Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FLNA | 2316 | filamin A  | X | FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25717257    | 2015 | Cell line : - Source : Department of the Second General Surgery of the Fourth Hospital of Hebei Medical University. Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 46 Stage : - | Immunohistochemistry,RT-PCR,Western blotting. | Down-regulation | - | FLNa showed low expression in colorectal adenocarcinoma, high correlation with the incidence and development of colorectal cancer, and was considered an indicator of prognosis. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]   | Chromosome | X |
| Location | Xq28 |
| Start | 153576900   |
| End | 153603006   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 26107   |
| OMIM ID | 300017    |
| HGNC ID | HGNC:3754    |
| Unigene ID | -    |
| Ensembl ID | ENSG00000196924    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | ?NM_001110556.1 |
|---|---|
| Exon |   | mRNA Sequence |    Download   Select all |
| Length |   |
CDS Information
| Location | |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS44021.1 |    
Protein Information
| Protein ID | |
|---|---|
| Protein Name | filamin A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 0   |
| Uniprot ID | Q12967 |    
| Ensembl Protein ID | ENSP00000361117   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1084 |
| S | Phosphorylation | 1459 |
| S | Phosphorylation | 2515 |
| S | Phosphorylation | 2144 |
| S | Phosphorylation | 1436 |
| Y | Phosphorylation | 1047;- |
| S | Phosphorylation | 1084;- |
| S | Phosphorylation | 1459;- |
| S | Phosphorylation | 2144;- |
| Y | Phosphorylation | 373;- |
| Y | Phosphorylation | 1604;- |
| Y | Phosphorylation | 2380;- |
| Y | Phosphorylation | 1525;- |
| S | Phosphorylation | 1533;- |
| S | Phosphorylation | 2024;- |
| S | Phosphorylation | 2025;- |
| S | Phosphorylation | 2150;- |
| S | Phosphorylation | 2155;- |
| S | Phosphorylation | 2276;- |
| S | Phosphorylation | 2319;- |
| S | Phosphorylation | 2321;- |
| S | Phosphorylation | 1081;- |
| T | Phosphorylation | 1089;- |
| T | Phosphorylation | 1334 |
| S | Phosphorylation | 1338 |
| S | Phosphorylation | 1343 |
| S | Phosphorylation | 1630 |
| S | Phosphorylation | 2045 |
| S | Phosphorylation | 2120 |
| S | Phosphorylation | 2406 |
| S | Phosphorylation | 2502 |
| S | Acetylation | 2 |
| K | Acetylation | 1538 |
| K | Acetylation | 837 |
| K | Acetylation | 2599 |
| K | Acetylation | 508 |
| K | Acetylation | 781 |
| K | Acetylation | 2613 |
| K | Acetylation | 504 |
| K | Acetylation | 994 |
| K | Acetylation | 700 |
| K | Acetylation | 891 |
| K | Acetylation | 973 |
| K | Acetylation | 2016 |
| K | Acetylation | 2505 |
| S | Phosphorylation | 966 |
| C | S-Nitrosylation | 717 |
| D | Proteolytic Cleavage | 1504 |
| T | Phosphorylation | 2328 |
| S | Phosphorylation | 2330 |
| S | Phosphorylation | 2 |
| S | Phosphorylation | 3 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 6 |
| S | Phosphorylation | 11 |
| T | Phosphorylation | 31 |
| T | Phosphorylation | 23 |
| S | Phosphorylation | 564 |
| S | Phosphorylation | 757 |
| T | Phosphorylation | 1288 |
| S | Phosphorylation | 1726 |
| S | Phosphorylation | 1938 |
| S | Phosphorylation | 2123 |
| S | Phosphorylation | 2162 |
| S | Phosphorylation | 2335 |
| T | Phosphorylation | 2478 |
| Y | Phosphorylation | 2479 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 387 |    RHOA |    1323 |    NP_001655.1 |    in vivo |    10051605    |
| 408 |    ARRB1 |    146 |    NP_004032.2 |    in vitro;in vivo |    16611986    |
| 409 |    ARRB2 |    147 |    NP_004304.1 |    in vitro;in vivo;yeast 2-hybrid |    16611986    |
| 891 |    CCNB1 |    454 |    NP_114172.1 |    in vitro;in vivo;yeast 2-hybrid |    17408621    |
| 998 |    CDC42 |    309 |    NP_001782.1 |    in vitro |    10051605    |
| 1634 |    DCN |    501 |    NP_001911.1 |    in vitro |    12106908    |
| 1813 |    DRD2 |    539 |    NP_000786.1 |    in vitro;yeast 2-hybrid |    11911837    |
| 1814 |    DRD3 |    540 |    NP_000787.2 |    in vivo;yeast 2-hybrid |    11911837    |
| 2152 |    F3 |    603 |    NP_001984.1 |    in vitro |    9490735    |
| 2811 |    GP1BA |    1976 |    NP_000164.4 |    in vivo |    11700320    |
| 2897 |    GRIK1 |    693 |    NP_000821.1 |    in vivo |    11943148    |
| 2899 |    GRIK3 |    691 |    NP_000822.2 |    in vivo |    11943148    |
| 3688 |    ITGB1 |    628 |    NP_391987.1 |    in vivo;yeast 2-hybrid |    118   070   989   722   563    |
| 3695 |    ITGB7 |    948 |    NP_000880.1 |    in vitro |    1   178   156   715   225   630    |
| 5045 |    FURIN |    653 |    NP_002560.1 |    in vivo |    9412467    |
| 5578 |    PRKCA |    1498 |    NP_002728.1 |    in vivo;yeast 2-hybrid |    12704190    |
| 5663 |    PSEN1 |    87 |    NP_000012.1 |    in vivo;yeast 2-hybrid |    9437013    |
| 5898 |    RALA |    1549 |    NP_005393.2 |    in vitro;in vivo |    10051605    |
| 6401 |    SELE |    566 |    NP_000441.2 |    in vitro |    8609175    |
| 6462 |    SHBG |    1646 |    NP_001031.2 |    yeast 2-hybrid |    15862967    |
| 7428 |    VHL |    1905 |    NP_000542.1 |    yeast 2-hybrid |    867   403   212   169   691    |
| 81793 |    TLR10 |    5884 |    NP_112218.2 |    yeast 2-hybrid |    16482509    |
| 83478 |    ARHGAP24 |    9804 |    NP_001020787.2 |    in vitro;in vivo;yeast 2-hybrid |    16862148    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Focal adhesion |    hsa04510 |    
| MAPK signaling pathway |    hsa04010 |    
| Proteoglycans in cancer |    hsa05205 |    
| Salmonella infection |    hsa05132 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 44-148  | CH |
| cl00030 | 44-148  | CH superfamily |
| cd00014 | 168-264  | CH |
| cl00030 | 168-264  | CH superfamily |
| smart00557 | 1448-1542  | IG_FLMN |
| cl19759 | 1448-1542  | Filamin superfamily |
| smart00557 | 2047-2136  | IG_FLMN |
| cl19759 | 2047-2136  | Filamin superfamily |
| smart00557 | 1868-1954  | IG_FLMN |
| cl19759 | 1868-1954  | Filamin superfamily |
| smart00557 | 672-766  | IG_FLMN |
| cl19759 | 672-766  | Filamin superfamily |
| smart00557 | 2238-2328  | IG_FLMN |
| cl19759 | 2238-2328  | Filamin superfamily |
| smart00557 | 1160-1252  | IG_FLMN |
| cl19759 | 1160-1252  | Filamin superfamily |
| smart00557 | 381-477  | IG_FLMN |
| cl19759 | 381-477  | Filamin superfamily |
| smart00557 | 1067-1156  | IG_FLMN |
| cl19759 | 1067-1156  | Filamin superfamily |
| smart00557 | 1545-1639  | IG_FLMN |
| cl19759 | 1545-1639  | Filamin superfamily |
| smart00557 | 480-571  | IG_FLMN |
| cl19759 | 480-571  | Filamin superfamily |
| pfam00630 | 1445-1536  | Filamin |
| smart00557 | 2429-2519  | IG_FLMN |
| cl19759 | 2429-2519  | Filamin superfamily |
| pfam00630 | 1866-1949  | Filamin |
| smart00557 | 2557-2646  | IG_FLMN |
| cl19759 | 2557-2646  | Filamin superfamily |
| pfam00630 | 1544-1633  | Filamin |
| smart00033 | 47-147  | CH |
| smart00557 | 281-375  | IG_FLMN |
| cl19759 | 281-375  | Filamin superfamily |
| pfam00630 | 1158-1244  | Filamin |
| smart00557 | 1665-1743  | IG_FLMN |
| cl19759 | 1665-1743  | Filamin superfamily |
| smart00557 | 1256-1352  | IG_FLMN |
| cl19759 | 1256-1352  | Filamin superfamily |
| smart00557 | 872-968  | IG_FLMN |
| cl19759 | 872-968  | Filamin superfamily |
| pfam00630 | 2045-2130  | Filamin |
| pfam00630 | 670-760  | Filamin |
| pfam00630 | 2238-2322  | Filamin |
| pfam00630 | 1064-1151  | Filamin |
| smart00557 | 1355-1442  | IG_FLMN |
| cl19759 | 1355-1442  | Filamin superfamily |
| pfam00630 | 379-471  | Filamin |
| smart00557 | 577-659  | IG_FLMN |
| cl19759 | 577-659  | Filamin superfamily |
| smart00557 | 769-869  | IG_FLMN |
| cl19759 | 769-869  | Filamin superfamily |
| pfam00307 | 169-264  | CH |
| pfam00307 | 46-149  | CH |
| smart00557 | 972-1064  | IG_FLMN |
| cl19759 | 972-1064  | Filamin superfamily |
| pfam00630 | 871-961  | Filamin |
| smart00557 | 2332-2423  | IG_FLMN |
| cl19759 | 2332-2423  | Filamin superfamily |
| pfam00630 | 1252-1345  | Filamin |
| pfam00630 | 968-1057  | Filamin |
| pfam00630 | 2427-2513  | Filamin |
| pfam00630 | 280-371  | Filamin |
| pfam00630 | 578-659  | Filamin |
| pfam00630 | 1353-1439  | Filamin |
| pfam00630 | 2554-2643  | Filamin |
| smart00033 | 172-264  | CH |
| pfam00630 | 1640-1736  | Filamin |
| pfam00630 | 477-567  | Filamin |
| pfam00630 | 2329-2417  | Filamin |
| smart00557 | 1797-1861  | IG_FLMN |
| cl19759 | 1797-1861  | Filamin superfamily |
| pfam00630 | 767-863  | Filamin |
| pfam00630 | 1807-1855  | Filamin |
| COG5069 | 41-267  | SAC6 |
| COG5069 | 49-145  | SAC6 |
Ontology Information
| HPRD ID | 3109 |    
|---|---|
| Molecular Class | Not Available |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
