Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FLI1 | 2313 | Fli-1 proto-oncogene, ETS transcription factor | 11 | SIC-1, EWSR2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21400501 | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Illumina HumanMethylation27 beadchips, Methylation-Sensitive High Resolution Melting (MS-HRM) analysis, and Exon arrays. | Methylation | - | The methylation patterns of 15 selected genes, hypermethylated in adenomas and carcinomas (FLI1, ST6GALNAC5, TWIST1, ADHFE1, JAM2, IRF4, CNRIP1, NRG1 and EYA4). |
| 25472652 | 2014 | Cell line : - Source : Biobank of the Taipei Veterans General Hospital. Sample Type : Blood Plasma No. of Sample : 75 independent CRC series and 353 CRC patients with available plasma Stage : - | whole-genome methylation arrays,High-resolution, genome-wide approach | Methylation | - | In both MSI and MSS, 228 promoter-associated CpG islands were hypermethylated, with AGBL4, ZNF625, MDFI, TWIST1, and FLI1 being most frequently hypermethylated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] | Chromosome | 11 |
| Location | 11q24.1-q2 |
| Start | 128556430 |
| End | 128683162 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 126733 |
| OMIM ID | 193067 |
| HGNC ID | HGNC:3749 |
| Unigene ID | Hs.504281 |
| Ensembl ID | ENSG00000151702 |
| PharmGKB ID | PA28170 |
mRNA Information
| mRNA ID | NM_001271012.1 |
|---|---|
| Exon | join(1..167,71581..71792,95424..95489,118832..118897, 120646..120705,122623..122670,123925..126733) | mRNA Sequence | Download Select all |
| Length | 3442 |
Protein Information
| Protein ID | NP_001257941.1 |
|---|---|
| Protein Name | Fli-1 proto-oncogene, ETS transcription factor |
| Molecular Wt. (Da) | 28953 |
| Protein Sequence | Download Select all |
| Length | 259 |
| Uniprot ID | P11234 |
| Ensembl Protein ID | ENSP00000272519 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 76 |
| S | Phosphorylation | 86 |
| S | Phosphorylation | 89 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2078 | ERG | 1298 | NP_001129626.1 | in vitro | 9681824 |
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
| 51567 | TTRAP | 5771 | NP_057698.2 | in vitro;in vivo | 12743594 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08541 | 114-204 | SAM_PNT-FLI-1 |
| cl15755 | 114-204 | SAM_superfamily superfamily |
| pfam00178 | 280-363 | Ets |
| cl02599 | 280-363 | Ets superfamily |
| smart00413 | 280-363 | ETS |
| cd08531 | 126-200 | SAM_PNT-ERG_FLI-1 |
| cd08540 | 126-199 | SAM_PNT-ERG |
| pfam02198 | 114-198 | SAM_PNT |
| smart00251 | 114-197 | SAM_PNT |
| cd08203 | 129-196 | SAM_PNT |
| cd08534 | 123-201 | SAM_PNT-GABP-alpha |
| cd08533 | 127-198 | SAM_PNT-ETS-1,2 |
| cd08542 | 118-198 | SAM_PNT-ETS-1 |
| cd08535 | 129-191 | SAM_PNT-Tel_Yan |
| cd08532 | 126-177 | SAM_PNT-PDEF-like |
| cd08543 | 118-191 | SAM_PNT-ETS-2 |
| cd08536 | 129-176 | SAM_PNT-Mae |
| cd08757 | 129-178 | SAM_PNT_ESE |
| cd08538 | 130-181 | SAM_PNT-ESE-2-like |
| cd08539 | 130-195 | SAM_PNT-ESE-3-like |
Ontology Information
| HPRD ID | 3371 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Guanyl-nucleotide exchange factor activity (GO:0005085) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.