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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FKBP4 2288 FK506 binding protein 4, 59kDa  12FKBP59, FKBP52 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22612312   2012Cell line : -

Source : -

Sample Type : Serum samples

No. of Sample : -

Stage : -

Immunoscreening of cDNA librariesUp-regulation--


Gene Details



NC_000012.11 (2904108..2914589)

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Gene Type protein coding
Gene Family Tetratricopeptide (TTC) repeat domain containing
Description The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]  
Chromosome 12
Location 12p13.33
Start 2904108  
End 2914589  
Strand +  
Gene Sequence

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Length 10482  
OMIM ID 600611   
HGNC ID HGNC:3720   
Unigene ID Hs.524183   
Ensembl ID ENSG00000004478   
PharmGKB ID PA28161   

mRNA Information


mRNA ID NM_002014.3
Exon join(1..303,2197..2341,2788..2930,3765..3885,4147..4303, 4909..4999,5098..5181,5451..5636,6176..6415,8210..10482)  
mRNA Sequence

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Length 3757  



CDS Information


   
Location 199..1578
CDS Sequence

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CCDS ID CCDS8512.1



Protein Information


      
Protein IDNP_002005.1
Protein NameFK506 binding protein 4, 59kDa
Molecular Wt. (Da)51674
Protein Sequence

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Length 459  
Uniprot IDQ06609
Ensembl Protein ID ENSP00000267868  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation143
SPhosphorylation451;-
SPhosphorylation453;-
KAcetylation282
YPhosphorylation411
YPhosphorylation293

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
475ATOX13779NP_004036.1in vitro;in vivo;yeast 2-hybrid15133031   
2280FKBP1A1741NP_000792.1in vitro;yeast 2-hybrid11164950   
2908NR3C1679NP_001019265.1in vitro8341706   
3662IRF43543NP_002451.2in vitro;in vivo10714679   
4306NR3C22991NP_000892.2in vitro9392437   
5264PHYH3609NP_006205.1in vitro10051602   
11146GLMN3451NP_444504.1in vitro;in vivo8955134   
64750SMURF26901NP_073576.1in vivo15761153   


Pathway Information


      
Pathway Name Pathway ID
Estrogen signaling pathway hsa04915


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0025443-134  FKBP_C
cl1951943-134  FKBP_C superfamily
pfam00515321-352  TPR_1
cl22897321-352  TPR_1 superfamily
smart00028322-352  TPR
pfam07719354-386  TPR_2
cl22897354-386  TPR_1 superfamily
pfam00515354-386  TPR_1
smart00028354-386  TPR
pfam13174356-386  TPR_6
cl15865356-386  TPR_6 superfamily
pfam13414322-384  TPR_11
COG05452-138  FkpA
PRK1090228-138  PRK10902
PRK115704-136  PRK11570
TIGR02917250-395  PEP_TPR_lipo
COG104750-162  SlpA
pfam13414274-349  TPR_11
TIGR00990240-399  3a0801s09
TIGR02917309-425  PEP_TPR_lipo
TIGR03302275-411  OM_YfiO
TIGR02552309-386  LcrH_SycD
PLN03088326-439  PLN03088
COG0457175-385  TPR
TIGR02521249-387  type_IV_pilW
TIGR02917276-430  PEP_TPR_lipo
pfam13424277-349  TPR_12
COG4785335-407  NlpI
pfam13432323-386  TPR_16
pfam13424319-385  TPR_12
TIGR02521308-386  type_IV_pilW
COG5010322-433  TadD
TIGR00990261-376  3a0801s09
TIGR03516155-254  ppisom_GldI
COG4976337-395  COG4976
pfam13414356-403  TPR_11
TIGR02917277-395  PEP_TPR_lipo
TIGR02917309-395  PEP_TPR_lipo
COG3063304-386  PilF
COG4235297-394  NrfG
pfam13371325-405  TPR_9
TIGR02917309-394  PEP_TPR_lipo


Ontology Information


   
HPRD ID1265
Molecular ClassEnzyme: Isomerase
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO