCAGATTCTTCAGCCTGTCTT GACCACCTCCCTCCTTAACATTTCTGGAGACTTGGAGATGCGGCGTTGAGATTCGGGGGAGAAAAGAAAG TTCCCTTGGATCCCGAGTTATTTAAGATCTCACCAAGTTATTCGCCGCCGCTGGTGGGTGGCGGCGGTCC GGGTGCTTTCTGGATTGCGCAGTAAAGAGGCATCTTGGGAGATGGGGCCAAGGTTTTAGGGGGTGCCACT CGCGAACGGTTCATCCGCTAGACTAGGGGGGCTCTTTGGCTGTGCGTCTGGCCAGAACTGGCCTTGACGA TGGAAGTTTCTGGAACCAAAGCGTTGCTTTCTCTCCCTTGTGTTATAGCTGGAGCTGCGGGAGCGCCTGC CCTGCCCGGAGCCCGCGGTCCCCTCTCGGCTGCCCCGCGGTGGCGTCACGCGCCCCTCCCGGAGCAAGCC CGGTGCGCAGGGCCGGGGGCGTGGGCGGCTGCTGCCAGAGGCGCTCTCTGTGTGTTTTTAAGGACTGATT TGGGCCGCATCCCCCGGAAACTAAAGTGGGGTGTTTTACCGTTTAAATAACGGCTACAGGTTTGAAAGCG GGGTTGGATTTTCGAGTTGTGTTTGGTAATAGTCTTTGAGGCAGGAAAGCGCCTTGTGGTCCAAAGTTGC CGGGAGGGTGGGGAGAGTCGGTGTCTTACCCGCTTCTTTCCAGCCTCTTTCAAATTGAAAACACTTCTCT GGTTTCCTTCTTTGGGCGGTAGTTTTGGAGGCTGTAATGAAATCGCACTTTCTCTAGACGTGGTAATTAA GGTGACTGTTTCCTCCGCAGATGTGCCCTACCCTTTGCACCTCCGGACCAGCGCTTTTTTTGGAATACTA TCTAGCCTTGAGACTGTTTAGCAGAAAGTGGCCATTTTCCTCCCTTGGCCCGGGCTCCCGGTTTCCTCCC TGAGGCTTGTTTAAAAGCGAAGTAGCAGGGCCCCGTGGGACGCGCCTTGGTCTGGGTAATCACCCCCACG CCCGGGTCATCCACCTTCCTCTCGGTGACCGAGGTTCAGCAGCCTCTGCTATTGCCGGCCGTCTTTGCCG ATGGCCTGCCTCCCTAATGACTTGTTTACATATCCTACCCCCAGTGGGTTAGGAGAAGCTCCGGGGCTGC CCCGACCCTCCGAGTGCAGGGTGTTTGGGGACCGGGAGGCTGCTGGGGCCTGACTCCAGCTGGGAGGGTT ATGAACTGCATCAGTGACGAGCTGCTTGAAATATCTGTTGCATTTACTCTTAGTCATAGCTGAGTGTCAG CTTTTTAATGAGGTTCATCCAGATTGAGAGCCACTTGGACTGCGTACTTCACTGCCTGCTTTTCCAAACA TGCCTGCAGAAATGCTCATTTTCGAGGTATTTTTCCCAATGGGAATTCAGGCCAGAGTGGGCACCACTTG AACAATCTTAGGGTGCTTCTTTTCCTTGGCCTCTGGCCATGGAGGGTGTTAGACAGTTCCATTAGGTGGC CCTTTGATAGCAAGGGAAGCAAAGGCTCAGGAAGAAATGGAGAAGCGTCCCCCACTCCCTAGGGGCAGAG GATTAGATACATCGGTGCATCCCTCAGGCTGGGCTAGCTTTATTCCTGGTGGACTCCAGAGGGCAAGAAA ATTGAATTGAACACTGGGTAGGCAGATTCAAGCCTTAGAGACCAAGGAAAATCCATGGGTTTTGCTTTTA GTGGTGTGCTCTTTGTTTTCAGTATTGACCTGAAACAAGACTCCTAAAATGAGAGATTTGCTGGTATGAA CTTGGGGGTTTAGCAGCCGGCTTCTACAAAGGCTTTTTTCTTGCCTTCGTTTCTAAAGTGTCTTTCGTCA AAATGGCTGTTAGTTATAGAACATCCTAGCAAAGTTTGAGCCTGTTGCTGCTGGAGGAAAAGGAGTTAGA ATTGATTCAAATGTCTTATTCTGAAAGGGCCTCACATCACTTGATAGTTTAATTTCCTCCTGGGAAATTT GTGTCTTACATTTGTCTTCCCCAGAGCTTTGTAAAAGGCCTGAACGCACCAGGGACTAGTGGGAGCCCAG ATGCAGAGCTTTAGAGAAGATTCTGGTGTTTCCAGAGAGGATGAAATGTCAGACTTGGGCTAGGATATTT GTTTTTCCTCCTAAGGTTGCATCTACTTTAAACAGAAATTCTCTCCTCGCCACCATTTATCTCTCCCCTG CAATGAAAGAAACCATGTTTAGGGCCCTCTCCCCCATTTAATAGCCCTCACATGGATGAACTATCCCAAG AATTTGGTGGGGTTCCACTCATAGTACATCCTGTCTTCAAGAGCAAGGTTTTCTAGATTATGTGCAGCAG TTCGTGTTTCACTTGTTGCTTTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTCGCTCTGTCGCCCAGGCT GGAGTGCTGTGGCGCTATCTCAGGTCACTGCAACCTCCGCCTTCCGGTTGAAGCGATTCTCCTGCCCCAG CCTCCCTAGTAGCTGGGATTGCAAGCATGCGCCACCATGTCCGGCTAATTTTTTGTGTTTTTAATAGAGA TGGTGTTTCACCATGTTGGCCAGGCTGGGCTTGAACTCCTGACCTCAAGCAATCCGCTGGCCTCGGCCTC CCAAAATGCTGGGATTACAGGTGTGAGCCATTGTGCCTGACCACTTATTGCTAATTTTTTATATGTCTCT TACTTCCAAGGACATTTAGACACTTTTTTTTTTTAAAGAGACTCAAAAAATTAGCATTTCCATTGGACCA ACTAAAATTTAGCAAGCTGAGCTGAGTAACTTTCTCCATATGTTTATTAAGTACTTGCCCCCTGCCCTCT CAACATGTGAGTAGAGAATGGTCACTTTGGGGAAGAAATAAGTCTTATTCTCATCTGAAGGGATTAATGT TTTGGTGTTACTTCCTCAATTCTGAAGAACCAAGTTGTCCAGAAATTTTCTCAGGGTTCTTTGGACTAGA GTTTGGCTGGTTAACAAGGGGTACTACCTAATTGCTTTTCTCTGATATTCTCAGCCTCTTTTTCTGGAGG AGTATCTCTGTCAGTTTCTTTTCATCAGCCCTTTTTTTTCCTTCATTCACTTACTCATTCATCCAGTTAA CAAACATGTTGGCATCTCCTGTGTACATGCTAGGTGCCGAGGGTGTTAGCAAAGGTTAGGGAGGCACAGA CCCTGTTCTGAAGGAGCCTGCAGTTTCGTGGGGAGAGAAGAGAATGAAGAACATAAATAACAATCATATA ATATGACCTAAGTGCTATGTGAGAGGGGCTAGTAATGTGGTTTGCAAATTTGGAGGAATGAAATTCTCCA GCTAGAAGGCCCAAGAAAGTCTTATGGAAGAAACAGCTTCTTAAGGTGGGGTTCAGAGAAAAGGGAAGGG CTGGCCTGTTGCAGAACAAGGAATGGCATGAAGAAAGTCTTGCACAGAGGCATGGATGTTGCTTCGAGCT GTGGCGCCCTATAGAAATAGAACATGAGCAGCTGGTCACAGTGGCTCATGCCTGTAATCCCAGCACTTTG GGAGGCCAAGGCAGGCGGATTGCTTGAGCCCATGAGATGGAGATGAGCCTGGACAACATGGTGAGACCCT GTGTCTACCAAAAAATACACAAATTAGATGAGTATGCTCGTGCTTACTGGTAGTCCCGGCTATTCAGGAG GCTGAGGTGGGAGGATCACTTGAGCCTAGGAGGCAGAGGCTGCAATAAGCTGTGATTGCACCACTGCATT CCAGCCTGGGGGACAGAGGAAGACCCTGTTTAAAAAAAAAAAAAAAAAAAAAGCCAGGCACAGTGGCTCA TGCCTGTAATCCCAGCCCTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGC CTGGCCAACATGGTGAAACCCTATTTCTACTAAAAATAAAAAAATTAGCCGGGCTTGGTGGCTCATGTCT GTAATCCCAGCTACTTGGGAGGCAGGAGAATCGTTTGAACCCGGGAGGCGGTGGTTGAGCCAAGATTGCG CCACTGCAACTCCAGCCTGAGTGACAGAGCAAGACTCCATCTCAAAGAAAAAAAGAAAGGAAGAAAGAAA TATAACATTATAACATGAGTTATGTATATGTTCAGATTTTCTAGAAGCCACATTGGAAATTAAGTTAAAA GAAAGAAATAGGTAAAAAAAATTTTTTTTTTTGAGACGGAGTCTCACTTTGTTGCCAGGCTGGAGTGCAG TGGCGCAATCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGA GTAGCTGGGACTACAGGCGCGCGCCACTGCACGCAGCTAATTTTTGTACTTTTAGTAGAGACGGGGTTTC ACCATGTTGGCCAGGATGGTGTCGACCTCTTGACCTCGTGATTTGCCCACCTCAGCCTCCCAAAGTGCTG GGATTACAGGCGTGAGCCACCGCGCCTGGCCAATATTTGTTTTTTAATTAACTTGTTTGTTTAGATTTTA TTTAATGTAACTATATTTCCAAAATATTATCATTTGAACATGTAATCAATATAGAAATTATTGATGAGAT ACTTTACATTTTTTTCATAACAAGTTTTTAAGATGCGGTGTATACTTTTTACTTATAGCATATCCGTTAG CACCAGCCACATTTCAAGTGTGCAGTGGCCACTGTGTGGGCCACAGGTCTAGAATATAAGACATGAAGAT GGAGAGTGAGAAATGCCTTTGGAAAGGTTGGAAGTTCCTGTCCTTCTGCTGCCAATTACCAAATCTCCTG AGAGTGCTATTAAGGAGTGACTCAAAGCACTACACAAAGAGAATTATAAATATCTTAATATTATATCTGA AATCCAAATGCATAATTCTTTACATTTGGTTGGTACTTTAGAGAGGAGAGAATGGGCACAGTCACCCACA CCACCCATTTGAGCCTCATAATCACCTGTGATGTGGCTTCCTCTAGGTGGGAAACCGAGGCTTAGAACGG TTAAGTGACTATCCCAGGGTGGCAAGATCATAAGTGGAAGGGTGTGAATTCATACTGTCTCCAGCGGACA AGAATAAAAAGACCCAGGCTGGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCACTGTA GGTGGATCTCCTGAGCCCAGGAGTTCATTACCAGCATGGGCAACATGGTGAGACCCCATTTTTATTAAAT ATACAGAAAATTAGCCCAGCTTCTCGGGAGGCTGAGGTGGGAGGATCACTTGAGTCTGGGGGATGGAGGT TGTAGTGAGTTGAGATCGTGCCACTGCACTCTAGCTTGGGTGACAGAGCAACACTCTGTCTCAGAAAGAA TAAAAAGATTTGGCCATGAATTCGTCAGCTAGTTTTCCTTACATAATTTTTGGACAAGGAGATCTGACAT TCATAGGTTTTTCTCTTAGAAGTGGGAGAGCTTCAAGGTCACGTGGTCCGTCCAGCCCCTGCTATCTCAC CAGACACTGTCCACCCTGTATGTTGGATCAGTACTCCAGTGAGAAGACAGCAGGCACTTTCACCCATGCA GCCCATTCAGTCTTCATAACCACCTGTGATGGAGGCAAGGCAAGTATTTCAGCCCCCTCTGATGAGTGGG AAACTGAGATGTGCCCCCTCTCTGCTCCCCACCGAGGACCTCTGCATGCAGGCATGAATCCCAGGAGCCT AGCTGATATTGGAGAGACGGGGCGGGGGGAACCAGCTGCAGGGTCTTGGAGGAAGCTGCTGTGTACACCT GCAAGGCTGCAGGTTACATCTATCTGTCAAGCAGTGAAGGAAGGAAGTTGTTTCTAAGGGATTGGAAAAA TTCATTAATTAGTAGAATGAGAAACTGAGGTGAAGCAGGAGGTGGCAGGGTCCCAGACAGCATGTTGGAC TAGTGGCCTGTGTCACTGTGTTTTTTGCAGGCGGGTGGCATGGGGTGTATGCTGACTTCTTATTCCAGGA GTTGGTGCCAGGAGGCCAGGTTTTCTTAACATCCTTGTTTTACAGATGTCAAACTTGAGGGCCAGAGGGG TAGGAGAGGAAGAGACTTTTTGTACCTTTTTTGGGAAAGAACAAGAGGGAAGCTGGCAGATGAATTTGAA GTGCATTGACCAGGGAGCTGAGAGAGGGCGGTCTGCAGCCAGCCCACACCTGGGAGGAGGCGGCAGGCTT TTCTGGGGACAGAGTGGCCAAGTCGAAGCAAGCTTAACCATCTCAACATGACACCACTCTTTCCCATTGG AACCTGAGAACTTGTTCAGTATTCTGACACTTAGCAAGGGACCTGGGTTTTCTTGGTCAGGTGTGCGTTT CTGGGTGACAGGCCTGCATCAGGTGTATTTTCGGGATGTAGTAAGTTGTGGAATATGGGTTTAGGGGCAT CCTCTGGCAAGCACTGCTTCTATCCCAGCTCTGGGAATGTGCCCCATGCAGTGTCCTAGATGGCCCATCT GTGGTCTGCTTCCAAGGGTCTTTCTTTTAGTTAGTTAGTTTTGAGACAGAGTCTCACTCCGTCACCCAGG CTGGAGTGCAGTGATGCAATCTCGGCTCACTGCAACCTCCACCTCCCAAATTCAAGCAATTCTCATGCGT TAGCCTCCTGAGTAGCTGGGATTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATTTTTAGTAGA CGAGGAATTTCACCATGTTGGCCAGTCTGGTCTCAACTCCCCACCTCAGGTGATACTCCCGCCTCAGCCT CCCAAAGTCCCGGGATTGTAGGTATGAGCCAACATGCCCTGGCACAAGGGTCTATCTTTGACCAATGGAA CTGCAAATCAAGCCTCTTTTGTTACCAGAGTTACCTTGGATTTACCCTTATCTACTTGGTTTGGATAAAT TGAGTTTGCATCAGATGGAGTCAGGCTTGATCAATCCCTTATTTACTTCCTCCCACCCTGTTCTCTAATA TCCAAAAACCTTGAGGCACTATTACATGCTAGCTACATTTCCTTGAGTAAAGTACTTAACCTCTTTGAGC CTCAGTTTCTCCATTGCATAAAAGGAATAATAAAACTTATCCCCCATAAGTTTATAGTGAGGAATGAATT AATTCCTCACTATAGTTCTAAATTAATTCTACTTAGGGCATCCTTGGTACATAGTGGGTGTTCAGTATTC ATTTCATTTTCTCTTTTCTGATTCCTTTCGTAAAAGTAGAAAAATGAAAGAGAAATGTTGACTTCTCTTT TGATTTGAAATCATTAAAACATTTTAGTAAGCCTTGGGAGGGAGCTAGTGGTGTGGCATGTGTATCCCGC TGGCCAAGCACATGTGAACGAAGCCAAGAATCCAGGGGCTTTTCTGCCAGCCAGCACTGACTCACTTGCG AGGGGCCCTGCCTGGCTCGGGGGAGGCAGGGCTGAAGTACCACATTAGGGCATGTTCCGGGGAAGTAGAT TCTCTGAATAACTTGGATGGCTCCCTGGAGCATTTAGGACAGAAGCCACCTGGAAAATAGAGATGGTCAC CCCCACGTAGCCTTGACAGTGCCCAGAAAGTCTTGTCACTTGGTAAATGTTAACAGCTATGATCCGTTCT TTAAGACCCTGGGGAGTTTTAAGTTTTACCCCACCAGACCTGAGAAGGGTAAAGGGCTGCAGATTCTGTT CTTTTAACTGGGGCCAGTGTGAGCCATCTTTGACTCAGTGCTTGCAATAGACCTTGATTCTGCAGTGGGA CCTCCCAGGCCCCCTTGCCCCCCGCAACTTCTGGACTCATATCCGTCAGACATCACTTGTCACCTTCCAG CATCAGGGAGAACTGGATCCCTCCTGGCTCCACACTCTTAGGCTCTTTGTAAGTAGCTGGTGAGGGTTTT CTTCTCTCTGCAAGGGAGGCTGGTAGAACTATGGATGTGATTCGTACAATTTTAGAGACAAAAAGAAAGT ACCCAGGAGGTCATTTATTTCAGCTGCTTCATTGCATAGGTCGGGGAGTTGAGCATGGAGTCCAGCAGCT ACTAACTAGTTATCTCTGTACCTGGCTTCCATTTACTGGTCCTTAGCTTGTTCCGTGATTCTTCATTGCC CCTTATTTCTCACCAGAGGGACTGGTTGGCCCTAGATGGAGTGGTCTTTTTAAAATTTTTTTTTTAAATT TTTTGAGACAGAGTCTCACTCTGTCACCTAGGCTGTAGTGCAGTGCTGCGATCTCGGCTCACTGCAACCT CCGCCTCCTGAGTTCAAGCAATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTACCAC TATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTCACCATATTGGCCAGGTTGGTCTTGAAC TCCTGACCTCAAATGATCTGCCCACCTTAGCCTCCCGAAGTGCTGGGATTGCAGGTGTGAGCCACCGCAC CTGGCCTGGGCAGAGTGAAGTCTTATGCTGGGGAGCCATCAGCATGCTCAAACCTCCTGCAATTGTAGCA CACTTTGTAAAACTGTTTCCCACAAAAGGGCAGAACTATTTGGGACTTTCATGAGACCATTCACTTTGTA GCACATACTACTTTGAAGTTTATACCTTGGAAAACCTCATGATGGTATTCCCAGGCTTGCACGTAATCTG CACTCAAAACATAGCTGTAGAATTGAACTAAAGCATCCCTCTGTCCAATTAAGACCTATAACCTCTCTTT TTGAGACAGAATCTCGCTCTGTCACCCAGGTTGGAGTGCAGTGGTGCAATCTCAGCTCACTGCATCCTTC GCCTCCTGGATTCAAGCGATTCTCTTGCCTTAGCCTCCGAAGTAACTGGGACTACAGGTGCGCGCCACCA CGCCTGGGTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCGCCATGGCCAGGCTGGTCTCAAACTCCTG GCCTCAAGTGATCCTCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGGTGCACCACCACACCCAGCC AGGACCTATGATCTAATTCATTGTTGGGGTAGCTTCACAATTTTCTTCTGGACGCCTTAGTAAGTCCACA CTTTAAGCAGCCACCACATGGCATACTTTACCTTCTGTTTTTCCTTTCCCCTCCCCTACCTAGACCCTCC TAACTTTTGGGGTTTTTTTCCTTTCCTCAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTAT CCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCC TCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGG TAAGGTGCTGGCTGGGGGCAGCCTGGACTCCTGGGCCTTGGGAACAGGATGGGCTGGGAGGGAGGTGATA TGGTTGCAGGTGATGTGGTCAACAGGGAAGGCTCCTTCCCAAGTGGAGCAAAGAACTCCCTTCCTGTAGG AGAAACTCTCAAGATACCTGGGTTGGTTCTGGTCTGGTTATAAACATAACTGACTTCATCAGAGGTTGGG GTCATGAAGGCTGGTGACATCCATTTACCTGAGATGACATGTTTGTGGGGGGTAATTTATGCTTTTCTCT TTCTGAGGAAAGAATATCTGATGAGGACCCTAGTGTCACACTTTAACATAGGTGATGTATAAAATGCAGC TGGTGGTGCAATGGGGAGAGAATGACCTTAGAATTTGCGTGTAGAACTTGGGTCAGACTACAGGGGATGT TGTAGGAGGTGAGAGCTTGCTAAAGACCTCTGACTTCCAGAAAATTGTTTCAAGGCCACATCTTCGCCAG GCATAGTGGGTCACACATGTAACCTCAGCACTCTGGGAGGCTAAGGCAAGAGGATCACTTGAGGCCAGGA GTTCAAGATCAGCCTAGGCAATATAGCGAGACCCCATCTCTACAAAAAAAAAGGAAATTAACTGGGTGTG ATGGTGCACGCTGCTAGTCCCAGCTACTTGCTACTCAGGAGGCTGAGACAGGAAGATTGCATGATCCTAA GAGTTGAGGCTGCAGTGAATTATGATTGCACTACTGCGCTCCAGCCTGGGTGAAAAAAAGGCACATCTTC TATAAGGGTCAGCAGTCATGGCTTCACGCCTGCATTTTCCTATCCTTAACTGTGTCTCACAGGTTCTGTT TGGGGGCCTGCCAAGCGATTTGCTTTGGATAGGTACTGTTTGAGGGGTTTTGAAGTGATTGAGACCCAGG AAGCATAAAGGGGCATGGAGACCTATGGCGTGTTGGAAATTCAGAGCCATCATCGGTAACAGGAAGGACT TACCCCACCATTCTTGGGATCTGTGTGAGCTGTGGAAAGGCCTCTTGGGAGATTATAGGTACAGAATACC GGTGGCTTTCGCGGGACTTTGAAAACTAATGTATGAGCATTTCTGCTGCCAGAGGATAGTGTGGTTCGTG ACTCAGTGGCTGGTCACACAGAGAAGGTTGACACACAGTGGGTGAAAGGTTGGAGGTGCGCGTGATGGGG TGGCTGTGTGCAAAAGGCTGCCACTCAGCTGGTCAGGGACTCGTTTGAATGATGAGTGATGGGTGAGAAT ATGTGTCCTCTGGATGGAGTTGGGGATGAACAGGGAAAGTTGTGTGAGACTTTATAGAAGGTGCAGTGGC TAGAGCAGGCATATTCATGTTGCTGTCAGTAACAGAACCGAAGGCAAGGTCTGAGCTGGAGCACGGTGGG GACCCAAAGTGGGAGAGACTGTGTCTGCCCACAGGGAGTTTATGGTCAGGAGGGATGGGCAAGTACAGGG ATAAGTAACACAAGACAGACTGTGTTTAAACCACCCAGTGAAGTTACAACCAGAGGTGGTGGGAATGCAG AGGAAGAGGGGAGCAGAGAGCACCTGAGATGGGCTTGAGTTCAGAAGGGGAAAAATGAAGGGCCCTCCAG GTTGAACAGCATGAGTGTTCAGAGACAGCATGTATATGGTTTATGGAGAACGGTTTGCCTGGTGAGTAGG TAGCTCTGGGAAACAACACTTGGAAAAATTGGATTGAGTTAGCATATGGAAGGCTTAATGCCCTGCTAAG AAAACTATACTTAGGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGG TGGATCACAAGGTCAGGAGTTCGAGACCATCCTGCCTAACACGGTGAAACCCCATCTCTATTAAAAATAC AAAAAAATTAGCCGGGCGTAGTGGCAGGCGCCTGTAGTCCCAGCTACTCCAGCTCCAGTCTCCAGCTGAG GCAGGAGAATGGCGTGAACCCGGGAGGCAGAGCATGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCC TGGGCAACAGAGTGAGACTCCGTCTCAAAAAAGAAAAAGAAAACTATACTTAGGCCAGGCGTGGATTATG CTGGTAATCTCAACATTTTGGGAAGCCGAGGCAGGAGGATTGCTTGAGCCAAGAAGTTTGAGACCAGCCT GGGCAACATGATGAGACCCTGTGTCTACAAAAAATAGAAAAATTAGCCAGGTGTGGTGGCACATGCTTGT AGTCCCAACTATTAGGGAGGCTGAGGTGGGAGGATCACTTGAACCTGGGAGGTAGAGGTTGCAGTGAGCC ATGATCACACCGCTTCACTTCAGCCTGGGTGACAGAGTGAAACTCTGTCTAAAAAAAAAAAAAAAAAAAA AGCAAGAAAAGAAAACTAGACTTAAATGGGTAGATGCTGGGAAACTTGAAAAGTTTTTAGCAAGTAGTGA CACTATCAGCTTTCAGAAAGTTAATTTGGCAGCTCAGTGTGGATGGCTGGGAGGAAAGAGTGAGGTGCAC CTGTGTTTGCATCCTGCTCTGCCACTTGATAGCTGCATTATTTACTTCAACAAACTACTCAAACACCATA CGTCACAGTTTGCTCATCTGTAAAACAGGGATAAATAATAAAGGGTTAAGTGGGGTAATCCAGATGAAGC ACTTCCATGTAAGGTGTTAATAGTTGCTATTGCTGCCACTGCTGCTGCCAGAAGGATGAGGTCGCAGGTT ATTTTGAGTGTCTGGCTAGAGGAAGTGCAGGTACTGACCAGGATGGGGACTGGGAGATGATAGAGGAAGG AAAAAGTAGTAAAGACACTACAGCAATAGCATCTGTGGGTTTAAGTAGGTTGGGTGTCAACTGTGGGCAA CTGGAGACTGAGATGAGAGTGTAAAGGGAGTGAGTCAGAGTGGGAGGTTTGAGGGGAGTTTAGATTTGAA TCCGCCAATTGTAGACAGCGATAAAGGAGTGGAAGAGTAGCAAGGAGCTAGTTGAGGTTTGAGAATGTGA ATTTATAATGGAGCCTAAAGTACTTTCTTTTTTTTGCAGCCCAAGAAGGGAGAAGTGGATCTCGGGCCTG GCTGCTTGTGAGCCAGCCCGACGGGATGAGTATAAGGAACTTTAGGGCCAGGGTGGGGGTGCTAGTAGAG GAGGGGGCTTCACGGAAGCTGCTGGGGCAGGGTGGAGGCTGGAACCTGGGGGCTGAAGATCTTGATGAGG ACAAAGTACCGGCCCTGTGAACAGAAGAAAGGGAGTAAGAGAGGTGGATGGGGCTCTTAGGAGCCATGTA CCCAGGAAGACTGACATTAAATGACCATTTTTTAAAAATCAACTTAATTTTCAAAGGCACATTGGCTCCC ACCTATAATCCCAGTACTGTGGGAGGCAGAGGCAGGAGGATCACTTGAGCCCAGGAGTTTAAGATCAGCT GGGTTTGTTTGTTTGTTGGTTGGTTGGTTTTAAGAGACAGAGTTTCACTCTGTTGCCCAGGCTGGAATGC AGTGGCATGATCTTGGCTTACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCT AAGTAGCTGGAATTACAGGTGCTCACCACTATGCCTGGCTAATTTTTATATTTTTAGTAGAGATGGGTTT CACCAGGTTGGCCTTGAACTCCTGACCTCAAGTGATCTGCCCACCTCGGCTTCCCAAAGTGCTGGGACTA TAGGTGTGAGCCACCACACCTGGCCAAACCAACTTAATTTAGGTATAACAGTTTGGGCTATTGTAATAAG ACTGCTGTGAACCTTCATGTGCAAGCCTGGGTGGGCACACATTTTCCTTGGACTGCCCTGGTTTTGATTT TGGCTCCACACCTTACTGACTGTTGGCTCTTGGGGAAGTTCCTCTTTGTGCCCTTTTATAAAATATATTG ATAATGAATGTGTGCTCATAAGGTCATTGTGAATATCAAATAAGCATGTCTGCAGAGCTCATAGGACATT GCCTGGTCCGTAGGCCATGAGCAGTCAATGGCCGTTGTGGGTCCCTTTCCCTGGGCCTCCAGGGGAGACG GCACATGGCGAGGAGCATGTTGTTTCATGGGACACAGCAACGGAAAGCCCCTGCACTTGGAGAACAAGCC CCAGGTCTCTGTTTGGTGGAGTAAGCCCCCGTCTCAGTGTGAGTGTGGTGCTTTCACATAGCCTGTCTCT CATGAGCTTTGTGACAGAACAGAGAACTGCTGTGCCCAGGACATTCTAAGGGGAGATCTGGCTTCATGCT TTGTAAGCTGTAAGGAACCTTGTAAGTGTAAAGTATATTGCATAGTCTTGGGCCTGCTGATTATTAAATA ATAATGCTGATATTTTTTAATTAATTAATTAATTTATTTGAGACGGAGTCTCACTCTGTCGCGAGGCTGG AGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTTCTGCCTCAGC CTCCCAAGTAGCTGGGATTACAGGCGCGTGCCACCACGCCCAGCTAGTTTTTTTGTATATTTAGTAGAGA CGGGGTTTCACCATGTTGGCCAGGATGGTCTCGGTCTCCTGACCTCATGATCTGCCCACCTCGGCCTCCC AAAGTGCTGGGATTACAGGTGTTAGCCACCATGCCTGGCCAATGCTGCTGTTGTCCTAAAAAAAAAATCA TAGGGCGAGCACAGTGGCTCACACCTGTAATCCCAGCACTATAGGAGGCCGATGCAGGAGGATTGCACGA GCCCGGGAGTTCCAGACCAGCCTGGGCAACATAGCAAGACCCCATCTCTAAAAATTTTAAAAATTAGCTG GGTAACGTGGCACACATCGGCAGTCCTAGCTATTCAGGAGGCTGAGATGGGAGAATTGCTTGAGAGTTGC TTGAGCCCAGGAGTTGAGGCTACAGTGAGCTATAATCAAGCCACTGCACTCCAGCCTGGGTGTCAGAAGG AGACCCTGTCTTTAAAAAAAAGAAGAAACACATTATAATCTATGTATTAAGGGCTTTGTCCAAAAGGTGA GAGCAAACCACCTAAAACCCTGTTCACACTGAGTTTTCCCCATTTAAAAGGCCTTGCTGTGATTTTAAGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTCTGTGTGTCTGTCGGGAG CCCCTCCCCACTGAGCGCAGTACCAACGCCCCTCAGTCTGCAAGTGCTCCTGAGGGATTGGGGAGGGCCT GGAGTTTCTGGCTGTCCTTGGAAAGTTGATTTAATAAGGGTTCCAGGAAAACCAGCCTCCCTCCCCTCTC CCTCTCCTTCCCCTCCTTTGGTTTGGGATCTTACAGAGCCTCAGCTTGTTTCAGATCAGGCTTTGAGAGT GGTGAGGGAGTTGTTTGGAAAGACTGAAGCCGGTTTCAGATGATAAGCCCCAACATTCTGAGCTTGCAGA GGGTGCATTTGTCTGTCTTTTGCAATAAGTCAAGTCTTGGTGGGCAAAGCCAGTGAGTGAGTACAACACT GCTTGCAAGGCCACTGCTGGTAGTTGGGGTGGGGGTCCTGCCCCCTTTTCAGCAGTACTGTGGGTTAAAC ACCCCAGTGCTCAGAAAACCTGCAGCTCAGAAGTGATTTAATGGGCTGAGTTTTACAGCTCCTCCCACCC ACCCAGATTTGAAGGAGTCTGGTGGCTTGTTAGAGGGGGGAGAGGTTGCACTTAATGGAAAAACCACACA TTTCCATTCTGGCCTCAAGCCCCCTGGATGCCCTGTGTGCACCACAAAGCGGGGCTTTGTCTCTGTGTTT TGCAGAAACCTGCACCTATGGGGGAGAGGCTGTGCGTGGTGCCAGAGCCATTGCCTAGCCTCAGATCATA GGGCCCTTGCAGGTCCTCCATCCCTGGGCGTCTCCAGCTGCCTTTGGCCCAAAGGGGTGTGCGTTTCAGC CTGGCTGCAGGGAGAGTCTCAAATAGGTACTACAGGTTTGGTAGTGGGACACCCTCTGTTCCACTATCAG ACCTGTAGTCTAGCATCTACACTGGACTGTGGTCCTGTGTCCCAAGGCTGCCTTGGGACACAGGCAAGAC CCTCCCCTACTCCCACCCCATCTCCAGCATGATTTCTTATGATGAAAAGAACTTGTTTGCTTCTCATTCA ACCTGGATGGTAAGAGGAGTTTCTTCATCCCCTGCCAGAAGGCGAATGGAATTCCATGGAGCAAAAGGTG ATGTCAGATGACCCTCTTGAGAACAAGGGTGGAGGATTTAGGCCTCTAGAAATCTGCAAGGTGCTAAGCT CATAACAGGTTTCCCCAGAGGATCAGCTCTGTCCCACTTCCCCTGGAGAAGTGGCTCCAGTGCCTGGAAG GGGTGTTTGCAAGTGTTCAGAGCTGGACAGGGAGGACCCAGCCCTCGGCCTGTGAGAGAATGTGAGGACG CTCACGTGGCCCTCTTGACCAAGCTGGGGCAAGCGCAGCAAAGCCACTCCGAGGCTGTGTTCTTGGCTCC GGCTTCTGCATTGCTACACCATTAGCTTCACTGATTTTCCACTCTGGCTCTGCCAGGCCCGCTCCCTGAA GTCAGGGAGGAGGAATTTCTCAGGGAAGAACAAATGGCTGTCCAGAGATCTTGCTGCCAGTGGGGGAAGG GAGGGATCCCAAACAAAGACTCTGTCAGGGTTTCCATCACCTGGTTCCTGTGACTACCTGGAGTCGGGTC AGCAGGAACTGGAGAGACAGCATCAGGGATTCTTTGGGAGCCTGTGGCCCCAGCACGGAGGGGTGTTTGC TCCTGGCCAGGCAGAAGCAGTGAGTGATGGCTTGTGTCTGGGCGGTGATGAATGGCCCTGGGAGAAGTGA GTCCTGGGGAGTCATTATCCGGGAGGGCGAGGTCTGGGGTCAGAGAGCCCGACCAGCAGCTGGCCCTATT TTCACAATGCCTCGTTCCTCCGGGGCCACTGGGGGCTCCAGCTCACCCTGTAGACACCACCTTTGCCTCT TTCTTCCTTCCCTGAGGCTTGGAAATGAGACAACTGTTTCCCTGTTGACCGGGGAAGTCCAGCTGCTCTC ATTCTCCTGGGCTCCTGAACGGGGCGGCCCAGGCCTTCCTCCTGGGCCTGGCTCTTTCACCAACTTGCAG GCAGGCAATCCCTTCTCCCCACCCACCATACTCCCCAGCCCCACTGCACCCTAAATAATTAAGCTGAAAG CTAACTGCCCTACCTGGATCTGAAGGGCCTGGGCTAAATCCCAAACTGTTTCCTCCTAGGAGAAGCCTGC TGGAGTCTGGGCCACTTCTGACCTTGGGGTTTGCTCTGACTTACAGCTGGTGGCAGCCAAGTAGCAGGGC CAATTGCCCTAACCCCTCCTCCCCGGTAGTGGGCCTGTTGCCTCTTAGCATTGCCAGTGTGGCACCAAGA GACATTGAACTTCTACCCTCAGAGTTCCCTCCCTTCTCCTGTTTCTTGGCTCACAACAGTTCTTGCCTTT CCACTTGCCAAACAGGTATCTACTGCCTTCATGTAAAGCATTTGTGCCCTGCAAACTAGGGGCTGTGGGG TGAGGGCTCCGTGTAGCTGGTTTCAGGCACTGAGAAAGATCCACCCTGGCAGAGCTTGAAACTCCACGCC CTCTCCTCGTTCACATGCTGTGGCGTGGCTGAGCCTCCCGGGATGGGTTGTGTAAAAGGTGGGGTGGGGG CTGTGCCATTTGTGTTCCCAGGCCCTGGACATGGAGACACAGGGAGCCTGAAGTGGGTGAGAGGGTCAAG GAGTTCCGCAAAGAGTAGACTTAGTGGTTACGAGGTTGGGCAGAGAAAGAGGTCAGAAACAGCAACACGG AGGTTTCTAGGAGTTAACCAACAGTGAACATTGAATTCAGAGCTTAGCCCTTCCTCACTTTTCTCTAGGA TCAAAAACTAGCTTCTGGCTAATGGTCCATTCATTGACTGATTTTTTTTCACTCATTCATTTATTCATTC ATCTAGTCAAGCAAGTCTCTTCCTTTTTCCGTAAATACAATGTATACTTTATACATTGTTTTATCCTAGT CCCTTAGCTGGAAATATCTGTTCCTGTCCTTTTCTTCCTTTTCACTTTTTATAATTCCTGCTCAAATCTT AGTTTAAGGTTTAGCTTGGGTTTAGATTAAAGCTTAACTTAAGGGCCACCTCCCTTTTGAAGCCTTCCCC TATCTCCAAATTAATTACCCCATTTTTTCTCTTTTTCTTTTTTCTGTGTTTTTTTTTTCTCCTGAGACCT AGTCTCGCTCTGTTGCCCAGGCTAGAGTGCAGTGGAGTGATCATGGCTCACTGCAGCCTCGACCTCCTGG GATCAAGCGATCCTCTGGCCTCAGCCTCCTAAAGTGTTAGGATTACAGGCATGAGCCACCATGCCCTTTT GAGATGTAGTCTCGCTTAGTCATCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAACCTCTGC CTCCCAGGTGCTAGCGATTCTTCTGCCTCACCCTCCCGAGAAGCTGGGATTACAGGCACCCACCACCATG CCCAGCTAATTTTTGTATTTTTTGTAGAGACAGGTTTTCGCCATGTTGGCCAGTCTGGTCTTGAGCTCCT GACTTCAAGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCTGG CCTCTTTTTAACTTTCATTCTAACACTTACTTTACTCTGCCTCACATTATGTGGAGTTTTTAATAGATGT CTGTTTACTCCACTAGAGCAAAGTTCTCTATAGTCAGCAAGTATATCTTTATCACTCTTTTAAAAACATT AGTGTTTAGGCTGGGCGCGGTGGCTCACTCCTGTAATCCCAGCACTGGCCAGCCTGGCGAAACCCTGTCT CTACTAAAAATACAAAAATTGGCCAGGTGTGGTGGCACGCACCTATAATCCCATCTACTCAGGTGGCTGA AGCAGGAGAATCACTTGAACCCGCGAGGCGGAAGTTGCAGTGAGCCGAGATCGCACCACTTCACTTCAGC CTGGGCAAAAGAGCGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAATTGGTGTTTTGTTAGATAATCTGG GTTCATCTTTCAAAATTCAGAAAATACAGACCTGTAAAGAGGAAAAGGAAGACTCCTATAATTCCATCAT TCAAAAGCAATCACTGTTAACTGAATTTATTGTTTTAGACTTTTTTCTTGCATTTATGTAAACCTGACTT TTCAGAATTAGGATTTATACTGTATACGATGTTTTGTGACTGATATCAGCATTTAGAGCCATACAGAGAA TGTTTTTCATTATGCTTAAGAACTACATAATGTTCCATTGTGTGGGTGTACAAAGTTGATCCAGTTCTCT ACATTTGGGCATTTAGGTTATTTTCAATAGTTTGCATTCAATAGAACATATTCTTACAAATAAAATCTGT CCATGTATCCAAGGATAGTTCCATTTGTTTTAAGTTTTGATTTTATCACTATTACATCACTATACCAAAT ATCCCCCAAAAGATTATACCAGTAAATGTCTTTTAAAATATAATAATAAATACCAGCCGGGTGCAGTTGC TCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACTTAAGGTCAGGAGTTTGAGACC AGCCTTGGTAACATGGCAAAACCCTTCTCTACTAAAAATACAAAAATTAGCCGGTCATGATGGCGGCCAC CTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATAGCTTGAACCCAGGAGGTGGAGGTTGCAGTG AGCTGAGATTGCACCACTGCACTCCATCCTGGGCGACAGAGCAACGCTCTGTCTCAAAAGTAATAATAAT AAATATCATCTCCACACTCTGCATGCTTGACATTTTCCCATTTTTACAATGATTCCATAGGCATAGGTTT TATGACCATAATCAGATGAGTAAACTGAGGTTTGAGGGGTTAAGTAACCTATCTTAAGTTTATATAGTGG GTGAGGGGTGGAACTAGGATTTAAACTCAGGTGGTTCTGCTATAGTATTTTTTTCCCATTGTATTACACT ATTTTTCTATATCAAATTGGGTTTCCCCACAAAATCTAGGTGGACCAACTTCTGAATGTAAACATTGCTG GCTCAGTCCCCTTTGTCTCACAGGAGTCAGGCATCCCCTCCCTTTGTCAGGGGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTGCTTGCAGTAATATCTCCTGTGGCATTCTGTA GAGAGGTTACACATCAGTCACAGGTCTGTGAACTGCCTTAATGAACAAGGTTCCCTAGCCTAGAATAATC AATGGAACAAAATCCCCATGGACGCTGCCATTTCCACTGTTGCCAAAGACCTACATGGAGAAGGTTCCCA AGGTGTCAGATCCGACACCTGAGTTTTCTTTATAGGTCACAGTTAGCCTAGAATGTGTGGTATGGGTATT GCCTGGACGCATAAACTAGATTGCTTCTAATATGGATGTGGTCCAACAATCTCTGATGAATGGAAGTAAA CATATCAAAAGCTTCAGAGGCTGGGACATTAACATTTTTTTGAGGCTACTAGTGTTTTTTATAAATAATG AAGAAGGGCCAGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATAGA GTGAGCTCAGAAGACCCGCTTGGGCAACATGGCATAAACCCCATCTCTACAAAAAATACAAAAAATTACC TGGGCGTGGTGGTGGGCGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGTAGGAGGATCACCTAGGCCTG GTGTGGTGGGTCACACCTGTAATCCTAGCACTTTTGGGGGCCAAGGTGGGCTGATTGCCTGAGCTCAGGA GTTCGAGACCAGCCTGGGCAACACGGTGAAACCCTGTTTCTACTAAAATACAAAAAACTAGCCGGGTGTG GTGGCGGGCGCCTGTAATCCCAAGTACTCGGGAGGCTGAGGCGGGAGAATCGCTTGAACCAGGGAGTCAG AGGTTGCAATGAGCCGAGATTGTGCCACTGCACTGCAGCCTGGCTACATAGCAAGACTTCCTCTTTAAAA AAAAAAAAAAAAAAAAAAAGGTGGGAGAGGGCTGAGTCAGTTTGCCTTGGAGGCATGGGGGAGGAGAAGG ATGTGAACAGGGAAGTGATCTAAGAGCTTCCCTAGGAAGGAAGGACACCCTTTTCCTGGAATGCTCTCCT GCTCTGCCACAGCTTTCAGTCAATTATCACTGCCTTTAGAATGCTTATCAGCACTCCAGCCCTTCAGAAG TGTCCTTCTCCTCCTCTGGTGTCAAACTCCAGAGTTTACTTTTGGAATTAAGGTTTATTTTCCTTAGGTT TTAGGAAGTAGCTTTTGAACCTTAGAAGAGTCAGTTTCCTTTACTAACTACTGAATGAAGTTAGGCATTC AAAACTTGGGTAGTCATGATTTGAAGTGTCACTTGCGGCCAGGCACAGTGGCTCACCTGTAATCCCAGCA TTTTGGGAGGTTGAGGCGGGCAGATCACCTGAAGTCAGGAGTTCAAGCCCAGCCTGGCCAACATAGTGTC TCTACTAAAAATATTAAAAAAAAAAAAAAATAACCGGGCGTGATGGCAGGCGCCTGTAATCCCAGCTACT CTGGAGGCTGAGACAGGAGAAGCACTTGAATCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATTGCACCAT TGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTTCCCCAAAAAATGAAATGTCAATTTCATTGAGACT GTATGAATGCCTGACATGCACTTGAAAGTGATGTTTATTTTATAATTTTAGCCCTTCTTCACTACCCCAA ACTCCCAGTGCATTTAAAAAATTTATTGGCCTAGCCATTCTCATGGGGTAATATATCATGACCATCAAAA GATGACACTAAAGTGAATCCTCCATGTATAGCTGGGCTTTCTGCCAGCCTTAGATTCTGGAGAAGCACCC CAGGCCAGGGAGAACGGGTGAAGAGGAGAAGCATTTATTGAAGGTGCTGGTAGCCGGAGCCCTGAGACCA ACACAGAATCGTTTTTTCTGAAGGACAACTCAAGGACAGTTGAGGGCTCTTCACTTCCCTCACATCAGAG GGAGCTTTGTGCTCACGATGGGCACGGAAAGGGATGCCAGTAAGCGATGCCCCTCTATCATCTCACAAGA CCCAGGTGAAACAGGACATTGGTTAGGGCTGGGACAGGGTCAGTCAGCCTTCTCATTTTACAGTGGAGGA AGCTGAGGCTTGAGAGGGGAGGTGACTTGCCTGAGGTCACACAGTAAGTGATCAGCTGTCATCTGAGTGA TTTCTTCAGGTACTCTCTCTGGCTGGACCCAGCCAGTGACAACTACCTGTGGCTCAAGCTGAGTTTGGGA CTAAATGGTTTTACAAGGACCTCAAAGTATACTCTCTCTCTTCTAGTAGGACATGGGGAATACTGACTTT GCTGAGAGTAAGGGCTCTTTTCCCAGGATTGTTCTAGATCCCCAGATCACTGGAACCCTGAGCATAGATA CTAGGCTTTAGCTTCCTGGCTACCACAGAGCCACACACTCTCAGGTAGAAAAATCCCTAAACTGGCTGGG CATGGTGGCTCATGCCAGTAATCCCAGCACTTTTGGAGGCCCAGGCAGGTGGATCACCTGACGTCAGGAG TTCAAGACCAGCCTGGCCAACATGGTAAAACCCTGTCTCTACAAAAAAAAAAAAAAAATTTAGCCACGCG TGGTGGCAAGTGCCTATACTCCCAGCTGCTTGGGGGGCTGAGGTGGGGGGATCACTTGAGCCAGGGAGGT GGAGGCTGCAGTGAGCTGAAATCATGGCACTGTTCTTTAGCCTGGGCTACAGAATGAGACCCTGTCTCAA AGAAAAAAAAAAAAAAACCCGAACCATGTTTTTAATTTCTTAAAACTGAGAGTACTAAATGCTCAACGTT CATGTTGTGTGCATAAAAGTGAGACTGAAGGATGAATGTGTGGGGTATGGATAGATGGGATGTGAATGAA GCAGTCTCTGGGTCCAAGCTCTCCTGGAAATTCGTGGAACAGACCAGTGGTCCCAGATTTTTAGATTTCA TAGGCCAGTAAAATTTCCCTCCAGATTTTTGGAACCAACAAAGGATCATCAACTTTTTTGCCAAGTAAGA ACGTTTTTAATAAACTAATGCTGCCTGCTACCATTACCACCTGATTCTTTTTTTTTTTTTTTTTTTTTTT TTTGAGACAGTTTCATTCTTGTTGCCCAGGCTGGGGTGCAATGGTGCGATCTCAGCTCACTGCAACCTCC ACCTCCTGAGTTCACGCAGTTCTCCTGCCTCAGCCTCCTGAGTAGGTGGGATTACAGGCATTCGCCACCA CACCTGGCTCATTTTGTATTTTTAGTAGACACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCC TGACCTCATGTGATCCGCCCACCTCAGCTTCCCAAAGTGCTGGGTTTACAGGCGTGAGCCACCGAGCCCA GCGCCATCTAATTCTTTTGTTGTGGTAAAATATATGTAACATAAAATTAACCATTTTAACTATTTTTATT TTTTTAAGTTAAATTGATTATGTAATGTTTTTGAGACAGGGTCACACTTTGTCACCCAGGCTGGAGTGCA GTGTTGCTATCTCAGCTCACTGCAGCCTCGACCTCCCGGGCTCAAGAGATCCTCCCACCTCAGCCTCCCA AGTAGCTGGGACCACAGGTGCACGCTACCATGCCTGGCTAATTTTGTTTTTCTTTTTTTTTTTTTTTTGT AGAGATGAGGTCTCACTTTGTTGCTCAGGCTGATCTCTAACCCCTGGACTCAAACAATCCTCTCACCTCA GCCTCCCGAAGTATTGGAGTTAAGAGATGTGAGCCACTGTGCCCGGCCAATTTTTAAATTTGTAATTGAT GCATAATGGTTATGTATAATCGTCGGGTACGGTATGATGTTTTGATCCACGCACACATTATGTAACGACC AAATCATGGTAATTGCTGTATTGTATCCATCACTTTAAATATTTATCATTTCTTTGTGGTGCATTTTCAC CAATTTTAAGTGCACAGTTTTGTAGCATAAAATTTATTCACGCTGTGTAGCCATCACCACCATCCATTTC ACCTTCCCTGACACCTTACCTGTTCAACGCTAACTCCCCCTTCTCCCCTCTTCCAGCCCCTTGGTAACCA CTATTCTACAGCTTTTCATTTTCAAAGGATGTTTTATTGTCTTTAGTCTCATCGTGTGAAACCTTAAGAG AATTTCTTTACGGTGGAGAAAAAGTAACTTTATGAAGCCCATTCCTTTCTCTACTCTGGAGAGGCTGGTG ACCCAGCCCCACCATTGCAGGAATGAGACGGGATTGCGGGGATATGGCAGGCACTTGGGGTGCTGAGAGT CCAGGTGAACTGTGAGCTCAAGCACCCATGTCGGGCTTGGGGGACCAGAAGACACATCCTGAAACAGCTG AAGCCTCTACTAATTCATCAGCAAGTTTAGGGAGCGGCAACTTTTCCCTGCCCAGCTGCTGGCGTTTCCT TCCCCATACAATTTCTGCTGAGTTTGGGGGAGGGGAGGTTGTTCGAGAGGCCCCAGCTGGGAGAGGTGGG GGGAGGGCGATACATTCTTTTCCTTAAGGAACCTGACCGAACTTTAAGGTCAGAGCTCAGTGGAGAGTGG GAGCTGCAGGGTTACCTCTTTGCCGTTGATTCATCTCTCCACCCTCCCCCACTCTTAATGATCTTTCCAT TACAGAACCCAGACCAGGAAGTGCATGACAGGTCGCAGCTGCAGACACATGGCTGGGAGGCCTGGGCTCC GGGCCAGTGGTGGGAGAGTCTGAGCTCCCCTCCAGCAGTGGGACCCCTGCACACACACACACACACACAC ACACACACACACCACTTTAACAACTTGGTGGAAGATGTTCTTTCTTATGCACTGTCACAGGTGATGACGA GTTGGACTTTGCTTTGAGTTTAGGATGTGATTTATATTATAATAAAGGCAGGAGAAGACACTCCCCCTGC CCCGGTCCAACCTGAGTGTTTAGATCCCCCCAACTTACAGTCCACCTAAGTGGTCCTTACCAGATCCTGG GAGCTTTCTATTATCGTGCAGATGCCCCAACTTCTTTTCCCAAAATAGGACCCACCCAATATGGCCTTAG AAGCTTCCCAGGGTATCCGGGGCAGTTGCTAGTCACAGTCTTAATGTCTCCGAAATAGTATGTTTTCCTC TCTATGTTTCTATTAAAATGTCAGCCCCAAAACATGTTTCTGGGTGGAGGTCTAGGTGCAACAGCACAGC CTTTGCAAACACAGATAGACTTGGGTTCAAGTCATAATAGATGAGTTGAGCCTCTCATTTTTCAGTCTTC ATTGGGGATGGCTCTTTCCATTTGCAAGTTGTTCAGGAAATGTTAATTGACCCTAAACTGTGTCCTAGGG GGCAGTTGTCACACAGGAGTTTCTGTCTTCACCACCAGCTGTGTCCTTGGCTTCCTTCCCTGAATCTGCC AAGGCTGGATTCTGGTGCTAAATGTGAAATGGTGACACAAACTTCTAGGAACTGTGAGCTTGGACGGCCC TCCTCCATAGCCGCAGGGCATCTACCTTTGCTCTTCTTGGATGAGTGAATGAACTTCCCTCTTTCCAGAG CAATGCTTTCTTCCTGTTTAGATAGGAGGGAGAGAAGCAAAGTGTATTGGGAATAGGTTGAGCGAAAGAG TGTAGTAAGAGTTTTCTGTACAGCTCTGTCCTTAATGTATCAGTAAACAATAGGGTGAGAACTTTTGCTG GGGAGAGAGGAAGGAGGGAAATTTCTTTTCAGACAACTCTTGGGTGCATTCCTTTGTTAATCACTTAATT ACAGCCCTTCTCCCAGTGAGGTAGTGAACTCCCCATTGTGAGAGGTAGGGAGGAGGTGGGGGACACTGGT GCTGATTGGAGAAAGGTGGCAAAATCCCTAGGGGAAAAAAGTACAGATTTGAAGGAGGCATCAGATGAAT CCGTGCATAGAAGCTTGAGCCCCAAACTCAGTTCTCAGGCTGCGTTATCCTTTACGACACCCAGAGTCCC TCTGTCTTTTAAGATCCACACACAACTCTCCAGGCCAATAGCTCTTGGCGCCTGCGATTCCCAAGTGGGA TTCTACACGTGTCTTGCTGCCCAGCTCGGGGGGATCTGTTTTTGGGGGGTCTCGGGGCGGGTGCAGGGTC CTGGCTGTGGCTTTGGCTAGTGCAGGCGGCTCGGCACTAAATTACAGTGACGAGGTGGGACGCACAAAAG GCCGAAATCTTTTTTTAATAAAAACAAAACAAAACTCTGGGCCCCAAGCCCCTGGGCTGCTGAATGGCCA TGGCTTCCTGTCAGGATTAGCCGGGCTGCCTGGGCCTGTGTGCTCGGCCTTTCTCCTCAGGAAATACCTT TAGTAAGCCCCGGTGGGGTCCCCATGGCAACGCACGGGGGGACCTGCTGGCAGAGGCCATTCAGTCTGCC ATTGTCCCCCGGCCCCTTTGTTGTGAGCTTTATTGCCGGCCCTCTGGCAAACACAGCAGTTTGCACCGTT TTGTCAGGCTGAATGTGGAGTTTTTACATTTTAATGGGCTCTTCTGGCAGTGGCCCATTTGCATGCAAAA TGTCCCCTCTTACTCTTTTCACTTTCTTCAATTTAAAAAAAAAAAAAAAGCCCTTCTCCAAATCCCCTGG GTCGGGGGGCTGGTGGACGCCATTGGCCCTGGGTGTCAGGCCCTGCTAATTGATTTGGTGCTCCCGGCTC TCTTTCCACACATACCTGTGCCCCCCATTTTTGCAGCTCTCCTTCTATTTGGGGACTCCGAGAGTTGAGA GAAACACATTTTTGGGGCTCTCTCCACCCAAACCCTTGTAGGATGGCAGCTGTGACCCGGGATTTCGGTG AGATGCTTCTGCACTCTGGCCGGGTCCTGCCAGCCGAAGGTAAGTTTTCAGTTCCATTTCAAAGCCAAAA TACGTAATAAAAAAACCTCTGCAGAGGGCCCCCGGAGCCCCGCTGCGCTGTTCTGTGCTCCTTTTAAGTT GCTTTCAAAGCCACCCCGAGTTCCTCCCCCACCCACAATTGCCCCCTCATTTATCTCTGGGGAGTTTATA CCAAGACTGTAAACATTCCTGGACCACCAGTTTCCCCCATGTTGCTGAGGAGTTTAGCCTTTCTCTCCTA ATTTTCTTAACTCAGAAATCAAAAAGATGGAATAGGGATGATAGAAATTGCTACCCTGAGACATCATGCT CATGGAGGATGCCTGGATTTTGTTGGGGGCCAGTTATCCAAGCCCTAAGCCCTTTGGAGTGTAGAACGTA GAGTAGGTAATACAAATACCTACTGTCAGCCCAGCACCCCAGCAACATGAGTAAGTGCAAGACACAGGCA TGAACATTTTCAGCTCTAGGGAAAGGCACATTCATGTTGGGGAGAGGTGGAGAATGCAGTTTGGCCAGTC TCAGAAGAGTGAGTTTTAAGGCCTAGGAAAGTGATGGAGATGATTGCTTGTTGGAGAGAGAGAAGGAGAA AGGCATTTAGGGGAAGAAAAGGAAAATGAAAGGAGCAGTGAGGATATTGGCTCCACTGGGGAGGTGGAAC TGGGGTAGTGGCCGAACCAGGGGTGGGAGAGGACGTGGTTGAGAGGCTCCAGACCAGCTGGGGCTGTCAT GGAGTGTTGGGGGTCTGGAGCAGTCAGGACTTGAAAGCCGGGACCCTTGTGAGCCCTGTGCAGTCCTGAG GATGTGGCCCAAGGGGGAGGGCGGACCAGCTCTTTTGCCTCGTGTTCTTAATCTTCTCAGTGGGTCATCA GGGGTCATCAGCTGTAAGCTGTAATCAACGGTGAGGGGCTCGAGAAGAGAAGGTGTCAGGTGACTGCTGG GGATTGAGCTGAGGACAGGAGAGGCAGGGTGCTGTCTCCTGTGGCCCAGGCAGAGCGGCACAGACCTGGA GTGGGCCACCCCTCATCACCCCATGTGCTGCGACAGTGCTGGCTGGACTGAACCCTGGAAGAGTACCTGG ACACAGTGGAGGGGCCAGGACCCAGCAGATGCAGCCTCTAGAGCTTGTCCCTGTTTTGTGACTTTGGGAG CCATTTTTCCATGTTTAAATGGGAAGGAACACAAGTCACCTGGTCACAAGGAAGCAGGCCCTATGAAATA TTAAGTGCAATGCCAAAACAGGGCATTGTTACTGGTCTTGAGTCTGCCACAATCACAATGAACACCTCCC CCATTTTCTCACCTGCCACATTTGGACAGCCGAGCCTGCTGGACTCGCAGGGGCAGGAGAGTGCATTTTA TAATTAAAAGCACTCAACTGTAAGGTAATGATTGATATGAGCTATGGGCTTGAGGAAATGAGGGAAGGAG GGGAGGATAAGGCCAAAGCAACCAACTTCAGAATCTCACGGGAGGAGGTAGGATGCAGGGGGTGCCATTA GACAGAATCAAAGGGCTGAACCAGAAGGGCTTCCTCACCTGGGGAAGTCAAGACACTGTGAAGATTGAGG CTGCCTTGCACAGCGGTAAAGCTGGACTCTGGATGTATGATGTATGTGGATTCTGGAGAACCAGGCTACC TGTGTTTGAATCCCAGCTCTGCCACTTAACAACCTAGCTGGGCCATCTTGGACTAATCCCAAATCTTTCT GTGCCCCAGTTTCCCCCTCTGAAGATAATAATTCCTTTTTTTTTTTTTTTTTGAGACGGAGTCTGGGTCT GTCACCCAGGCTGGAGTGCAGTGGTGTGATTTCGGTTCACTGCAACCTCTGCCTCCTAGGTTCAAGTGAT TCTCCTGCCTCAGCCTCCTCAGTAGCTGGGATTACAGGCGTGCATCACCACGCCTGGCTAATTTTTTGTA TTTTTAGTAGAAATAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGATCTCAGGTGATCCAC CCACTTCGGCCTCCCAAAGTGCTAGGATTACAGGCATTAGCCACTGCACTGGGCCCGAAGATAATAATTC TAACTCTTAAATACTTCACAAGATTCTAAGTTAACACATGCTGAGAACTATGCTGGTATGTAGTAAGCCT CCGCATCCATAGGATAGAAATCATAGTAGGATCAACCTCATAAGTTTCCTATGAGGATGAAATGGGAGGG TCTGTGTTAAAAGCTTTGTGCAGCCTATGGGATATAGTGAGCGTGCTGGAAATATTGGCCAGTAGTAGTA TTGCTGTTTACTCAGATGTTTATGGATCCCTAGATAATATATGGGAAGGCACATGGTAAATTACAAAGTG CTATGCAAATGTGTTGTTATTCTTCACTGGGTTCCTGTTAAGTTGTGGGGTTTGGGGATGGATAACTTCC AGACCAGAGTGGCTGCTGTGGGACCGGGCTGGTGAAGCGGTATTTCAAAATACATTTTCAGGTGTGTTTG TCCATGTGGCATGAATGCCCTGCATTCATAGTCTCTGCAGAGAGGTGTGTTCCCTGGGATATCTTTGGTG GCTCTGTTCTATCCCTCAACTTACAAATTGAAATCATTATTTGTTACTGTTTTCTCCCATGAACCTTCTG TTCCTGGCCAGCTGTACAGCCTGGCCTCATCTCCCACTGCCCCTCAGACCAGGGTACAGCCATGCCTGTA AGCACTTCATTCTCTTCTGTTCCCCCCAGACATTTCACTTCTCATCTAAATCCTCTCTTTTCCCTTCCCC GTCATTTTGTCCAACCTCTGCTCTCACTGCTGATACTTTTCTTTATGTTTCATGACGTCAGAGCCTGTGC TAGACCTGCCTGTACTTGGTCCTGACATTCTCCATTTGTCTCATGTTGCAGTATAAAATCTTAATCCATA TTAAGGTGCTGTGCAAATCTGAGCACCCCTGTTAGGGCAAGACATATGCCTTCTGGGCCTTTGTTTCACC CATTTCTCCTTGCACAGTGACAAGGGCTCCCAGAGTCACCTAATGGTAGCTATGTTGATGAAAGTTCCCT GACTCCTCCTTGGATTTTTGAGAACTGGGGTCTCATCTTGTCATAAGAATAGCAAGGTTTGTATGGGTTT GGGTCTCTGATGGTTCCCATGACTGGTGGAAGACACAGATTTAGAATCAAGAATTGGGAGGCCGAGGTGG GTGGATCACTTAAGTTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACTCCATCTCTACTAAAAA TACAAAATTAGCCGGGCGTGGTGGCGCTTGTCTATAGTCCCAGCTACTCGGGACTGAGGCACGAGAATCA CTTGAACCTGGGAGGCGGAAGTTGCAGTGAGCCAAGATCCCAGAACTGCCTTCTAAATGACTGTGGGAGA TTTTTGTCCAGTCCTGCTAGAAGCAAAATGCTGTACCTGTTGGCTTGTTGGAAGTACAAGCCTGCAGTAT TTGGGGGGAAAGTAGGAAGGGAAGAGGGATTCAGTAGGGCCTCATTATCATTAATCGTGTTCCTGAACTT GAAAGCACCATGGGAAAATCCCCTCCCACCCCTGCCTCTGTCCTTTCTAGCTGCTTCCTTGAGGATTATC AAAAAGTGTGGGTCTCCGGTGGGCTCCTAATTCCTTCTTAGGGGATAGAGACACCTTAGAGAAGCAGGGT AGGTTTGATGTATGAATCCTTGTCACTCGCACTAAAAGGAGCACTGGTTGCAGCCTGCACAAATTCCCAA GGTCCACCCGCCAGCTGCTTTGACCCAGGAACCTGCGTGGTAATGAGATCAGCAGCCTGAGTTCTCGAAC GATGTTCAAGGCAAACCCTAACCCTGACCTTCCCACTCCTGTTGATGAGAACGGTGACTCCATTCTATTG GCATCAAAGCATAAGGCCCCTTTTTTTTCACAATGCACTTTTTTTGTTGTTGTTGAGACAGTGTCTCTGT TGCCCAGGCTGGAGTGCAGTGGCAAGATTATAGCTCCTGCAGCCTTGAGTTCCTGGGCTCAAGGGATCCT CCCTCCTCTGCCTCCCAAGTGCCTGGGGACTACAGGCATGCACCACTATGCCTGGCTAATTTTTTTATTT TTCGCAGAGACAGGGTCTCACTATGTTGCCAGGGCTGGTTTTGAACTCCTGGCCTCAAGCAGTCCTCCCA CCTTGGCCTCCCAAAGGGCTGGGATTACAGGCATGAGCCACTGCACCCAGTCCGCAATGCACTGTTAACA CATGGCACCTAGAGCCTGTAATAGTGAACAGCCAGTCTTTTTCAGCCTCAGGCTAGGTCACCAGGGAATC CAGATACCAGATGCCCTCCAGCCTCCATTCCCCACCTCATCTCTCAGGAAACAGATGCACAAAGCAAGTG TTTTGGTGCTGCTTCCCTCACAGCATCCCCATGTGCATTTTGAGGACAACCTTTGTATCTGATTCCAATT AATCAGGTTCTCCAGGAGTTGGAATGTTGGTTTCAAGTGACTGAACAATAAAGTGGCTTTCTTCATCTTT CTTGGCCAGTCCAATAAAAGTGTCAGGTAGCTTTTCTCTTGCTAATGGACACCTAACGACACCCTGGCCT GTTGGTCTTGACCAGAGAAAGGCCAGCTCAGGGCAGCTGGAGCTGAAGAGGCAAGGACCTTTCTAATGAG GACATAAGTGAGGGACACTGGAAAGACCAAAAGAGAATGGAAAGTACTGACATGGTAGTTGCAGGGTGCT AGTGAGCAGTCATGCCCCCAAATCAGCCACCTTACATAGAACTCCCCAAGTTCAGGGCCACTGGATGGGG TTGTGACGCAGTCAAGCAGGGCCCAGAAAGCATACAAGCAGTTGGTTTCATCTCCTGTAAGAAAGTGGCA TCATCCCTGCTTTGTAAACGGAGAACCTGACACACACCAAGAGCACTCCTAGCCGTGGAAAAAAGCCGCT AGAACCCGAGGTTAGTCTGATTTTTGGTTCCTCTGAAAATTAGCTTTTGCTGGATGCTAGATTCAGTTCT GGACTTACTGAGTAGTCTCTGGGTTTTTGACATTGTTAGGCACTGTGGGAAAATTATAACAGGTACGTCT GCGCTGAGTTGCTTGCTAATTCCTAGGAGAGACTTGGACATTTTGGACAATTAAGAAGCAATACAGGCCA GGCACGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGCTCATCTGAGGTCAGG AGTTCGAGACCAGCCTGACCAGCATGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGCGTG GTGGCACATGCCTGTAATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACTGGGGAGG CAAAGGTTGCAGTGATCCGAGATCACGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAATTCTGTCTC AAAAAAACAAACAAACAAAAAGAAGCAATACAGCTCTTTGAGAAAGATGCAGTCATAAGTGGTGCAGAGT TGCAGTCTGCCCATTCCTGCTCCTCACTCATCGCTGTTCCGAACAAGTCAGCCAGGAAGCCGCACTGCAC CAAGGCTTTTAAAGATACCAGAAAACACCTGTGAAGCTGGAGGTGACCATTCACCAAATTCGAATCCCTC TAATGATCCGCAGCGTAAAATCCCTGGAGAAGGTGTGTGCTGACTTGATTCAGAGGAGGAAAGGAAAAGA ATGTCTAAGTGAAGGGACCAGTTTGAATGCCTGCCAAGACTTTGAGAATCACTATAAGAAAATCTCCTTG TGGTGAAGGTTCAGAGACATGGGATCGTTTCCAGATGAGAATCCACAAGCTACCCACTGACTTGCACAGT CCTTCTGAGATTGTTAAGCAGTTGACTTCCATCAGTGTTGAGCCAGGAATTGAGGTGGAAGTCACCATTG CAGATGCTCAAAGTCAACTATTTTAATAAACTGATTAGCGGTTGTTATAAAAAAAAAAAAAAAAAGCAGC AGCAATATGGGTTGAGCGCAGCGGCTCACACCTGTAATCCCAACACTTTGGGAGGTCAAGGTGGGTGGGT TGCTTGAGTCCAGGAGTTCAAGACCAGCCTGGGCAACATTTGAAATTTTAACTTATTTTTTAAAAAAGAA AGAAACATTATACCCAATATCTGTCAATTGATGACTGCAATGTGGTATGTCTACACAATTGAATATTATT AGGTCATTAAAAGGAACAAAGTGCTGATTCTATGCTATAACATGGAGGAAGTTTGAACACATGCTAAGTG AAAGAAGCCAGTCACAAAAGATCACATATTGTATGATTCCATTGATATGAAATATCTAGAATAGCCAAAT CCATAGACAGAAAGCAGATTAGTGGTTGCTTAGACTGGGGATAGGGGATGGAGGAGTGACTACTATGGGT CAGGCATTTTTTGAGGGGCGAGGGATGGTAAAAATGTTCTAAAGTGAGATTGTGGTGAATGATTGCACAA CTCTGAATATACAAAAACCATTAAATGGATGAATATTACAGCATGTGAATTACCTGTCTGCTGTTTAAAT AAAATAGAAACAATACAAAATGGAATGTAATTGAGTGTGAATTTGTGTGATTCAGGCGGTAACTGTTTTA CAGAAAATTAGAGATGAGACATTGATATAAACAAGGCTTCCTAGTTTCTTGTTTTGTTTTAAGACAGGGT CTGGCTGGGTGCGGTGGCTCACACCTGTAATCCCAGCACTTGCTAACTGAAGATGCAAGGACCGAGGCGG GCAGATCACTTAAGGTCTGGAGTTCAAGGACAGCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAT GCAAAAATAAGCCAGCCATTGTGGCATATGCCTGTAGTCCCAGCTGCTCCAGAGGCTGAAGTGGGAAAAT GGCTTGAACCTGGGAGGCAGAAGTTGCAGCAAGCCAAGATTGTGCCACTGCACTCCAGACTGGGCAACAA AGCAACTCTGTCTTAAAAAAAAAAAAGGGTCTTTGTCATCCCGTCCAGTGGCATGATCATAGCTCACCGT AGCCTCCAACTCCTGGGCTCAAGCAATCCTGTCTCAGCCCACTGAGTAGCTGGGACTACAGGCATGTGCC ACCAAGTCTGGCTAGTTTTTAAATTTTTTTGTAGAGACGAGGTCTCACTATGTTGCCTAGGCTGGTCTTG AACTCCTGGGCTCAAATGAGCCTCCTGCCTCAGCCTCCCCAAGTGCTGGGATTGCAGGCATAAGCCACTG CACCCAGCCCCTGGACGTTTTGGATGGTGGACTTTGAGTAGTTTGGGGTAGGAGGACTCTGGAGTGGCGC TGACAGTCCTCAGGAAGGAGTAAGCTTTGCCATGCCAGGGAGGATGCAGCCGTGCTGAAAGCATCCCAAC TGGGGAGGGGGGGGGGCGCGGTGGGGAGGGACAGCCCCTGGTAGAGAGAATGGGGCTGGGTGGAGAGAGT GGAAGCCAATTGCAGGGAGTCTTGAAGGTGAGGCAGGGATGTGGATTTTACTCTGTACACAGGGTAGATT TTGATCAGGAAAATAATGTCAAGCACATGACAGCTTGGAAGCAGGAGTCTGAGCTGCAGCCCCAGGGAGG CCATTTAAAAGATTATCCCGGCTGGGCGCCATGGCTCATGCCAGCACTTTGGGAGGCCGAGGCAGGCAGA TCACGAGGTCAGGAGCTTTAGACCAGCCTGACCAACATTCCCCTTCTCTACTAAAAATACAAAAATTAGC TGGGCATGGTGGCGCATGCCTGTAATCCCAGCAACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCG GGAGGCAGAGGTTGCAGTGAGCCGAGATCGCAGCACTTCACTCCAGCCTGGGCGAAAGAGCAAAACTCCA TCTCAAAAAAAAAAAAAAAAAAAATTTATCCCGAGATGGTTCCGGTAAAGGGATAGGACAGAGCATACCT GAGCCACGTTTGGAAGGGAACCGGGGTCTAAACTTGCATCAGGAGGAAAGCGAGCTGGTTCTTGAGGCTT TTACAGATCACGTATAGTGGAGTTTTGTTTGCACGTTCTGGTTGGGACGGGCAGGAAGTTACGGATCCAA GCTGGTATCAGCTAGAGCGGGTCTCACCAGGGCCAGTGTTCCTTTGCTGCATTCTCTTGGGGGGAAATAA ATGCCTGGGGGTTCTCTTTGCTACATTTTTGTCTTTGGGAGCTGCTTTTTTCTCTGGGATCGGCTGCAAT AGGCCTTGTGATGCCAGAGGGTAAGAATTCAAGTTTACTCTTGACCAATGGGTTGCACAGATCACAAGCT GCAAAATATTTAATCACCGAGGTCATTTGAGGGAAATGAGATTTGATCAATAGAAGTGTCTGCTCTGTTC CTTAAGAGTTGAGTCTAAACTGCTTTTCTCCTTACCTTCGTTTGGCAAAACCACAGACCATTAAAAATGG AAAGAATAACTTTTTCTAAGGCCCACAAAAGCTTATTTTTAATCAGTTGTGTGGTCTACTCACCTTTGTG GTGTTCCCCTTGACCGGACTCACAAAAATAAACGTGTGCAAGCCTAGTGGTTTCTGAGCCCTTTTAAAGC AGTACCCCTGTTTCTGACAACTCTTATTTAAGATAAAGCCCATGGGTCAATGCAGGACTGGGTCTGCAAC CTTGGCCCCCCCAAGAGAAACCACTGTCAGTCCCTGTCAGTTGCTGATCATGATGCGCGGGACACCCATT TTCATTTTTAAGGTTTCTAGCGGAAGCCTGTTGAGCACTTGAGGAAGACCGTGTTTCAAATAAGGGGGAG TGAAAGAGAAAAGGGAGAGTAGAAAGGAAGGCAGTGAAGAGCCAGAGTGACTGCACGTGTGGTATTTATT GAGCAAGCATTTCTTGAGCAACTCCTGGGCGCCAGGCATCGTAGTAGGTGCTGGGGATTTAAAGGTACCG ATGACACATCACCGCACTCAGGTTCAGAAAGAGGACTGCCCTTCAGTGTGACAGGTGCCAGGAGGGGGAG GGCACCTAACCCAGACTGGGAGTCAGCACCGCCCTGGAGGAGAAGTCACCAGCTAGGCTGAGACAGAAGA GTGAGTAGTGAGAGCTGGACAGAAAAAAATCAGGGGCCCTGTGGCCACTGGGGCAGCCGTGAGCCACAGC AGGGGCTGAGGGAGAACATGCTGTTTCAGAGCCTTATGCATCGGGGAGCGGCAGTCGCTCCACTGAGTCT CTTAGGGTGAACAAATGGTGAGAAAAGTCCTCTCCAAGGCTGTGGGCGGGATGTGGGTGGTAGGTGAGAG GTGGAAGATGCCAGGAGTACATTTGAACATCCTAAAAGGAAATAGAAAGTTCATTTCCCCTCGTGAGTGC AGAGGGGTGTGCTCAGGAGATGGGTAACAGCCCAGGATGGTGAACTCAGGTGTGTCCGGGCCACGGGCCT TCTTGAACGCGTGCGGGAAGAGGCACTGGTCAGGGGAGGGACAGGTGCTCTTGGTGGTATCAGATCTTGT GAGGTGCAGACACCCCGGTGGGTCCAGTGCTCCCACCCAGGGACAGAGAAGGATGGGGCACGGGGAGGGA GAGTGGATGGTGGGGGGCCTGAGGGTGTGCCCAGTCAGAGGGCTGAGGAGAAAGGACCTTTGTGTGCGAC AGCTCCTGCTGCCAGAGCAAGTGTGGGTTTTATGGCAGCTGTGGCCTCCCGTCCTAATATAGTCAACAGC TCCAAATCCCCTGCCCTGACACCTGTTAGCGAGAGGTTCCCTGAGCTGACCTCTCCTTGGGCTGCCCCCC CAGCATGTGCATCTGACGCGTCGAGGGCCAGACCCCCACCCTCTCCGAATCACACGCATCCTGGTCAGCC CCCAGTTGACAAATTGCCTTCTCTCGACTTGGGCAGGGGCTGCTGGGGTTTTGAGGGGCGGGGTTTGTTC AGCTGTTGCTAGGGAAGGGTGAGGCTGAGCTATCCCAAAGGAAATGGGGTGTTCCTCTGGCAAGTGGCAA TCTTGGCAAAGAACTGAGCATCTGGGGAGGGGGCAACTCCGGACACAAAGAAGTCCTGGGGAGGGCCGAC CTTTCCCCTTAGGATGGGGGAAATGAAATGCGCTTAATGCTGCTACAGCTGCTTCCTAACTTTGCCTCTT TCTTCCTTTGACTTTTGGAGGAGTGGGGTGGAAAAGAGATGGGGGTTCCCAGGCAGCCAGCTGTTTTCCC CACTGACCCATGCTCCAATTCCCACTGCCCTGGCTCAGTAGCCTCCAGTAAGTGATGCCCAGGATGGTGC GGCTCCGTGTGGCCAGCGTAATTCCCTTTGTCTCTCCCCTCCTCCCCTCTCCCTGTCTTCCTCTCTCGCC CCTTGGCTTCCCTTCCCGGCCCCGTGGTGGCTGCAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTC CTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAAC TGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGC AGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCAC CTACTTCTCCGTCAATGTTTCAGGTTGGTAGCCAAGCCCTGCCCTTGCCCCTCCCTAGACCCACCCCCTC CAGCCCTCTCTGCCAGTTTCAGAGGAAGGTGAACCTCCTCCCCCTCCGTGATCTGCCCCCACTCTGCTTC AGAAACTGCTGCCCACTAACATTGCTCCCTGCCTGCCGCGTGGCTTGGCTCTCAGAGAGGTGACTAGGTG GGGTGGGCCCCAGGGCCGGAGATCTGGGGCTTCCAGGACACACCTCGGAGGTGATTGCCAGGGCTCTTGG GATGTTAAGACCCTGTGATTTTTTTCCACCACAGCTTGCCCAGATCTCCAGGAGGCTAAGTGGTGCTCGG CCAGCTTCCACTCCATCACTCCCTTGCCATTTGGACTTGGTACTCGGCTTAGTGATTAGAGGCCCTGAAC AGGTGGTGGTATCCCTGCTCTGCTGGAGAGGAACCCAGGTGCACCGCAAGGGAGCTGTGCGAGGGCAGCC AGGGAGCCCTGGAGCTCTGTGAACTTGGGAACTTGCCACTCTTAGAATGTGACTTTCACAAAACTAGGAG TTGAGGAAGTGGAGCTGAAATTTTCTTTATGCCATTTATGCACCTCAGGGTGTGGACTTGGCAGCAGATC CCCAAAGGTGATAGGAAGGACTGGAGAAAGATCTGGCATGAACCCTGATGGGTGACCACATGTGTATCAA GCGTGTTCTTACAAGAAATAAATACTTATTGGGGAGAGGTGTTGGCAGCTGCTGGGGTGGTGGGTGCCCT ATCTGCTCTGATTAAGGAGGGCAGCCCCCAAACCTTAGTAGACACATGCTAGAAAAATTCTGACTGTGGG GTGTTTAGCCCATCCTTTGGAAATAGCATCTAGCCACAGTGTGTCTAGACCTGCCTGGGTTTCCCTATAG TCAGCCGTCCAAAGAAGAATACAGGTTGCCTGGCTCCAGCACACCCAGGTGGCACCACAAGTTGAGAAAG CGCCTTTGAATGTAGGACGGAATTAAGTTAAATAGGAACAGCTGACCCTGATGGAACCACCCAGTGTGAA GGCTTCCAGGCAGTGGGGGCAGTGCTTCGGGGAAGGAAGCAAACACGCACAGGAACTGTTCTTAAACAGT TTCCATCCCACCAAGAGATCATCACTAAGGGAGCAGTGGGACTGGGATCCCCATGGGGAGGGTGTCCGTG TTCATCTGGAACTGCACTAGCCTTGGTGAAATCTAGGGGTCCCTAGGAGGAACCTCAGTGCCCCTTCTTC TTCCCATAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGA AACAGATAACACCAAACCAAACCGTATGCGTGAGACACTGTTTCCTATCTTACTGCCCTTTGGGTCTGGG CATTGGGTTTAAGAGGGGAGGGGAAGGCTGAAAGGGGAGGAAGAGGAGGGCACATGGGGTCACGGTGCCT GTTCTGCTAAGTGCCAGGCACTGCTCACAGGTGTTGGGCAGATGGGCAAGACACCTCCAGGTCCTGGCCT GGGCCCTGCTCCTGAGCCTGACCAGCTGCTCCTCTCCACCCTGCCTGTCTCTCTTGGCTTTCCCCGGGCA GCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGA CAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGA ATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTACGTGTGTGTGCATGCGAAAGTTAGAGTAATGGG AACAGGGGAGGCCGAGTTAGGAAGTCCTGATTACATGCTTTTCATTTTTTTAAGTAATACTTTCCACCTA TACAGGTTATTCATTAAAATTTTTAAATACAAAAAAATGCAAATAAAGTTTAAACATTTCTTCAGTCTTC TTTCTGTAATATGGTTTTTACATAGTTGATCACATCATGTATGTAATTTCCTTGCCTTGTCATTTGTTAA CATGAGTCTTTTCCTGATATATTTCAAGCATGAATATTTGAAACATAATTTTTCATGACTGTATAAGATT CCATTATTTTAAAATCCCATAATTTGGCTGGGCATGGTGGCTCACGCCTAAAATCCTATCACTTTGGGAG GCCGAGGTGGGCGGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACATGGCGAAACCTCCTCT GTACTAAAAATACAAAAAATTAGCCATGTGTGGTGGCAGGCTCCTGTAATCCCAGCTACTGGGGAGGCTG AAGCAGGAGATTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCTGAGATCACGTCATTTCACTCTAGC CTGGGTGACAGAGTGAGACTCTGTCTCCAAAAAACAACAGAAAAAGTCCTATAATTTAATGAACTATTTT GTGATATTAGGTATTTTCTGGTTTTTCACCATAATAAATAATGTTGCAGTGAATCTCTGTCAGCATTTTT TTAAGCGTGCTTCCTTAGGACAGATTGTTACAAGTGAAATTACTAACTTAAAGGGTGTAAGCATTTTTTT TTTTTTTTTAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCA AGCTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTACCTGGGATGTGCAGCCACCA TTCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCCCCATGTTGGCCAGGCTGGTCTTGAACTC ATGACCTCAAGTGATCTGTCCGCCTGGGCCTCCCAAAGAGCTGGGATTACAGGCTTGAGCCACCGCACCC AGCCAGAAATATTTTAAATTAATTCACCATGCACTCACTACATGCAAGACACCATGCTTTAAATGCTGCA AGATAGCGTTCCTGCCCATAAAAATTTTGCAGTCTGATAGGAGGCAAATGTCCATGAGCAGCTACCGTAA AAAGTAGACTGTGATCAGTGCTTTGGTAGGCAGAGAGGAAAGGGTGAGCACAGTTCTGACCAGAGACTGG ACTGGAGGAGATGGTTTTTGAAATGAGCTGTCAAGGACAGTGGGGGCTGGATTCTTAGTGTAATAGGAGA GGTGCACAGTTGGGAACATTCTTGGTGTATTTGGGAGTGTTTGCAGAAGGCACATCTGTCCGGATCACGA ATGATCTTGAACGTCACAGTGGAGACTTCTGGAGTCTTTACACCCCATCTGCCAGCTTGCAGAGTGTGAA CGGGCTGGTAGGGGGGCAATCCACGCCTTGTCCTAGCCAACCCTGCAGCCTGGGGCCCTGTGCCACCAGG CTCTGATATGGAGGGCAGGTGCCACGGGGTGCCGACATTGTCATGGGGCCTGCATTTTCCTCTGGACCCT CAATGTATCCCTTTGGCATTTCCCCTCAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGT GCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAG CTGGATGTCGTGGGTAAGAGGGCAGAGGCAGCAGGAGGAATGAGTTTAGTGGGAAGAGCCAGGCTTGGAG AACACAGCCGGGGTGTCCAGGTTTCTTAGGGGCAGAGTCAGGATAGCGATTGGCACTTCTTGGCTTTGTC ACCTTGAGCAGGTCACTTCTCCCTTTTGAGCCTCACTTTTCTTATCTGTAAAATAGAGTTAAGATCAGAC AGTAACACGGTCAAAGCTGGTTGTCACTGTGAAATTGAAGGTGCTGTTCAGAGTCTGTCCTGAAGGAGGC GTTGTTGGAGAGGTGTTAAATGTAGCGTAATAGGAGCTGTCGCTTAATGCTAGCAAGATGCCAGGCTCCT TAAATACCTGCCCTGTAATGCTCATGGCACACCTGCAAGGTGGGCAGTATTAGTCTAGCCCTGCACAGGA GCACAGGCGCATAGGCTCAGAGAGGTCAGACACCTTGCTAATGCAGAACTGCACACCTGTGCCAACTTCA GGGCATCACAGGAGACTCTGGGAAGAACATTGAGCCTCTTGGAGCTATTACCGCAACCTTTTCCTTCTAG GAGTTCTGAAACTCACTCCCTAGAGATCATTGGGTACAGAATCTCTCAGCCAGTGTTCTTCTTGATTATG ATGATATGGTCTAAGAAGGAGATTGTGGCCAGGAGCAGTGGCTTATGAGCTCCAGGTGGCATGATGGGAT TACTCACGCCTGTGATCCCATCACTTTAGGAGGCCAAGGCTGGAGGATTGCTTGAGGCCAGGAGTGTGAG ACCAGCCTGGGCAACACAGTGAGACCCTGTCTCTATAAAAAAATTTAAAAATTAGCCTAGTGCAGTGTCA TGTACTTGTAGTACCAGCTGAGTTAACTGAGGCTACTGAGGTGGGAAGATCACTTGAGCCCAGGAATTCG AAGCTGCAGTGAGCTATGATGACACCCTTGTGCTCCAGCATGGGTGACAGAGTGAGACCCTGCCTTTAAA AAAAAAAAAGGTAAAAAGGAGATTCTGATCCAAGAGGTTGGGGTAAGATCTGAGATTCCGCGTTTCTAAC AAGCTCCTAGGGGATGCTGGTAGCACTGCTCGTGGACCACACTTTGAATAGCAGGAGTCAAAGTGACTCT GGTTTTTTAAGGAGGAGCAGGTTGTGCTGAGGTCTGGGGGTGCAACTGAATTAGAAGGTTCTCCATTAAA GCATGAGCGACTTACTGTGACTGTAAATATGATGACTGCCTTGGGGAGGAGGATCCTGATGGCTTAGGGC CTGAAGAGAGGGTGTCCCTTTCCCCAGCTCTGTTTTGAGAGGCTTGGGCTCAGCAGAAGTGCTGGGAGGT TTACAACCCATCACTGGGAAAGCCAAGTGGGGCGCAGGTGAGCCCACCCCTCTTTAGCCATGGCAAGGTC CCCATGACAAGTGCCTCCTCTCCCATCTTCCACAGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGG TTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGC AGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTA TGTCCAGATCTTGAAGGTAATCATGGCACCAGTCTTCGTGGGCCAGTCTACTGGGAAGGAGACCACTGTC TCGGGGGCTCAAGTTCCTGTGGGCAGGCTCAGTTGCCCCCGAATGGGATCATTCCTCACGCTTCAGGCAC ACACACTCCATCTCAGTAGGGATCTAGCCACATCCCCCAGGACTAGTAACAGAGGTCACAAAGTGGAGGT GAGCTGGGAACAGAGGGCTGCAGGGATGGGTGGTGCTGGTCTGTAATAAGCTTTGAGAGCAACGTCACTG GGGCTTTGGGGTCAGCTACACAAGGAAGGCATTTGGACCCCTGCCTTTTCATTGCCCGAAACCAGAGCCT TTCCACCAAGCGTTTCCCAGTCTTAGCCCTGTGTCCTGAGTTACGTACGATCTTTCTGGCAAATGGGGTG CATGATAAGAGCATCTCTTACGAAGAGTTGGAAAAACAAATGCCATATATAAATTCTAAGCCATATGAGG ACGAGGAGTAATGGCATTTTCTTCCTTTTTCCTCTCACTCCCAGACATTCATTGTCCCTGAATGCTCCAT TAATCCAGGGAAGGTAATTGCCTAAATCTCCAGTGGATCTCGCAACAGGAAGGAACCAGAAGCTGGGAAA GTTGTTTACCTCTTTGTCCCAGAGTTAGACCTCATCCTCCCCTAGCTTAGCTGTCTCAGAGATATACTGG CCCTCCCTTCTCTTCTCTTTGCTGCTGGTGCTAAAACTGCTCTGTAGGTCATTGGCCACTGTCTCCACTC ACAACCCCTGCTCCAGTCCTGGAGGGAGTGGGTTAAACACAAATAGAACATTCCATTTGAAGCAGTGATT CTTTTTTTTTTTTTTTTTTTTTAATCAAATGCTTTGGACTTTTGAAGTCCACTTGTTCTGTACTTGTAAA AGGGAAAGAAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTAGATCACTTGAGGTCAGGAG TTTGAGACCAGCCCGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGTGCATAG TGGTTGGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAAGCTAACTGCTTGAACCCAGAAGGCAGA GGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGTGAGACTCTGCGTTA AAAAAAAAAAAAAAAAAAAAAACTAAAAGGGAAAGGTAATAAATCTCACTTAACATCTCCCTTCGCTCCC TGGGCCTGCCTGAAAGTTACACGGGAGCAACGTGCGTGGCCACATCTCAGCTTTGCCCAACTGACTGGTG TGTCGTTGGTTTGTTCCAGCATTCGGGGATTAATAGCTCGGATGCGGAGGTGCTGACCCTGTTCAATGTG ACAGAGGCCCAGAGCGGGGAGTATGTGTGTAAGGTTTCCAATTATATTGGTGAAGCTAACCAGTCTGCGT GGCTCACTGTCACCAGACCTGTGGCAAAAGGTAATGGGGAGATGGATGGGACCCTGTGCTGGGGATTTGA TGTAGGCCCCAAGCTGCTGGGGCAGGCGGGGAAGCCAGTACTGGACTGTCCTTGCCACCCTACTGTATTT CTAGTGCCCAGAGCCATGGAAAAATACCCGGCCTGGGAGGCTGGTTTGGTTTGGTATTGTGTTGGTGTCT GTGGGTTCCCTCTCTGCCTTCTGTGTGTTCCTTGGCTTTGTGTGGATCCATGTGAGGACTCACGGGGACA CGGTTTTGCTGTGTTACAAATGGTACTTCAGACTGAAGTTGTGAGTGAGTGGTGATTAAGAGAAGGGGCC ATAGGCCAGGCACAGTGGCTCACGCCTGTCATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCGCTTG AAGCCAGGAGTTTGAGACCAGCCTGGGCAACATAGCAAGACCCCATCTCTACAAATTAAATAAATTAGCC AAGTATGGTGGCGTGTGCCTGTAGTCCCAGCTAGTCTGAAGGCTGAGGCAGGAGGATTGCCTGAGCTTAG GTCGAGGCTGCAGTGAGCTATGTTTATGCCACTGCACCCCAGCCTGGGTTGACAGAATGGTACCCCATCT CTTAAAAAAGAGAGAGAAGGGGTTAGGCATTCCCTTGCATACTCGCATCTGCTGGCTGTGTATGCACATG TGCGTGTGTGTATGCGTGTGCATGTGTGTGTCTGCAGCCCCCGCCATCCCTCCTGTGTTCACCTTCTGGC TATCTTTACCTGAAACCAAACAGCCCCTGCCCGCCGGCCCCATTTCTCCATGCCGCTCACCGCCCGCATG CTCGGATGGGCCAGTGGCTGCCAGCATCTGGTGAAGGGTCGTAACCAGCCATCGTCTTCTCAGGTCTGCC GGAGTTCTTCCCTCAGGGTCTCACCCTCTTCCTCTAACAGGTTTTGCTGCCTGGTGGTTTTCGTTTGTTC CTTGTTGCAAAGAAGATGTCAGGGAGCATTTCTTCCTCTAGTCCCCCTTCTTTCTGTCTCCTTCCCTTGC TCTGCGTCTCTTAGAGGTCTCATGTCCTGTGCTTGTCCATTTTGCTTCCGTTGTCTCTTCTAGACTGCTG GAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTCCTTTGAGGACGCAGGGGA GTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCTGCATGGTTGACCGTTCTGGAAGGT ACACACTGTAACTTCTCCTCTCGATGTCCTGCCCTCGCCACGGGCACGGGGGGAGCATGCATTTCCAGGC TTGGGGAGACACAGAGGCAGGAGAGCTGGAAGAATGGGCTCCTGCCTGCCTGGTGCCACATCCTGCCCCA GCTTTGAGGGCTGAATCCTCTCAGCTCAGAGAAGAGCTTCCCTAGTTTTGCAGGCGCACGGAGGCCTCCC ACCCGTACACCTGCCTCTGCTCTCCCCCTGGCCATTGCAATGCATGCCCGGGATCTGGGTTTACCCTGCA GCCCGACTCCTCCAGGGCAGGCTCCTTCCGTCCTTGGGTCCAGCAGCCTCCCCCCTCCGCTGGGTACTGA GCATCTGAAAAGTCTCAGATAGGGCCCTACACCTCTTCTCCCTTCTCAAGTGCTCAGCCCAGGGGTGGGG CTTGCTGCTTGCAAAGAGCAGCCCACCCTCCTGTACTGCCATCCTATTGCCTTTGAAGAAGGAGGTCAGC CTGGACAGGTGAACTGAGTTGCCTTCAGAAAGGCCTGTCTCAGGCAGCCGCAGCAGGCTTCACGATGTCC ATGTATCCTGTTTGCCTGCTGCCGTCTCTCCTCTCCCAAGAGGGGAGGTCTGCGTGTTGAGCCAGGGAGG AAGGAGCCTGCAGCCTGCTCAGGGTGGTGGCTGGTGACTGCGGGGCCAGGGCTTGCTGCTGTCTCTCGGA ATGTCCTGCATGTGGGTCTGGCTGTTCCTGCTGGCACTGCCCTCTTCTCTCTCCCCTCCTTTCCCACTCT GCCCTGCTTGCCCGTCAGGGTCTCCGGATGCCCCTGCTGGAGGCAGAGAAGCGTTCTGTTTTTATCATCG TCCCTGTCTTGGTCCTGTCCGTGCTCCCCATGTGCTCCCAATCAGTTGTCTTCGTTCCTCAACATCAGGG AAAGAAAAAACAGCAACACTTCTCCCTGTCATCAGCTCTGCTGTCTCCTTGTCAGGCCTTGGGACGTTCT CTGGGCTCAGTCTAGGGTCGTGCCTCATGCCTCATGCCTCTCTGGGAAGGTTCCCAGGGGCGCCGCCTCC ATGGTTGGCTGGTGGGTTTTAAAGGGGAAGGTTGGGAGGAGGCCTGTGGAAGGAGGAGGGCCGTCCACAC CCGTGGGGCAAAGCGTGTTCCATGAAACCAGTGCTGTGCGTGCTGGGATGAAAGCCTCCCAGCCTCTCGT GCTGAAGGGAAAGGTGGACCGAACTGGCTTAGCTGCTGTGGCAATGGGGTGGGGGGTGAGTCCTAATCAG AAGGTGGGAGAAGAGAATAACAAAATGGAACTCCGCCCCCTGCCGCCACATTTCCTTAAGTTTTAGGAGT TGGGGCCTATGAGTAGAATTTGAAAGAACTACCAAAAAAGCTTATTTTTGGAAATTAAGTCAGCTTTGCC TGTGGTTTGGCTAGGAATAAATATTTACCTGTGTGCCCCTACAGAGATGACACAGACCCAAAGTGGGACA TTGAGCAAGGCACAGGCTGGTTCCCCTCCTGTCCTCTGTCCTCATTCTGTGAGTGCCACCATCACCAGGT ACTGTGGCCTGCAGAAATAAACGAGGCACCAACCCTGCCCTCAGGGACCCCGTGTCTTCTTAGGGACAGA GGACTCAGAAACATCTGTGTCCCCGCATGTTAAGTGCATGCACACAGTGCTGAGGCTTTGCAGAGAAGGG CCATGGCTCCCTGAGGAGACCAAGAAAGGCACATAGAAGTGACTTCTCAGCTGGCCCTTGCAGGATCCCT GGGTGCCTGTACCTCTCCAGTCCAGCTGAGCAAGGAGGCTCAGGAATTAATGAAGATGGGGCTTGTGTAG CACGATGGTTCTAGGCCATCCCTTTTCCATGGCTCAAGTCCATTGAAGGCAGCCTCCAAAATCAGGGGGT TGCCTGATCCTCCTAGTGCCACAATCCCAGTCCTAGCTAGAACTTGCCATGGTTCTTCTCCCTAAAAGTT CCCAGGGGACAGGAGACAGGTGTTGCTTTTCTAATGGAGCGGGACCTCGCATGGACGGGGCCCTCCAAGC CTGCTAACACCCTGTTCGCACTGACTCAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTAC CTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTACA AGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGCAT CCCTCTGCGCAGACAGGTAACAGAAAGTAGATGGGGGATTTGCACACTCAGCACCACCTCTCTCTCTGGG CCTCTAATGCCCTGCCCTCTCCATTGTCCCTAATTTATAGCTTTGGGCCTTATTTTCTGGCTTCTGGGCA AGGCACAGTGGAATATCATGAACTAAGTGCTCTAGAGTCTGTTTCAAGCTAGTGTAGCCCGTGAATTTCC TGCACCCTCCATATCACACTGCAAGTCCTCCGGACTCCTGGGACATGGATTGGGAGGAAGTCCTATTTGG ACAGAATGTGCAGCCAATAGCATGAATTTGAACTGTCCCCAAGGGCTGCTTAGAAGTGCAGAGATGCAGG GTAGAGAAGAGAACTGTTTGTATTAGTCCATTTTCACACTGCTGAGAAAGACATACCCAAGACCGGGCAA TTTACAAAAGAAAGAGGTTTAATGGACTCACAGTTCCACGTGGCTGGGGAGGCCTCACAATTGCAGAAGG CAAAAGGCACGTCTCACATGGCGGCAGACGAGAAGAGAGCTTGTACAGGGAAACTCCCCTTTATAAAATC ATCAGATCTCGTGAGATTTATTCACTATCACAAGAACAGCACAGGGAAGACCTGCCCCCATGAGTCAATG ACCTCCTACCAGGTCCCTCCCATAACACGTGGGAATTCAAGATGAGATTTGGGTGGGGACACAGCCAAAC CATCTCAGCCATACCATACCCTTGTCCCCTGTGTGCCCACCCTTCCCCACGGGAGGAAATGGTACAGATG GCACAGGTGTGTGCAAGAATGACCGTTCCCTCAGAAGCCTGTGCTCATTCTGGAAGGTGCTTTGGGAGTT AGGAATCCATAAGCTAAGGCAAAGTATTTGCAAAGAGTCAGGAGAACAGAGTTGTTACTGCAATGATCAG TTATAAAATGTCAAGCTGGAAGAGGTGCATTTGGTCTGCTTATTTTAAAGGTGAGTGAAGTCCAGAAAGG CCAGCTTGTGGCAGAAATAGGTCAGTCCTAGAAGTTGGGCCTCCTGGCCTACCATGGTCTTTGGACCACT CTGTGTTGAGGAAAGAACATCAGATACACAGACATGTGCCTCTGCCATTGTTGGGAAGCCCTGACTAAGA ATGGGAAGGAGTCACCCCGTCCCCCCTCCTTGCTCTAGGGTGACCCCACTCTTCCTTGCAGGTGTCTGCT GACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTC CCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGGTA ATAATACTTTGACTCCCAACTTTTTGAAGGCATTCCTTGCTTGCTATTCTAGTGGTGGAAGGTGTGTATA CTAACACCTTCTGGGCGGTGAAGGTTCATGAAATGCCTGCAGAAACATTCATTCCACTTTCTGCTCGCAG TTGGGTGAAATACAGAGAGGTGGAGATGGGGTGCCTCTCAAGGTTTGAACTTCACCAGCCCCAACTTATG CCACTCTCTGTTTCCCCCGAAAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGG TGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGTT GAAGTGTAAGTGATGCTTCTGTCCTTGCAAAGAAAATCTTGTCCCATTCCAAGCAAACAGCAGGCCTCGG GCCCAGCAGAACAGCTTCTCTGGTGCCTTTGCTGCCCACACCTGCTCCGCTGCCTGCTTGGGGTTACCTG GGAGTGGAGGGGGTGTTCTGCACCTTGAGATTGTTCTATGACGTCACTCTGTTCCTTGGCGTCAACCTGG GCTGTGGTCAGGTGTTTATCCTGGATCCATCGCTTGCAGGCTTTCCTCACCACATCCCTGCCCACTCACT ACCACCTATTGCAACAACGGCTCCCATGAGAGGGAAGAGAAAACAAGTTTGGATGAAGTGGGGAGGAGAG AATCAAGTCCCAGGGAAAAGCAGCCCCTCGACACATACCCCACTCCCTTAGCCTTTATCCTGCCCTCCTC CCTTCCCAAGTAAATGAGTCTCAACGTGTTCTTTAAAGCGGACGCAACAGAGAAAGACTTGTCAGACCTG ATCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCA CGCAGGATGGTGGGTGCCGGCCAGACTGGCTTTCCCTGCCCAGCGGGGAGAAGATCTGAGCTGGGGTATC AGTCCCAAGGCCTCTCTCAGCCACAGCTAGGGAAGGGGGTTAAGAGAGGCTGCTTTGGCAGAGGTTTAAA ATGTGTTATCTCGGGATCTGGGCTCCGCTCATTGGTGTTCATTCAGGAATACAGATACCTAGATTCACAC ACGTGGTGTGTTAACAGAGGCAGCTGAGTAATTATGGTCTAAGAGCGCTCAGGCTGGGTGCAGTGGCTCA TGCCTGTAATCCCAGCAATTTGGGAGGCCGAGGCAGGAAGATCACTTGAGATCAGGAGTTCGAGACCAGT CTGGTCAAAATGGTGAAACCCCATCTCTACTAAAAAATACAAAAGTTAGCCAGGCATGGTCACGCATGCC TATAATCCCAGCTACTCAGGAGGCTGACGCATAAGACTTGCTTGAACCCGGGAGGTGGAGGTTGCAGTGA GCCAAGATCACGCCATTGTACTCCAGCTTGGGAGATACTCCCGCTGTCTCAAAAATAAAATAAATAAATA GGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACCTTGGGAGGGTGAGGCGGGTGGATCACTTGAGG TCAGGAGTTGGAGACCAGCCTGGCCAACAGGTGAAACCCCATCTCTACTAAAAATACAAAAAGTAGCCGG GCGTGGTGGCGCATGCCTGTAATTCCAGCTACTCGGGAGGCTGTGGCAGGAGAATCGTTTGAACACGGGA GGCGGAGGTTGCGGTTAGCCGAGATCGCGCCATTGCACTCCAGCTTGGGCAACGAGCAAAACTCCATCTC AAAAAAAAAAAAAAAAAAAAAAAAAATTAGCCAGGCATTGTTCATGCCTGTAATCCCAGCTGCTTGGGAG GCTGAGGCAGGAGAATCACTTGAATCCAGAAGGCAGAGGTTGCAGTGAGCCGAAATTGCGCCACTGCACT CCAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAATAAACAGACAAACTGGGGCTCTTACCCCAATGTT GCTCGGGAATTTTCTGGACTATGCTGGGAGTAATTATTTCTCTGATTTTTTTTGGGTAGTAGAATGGATT TCCCAGGTCCCCTAAGAGGAGGCAGGAGATGGGAGGTTGGCCGGGGTGTGCTGCTGGGGGTGGGGTTTCT TTGAGGTGAAGCCAAACCTGCTCACCTGCTGCTGGCCCCATGGCCTCTTCTCCTGTGCCTGCAGGTCCCT TGTATGTCATCGTGGAGTATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGG GCTGGAATACTGCTACAACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGC GCCTACCAGGTGGCCCGAGGCATGGAGTATCTGGCCTCCAAGAAGGTGTGGAACCTGAAGGCTCCCCTGG GTAATGCCAGGGTGGGAACAGAGCCCCCCTAGTCTTCCAGCCTGTGACTTATCATCTTGTGGTGGCGTTG TGGATGCACTGAGCACTGGCCCTGTGTGCCCTGTGTGTTGTCTTAGGCTCTCTGGGAACTGCAGAGTCAG GAGCACCAGTGTAGCCAGGTGGCCTTGGGGTCAGACTGATGCAGGGTCCGATCTGTGCACTGCCACTTTC TGCGTAGCCTCAGGCAGCTACTTAGCATCTTAAAATTCTTCAAATACAAAATAATAATAATATCAGCTGG GTGCAGTGGCCAAGGCGGGAGGATTGCTTGAGCTCAGGAGTGTGAGACCAGGTTGGGCAATATATTGAAA CCCCGTCTTTAAAAAAAAAAAAAAAATTAAAAAATTAGCTGGGTGTGGTAGTGCGTGCCGATAGTCCCAG CTACTCGGGAGGCTGAGGTGGGAGGCTAGCTTGAGCCCAAGAGTTTGAGGCTGCACTGAGCCATGATCAC ACCACTGCACCCCAGCCGGGGCGACAGAGCAAGGCCCTGTCTCAAAAGAAAATAAAGTATAACAATACCT GTTGTAGAATTGTTATGAAGATAAAATGAAACTGTCTGTGAGTGTTGAGTGCAGTGTTTGGTGTGTAAGG GCTGGCCTGGTTTGAGCCCAGCCCCATGTGGACTTGCTGTGCTGGGAGGCAGGACCTAGGAGCATGCATC GCTGCAGACGCAGCAGAGGCATAAGGGGCCAGTCTTTGGGGAAGGAAGGGAGGAGCGCTTGCTGTGATGA GAAGCCTGGAGCTGGCAGAGAATGTTAGAAGAGGGAAAGCAAAGGTTCGGGGGGCAGAGCAGTGTGGCAG AAGTTCTATGAGACAAGTCGGCTAGTTGCATGGGTGGCGGCCGCCCAGAGCCTTCCAGCTCCCTCACCTC CCCGCCTCCCGCTCTCCCTTCCTCCTTCCTCAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGG TGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTA TAAAAAGACAACCAACGTGAGTGCCGACAAGGCCGCCCTGTGCTGGTGGTTTCATCTGAGAAGCAAGGAG TGGGGTGGGCTGAGAACCCACCCCCCAGTCCCTTCCCACCTGTGCCCTCATGGCCCTGCCTGGGGCCACT CCAACCTCCCCTGTGCTGCTTTCAGGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGAC CGGATCTACACCCACCAGAGTGATGTGTGAGTTTGTAATAGCAATTGCCAGGGAGGTGTGGGATAGAGAG CTTCTAGCACTGTAGAGTCCTGCTTTCTCCCTGGACTGAGGAGTCCTCTTTCTGCCCCAGAGAGAAAAAC AAAACATTGTCTGTGGCCATTCCCTCTGCTCCAGATGTTGAAAGGCTGATCTGTTCTCCATGCTGTCTCC TGGCACTGCCCTGGGTAGAGGATTTGTGCTGGGGGAGGGGAGGCGGAGAAGCTCTAACACCCTGTGGCTC TCCGCCCATTTGCAGGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATAC CCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACT GCACCAACGAGCTGTAAGCCCGAGGAGATGTCGGAGGCCCTGAGCCAGGCCTTGGGGCAAGAGTGGGCTT GAGGGGCAGGGGGCTAGACTAGAGAGTATCCATCTCCAGGAGACGTCCCTGACCTTACAGTCCTGCCGCA GGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGA AGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGTAAGGCTGCCCGTGCCAGAGCCAGAGCTCAGG CCGTCCCCACTGCGTGCACGCACCTCCCTGAGCAGGGAGGAGGGGCCCGGCCCATCGCTGCTTCCTCTCG CCCATCACAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGG AGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGC CCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCTGACTGCCACCCACACGCCCTCCCCA GACTCCACCGTCAGCTGTAACCCTCACCCACAGCCCCTGCTGGGCCCACCACCTGTCCGTCCCTGTCCCC TTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGGGGCCTTCCTGTGTGGCCTGCCTTCACCCCACTCAGCT CACCTCTCCCTCCACCTCCTCTCCACCTGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCA CTTCATCCCCTCCCAGATGTTGGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGT GGGAGCCAATGAACAGGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCC TTCACCCATAAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCA GTGCTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCCGAT ACTAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTTGGGGGCAGT GTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGAAAACACAAAGTGTAT AAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAGATTTACCCATCGGGTAAGATG CTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAACAAAAAAGAAAAAAAAGGAAAATGTTTTT AAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTTATTTTTTTAAATTATGTTCTAAACCTATTTTCA GTTTAGGTCCCTCAATAAAAATTGCTGCTGCTTCATTTATCTATGGGCTGTATGAAAAGGGTGGGAATGT CCACTGGAAAGAAGGGACACCCACGGGCCCTGGGGCTAGGTCTGTCCCGAGGGCACCGCATGCTCCCGGC GCAGGTTCCTTGTAACCTCTTCTTCCTAGGTCCTGCACCCAGACCTCACGACGCACCTCCTGCCTCTCCG CTGCTTTTGGAAAGTCAGAAAAAGAAGATGTCTGCTTCGAGGGCAGGAACCCCATCCATGCAGTAGAGGC GCTGGGCAGAGAGTCAAGGCCCAGCAGCCATCGACCATGGATGGTTTCCTCCAAGGAAACCGGTGGGGTT GGGCTGGGGAGGGGGCACCTACCTAGGAATAGCCACGGGGTAGAGCTACAGTGATTAAGAGGAAAGCAAG GGCGCGGTTGCTCACGCCTGTAATCCCAGCACTTTGGGACACCGAGGTGGGCAGATCACTTCAGGTCAGG AGTTTGAGACCAGCCTGGCCAACTTAGTGAAACCCCATCTCTACTAAAAATGCAAAAATTATCCAGGCAT GGTGGCACACGCCTGTAATCCCAGCTCCACAGGAGGCTGAGGCAGAATCCCTTGAAGCTGGGAGGCGGAG GTTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCAACAGAGAAAACAAAAAGGAAAACAAA TGATGAAGGTCTGCAGAAACTGAAACCCAGACATGTGTCTGCCCCCTCTATGTGGGCATGGTTTTGCCAG TGCTTCTAAGTGCAGGAGAACATGTCACCTGAGGCTAGTTTTGCATTCAGGTCCCTGGCTTCGTTTCTTG TTGGTATGCCTCCCCAGATCGTCCTTCCTGTATCCATGTGACCAGACTGTATTTGTTGGGACTGTCGCAG ATCTTGGCTTCTTACAGTTCTTCCTGTCCAAACTCCATCCTGTCCCTCAGGAACGGGGGGAAAATTCTCC GAATGTTTTTGGTTTTTTGGCTGCTTGGAATTTACTTCTGCCACCTGCTGGTCATCACTGTCCTCACTAA GTGGATTCTGGCTCCCCCGTACCTCATGGCTCAAACTACCACTCCTCAGTCGCTATATTAAAGCTTATAT TTTGCTGGATTACTGCTAAATACAAAAGAAAGTTCAATATGTTTTCATTTCTGTAGGGAAAATGGGATTG CTGCTTTAAATTTCTGAGCTAGGGATTTTTTGGCAGCTGCAGTGTTGGCGACTATTGTAAAATTCTCTTT GTTTCTCTCTGTAAATAGCACCTGCTAACATTACAATTTGTATTTATGTTTAAAGAAGGCATCATTTGGT GAACAGAACTAGGAAATGAATTTTTAGCTCTTAAAAGCATTTGCTTTGAGACCGCACAGGAGTGTCTTTC CTTGTAAAACAGTGATGATAATTTCTGCCTTGGCCCTACCTTGAAGCAATGTTGTGTGAAGGGATGAAGA ATCTAAAAGTCTTCATAAGTCCTTGGGAGAGGTGCTAGAAAAATATAAGGCACTATCATAATTACAGTGA TGTCCTTGCTGTTACTACTCAAATCACCCACAAATTTCCCCAAAGACTGCGCTAGCTGTCAAATAAAAGA CAGTGAAATTGACCTGA    Download   Select all
Length	57697
OMIM ID	136350
HGNC ID	HGNC:3688
Unigene ID	Hs.264887
Ensembl ID	ENSG00000077782
PharmGKB ID	-

mRNA Information

mRNA ID	NM_023106.2
Exon	join(1..854,11301..11479,40400..40483,40742..40914, 42590..42713,44136..44326,46894..47038,49100..49302, 50462..50607,50844..50965,51419..51529,52775..52965, 53934..54056,54206..54276,54546..54683,54812..54917, 55031..57697)
mRNA Sequence	>2260 AGATGCAGGGGCGCAAACGCCAAAGGAGACCAGGCTGTAGGAAGAGAAGGGCAGAGCGCCGGAC AGCTCGGCCCGCTCCCCGTCCTTTGGGGCCGCGGCTGGGGAACTACAAGGCCCAGCAGGCAGCT GCAGGGGGCGGAGGCGGAGGAGGGACCAGCGCGGGTGGGAGTGAGAGAGCGAGCCCTCGCGCCC CGCCGGCGCATAGCGCTCGGAGCGCTCTTGCGGCCACAGGCGCGGCGTCCTCGGCGGCGGGCGG CAGCTAGCGGGAGCCGGGACGCCGGTGCAGCCGCAGCGCGCGGAGGAACCCGGGTGTGCCGGGA GCTGGGCGGCCACGTCCGGACGGGACCGAGACCCCTCGTAGCGCATTGCGGCGACCTCGCCTTC CCCGGCCGCGAGCGCGCCGCTGCTTGAAAAGCCGCGGAACCCAAGGACTTTTCTCCGGTCCGAG CTCGGGGCGCCCCGCAGGGCGCACGGTACCCGTGCTGCAGTCGGGCACGCCGCGGCGCCGGGGC CTCCGCAGGGCGATGGAGCCCGGTCTGCAAGGAAAGTGAGGCGCCGCCGCTGCGTTCTGGAGGA GGGGGGCACAAGGTCTGGAGACCCCGGGTGGCGGACGGGAGCCCTCCCCCCGCCCCGCCTCCGG GGCACCAGCTCCGGCTCCATTGTTCCCGCCCGGGCTGGAGGCGCCGAGCACCGAGCGCCGCCGG GAGTCGAGCGCCGGCCGCGGAGCTCTTGCGACCCCGCCAGGACCCGAACAGAGCCCGGGGGCGG CGGGCCGGAGCCGGGGACGCGGGCACACGCCCGCTCGCACAAGCCACGGCGGACTCTCCCGAGG CGGAACCTCCACGCCGAGCGAGGGTCAGTTTGAAAAGGAGGATCGAGCTCACTGTGGAGTATCC ATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGC CTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGC CTGAACAAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGA GAAAGAAACAGATAACACCAAACCAAACCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATG GAAAAGAAATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGA CCCCAAACCCCACACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGG AGGCTACAAGGTCCGTTATGCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAG GGCAACTACACCTGCATTGTGGAGAATGAGTACGGCAGCATCAACCACACATACCAGCTGGATG TCGTGGAGCGGTCCCCTCACCGGCCCATCCTGCAAGCAGGGTTGCCCGCCAACAAAACAGTGGC CCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTACAGTGACCCGCAGCCGCACATCCAGTGG CTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACAACCTGCCTTATGTCCAGATCT TGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCACTTAAGAAATGTCTC CTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCCCATCACTCT GCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGTACC TGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGT CTACAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTG GCCAAGAGCATCCCTCTGCGCAGACAGGTAACAGTGTCTGCTGACTCCAGTGCATCCATGAACT CTGGGGTTCTTCTGGTTCGGCCATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGT CTCTGAGTATGAGCTTCCCGAAGACCCTCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGC AAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTGGTGTTGGCAGAGGCTATCGGGCTGGACAAGG ACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGTTGAAGTCGGACGCAACAGAGAAAGA CTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGGGAAGCATAAGAATATCATC AACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAGTATGCCTCCAAGG GCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACAACCCCAG CCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCGA GGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGG TGACAGAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGA CTACTATAAAAAGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTT GACCGGATCTACACCCACCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCA CTCTGGGCGGCTCCCCATACCCCGGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGG TCACCGCATGGACAAGCCCAGTAACTGCACCAACGAGCTGTACATGATGATGCGGGACTGCTGG CATGCAGTGCCCTCACAGAGACCCACCTTCAAGCAGCTGGTGGAAGACCTGGACCGCATCGTGG CCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCCCTGGACCAGTACTCCCCCAGCTT TCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCTTCTCTCATGAGCCGCTG CCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACTCAAACGCCGCT GACTGCCACCCACACGCCCTCCCCAGACTCCACCGTCAGCTGTAACCCTCACCCACAGCCCCTG CTGGGCCCACCACCTGTCCGTCCCTGTCCCCTTTCCTGCTGGCAGGAGCCGGCTGCCTACCAGG GGCCTTCCTGTGTGGCCTGCCTTCACCCCACTCAGCTCACCTCTCCCTCCACCTCCTCTCCACC TGCTGGTGAGAGGTGCAAAGAGGCAGATCTTTGCTGCCAGCCACTTCATCCCCTCCCAGATGTT GGACCAACACCCCTCCCTGCCACCAGGCACTGCCTGGAGGGCAGGGAGTGGGAGCCAATGAACA GGCATGCAAGTGAGAGCTTCCTGAGCTTTCTCCTGTCGGTTTGGTCTGTTTTGCCTTCACCCAT AAGCCCCTCGCACTCTGGTGGCAGGTGCCTTGTCCTCAGGGCTACAGCAGTAGGGAGGTCAGTG CTTCGTGCCTCGATTGAAGGTGACCTCTGCCCCAGATAGGTGGTGCCAGTGGCTTATTAATTCC GATACTAGTTTGCTTTGCTGACCAAATGCCTGGTACCAGAGGATGGTGAGGCGAAGGCCAGGTT GGGGGCAGTGTTGTGGCCCTGGGGCCCAGCCCCAAACTGGGGGCTCTGTATATAGCTATGAAGA AAACACAAAGTGTATAAATCTGAGTATATATTTACATGTCTTTTTAAAAGGGTCGTTACCAGAG ATTTACCCATCGGGTAAGATGCTCCTGGTGGCTGGGAGGCATCAGTTGCTATATATTAAAAACA AAAAAGAAAAAAAAGGAAAATGTTTTTAAAAAGGTCATATATTTTTTGCTACTTTTGCTGTTTT ATTTTTTTAAATTATGTTCTAAACCTATTTTCAGTTTAGGTCCCTCAATAAAAATTGCTGCTGC TTCATTTATCTATGGGCTGTATGAAAAGGGTGGGAATGTCCACTGGAAAGAAGGGACACCCACG GGCCCTGGGGCTAGGTCTGTCCCGAGGGCACCGCATGCTCCCGGCGCAGGTTCCTTGTAACCTC TTCTTCCTAGGTCCTGCACCCAGACCTCACGACGCACCTCCTGCCTCTCCGCTGCTTTTGGAAA GTCAGAAAAAGAAGATGTCTGCTTCGAGGGCAGGAACCCCATCCATGCAGTAGAGGCGCTGGGC AGAGAGTCAAGGCCCAGCAGCCATCGACCATGGATGGTTTCCTCCAAGGAAACCGGTGGGGTTG GGCTGGGGAGGGGGCACCTACCTAGGAATAGCCACGGGGTAGAGCTACAGTGATTAAGAGGAAA GCAAGGGCGCGGTTGCTCACGCCTGTAATCCCAGCACTTTGGGACACCGAGGTGGGCAGATCAC TTCAGGTCAGGAGTTTGAGACCAGCCTGGCCAACTTAGTGAAACCCCATCTCTACTAAAAATGC AAAAATTATCCAGGCATGGTGGCACACGCCTGTAATCCCAGCTCCACAGGAGGCTGAGGCAGAA TCCCTTGAAGCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGG GCAACAGAGAAAACAAAAAGGAAAACAAATGATGAAGGTCTGCAGAAACTGAAACCCAGACATG TGTCTGCCCCCTCTATGTGGGCATGGTTTTGCCAGTGCTTCTAAGTGCAGGAGAACATGTCACC TGAGGCTAGTTTTGCATTCAGGTCCCTGGCTTCGTTTCTTGTTGGTATGCCTCCCCAGATCGTC CTTCCTGTATCCATGTGACCAGACTGTATTTGTTGGGACTGTCGCAGATCTTGGCTTCTTACAG TTCTTCCTGTCCAAACTCCATCCTGTCCCTCAGGAACGGGGGGAAAATTCTCCGAATGTTTTTG GTTTTTTGGCTGCTTGGAATTTACTTCTGCCACCTGCTGGTCATCACTGTCCTCACTAAGTGGA TTCTGGCTCCCCCGTACCTCATGGCTCAAACTACCACTCCTCAGTCGCTATATTAAAGCTTATA TTTTGCTGGATTACTGCTAAATACAAAAGAAAGTTCAATATGTTTTCATTTCTGTAGGGAAAAT GGGATTGCTGCTTTAAATTTCTGAGCTAGGGATTTTTTGGCAGCTGCAGTGTTGGCGACTATTG TAAAATTCTCTTTGTTTCTCTCTGTAAATAGCACCTGCTAACATTACAATTTGTATTTATGTTT AAAGAAGGCATCATTTGGTGAACAGAACTAGGAAATGAATTTTTAGCTCTTAAAAGCATTTGCT TTGAGACCGCACAGGAGTGTCTTTCCTTGTAAAACAGTGATGATAATTTCTGCCTTGGCCCTAC CTTGAAGCAATGTTGTGTGAAGGGATGAAGAATCTAAAAGTCTTCATAAGTCCTTGGGAGAGGT GCTAGAAAAATATAAGGCACTATCATAATTACAGTGATGTCCTTGCTGTTACTACTCAAATCAC CCACAAATTTCCCCAAAGACTGCGCTAGCTGTCAAATAAAAGACAGTGAAATTGACCTGAAAAA AAAAAAAAAAAA    Download   Select all
Length	5644

CDS Information

   

Location	join(7729..7739,11301..11479,40400..40483,40742..40914, 42590..42713,44136..44326,46894..47038,49100..49302, 50462..50607,50844..50965,51419..51529,52775..52965, 53934..54056,54206..54276,54546..54683,54812..54917, 56240..56446)
CDS Sequence	>lcl|NM_001174063.1_cds_NP_001167534.1_1 [gene=FGFR1] [protein=fibroblast growth factor receptor 1 isoform 10 precursor] [protein_id=NP_001167534.1] [location=943..3405] ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGT CCCCGACCTTGCCTGAACAAGCCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCC CGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGG GTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCG CAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAA TGTTTCAGATGCTCTCCCCTCCTCGGAGGATGATGATGATGATGATGACTCCTCTTCAGAGGAGAAAGAA ACAGATAACACCAAACCAAACCGTATGCCCGTAGCTCCATATTGGACATCCCCAGAAAAGATGGAAAAGA AATTGCATGCAGTGCCGGCTGCCAAGACAGTGAAGTTCAAATGCCCTTCCAGTGGGACCCCAAACCCCAC ACTGCGCTGGTTGAAAAATGGCAAAGAATTCAAACCTGACCACAGAATTGGAGGCTACAAGGTCCGTTAT GCCACCTGGAGCATCATAATGGACTCTGTGGTGCCCTCTGACAAGGGCAACTACACCTGCATTGTGGAGA ATGAGTACGGCAGCATCAACCACACATACCAGCTGGATGTCGTGGAGCGGTCCCCTCACCGGCCCATCCT GCAAGCAGGGTTGCCCGCCAACAAAACAGTGGCCCTGGGTAGCAACGTGGAGTTCATGTGTAAGGTGTAC AGTGACCCGCAGCCGCACATCCAGTGGCTAAAGCACATCGAGGTGAATGGGAGCAAGATTGGCCCAGACA ACCTGCCTTATGTCCAGATCTTGAAGACTGCTGGAGTTAATACCACCGACAAAGAGATGGAGGTGCTTCA CTTAAGAAATGTCTCCTTTGAGGACGCAGGGGAGTATACGTGCTTGGCGGGTAACTCTATCGGACTCTCC CATCACTCTGCATGGTTGACCGTTCTGGAAGCCCTGGAAGAGAGGCCGGCAGTGATGACCTCGCCCCTGT ACCTGGAGATCATCATCTATTGCACAGGGGCCTTCCTCATCTCCTGCATGGTGGGGTCGGTCATCGTCTA CAAGATGAAGAGTGGTACCAAGAAGAGTGACTTCCACAGCCAGATGGCTGTGCACAAGCTGGCCAAGAGC ATCCCTCTGCGCAGACAGGTGTCTGCTGACTCCAGTGCATCCATGAACTCTGGGGTTCTTCTGGTTCGGC CATCACGGCTCTCCTCCAGTGGGACTCCCATGCTAGCAGGGGTCTCTGAGTATGAGCTTCCCGAAGACCC TCGCTGGGAGCTGCCTCGGGACAGACTGGTCTTAGGCAAACCCCTGGGAGAGGGCTGCTTTGGGCAGGTG GTGTTGGCAGAGGCTATCGGGCTGGACAAGGACAAACCCAACCGTGTGACCAAAGTGGCTGTGAAGATGT TGAAGTCGGACGCAACAGAGAAAGACTTGTCAGACCTGATCTCAGAAATGGAGATGATGAAGATGATCGG GAAGCATAAGAATATCATCAACCTGCTGGGGGCCTGCACGCAGGATGGTCCCTTGTATGTCATCGTGGAG TATGCCTCCAAGGGCAACCTGCGGGAGTACCTGCAGGCCCGGAGGCCCCCAGGGCTGGAATACTGCTACA ACCCCAGCCACAACCCAGAGGAGCAGCTCTCCTCCAAGGACCTGGTGTCCTGCGCCTACCAGGTGGCCCG AGGCATGGAGTATCTGGCCTCCAAGAAGTGCATACACCGAGACCTGGCAGCCAGGAATGTCCTGGTGACA GAGGACAATGTGATGAAGATAGCAGACTTTGGCCTCGCACGGGACATTCACCACATCGACTACTATAAAA AGACAACCAACGGCCGACTGCCTGTGAAGTGGATGGCACCCGAGGCATTATTTGACCGGATCTACACCCA CCAGAGTGATGTGTGGTCTTTCGGGGTGCTCCTGTGGGAGATCTTCACTCTGGGCGGCTCCCCATACCCC GGTGTGCCTGTGGAGGAACTTTTCAAGCTGCTGAAGGAGGGTCACCGCATGGACAAGCCCAGTAACTGCA CCAACGAGCTGTACATGATGATGCGGGACTGCTGGCATGCAGTGCCCTCACAGAGACCCACCTTCAAGCA GCTGGTGGAAGACCTGGACCGCATCGTGGCCTTGACCTCCAACCAGGAGTACCTGGACCTGTCCATGCCC CTGGACCAGTACTCCCCCAGCTTTCCCGACACCCGGAGCTCTACGTGCTCCTCAGGGGAGGATTCCGTCT TCTCTCATGAGCCGCTGCCCGAGGAGCCCTGCCTGCCCCGACACCCAGCCCAGCTTGCCAATGGCGGACT CAAACGCCGCTGA    Download   Select all
CCDS ID	-

Protein Information

      

Protein ID	NP_001167534.1
Protein Name	fibroblast growth factor receptor 1
Molecular Wt. (Da)	89242
Protein Sequence	>2260 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSI NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDD DDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK NGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPI LQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA FLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVSADSSASMNSGVLLVRPSRLS SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVK MLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPV EELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS MPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR    Download   Select all
Length	820
Uniprot ID	P78347
Ensembl Protein ID	ENSP00000404240

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	675
Y	Phosphorylation	699
Y	Phosphorylation	588
Y	Phosphorylation	612
Y	Phosphorylation	586
Y	Phosphorylation	610
Y	Phosphorylation	677
Y	Phosphorylation	701
V	Proteolytic Cleavage	366
V	Proteolytic Cleavage	279
V	Proteolytic Cleavage	277
V	Proteolytic Cleavage	368
Y	Phosphorylation	764
Y	Phosphorylation	677
Y	Phosphorylation	675
Y	Phosphorylation	729
Y	Phosphorylation	653;-
Y	Phosphorylation	653;-
Y	Phosphorylation	653;-
Y	Phosphorylation	564;-
Y	Phosphorylation	651;-
Y	Phosphorylation	562;-

Enzyme Information

   

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                                                                      

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
1387	CREBBP	2534	NP_004371.2	in vitro;in vivo	15929978
1398	CRK	1267	NP_058431.2	in vitro	10464310
2224	FDPS	606	NP_001995.1	in vitro;in vivo;yeast 2-hybrid	12020352
2246	FGF1	567	NP_000791.1	in vitro;in vivo	1   103   225   010   336   500
2247	FGF2	622	NP_001997.5	in vitro;in vivo	1   095   094   911   030   350
2248	FGF3	1289	NP_005238.1	in vitro	8663044
2249	FGF4	1294	NP_001998.1	in vitro	11486033
2252	FGF7	1022	NP_002000.1	in vitro	8663044
2253	FGF8	2727	NP_149353.1	in vitro;in vivo	10574949
2254	FGF9	2951	NP_002001.1	in vitro;in vivo	10574949
2885	GRB2	150	NP_002077.1	in vivo	9480847
4684	NCAM1	301	NP_851996.2	in vivo	12121226
5295	PIK3R1	1381	NP_852664.1	in vitro;in vivo	15117958
5296	PIK3R2	4404	NP_005018.1	in vitro;in vivo	15117958
5335	PLCG1	1398	NP_002651.2	in vitro;in vivo	126   010   801   689   310
6195	RPS6KA1	3402	NP_001006666.1	in vitro;in vivo	15117958
6452	SH3BP2	3657	NP_003014.3	in vitro;in vivo	15117958
6503	SLA	3060	NP_006739.2	in vitro;in vivo	15117958
8440	NCK2	5378	NP_003572.2	in vitro;in vivo	15117958
8817	FGF18	4766	NP_387498.1	in vitro	10751172
8822	FGF17	4765	NP_003858.1	in vitro	10751172
8829	NRP1	3642	NP_003864.4	in vitro	15695515
10313	RTN3	18516	NP_958831.1	in vitro;in vivo	15117958
10818	FRS2	6372	NP_006645.3	in vitro;in vivo	11   877   385   110   906   200   000   000
23371	TENC1	16256	NP_056134.2	in vitro;in vivo	15117958
54756	IL17RD	8431	AAM77571.1	in vivo	12604616

Pathway Information

                                                                        

Pathway Name	Pathway ID
Adherens junction	hsa04520
Central carbon metabolism in cancer	hsa05230
MAPK signaling pathway	hsa04010
Melanoma	hsa05218
Pathways in cancer	hsa05200
PI3K-Akt signaling pathway	hsa04151
Prostate cancer	hsa05215
Proteoglycans in cancer	hsa05205
Rap1 signaling pathway	hsa04015
Ras signaling pathway	hsa04014
Regulation of actin cytoskeleton	hsa04810
Signaling pathways regulating pluripotency of stem cells	hsa04550

Structure Information

PDB ID	1AGW
Resolution	2.4
Method	?? X-RAY DIFFRACTION
Chains	A, B
Molecule	FGF RECEPTOR 1
Model	View

Domain Information

ID	Location	Description
cd05098	464-765	PTKc_FGFR1
cl21453	464-765	PKc_like superfamily
cd04974	270-359	Ig3_FGFR
cl11960	270-359	Ig superfamily
cd05857	163-247	Ig2_FGFR
cl11960	163-247	Ig superfamily
cd04973	40-118	Ig1_FGFR
cl11960	40-118	Ig superfamily
cd05053	465-759	PTKc_FGFR
cd05099	465-779	PTKc_FGFR4
cd05100	465-799	PTKc_FGFR3
cd05101	454-765	PTKc_FGFR2
cd00192	482-755	PTKc
cd05054	470-754	PTKc_VEGFR
cd05055	464-751	PTKc_PDGFR
cd05103	470-754	PTKc_VEGFR2
cd05045	477-758	PTKc_RET
cd14207	470-754	PTKc_VEGFR1
cd05102	470-754	PTKc_VEGFR3
cd05106	464-756	PTKc_CSF-1R
cd05107	460-758	PTKc_PDGFR_beta
cd05105	460-758	PTKc_PDGFR_alpha
cd05104	464-756	PTKc_Kit
cd05032	471-756	PTKc_InsR_like
cd05039	471-757	PTKc_Csk_like
cd05044	484-754	PTKc_c-ros
cd05036	472-755	PTKc_ALK_LTK
cd05034	482-755	PTKc_Src_like
cd05047	484-757	PTKc_Tie
cd05089	484-771	PTKc_Tie1
cd05148	471-757	PTKc_Srm_Brk
cd05050	472-756	PTKc_Musk
cd05048	472-750	PTKc_Ror
cd05068	471-750	PTKc_Frk_like
cd05061	471-754	PTKc_InsR
cd05049	472-754	PTKc_Trk
cd05051	472-750	PTKc_DDR
cd05056	471-757	PTKc_FAK
cd05038	474-758	PTKc_Jak_rpt2
cd05088	484-758	PTKc_Tie2
cd05052	471-755	PTKc_Abl
cd05060	482-757	PTKc_Syk_like
cd05083	471-756	PTKc_Chk
cd05035	478-758	PTKc_TAM
cd05082	471-757	PTKc_Csk
cd13999	484-754	STKc_MAP3K-like
cd05041	484-755	PTKc_Fes_like
cd05058	484-758	PTKc_Met_Ron
cd05062	471-754	PTKc_IGF-1R
cd05057	472-756	PTKc_EGFR_like
cd05059	478-754	PTKc_Tec_like
cd05075	477-758	PTKc_Axl
cd05043	475-754	PTK_Ryk
cd05046	473-754	PTK_CCK4
cd14204	475-759	PTKc_Mer
cd05092	475-750	PTKc_TrkA
cd05074	473-759	PTKc_Tyro3
cd05033	482-758	PTKc_EphR
cd05085	481-754	PTKc_Fer
cd05072	471-764	PTKc_Lyn
cd05084	481-754	PTKc_Fes
cd05040	482-754	PTKc_Ack_like
cd05095	472-750	PTKc_DDR2
cd05067	471-754	PTKc_Lck_Blk
cd05097	472-750	PTKc_DDR_like
cd00180	484-754	PKc
cd05093	473-750	PTKc_TrkB
cd05096	472-750	PTKc_DDR1
cd05109	482-757	PTKc_HER2
cd05091	484-750	PTKc_Ror2
cd05090	472-750	PTKc_Ror1
cd05858	270-359	Ig3_FGFR-2
cd05073	467-750	PTKc_Hck
cd05094	473-750	PTKc_TrkC
cd05113	474-751	PTKc_Btk_Bmx
cd05112	476-754	PTKc_Itk
cd05108	482-795	PTKc_EGFR
cd05066	477-758	PTKc_EphR_A
cd05063	482-758	PTKc_EphR_A2
cd14205	484-757	PTKc_Jak2_rpt2
cd05079	482-758	PTKc_Jak1_rpt2
cd14203	482-750	PTKc_Src_Fyn_like
cd05080	484-754	PTKc_Tyk2_rpt2
cd05069	471-764	PTKc_Yes
cd05114	478-758	PTKc_Tec_Rlk
cd05081	484-757	PTKc_Jak3_rpt2
cd05116	482-747	PTKc_Syk
cd05115	475-747	PTKc_Zap-70
cd05070	471-764	PTKc_Fyn
cd05071	471-750	PTKc_Src
cd05110	482-757	PTKc_HER4
cd05065	484-758	PTKc_EphR_B
cd05111	481-757	PTK_HER3
cd05729	163-247	Ig2_FGFR_like
cd14061	484-757	STKc_MLK
cd05064	472-758	PTKc_EphR_A10
cd06606	477-753	STKc_MAPKKK
cd14058	484-751	STKc_TAK1
cd14059	510-755	STKc_MAP3K12_13
cd14060	485-755	STKc_MLTK
cd14206	484-750	PTKc_Aatyk3
cd14145	472-757	STKc_MLK1
cd05122	480-750	PKc_STE
cd13968	484-643	PKc_like
cd14146	484-757	STKc_MLK4
cd14148	484-757	STKc_MLK2
cd05042	482-758	PTKc_Aatyk
cd14066	484-757	STKc_IRAK
cd05087	482-750	PTKc_Aatyk1
cd14147	478-755	STKc_MLK3
cd14065	484-754	PKc_LIMK_like
cd13978	484-756	STKc_RIP
cd14007	480-752	STKc_Aurora
cd14014	480-756	STKc_PknB_like
cd14003	479-753	STKc_AMPK-like
cd05117	479-753	STKc_CAMK
cd08215	484-750	STKc_Nek
cd06614	482-753	STKc_PAK
cd06627	480-750	STKc_Cdc7_like
cd06611	467-753	STKc_SLK_like
cd06632	481-752	STKc_MEKK1_plant
cd14062	484-755	STKc_Raf
cd14002	476-700	STKc_STK36
cd14099	481-753	STKc_PLK
cd14155	513-759	PKc_TESK
cd14151	471-757	STKc_B-Raf
cd14027	528-752	STKc_RIP1
cd14154	484-757	STKc_LIMK
cd05086	484-758	PTKc_Aatyk2
cd06612	484-753	STKc_MST1_2
cd14000	484-754	STKc_LRRK
cd07829	484-703	STKc_CDK_like
cd08530	482-750	STKc_CNK2-like
cd13992	520-757	PK_GC
cd07833	479-714	STKc_CDKL
cd06623	478-752	PKc_MAPKK_plant_like
cd06644	468-752	STKc_STK10
cd05037	503-754	PTK_Jak_rpt1
cd14221	484-755	STKc_LIMK1
cd05118	479-714	STKc_CMGC
cd06629	477-753	STKc_Bck1_like
cd06610	483-752	STKc_OSR1_SPAK
cd14008	484-750	STKc_LKB1_CaMKK
cd14009	484-722	STKc_ATG1_ULK_like
cd08225	482-752	STKc_Nek5
cd14080	480-690	STKc_TSSK-like
cd14158	475-757	STKc_IRAK4
cd14150	482-757	STKc_A-Raf
cd06643	466-752	STKc_SLK
cd13996	484-754	STKc_EIF2AK
cd06613	482-753	STKc_MAP4K3_like
cd06624	462-753	STKc_ASK
cd14156	513-757	PKc_LIMK_like_unk
cd06609	484-750	STKc_MST3_like
cd06625	480-750	STKc_MEKK3_like
cd06628	481-751	STKc_Byr2_like
cd08529	480-750	STKc_FA2-like
cd14149	471-755	STKc_C-Raf
cd14042	509-750	PK_GC-A_B
cd14222	484-764	STKc_LIMK2
cd05619	476-722	STKc_nPKC_theta
cd13979	476-746	STKc_Mos
cd07830	479-750	STKc_MAK_like
cd08217	484-753	STKc_Nek2
cd07840	484-703	STKc_CDK9_like
cd06608	474-752	STKc_myosinIII_N_like
cd14064	484-755	PKc_TNNI3K
cd14121	484-749	STKc_ULK3
cd14056	482-746	STKc_TGFbR_I
cd14072	480-753	STKc_MARK
cd08218	482-752	STKc_Nek1
cd14162	480-718	STKc_TSSK4-like
cd14119	484-750	STKc_LKB1
cd13993	477-751	STKc_Pat1_like
cd05570	482-710	STKc_PKC
cd08219	482-746	STKc_Nek3
cd14069	479-690	STKc_Chk1
cd14073	477-746	STKc_NUAK
cd14071	482-750	STKc_SIK
cd14063	478-757	PK_KSR
cd07841	477-692	STKc_CDK7
cd05581	481-711	STKc_PDK1
cd14081	480-749	STKc_BRSK1_2
cd06605	484-752	PKc_MAPKK
cd05616	484-744	STKc_cPKC_beta
cd14202	470-723	STKc_ULK1
cd14116	470-752	STKc_Aurora-A
cd14161	484-750	STKc_NUAK2
cd14165	479-752	STKc_TSSK1_2-like
cd08228	482-745	STKc_Nek6
cd05580	480-700	STKc_PKA_like
cd14075	480-753	STKc_NIM1
cd14068	484-755	STKc_LRRK2
cd06641	484-752	STKc_MST3
cd07851	470-703	STKc_p38
cd14079	479-716	STKc_AMPK_alpha
cd13987	484-695	STKc_SBK1
cd08224	480-746	STKc_Nek6_7
cd06917	484-750	STKc_NAK1_like
cd05123	484-729	STKc_AGC
cd05620	482-722	STKc_nPKC_delta
cd07860	484-779	STKc_CDK2_3
cd14084	475-752	STKc_Chk2
cd14078	484-752	STKc_MELK
cd13997	484-751	PKc_Wee1_like
cd14120	484-723	STKc_ULK1_2-like
cd13994	484-753	STKc_HAL4_like
cd07834	482-695	STKc_MAPK
cd13998	511-746	STKc_TGFbR-like
cd07862	484-694	STKc_CDK6
cd08221	484-752	STKc_Nek9
cd14664	484-757	STK_BAK1_like
cd05589	484-710	STKc_PKN
cd08223	479-753	STKc_Nek4
cd14077	479-752	STKc_Kin1_2
cd06631	481-750	STKc_YSK4
cd05582	482-744	STKc_RSK_N
cd06642	484-752	STKc_STK25
cd06640	484-752	STKc_MST4
cd05592	482-710	STKc_nPKC_theta_like
cd08222	477-746	STKc_Nek11
cd14048	484-752	STKc_EIF2AK3_PERK
cd05615	484-744	STKc_cPKC_alpha
cd07866	475-695	STKc_BUR1
cd14053	487-695	STKc_ACVR2
cd07835	484-779	STKc_CDK1_CdkB_like
cd06648	474-752	STKc_PAK_II
cd14098	484-749	STKc_Rad53_Cds1
cd07838	484-696	STKc_CDK4_6_like
cd07863	484-694	STKc_CDK4
cd07857	482-714	STKc_MPK1
cd14050	484-750	PKc_Myt1
cd07832	479-703	STKc_CCRK
cd07842	485-696	STKc_CDK8_like
cd07836	484-726	STKc_Pho85
cd14117	472-701	STKc_Aurora-B_like
cd14025	484-762	STKc_RIP4_like
cd06622	484-752	PKc_PBS2_like
cd14663	480-753	STKc_SnRK3
cd13975	480-758	PKc_Dusty
cd06647	484-701	STKc_PAK_I
cd14187	468-753	STKc_PLK1
cd07873	484-728	STKc_PCTAIRE1
cd07877	471-703	STKc_p38alpha
cd07878	471-703	STKc_p38beta
cd14076	479-691	STKc_Kin4
cd05078	478-755	PTK_Jak2_rpt1
cd14052	477-758	PTKc_Wee1_fungi
cd13985	482-754	STKc_GAK_like
cd06655	474-778	STKc_PAK2
cd05587	484-728	STKc_cPKC
cd14189	481-752	STKc_PLK3
cd06636	484-752	STKc_MAP4K4_6_N
cd05584	482-703	STKc_p70S6K
cd06637	484-752	STKc_TNIK
cd07846	479-754	STKc_CDKL2_3
cd07871	480-728	STKc_PCTAIRE3
cd05077	510-755	PTK_Jak1_rpt1
cd14152	480-760	STKc_KSR1
cd14142	491-757	STKc_ACVR1_ALK1
cd06645	474-752	STKc_MAP4K3
cd14175	509-752	STKc_RSK1_C
cd06633	484-751	STKc_TAO3
cd13989	484-715	STKc_IKK
cd14188	477-752	STKc_PLK2
cd07831	479-752	STKc_MOK
cd14045	511-757	PK_GC_unk
cd06654	474-787	STKc_PAK1
cd14143	484-746	STKc_TGFbR1_ACVR1b_ACVR1c
cd06638	474-752	STKc_myosinIIIA_N
cd14208	478-755	PTK_Jak3_rpt1
cd06620	474-751	PKc_Byr1_like
cd14164	480-750	STKc_TSSK6-like
cd14201	510-723	STKc_ULK2
cd13983	518-701	STKc_WNK
cd07880	471-695	STKc_p38gamma
cd08220	484-750	STKc_Nek8
cd07848	484-714	STKc_CDKL5
cd14039	484-692	STKc_IKK_alpha
cd14026	509-755	STKc_RIP2
cd14097	481-752	STKc_STK33
cd07847	480-714	STKc_CDKL1_4
cd08528	484-696	STKc_Nek10
cd14054	484-708	STKc_BMPR2_AMHR2
cd08229	482-745	STKc_Nek7
cd14167	484-752	STKc_CaMKI_alpha
cd14044	511-757	PK_GC-C
cd14144	482-746	STKc_BMPR1
cd06656	474-778	STKc_PAK3
cd06635	482-752	STKc_TAO1
cd06630	481-750	STKc_MEKK1
cd14070	479-753	STKc_HUNK
cd14004	482-753	STKc_PASK
cd05578	485-703	STKc_Yank1
cd14178	509-767	STKc_RSK3_C
cd14118	541-714	STKc_CAMKK
cd06621	476-709	PKc_Pek1_like
cd14186	484-701	STKc_PLK4
cd06653	480-695	STKc_MEKK3_like_u1
cd06607	484-688	STKc_TAO
cd14046	482-692	STKc_EIF2AK4_GCN2_rpt2
cd07872	484-728	STKc_PCTAIRE2
cd14012	517-750	PK_eIF2AK_GCN2_rpt1
cd07865	484-695	STKc_CDK9
cd06652	480-695	STKc_MEKK2
cd14047	483-694	STKc_EIF2AK2_PKR
cd07854	482-715	STKc_MAPK4_6
cd06646	474-751	STKc_MAP4K5
cd14006	484-703	STKc_MLCK-like
cd14057	509-757	PK_ILK
cd14067	502-752	STKc_LRRK1
cd07845	484-703	STKc_CDK10
cd14103	484-703	STKc_MLCK
cd14177	489-752	STKc_RSK4_C
cd14001	512-696	PKc_TOPK
cd14137	477-703	STKc_GSK3
cd14093	522-700	STKc_PhKG
cd14037	475-750	STKc_NAK_like
cd07864	484-695	STKc_CDK12
cd06617	476-752	PKc_MKK3_6
cd06659	474-752	STKc_PAK6
cd07861	484-695	STKc_CDK1_euk
cd07856	482-703	STKc_Sty1_Hog1
cd05856	163-247	Ig2_FGFRL1-like
cd06634	482-752	STKc_TAO2
cd05611	482-711	STKc_Rim15_like
cd06639	494-712	STKc_myosinIIIB_N
cd14086	476-768	STKc_CaMKII
cd14036	477-759	STKc_GAK
cd13995	482-752	STKc_MAP3K8
cd07839	484-713	STKc_CDK5
cd07879	471-714	STKc_p38delta
cd14083	475-722	STKc_CaMKI
cd14199	531-701	STKc_CaMKK2
cd05590	484-711	STKc_nPKC_eta
cd14095	480-753	STKc_DCKL
cd14220	482-757	STKc_BMPR1a
cd14159	484-695	STKc_IRAK1
cd14043	527-750	PK_GC-2D
cd14055	484-693	STKc_TGFbR2_like
cd07849	484-703	STKc_ERK1_2_like
cd06626	470-753	STKc_MEKK4
cd14194	480-708	STKc_DAPK1
cd07837	484-779	STKc_CdkB_plant
cd06616	471-703	PKc_MKK4
cd14166	475-717	STKc_CaMKI_gamma
cd14038	484-701	STKc_IKK_beta
cd14106	478-710	STKc_DRAK
cd14198	482-710	STKc_DRAK2
cd14209	482-744	STKc_PKA
cd14185	480-717	STKc_DCKL3
cd05579	487-710	STKc_MAST_like
cd05595	482-744	STKc_PKB_beta
cd07844	483-779	STKc_PCTAIRE_like
cd14091	462-752	STKc_RSK_C
cd06658	474-753	STKc_PAK5
cd14193	484-703	STKc_MLCK4
cd14010	557-709	STKc_ULK4
cd14176	512-752	STKc_RSK2_C
cd14074	480-742	STKc_SNRK
cd14087	484-701	STKc_PSKH1
cd14169	484-722	STKc_CaMKI_beta
cd06651	481-751	STKc_MEKK3
cd14153	477-757	PK_KSR2
cd00096	174-244	Ig
cd05630	484-733	STKc_GRK6
cd14197	481-710	STKc_DRAK1
cd05572	484-703	STKc_cGK
cd14200	525-701	STKc_CaMKK1
cd06619	511-752	PKc_MKK5
cd05591	482-710	STKc_nPKC_epsilon
cd07870	511-712	STKc_PFTAIRE2
cd14111	529-701	STKc_SPEG_rpt2
cd14190	484-703	STKc_MLCK2
cd05612	482-700	STKc_PRKX_like
cd14094	527-752	STKc_CASK
cd07850	482-703	STKc_JNK
cd14090	481-703	STKc_Mnk
cd06650	544-758	PKc_MEK1
cd14192	484-703	STKc_MLCK3
cd05613	480-701	STKc_MSK1_N
cd14135	483-695	STKc_PRP4
cd05593	482-713	STKc_PKB_gamma
cd14210	484-703	PKc_DYRK
cd07853	605-693	STKc_NLK
cd13982	482-749	STKc_IRE1
cd14219	482-746	STKc_BMPR1b
cd05632	484-715	STKc_GRK5
cd07858	605-703	STKc_TEY_MAPK
cd07852	604-703	STKc_MAPK15-like
cd06615	544-702	PKc_MEK
cd14174	484-703	STKc_Mnk1
cd14141	530-693	STKc_ACVR2a
cd05602	482-694	STKc_SGK1
cd14168	484-749	STKc_CaMKI_delta
cd05577	585-701	STKc_GRK
cd07855	484-693	STKc_ERK5
cd06657	466-752	STKc_PAK4
cd14011	605-751	PK_SCY1_like
cd07843	605-715	STKc_CDC2L1
cd14131	482-750	PKc_Mps1
cd06649	502-709	PKc_MEK2
cd07874	482-693	STKc_JNK3
cd00096	273-355	Ig
cd05603	482-710	STKc_SGK2
cd14196	513-703	STKc_DAPK2
cd07875	482-703	STKc_JNK1
cd14019	484-695	STKc_Cdc7
cd14105	480-710	STKc_DAPK
cd14049	484-752	STKc_EIF2AK1_HRI
cd05586	484-716	STKc_Sck1_like
cd14195	480-708	STKc_DAPK3
cd14133	484-703	PKc_DYRK_like
cd05609	610-710	STKc_MAST
cd14140	511-695	STKc_ACVR2b
cd05728	173-247	Ig4_Contactin-2-like
cd05614	480-701	STKc_MSK2_N
cd14096	484-700	STKc_RCK1-like
cd05617	484-715	STKc_aPKC_zeta
cd14110	510-702	STKc_obscurin_rpt2
cd14173	484-703	STKc_Mnk2
cd14184	476-701	STKc_DCKL2
cd08216	480-688	PK_STRAD
cd14132	476-694	STKc_CK2_alpha
cd14183	476-733	STKc_DCKL1
cd07859	605-703	STKc_TDY_MAPK
cd13986	484-755	STKc_16
cd05076	604-754	PTK_Tyk2_rpt1
cd05631	604-701	STKc_GRK4
cd05594	482-713	STKc_PKB_alpha
cd14163	480-691	STKc_TSSK3-like
cd14085	480-701	STKc_CaMKIV
cd06618	604-752	PKc_MKK7
cd14109	528-703	PK_Unc-89_rpt1
cd14179	482-716	STKc_MSK1_C
cd05608	602-698	STKc_GRK1
cd14181	507-700	STKc_PhKG2
cd05604	482-700	STKc_SGK3
cd05571	611-744	STKc_PKB
cd14182	529-700	STKc_PhKG1
cd13977	557-756	STKc_PDIK1L
cd05598	620-700	STKc_LATS
cd14033	484-752	STKc_WNK4
cd05605	604-715	STKc_GRK4_like
cd05583	484-701	STKc_MSK_N
cd14114	476-714	STKc_Twitchin_like
cd05618	480-701	STKc_aPKC_iota
cd04968	255-358	Ig3_Contactin_like
cd14191	484-703	STKc_MLCK1
cd08226	509-709	PK_STRAD_beta
cd05573	619-701	STKc_ROCK_NDR_like
cd07876	531-693	STKc_JNK2
cd07869	484-704	STKc_PFTAIRE1
cd13990	511-753	STKc_TLK
cd14136	604-695	STKc_SRPK
cd05731	283-358	Ig3_L1-CAM_like
cd14104	484-703	STKc_Titin
cd05747	156-237	Ig5_Titin_like
cd14088	489-701	STKc_CaMK_like
cd05725	273-358	Ig3_Robo
cd05723	174-245	Ig4_Neogenin
cd14113	484-708	STKc_Trio_C
cd05610	478-695	STKc_MASTL
cd14102	606-752	STKc_PIM3
cd14112	474-708	STKc_Unc-89_rpt2
cd14018	536-746	STKc_PINK1
cd05736	277-361	Ig2_Follistatin_like
cd05607	484-701	STKc_GRK7
cd05588	482-701	STKc_aPKC
pfam13895	168-247	Ig_2
cd05731	178-247	Ig3_L1-CAM_like
cd14665	470-701	STKc_SnRK2-3
cd05725	174-247	Ig3_Robo
cd14101	480-753	STKc_PIM2
cd14005	480-693	STKc_PIM
cd14020	531-695	STKc_KIS
cd14180	531-703	STKc_MSK2_C
cd05869	264-358	Ig5_NCAM-1
cd05750	177-242	Ig_Pro_neuregulin
cd14160	512-695	PK_IRAK3
cd05585	555-715	STKc_YPK1_like
pfam00047	173-232	ig
cd05736	177-237	Ig2_Follistatin_like
cd05728	262-358	Ig4_Contactin-2-like
pfam13895	254-358	Ig_2
cd05729	267-348	Ig2_FGFR_like
pfam00047	270-341	ig
cd05723	272-358	Ig4_Neogenin
cd05856	269-348	Ig2_FGFRL1-like
pfam13895	45-118	Ig_2
cd05750	283-348	Ig_Pro_neuregulin
cd05728	48-109	Ig4_Contactin-2-like
cd05857	267-358	Ig2_FGFR
cd04968	168-247	Ig3_Contactin_like
cd00096	51-115	Ig
cd05750	66-116	Ig_Pro_neuregulin
pfam00047	48-103	ig
pfam07714	478-754	Pkinase_Tyr
pfam07679	160-247	I-set
smart00410	262-358	IG_like
smart00408	47-108	IGc2
smart00221	478-754	STYKc
smart00219	478-754	TyrKc
smart00220	480-753	S_TKc
pfam00069	478-753	Pkinase
COG0515	480-822	SPS1
PHA02988	509-754	PHA02988
PTZ00024	480-703	PTZ00024
smart00409	262-358	IG
PTZ00267	540-752	PTZ00267
PTZ00426	482-701	PTZ00426
pfam07679	262-358	I-set
PTZ00263	463-701	PTZ00263
smart00409	173-247	IG
smart00410	173-247	IG_like
PLN00009	484-714	PLN00009
smart00408	173-237	IGc2
PTZ00283	559-751	PTZ00283
PTZ00036	480-714	PTZ00036
PTZ00266	482-749	PTZ00266
PRK13184	484-701	pknD
PLN00034	531-702	PLN00034
PHA03209	482-693	PHA03209
smart00408	270-348	IGc2
TIGR03903	510-695	TOMM_kin_cyc
PHA03212	529-695	PHA03212
PHA03390	534-709	pk1
pfam07679	45-118	I-set
smart00410	44-118	IG_like
smart00409	44-118	IG

Ontology Information

   

HPRD ID	6764
Molecular Class	Receptor tyrosine kinase
Molecular Function	DNA binding (GO:0003677)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P11362	DB00039	Palifermin	BiotechDrug
P11362	DB00398	Sorafenib	SmallMoleculeDrug
P11362	DB08896	Regorafenib	SmallMoleculeDrug
P11362	DB08901	Ponatinib	SmallMoleculeDrug
P11362	DB09078	Lenvatinib	SmallMoleculeDrug
P11362	DB09079	Nintedanib	SmallMoleculeDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO