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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FHL1 2273 four and a half LIM domains 1  XSLIM1, KYO-T, bA535K18.1, FHL1B, XMPMA, FLH1A, MGC111107 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25272045   2014Cell line : HepG2, LS180,293T

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

 DNA bisulfite modification and sequencing experiments,chromatin immunoprecipitation assays,Luciferase reporter assays,RT-PCR and Western blottingDown-regulation and Hypermethylation-miR-410 may function as an oncomiR and are consistent with its key function in regulating FHL1 in certain digestive system cancers.


Gene Details



NC_000023.10 (135228861..135293518)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]  
Chromosome X
Location Xq26.3
Start 135228861  
End 135293518  
Strand +  
Gene Sequence

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Length 64658  
OMIM ID 300163   
HGNC ID HGNC:3702   
Unigene ID Hs.435369   
Ensembl ID ENSG00000022267   
PharmGKB ID PA28141   

mRNA Information


mRNA ID NM_001159702.2
Exon join(699..927,23206..23279,59706..59887,60315..60489, 61091..61260,61754..61940,62542..62741,63170..64658)  
mRNA Sequence

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Length 2724  



CDS Information


   
Location 330..1301
CDS Sequence

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CCDS ID CCDS14655.1



Protein Information


      
Protein IDNP_001153174.1
Protein Namefour and a half LIM domains 1
Molecular Wt. (Da)36132
Protein Sequence

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Length 323  
Uniprot IDP63000
Ensembl Protein ID ENSP00000258737  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation233

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3516RBPJ920NP_005340.2in vivo15710417   
4604MYBPC11185NP_002456.2in vitro;in vivo;yeast 2-hybrid16407297   
6015RING13624NP_002922.2in vivo15710417   
6722SRF2788NP_003122.1in vitro15610731   
59269HIVEP39442NP_078779.2in vitro;in vivo;yeast 2-hybrid14999091   


Pathway Information


      
Pathway Name Pathway ID
Jak-STAT signaling pathway hsa04630


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09424101-158  LIM2_FHL1
cl02475101-158  LIM superfamily
cd09429162-214  LIM3_FHL1
cl02475162-214  LIM superfamily
cd0934440-93  LIM1_FHL1
cl0247540-93  LIM superfamily
cd09346162-213  LIM3_FHL
cd09345101-154  LIM2_FHL
cd09431162-218  LIM3_Fhl2
cd0934337-92  LIM1_FHL
cd09430162-213  LIM5_LIMPETin
cd0942237-96  LIM1_FHL2
cd0942337-92  LIM1_FHL3
cd0942798-155  LIM2_FHL3
cd09426101-157  LIM2_FHL2
cd0942137-92  LIM3_LIMPETin
cd09425101-154  LIM4_LIMPETin
smart0013240-92  LIM
cd0934540-92  LIM2_FHL
cd0942640-96  LIM2_FHL2
cd08368162-213  LIM
smart00132100-153  LIM
cd09347162-212  LIM4_FHL
cd09343158-213  LIM1_FHL
smart00132162-212  LIM
cd09432162-212  LIM6_LIMPETin
cd09427162-214  LIM2_FHL3
cd09422158-215  LIM1_FHL2
cd0836840-92  LIM
pfam00412101-158  LIM
cd08368101-154  LIM
cd09345162-213  LIM2_FHL
cd09421158-213  LIM3_LIMPETin
cd09346101-153  LIM3_FHL
cd0934740-93  LIM4_FHL
cd09428101-153  LIM2_FHL5
cd09350162-213  LIM1_TRIP6
cd09348159-215  LIM4_FHL1
cd0934837-95  LIM4_FHL1
cd09341150-213  LIM2_Testin_like
cd09434162-212  LIM4_FHL3
cd0934240-102  LIM3_Testin_like
cd09338162-209  LIM3_Paxillin_like
cd0942540-92  LIM4_LIMPETin
cd09349162-213  LIM1_Zyxin
cd09430101-153  LIM5_LIMPETin
cd09363101-150  LIM3_Enigma_like
pfam00412162-213  LIM
cd0934640-92  LIM3_FHL
cd0942840-92  LIM2_FHL5
cd0943440-93  LIM4_FHL3
cd0943240-93  LIM6_LIMPETin
cd09419162-214  LIM3_Testin
cd09336101-154  LIM1_Paxillin_like
cd0945940-91  LIM3_ENH
cd09417161-214  LIM2_LIMPETin_like
cd09423158-213  LIM1_FHL3
cd0942298-158  LIM1_FHL2
pfam0041240-92  LIM
cd09338101-150  LIM3_Paxillin_like
cd09426162-214  LIM2_FHL2
cd0933140-89  LIM1_PINCH
cd09433162-215  LIM4_FHL2
cd0943340-92  LIM4_FHL2
cd09461101-150  LIM3_Enigma_like_1
cd0942040-91  LIM3_Prickle
cd0942940-92  LIM3_FHL1
cd09431101-153  LIM3_Fhl2
cd0943040-92  LIM5_LIMPETin
cd0946140-89  LIM3_Enigma_like_1
cd0943140-92  LIM3_Fhl2
cd09341May-33  LIM2_Testin_like
cl02475May-33  LIM superfamily
cd09840162-213  LIM2_CRP2
cd09421101-155  LIM3_LIMPETin
cd09336162-213  LIM1_Paxillin_like
cd09459101-150  LIM3_ENH
cd0936340-91  LIM3_Enigma_like
cd0942740-92  LIM2_FHL3
cd09352162-209  LIM1_Ajuba_like
cd09342162-209  LIM3_Testin_like
cd09344162-212  LIM1_FHL1
cd0934040-89  LIM1_Testin_like
cd09406161-213  LIM1_Leupaxin
cd09425162-213  LIM4_LIMPETin
cd09372162-213  LIM2_FBLP-1
cd09348100-153  LIM4_FHL1
cd09434101-153  LIM4_FHL3
cd0984040-92  LIM2_CRP2
cd09396101-154  LIM_DA1
cd09482162-213  LIM2_CRP3
cd0946040-91  LIM3_ZASP_Cypher
cd09354162-213  LIM2_LPP
cd0939340-93  LIM3_Lrg1p_like
cd09351162-213  LIM1_LPP
cd09339162-213  LIM4_Paxillin_like
cd09342101-150  LIM3_Testin_like
cd09457162-209  LIM2_ENH
cd09448162-209  LIM_CLP36
cd09406101-150  LIM1_Leupaxin
cd09343101-154  LIM1_FHL
cd0940340-92  LIM2_CRP
cd09362162-209  LIM2_Enigma_like
cd0936440-91  LIM1_LIMK
cd09360162-209  LIM_ALP_like
cd09393162-212  LIM3_Lrg1p_like
cd09428162-213  LIM2_FHL5
cd0941940-90  LIM3_Testin
cd09361119-154  LIM1_Enigma_like
cd0948240-92  LIM2_CRP3
cd0934940-92  LIM1_Zyxin
cd09418150-213  LIM2_Prickle
cd09396162-213  LIM_DA1
cd0946340-91  LIM1_LIMK2
cd0939440-93  LIM1_Rga
cd0940159-92  LIM_TLP_like
cd09405101-150  LIM1_Paxillin
cd09411162-213  LIM4_Paxillin
cd0933258-92  LIM2_PINCH
cd09361162-213  LIM1_Enigma_like
cd0939640-86  LIM_DA1
cd09329162-213  LIM3_abLIM
cd09450162-209  LIM_ALP


Ontology Information


   
HPRD ID5924
Molecular ClassUnclassified
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO