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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FLNA 2316 filamin A  XFLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25717257   2015Cell line : -

Source : Department of the Second General Surgery of the Fourth Hospital of Hebei Medical University.

Sample Type : CRC tumor and adjacent normal tissues

No. of Sample : 46

Stage : -

Immunohistochemistry,RT-PCR,Western blotting.Down-regulation-FLNa showed low expression in colorectal adenocarcinoma, high correlation with the incidence and development of colorectal cancer, and was considered an indicator of prognosis.


Gene Details



NC_000023.10 (153576900..153603006, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]  
Chromosome X
Location Xq28
Start 153576900  
End 153603006  
Strand -  
Gene Sequence

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Length 26107  
OMIM ID 300017   
HGNC ID HGNC:3754   
Unigene ID -   
Ensembl ID ENSG00000196924   
PharmGKB ID -   

mRNA Information


mRNA ID ?NM_001110556.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS44021.1



Protein Information


      
Protein ID
Protein Namefilamin A
Molecular Wt. (Da)0
Protein Sequence

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Length 0  
Uniprot IDQ12967
Ensembl Protein ID ENSP00000361117  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1084
SPhosphorylation1459
SPhosphorylation2515
SPhosphorylation2144
SPhosphorylation1436
YPhosphorylation1047;-
SPhosphorylation1084;-
SPhosphorylation1459;-
SPhosphorylation2144;-
YPhosphorylation373;-
YPhosphorylation1604;-
YPhosphorylation2380;-
YPhosphorylation1525;-
SPhosphorylation1533;-
SPhosphorylation2024;-
SPhosphorylation2025;-
SPhosphorylation2150;-
SPhosphorylation2155;-
SPhosphorylation2276;-
SPhosphorylation2319;-
SPhosphorylation2321;-
SPhosphorylation1081;-
TPhosphorylation1089;-
TPhosphorylation1334
SPhosphorylation1338
SPhosphorylation1343
SPhosphorylation1630
SPhosphorylation2045
SPhosphorylation2120
SPhosphorylation2406
SPhosphorylation2502
SAcetylation2
KAcetylation1538
KAcetylation837
KAcetylation2599
KAcetylation508
KAcetylation781
KAcetylation2613
KAcetylation504
KAcetylation994
KAcetylation700
KAcetylation891
KAcetylation973
KAcetylation2016
KAcetylation2505
SPhosphorylation966
CS-Nitrosylation717
DProteolytic Cleavage1504
TPhosphorylation2328
SPhosphorylation2330
SPhosphorylation2
SPhosphorylation3
SPhosphorylation4
SPhosphorylation6
SPhosphorylation11
TPhosphorylation31
TPhosphorylation23
SPhosphorylation564
SPhosphorylation757
TPhosphorylation1288
SPhosphorylation1726
SPhosphorylation1938
SPhosphorylation2123
SPhosphorylation2162
SPhosphorylation2335
TPhosphorylation2478
YPhosphorylation2479

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
387RHOA1323NP_001655.1in vivo10051605   
408ARRB1146NP_004032.2in vitro;in vivo16611986   
409ARRB2147NP_004304.1in vitro;in vivo;yeast 2-hybrid16611986   
891CCNB1454NP_114172.1in vitro;in vivo;yeast 2-hybrid17408621   
998CDC42309NP_001782.1in vitro10051605   
1634DCN501NP_001911.1in vitro12106908   
1813DRD2539NP_000786.1in vitro;yeast 2-hybrid11911837   
1814DRD3540NP_000787.2in vivo;yeast 2-hybrid11911837   
2152F3603NP_001984.1in vitro9490735   
2811GP1BA1976NP_000164.4in vivo11700320   
2897GRIK1693NP_000821.1in vivo11943148   
2899GRIK3691NP_000822.2in vivo11943148   
3688ITGB1628NP_391987.1in vivo;yeast 2-hybrid118   070   989   722   563   
3695ITGB7948NP_000880.1in vitro1   178   156   715   225   630   
5045FURIN653NP_002560.1in vivo9412467   
5578PRKCA1498NP_002728.1in vivo;yeast 2-hybrid12704190   
5663PSEN187NP_000012.1in vivo;yeast 2-hybrid9437013   
5898RALA1549NP_005393.2in vitro;in vivo10051605   
6401SELE566NP_000441.2in vitro8609175   
6462SHBG1646NP_001031.2yeast 2-hybrid15862967   
7428VHL1905NP_000542.1yeast 2-hybrid867   403   212   169   691   
81793TLR105884NP_112218.2yeast 2-hybrid16482509   
83478ARHGAP249804NP_001020787.2in vitro;in vivo;yeast 2-hybrid16862148   


Pathway Information


                        
Pathway Name Pathway ID
Focal adhesion hsa04510
MAPK signaling pathway hsa04010
Proteoglycans in cancer hsa05205
Salmonella infection hsa05132


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0001444-148  CH
cl0003044-148  CH superfamily
cd00014168-264  CH
cl00030168-264  CH superfamily
smart005571448-1542  IG_FLMN
cl197591448-1542  Filamin superfamily
smart005572047-2136  IG_FLMN
cl197592047-2136  Filamin superfamily
smart005571868-1954  IG_FLMN
cl197591868-1954  Filamin superfamily
smart00557672-766  IG_FLMN
cl19759672-766  Filamin superfamily
smart005572238-2328  IG_FLMN
cl197592238-2328  Filamin superfamily
smart005571160-1252  IG_FLMN
cl197591160-1252  Filamin superfamily
smart00557381-477  IG_FLMN
cl19759381-477  Filamin superfamily
smart005571067-1156  IG_FLMN
cl197591067-1156  Filamin superfamily
smart005571545-1639  IG_FLMN
cl197591545-1639  Filamin superfamily
smart00557480-571  IG_FLMN
cl19759480-571  Filamin superfamily
pfam006301445-1536  Filamin
smart005572429-2519  IG_FLMN
cl197592429-2519  Filamin superfamily
pfam006301866-1949  Filamin
smart005572557-2646  IG_FLMN
cl197592557-2646  Filamin superfamily
pfam006301544-1633  Filamin
smart0003347-147  CH
smart00557281-375  IG_FLMN
cl19759281-375  Filamin superfamily
pfam006301158-1244  Filamin
smart005571665-1743  IG_FLMN
cl197591665-1743  Filamin superfamily
smart005571256-1352  IG_FLMN
cl197591256-1352  Filamin superfamily
smart00557872-968  IG_FLMN
cl19759872-968  Filamin superfamily
pfam006302045-2130  Filamin
pfam00630670-760  Filamin
pfam006302238-2322  Filamin
pfam006301064-1151  Filamin
smart005571355-1442  IG_FLMN
cl197591355-1442  Filamin superfamily
pfam00630379-471  Filamin
smart00557577-659  IG_FLMN
cl19759577-659  Filamin superfamily
smart00557769-869  IG_FLMN
cl19759769-869  Filamin superfamily
pfam00307169-264  CH
pfam0030746-149  CH
smart00557972-1064  IG_FLMN
cl19759972-1064  Filamin superfamily
pfam00630871-961  Filamin
smart005572332-2423  IG_FLMN
cl197592332-2423  Filamin superfamily
pfam006301252-1345  Filamin
pfam00630968-1057  Filamin
pfam006302427-2513  Filamin
pfam00630280-371  Filamin
pfam00630578-659  Filamin
pfam006301353-1439  Filamin
pfam006302554-2643  Filamin
smart00033172-264  CH
pfam006301640-1736  Filamin
pfam00630477-567  Filamin
pfam006302329-2417  Filamin
smart005571797-1861  IG_FLMN
cl197591797-1861  Filamin superfamily
pfam00630767-863  Filamin
pfam006301807-1855  Filamin
COG506941-267  SAC6
COG506949-145  SAC6


Ontology Information


   
HPRD ID3109
Molecular ClassNot Available
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO