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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25926745 | 2015 | Cell line : - Source : Three colorectal cancer patient datasets, GSE14333,30 GSE14538,31 and GSE4096732 were identified in the GEO database; datasets compiled using the HG-U133 microarray platform. Sample Type : - No. of Sample : - Stage : - | Univariate Cox regression analysis | Up-regulation | - | Expression levels of VEGFA, FLT1, and KDR in two independent colon cancer datasets and found that high expression levels of all three factors afforded a very poor prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / I-set domain containing, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009] | Chromosome | 13 |
| Location | 13q12 |
| Start | 28874483 |
| End | 29069265 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 194783 |
| OMIM ID | 165070 |
| HGNC ID | HGNC:3763 |
| Unigene ID | Hs.594454 |
| Ensembl ID | ENSG00000102755 |
| PharmGKB ID | PA28180 |
mRNA Information
| mRNA ID | NM_002019.4 |
|---|---|
| Exon | join(1..349,27512..27608,28000..28226,56784..56908, 60909..61071,61174..61310,63819..63993,64962..65079, 67208..67377,67811..67970,89235..89349,98061..98169, 105025..105333,110098..110244,137444..137575, 149578..149684,155829..155961,161000..161104, 165401..165514,167579..167667,172183..172339, 172770..172867,173544..173666,175595..175706, 177532..177631,183031..183136,183397..183539, 186202..186286,188357..188451,191761..194783) | mRNA Sequence | Download Select all |
| Length | 7123 |
Protein Information
| Protein ID | NP_002010.2 |
|---|---|
| Protein Name | fms-related tyrosine kinase 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1338 |
| Uniprot ID | P62826 |
| Ensembl Protein ID | ENSP00000376176 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 1169 |
| Y | Phosphorylation | 794 |
| Y | Phosphorylation | 1213 |
| Y | Phosphorylation | 1242 |
| Y | Phosphorylation | 1327 |
| Y | Phosphorylation | 1333 |
| Y | Dephosphorylation | 1213 |
| Y | Phosphorylation | 1048;- |
| Y | Phosphorylation | 1053;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 | CTNNB1 | 286 | NP_001895.1 | in vivo | 12920240 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 12509223 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 9722576 |
| 4690 | NCK1 | 2740 | NP_006144.1 | yeast 2-hybrid | 9600074 |
| 5335 | PLCG1 | 1398 | NP_002651.2 | in vivo | 92 995 379 398 617 900 000 000 000 000 |
| 5781 | PTPN11 | 1470 | NP_002825.3 | yeast 2-hybrid | 9600074 |
| 7525 | YES1 | 1285 | NP_005424.1 | in vivo | 12509223 |
| 8828 | NRP2 | 3643 | NP_957718.1 | in vivo | 11278319 |
| 8829 | NRP1 | 3642 | NP_003864.4 | in vitro | 10842181 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Endocytosis | hsa04144 |
| Focal adhesion | hsa04510 |
| HIF-1 signaling pathway | hsa04066 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Rheumatoid arthritis | hsa05323 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14207 | 819-1157 | PTKc_VEGFR1 |
| cl21453 | 819-1157 | PKc_like superfamily |
| cd07702 | 353-424 | Ig2_VEGFR-1 |
| cl11960 | 353-424 | Ig superfamily |
| cd05742 | 245-327 | Ig1_VEGFR_like |
| cl11960 | 245-327 | Ig superfamily |
| cd00096 | 679-745 | Ig |
| cl11960 | 679-745 | Ig superfamily |
| cd00096 | 573-646 | Ig |
| cl11960 | 573-646 | Ig superfamily |
| cd05054 | 819-1157 | PTKc_VEGFR |
| cd05103 | 819-1161 | PTKc_VEGFR2 |
| cd05102 | 819-1161 | PTKc_VEGFR3 |
| cd05055 | 812-1158 | PTKc_PDGFR |
| cd05106 | 812-1154 | PTKc_CSF-1R |
| cd05104 | 812-1154 | PTKc_Kit |
| cd05105 | 812-1158 | PTKc_PDGFR_alpha |
| cd05053 | 813-1158 | PTKc_FGFR |
| cd00192 | 833-1154 | PTKc |
| cd05107 | 812-1158 | PTKc_PDGFR_beta |
| cd05099 | 813-1160 | PTKc_FGFR4 |
| cd05101 | 802-1165 | PTKc_FGFR2 |
| cd05098 | 813-1165 | PTKc_FGFR1 |
| cd05100 | 813-1158 | PTKc_FGFR3 |
| cd05045 | 826-1161 | PTKc_RET |
| cd05032 | 820-1156 | PTKc_InsR_like |
| cd05039 | 820-1154 | PTKc_Csk_like |
| cd05050 | 821-1150 | PTKc_Musk |
| cd05036 | 821-1155 | PTKc_ALK_LTK |
| cd05048 | 821-1155 | PTKc_Ror |
| cd05047 | 833-1159 | PTKc_Tie |
| cd05034 | 831-1154 | PTKc_Src_like |
| cd05089 | 825-1185 | PTKc_Tie1 |
| cd05044 | 831-1156 | PTKc_c-ros |
| cd05049 | 824-1154 | PTKc_Trk |
| cd05068 | 819-1159 | PTKc_Frk_like |
| cd05059 | 827-1155 | PTKc_Tec_like |
| cd05083 | 820-1154 | PTKc_Chk |
| cd05082 | 820-1157 | PTKc_Csk |
| cd05058 | 833-1154 | PTKc_Met_Ron |
| cd05060 | 831-1159 | PTKc_Syk_like |
| cd05041 | 833-1154 | PTKc_Fes_like |
| cd05038 | 822-1154 | PTKc_Jak_rpt2 |
| cd05046 | 822-1156 | PTK_CCK4 |
| cd05052 | 820-1154 | PTKc_Abl |
| cd05148 | 820-1155 | PTKc_Srm_Brk |
| cd05035 | 827-1158 | PTKc_TAM |
| cd05061 | 820-1164 | PTKc_InsR |
| cd13999 | 833-1154 | STKc_MAP3K-like |
| cd05051 | 821-1150 | PTKc_DDR |
| cd05056 | 820-1159 | PTKc_FAK |
| cd05057 | 826-1154 | PTKc_EGFR_like |
| cd05088 | 827-1159 | PTKc_Tie2 |
| cd14204 | 824-1160 | PTKc_Mer |
| cd05075 | 826-1160 | PTKc_Axl |
| cd05074 | 825-1154 | PTKc_Tyro3 |
| cd05043 | 824-1156 | PTK_Ryk |
| cd05085 | 830-1154 | PTKc_Fer |
| cd05092 | 824-1154 | PTKc_TrkA |
| cd05033 | 827-1154 | PTKc_EphR |
| cd05040 | 999-1156 | PTKc_Ack_like |
| cd05062 | 820-1156 | PTKc_IGF-1R |
| cd05084 | 830-1155 | PTKc_Fes |
| cd05072 | 820-1164 | PTKc_Lyn |
| cd05067 | 819-1160 | PTKc_Lck_Blk |
| cd05091 | 821-1154 | PTKc_Ror2 |
| cd05090 | 821-1154 | PTKc_Ror1 |
| cd05113 | 824-1151 | PTKc_Btk_Bmx |
| cd05094 | 824-1160 | PTKc_TrkC |
| cd05093 | 824-1161 | PTKc_TrkB |
| cd05112 | 827-1154 | PTKc_Itk |
| cd00180 | 833-1154 | PKc |
| cd05066 | 826-1158 | PTKc_EphR_A |
| cd05073 | 815-1157 | PTKc_Hck |
| cd05097 | 821-1150 | PTKc_DDR_like |
| cd05096 | 821-1150 | PTKc_DDR1 |
| cd05063 | 831-1158 | PTKc_EphR_A2 |
| cd05108 | 831-1151 | PTKc_EGFR |
| cd05114 | 827-1159 | PTKc_Tec_Rlk |
| cd05109 | 827-1154 | PTKc_HER2 |
| cd05115 | 833-1154 | PTKc_Zap-70 |
| cd05095 | 821-1154 | PTKc_DDR2 |
| cd05065 | 827-1158 | PTKc_EphR_B |
| cd14203 | 831-1156 | PTKc_Src_Fyn_like |
| cd05116 | 831-1154 | PTKc_Syk |
| cd05069 | 820-1164 | PTKc_Yes |
| cd05081 | 822-1159 | PTKc_Jak3_rpt2 |
| cd05070 | 820-1164 | PTKc_Fyn |
| cd05071 | 820-1164 | PTKc_Src |
| cd14205 | 822-1157 | PTKc_Jak2_rpt2 |
| cd05111 | 822-1150 | PTK_HER3 |
| cd05079 | 822-1158 | PTKc_Jak1_rpt2 |
| cd05110 | 990-1193 | PTKc_HER4 |
| cd05080 | 822-1154 | PTKc_Tyk2_rpt2 |
| cd06606 | 826-1152 | STKc_MAPKKK |
| cd14061 | 833-1154 | STKc_MLK |
| cd14058 | 833-1161 | STKc_TAK1 |
| cd05064 | 821-1158 | PTKc_EphR_A10 |
| cd04976 | 353-424 | Ig2_VEGFR |
| cd14206 | 831-1150 | PTKc_Aatyk3 |
| cd14066 | 833-1157 | STKc_IRAK |
| cd14059 | 833-1154 | STKc_MAP3K12_13 |
| cd06627 | 829-1150 | STKc_Cdc7_like |
| cd05087 | 831-1150 | PTKc_Aatyk1 |
| cd14146 | 833-1154 | STKc_MLK4 |
| cd05042 | 831-1150 | PTKc_Aatyk |
| cd14147 | 999-1157 | STKc_MLK3 |
| cd05122 | 828-1150 | PKc_STE |
| cd14148 | 999-1157 | STKc_MLK2 |
| cd14145 | 827-1154 | STKc_MLK1 |
| cd14060 | 834-1154 | STKc_MLTK |
| cd14007 | 828-1152 | STKc_Aurora |
| cd14062 | 833-1154 | STKc_Raf |
| cd14065 | 833-1154 | PKc_LIMK_like |
| cd06623 | 827-1152 | PKc_MAPKK_plant_like |
| cd14000 | 833-1156 | STKc_LRRK |
| cd07833 | 833-1150 | STKc_CDKL |
| cd06614 | 833-1152 | STKc_PAK |
| cd14003 | 828-1145 | STKc_AMPK-like |
| cd13979 | 825-1145 | STKc_Mos |
| cd08215 | 825-1150 | STKc_Nek |
| cd07829 | 828-1103 | STKc_CDK_like |
| cd13997 | 833-1151 | PKc_Wee1_like |
| cd14002 | 825-1099 | STKc_STK36 |
| cd05118 | 828-1145 | STKc_CMGC |
| cd14014 | 828-1151 | STKc_PknB_like |
| cd14155 | 991-1159 | PKc_TESK |
| cd08530 | 826-1145 | STKc_CNK2-like |
| cd05117 | 828-1145 | STKc_CAMK |
| cd13978 | 833-1149 | STKc_RIP |
| cd14151 | 820-1157 | STKc_B-Raf |
| cd05086 | 831-1154 | PTKc_Aatyk2 |
| cd06632 | 826-1152 | STKc_MEKK1_plant |
| cd05123 | 833-1144 | STKc_AGC |
| cd14221 | 1000-1158 | STKc_LIMK1 |
| cd07830 | 828-1145 | STKc_MAK_like |
| cd14027 | 1005-1153 | STKc_RIP1 |
| cd14064 | 833-1157 | PKc_TNNI3K |
| cd06628 | 997-1151 | STKc_Byr2_like |
| cd14154 | 833-1160 | STKc_LIMK |
| cd06631 | 1002-1150 | STKc_YSK4 |
| cd08217 | 1014-1152 | STKc_Nek2 |
| cd14120 | 833-1149 | STKc_ULK1_2-like |
| cd06611 | 820-1092 | STKc_SLK_like |
| cd06608 | 813-1087 | STKc_myosinIII_N_like |
| cd13992 | 831-1154 | PK_GC |
| cd14202 | 819-1150 | STKc_ULK1 |
| cd14009 | 833-1150 | STKc_ATG1_ULK_like |
| cd07846 | 1002-1152 | STKc_CDKL2_3 |
| cd14121 | 833-1170 | STKc_ULK3 |
| cd06605 | 831-1152 | PKc_MAPKK |
| cd06617 | 833-1152 | PKc_MKK3_6 |
| cd06629 | 997-1152 | STKc_Bck1_like |
| cd14063 | 827-1150 | PK_KSR |
| cd14150 | 831-1159 | STKc_A-Raf |
| cd14008 | 833-1090 | STKc_LKB1_CaMKK |
| cd14156 | 833-1157 | PKc_LIMK_like_unk |
| cd14158 | 830-1157 | STKc_IRAK4 |
| cd08529 | 829-1150 | STKc_FA2-like |
| cd06644 | 820-1152 | STKc_STK10 |
| cd07841 | 826-1110 | STKc_CDK7 |
| cd06620 | 825-1153 | PKc_Byr1_like |
| cd08222 | 958-1151 | STKc_Nek11 |
| cd14149 | 820-1159 | STKc_C-Raf |
| cd08225 | 826-1153 | STKc_Nek5 |
| cd07832 | 829-1114 | STKc_CCRK |
| cd14001 | 974-1154 | PKc_TOPK |
| cd14222 | 992-1160 | STKc_LIMK2 |
| cd05570 | 831-1144 | STKc_PKC |
| cd07847 | 997-1152 | STKc_CDKL1_4 |
| cd14137 | 826-1102 | STKc_GSK3 |
| cd06612 | 833-1152 | STKc_MST1_2 |
| cd06917 | 833-1150 | STKc_NAK1_like |
| cd13993 | 826-1151 | STKc_Pat1_like |
| cd14069 | 828-1089 | STKc_Chk1 |
| cd14111 | 997-1100 | STKc_SPEG_rpt2 |
| cd06621 | 1003-1101 | PKc_Pek1_like |
| cd06648 | 994-1152 | STKc_PAK_II |
| cd05620 | 1002-1144 | STKc_nPKC_delta |
| cd05037 | 1005-1155 | PTK_Jak_rpt1 |
| cd05592 | 1002-1144 | STKc_nPKC_theta_like |
| cd07857 | 826-1115 | STKc_MPK1 |
| cd06619 | 1006-1145 | PKc_MKK5 |
| cd13975 | 991-1159 | PKc_Dusty |
| cd14011 | 916-1145 | PK_SCY1_like |
| cd07834 | 991-1102 | STKc_MAPK |
| cd05619 | 1002-1144 | STKc_nPKC_theta |
| cd06609 | 1005-1150 | STKc_MST3_like |
| cd06618 | 1019-1152 | PKc_MKK7 |
| cd08218 | 949-1153 | STKc_Nek1 |
| cd13985 | 831-1154 | STKc_GAK_like |
| cd14080 | 829-1089 | STKc_TSSK-like |
| cd07840 | 833-1145 | STKc_CDK9_like |
| cd14187 | 1002-1151 | STKc_PLK1 |
| cd13994 | 833-1152 | STKc_HAL4_like |
| cd07849 | 998-1102 | STKc_ERK1_2_like |
| cd05589 | 833-1153 | STKc_PKN |
| cd08220 | 833-1150 | STKc_Nek8 |
| cd08228 | 1002-1145 | STKc_Nek6 |
| cd14025 | 1005-1150 | STKc_RIP4_like |
| cd06610 | 995-1152 | STKc_OSR1_SPAK |
| cd05581 | 827-1145 | STKc_PDK1 |
| cd14664 | 833-1156 | STK_BAK1_like |
| cd14052 | 826-1092 | PTKc_Wee1_fungi |
| cd06625 | 828-1094 | STKc_MEKK3_like |
| cd08221 | 997-1152 | STKc_Nek9 |
| cd06622 | 1003-1152 | PKc_PBS2_like |
| cd05862 | 245-330 | Ig1_VEGFR |
| cd14010 | 1006-1099 | STKc_ULK4 |
| cd06638 | 811-1152 | STKc_myosinIIIA_N |
| cd08223 | 992-1145 | STKc_Nek4 |
| cd05572 | 1002-1106 | STKc_cGK |
| cd05582 | 995-1144 | STKc_RSK_N |
| cd06642 | 1005-1152 | STKc_STK25 |
| cd07838 | 832-1095 | STKc_CDK4_6_like |
| cd06636 | 827-1092 | STKc_MAP4K4_6_N |
| cd08224 | 991-1145 | STKc_Nek6_7 |
| cd05730 | 671-748 | Ig3_NCAM-1_like |
| cd06613 | 997-1091 | STKc_MAP4K3_like |
| cd06643 | 820-1092 | STKc_SLK |
| cd06654 | 936-1152 | STKc_PAK1 |
| cd13996 | 833-1154 | STKc_EIF2AK |
| cd08229 | 1002-1145 | STKc_Nek7 |
| cd06640 | 1005-1152 | STKc_MST4 |
| cd06647 | 932-1100 | STKc_PAK_I |
| cd06655 | 932-1152 | STKc_PAK2 |
| cd14199 | 992-1150 | STKc_CaMKK2 |
| cd14068 | 833-1154 | STKc_LRRK2 |
| cd14201 | 820-1147 | STKc_ULK2 |
| cd14044 | 966-1150 | PK_GC-C |
| cd07845 | 993-1102 | STKc_CDK10 |
| cd06641 | 1005-1152 | STKc_MST3 |
| cd07858 | 1004-1102 | STKc_TEY_MAPK |
| cd14099 | 1002-1152 | STKc_PLK |
| cd05587 | 988-1111 | STKc_cPKC |
| cd05577 | 996-1144 | STKc_GRK |
| cd07862 | 993-1093 | STKc_CDK6 |
| cd07856 | 1002-1110 | STKc_Sty1_Hog1 |
| cd06626 | 1002-1152 | STKc_MEKK4 |
| cd07863 | 995-1093 | STKc_CDK4 |
| cd14081 | 828-1144 | STKc_BRSK1_2 |
| cd07843 | 1005-1102 | STKc_CDC2L1 |
| cd06656 | 932-1152 | STKc_PAK3 |
| cd05616 | 988-1111 | STKc_cPKC_beta |
| cd07839 | 1001-1107 | STKc_CDK5 |
| cd14047 | 1005-1154 | STKc_EIF2AK2_PKR |
| cd06616 | 1017-1152 | PKc_MKK4 |
| cd14106 | 1005-1110 | STKc_DRAK |
| cd06607 | 976-1087 | STKc_TAO |
| cd13998 | 994-1144 | STKc_TGFbR-like |
| cd06630 | 830-1150 | STKc_MEKK1 |
| cd14006 | 833-1116 | STKc_MLCK-like |
| cd06637 | 827-1152 | STKc_TNIK |
| cd07873 | 994-1159 | STKc_PCTAIRE1 |
| cd07866 | 825-1093 | STKc_BUR1 |
| cd14118 | 1009-1152 | STKc_CAMKK |
| cd14079 | 828-1090 | STKc_AMPK_alpha |
| cd06633 | 990-1151 | STKc_TAO3 |
| cd07848 | 997-1109 | STKc_CDKL5 |
| cd07871 | 974-1109 | STKc_PCTAIRE3 |
| cd06624 | 833-1152 | STKc_ASK |
| cd14048 | 1005-1152 | STKc_EIF2AK3_PERK |
| cd07860 | 987-1109 | STKc_CDK2_3 |
| cd08219 | 997-1153 | STKc_Nek3 |
| cd06639 | 811-1152 | STKc_myosinIIIB_N |
| cd14209 | 1002-1129 | STKc_PKA |
| cd05611 | 1002-1144 | STKc_Rim15_like |
| cd07852 | 1004-1102 | STKc_MAPK15-like |
| cd14045 | 976-1150 | PK_GC_unk |
| cd07855 | 992-1149 | STKc_ERK5 |
| cd14189 | 1002-1152 | STKc_PLK3 |
| cd07835 | 987-1109 | STKc_CDK1_CdkB_like |
| cd05724 | 668-748 | Ig2_Robo |
| cd07859 | 1004-1102 | STKc_TDY_MAPK |
| cd05615 | 988-1111 | STKc_cPKC_alpha |
| cd14105 | 991-1144 | STKc_DAPK |
| cd14056 | 831-1157 | STKc_TGFbR_I |
| cd14067 | 976-1156 | STKc_LRRK1 |
| cd14116 | 1001-1152 | STKc_Aurora-A |
| cd06659 | 1006-1152 | STKc_PAK6 |
| cd05595 | 1002-1144 | STKc_PKB_beta |
| cd05077 | 1005-1154 | PTK_Jak1_rpt1 |
| cd07831 | 991-1095 | STKc_MOK |
| cd13995 | 971-1152 | STKc_MAP3K8 |
| cd14053 | 835-1105 | STKc_ACVR2 |
| cd14012 | 993-1150 | PK_eIF2AK_GCN2_rpt1 |
| cd07853 | 992-1094 | STKc_NLK |
| cd14049 | 982-1152 | STKc_EIF2AK1_HRI |
| pfam13895 | 667-749 | Ig_2 |
| cd06658 | 997-1152 | STKc_PAK5 |
| cd06635 | 990-1154 | STKc_TAO1 |
| cd14164 | 828-1114 | STKc_TSSK6-like |
| cd14042 | 976-1154 | PK_GC-A_B |
| cd05578 | 1006-1102 | STKc_Yank1 |
| cd14072 | 826-1136 | STKc_MARK |
| cd05579 | 1002-1145 | STKc_MAST_like |
| cd14057 | 1000-1151 | PK_ILK |
| cd05728 | 664-748 | Ig4_Contactin-2-like |
| cd08528 | 997-1156 | STKc_Nek10 |
| cd06653 | 828-1094 | STKc_MEKK3_like_u1 |
| cd05590 | 833-1109 | STKc_nPKC_eta |
| cd14194 | 991-1107 | STKc_DAPK1 |
| cd14004 | 997-1152 | STKc_PASK |
| cd14055 | 831-1150 | STKc_TGFbR2_like |
| cd05607 | 994-1100 | STKc_GRK7 |
| cd05580 | 1002-1099 | STKc_PKA_like |
| cd07872 | 974-1109 | STKc_PCTAIRE2 |
| cd14152 | 826-1161 | STKc_KSR1 |
| cd14200 | 992-1144 | STKc_CaMKK1 |
| cd07851 | 812-1102 | STKc_p38 |
| cd14186 | 991-1100 | STKc_PLK4 |
| cd13983 | 1001-1152 | STKc_WNK |
| cd13968 | 833-1042 | PKc_like |
| cd05863 | 354-424 | Ig2_VEGFR-3 |
| cd14090 | 1006-1102 | STKc_Mnk |
| cd07865 | 816-1091 | STKc_CDK9 |
| cd07877 | 1004-1119 | STKc_p38alpha |
| cd06652 | 828-1094 | STKc_MEKK2 |
| cd14188 | 1002-1152 | STKc_PLK2 |
| cd14153 | 1005-1157 | PK_KSR2 |
| cd07844 | 974-1108 | STKc_PCTAIRE_like |
| cd14050 | 1008-1150 | PKc_Myt1 |
| cd14093 | 1005-1099 | STKc_PhKG |
| cd14119 | 1001-1145 | STKc_LKB1 |
| cd07861 | 1001-1109 | STKc_CDK1_euk |
| cd14665 | 997-1150 | STKc_SnRK2-3 |
| cd04969 | 680-748 | Ig5_Contactin_like |
| cd05076 | 991-1154 | PTK_Tyk2_rpt1 |
| cd14223 | 998-1144 | STKc_GRK2 |
| cd05078 | 1005-1154 | PTK_Jak2_rpt1 |
| cd05630 | 1000-1144 | STKc_GRK6 |
| cd05606 | 995-1144 | STKc_beta_ARK |
| cd13987 | 1005-1156 | STKc_SBK1 |
| cd14196 | 991-1102 | STKc_DAPK2 |
| cd07693 | 660-744 | Ig1_Robo |
| cd14043 | 976-1150 | PK_GC-2D |
| cd14197 | 991-1109 | STKc_DRAK1 |
| cd14190 | 993-1108 | STKc_MLCK2 |
| cd14162 | 828-1090 | STKc_TSSK4-like |
| cd14084 | 831-1107 | STKc_Chk2 |
| cd14103 | 994-1102 | STKc_MLCK |
| cd14078 | 825-1152 | STKc_MELK |
| cd05864 | 354-424 | Ig2_VEGFR-2 |
| cd05608 | 983-1097 | STKc_GRK1 |
| cd14159 | 833-1157 | STKc_IRAK1 |
| cd14033 | 999-1152 | STKc_WNK4 |
| cd05631 | 1000-1144 | STKc_GRK4 |
| cd07850 | 971-1130 | STKc_JNK |
| cd06634 | 990-1092 | STKc_TAO2 |
| cd14036 | 991-1160 | STKc_GAK |
| cd14131 | 825-1150 | PKc_Mps1 |
| cd04978 | 679-748 | Ig4_L1-NrCAM_like |
| cd07854 | 993-1102 | STKc_MAPK4_6 |
| cd05763 | 680-748 | Ig_1 |
| cd14104 | 998-1110 | STKc_Titin |
| cd07870 | 1002-1103 | STKc_PFTAIRE2 |
| cd14663 | 826-1094 | STKc_SnRK3 |
| cd14192 | 994-1102 | STKc_MLCK3 |
| cd14071 | 1005-1144 | STKc_SIK |
| cd14138 | 976-1152 | PTKc_Wee1a |
| cd05605 | 994-1100 | STKc_GRK4_like |
| cd14143 | 993-1144 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07878 | 1004-1119 | STKc_p38beta |
| cd06649 | 970-1101 | PKc_MEK2 |
| cd06650 | 1003-1108 | PKc_MEK1 |
| cd14165 | 828-1152 | STKc_TSSK1_2-like |
| cd14135 | 1001-1094 | STKc_PRP4 |
| cd05613 | 827-1153 | STKc_MSK1_N |
| cd05736 | 679-749 | Ig2_Follistatin_like |
| cd04968 | 673-749 | Ig3_Contactin_like |
| cd14046 | 825-1152 | STKc_EIF2AK4_GCN2_rpt2 |
| cd05617 | 1002-1144 | STKc_aPKC_zeta |
| cd07836 | 1001-1102 | STKc_Pho85 |
| cd07869 | 1002-1113 | STKc_PFTAIRE1 |
| cd14107 | 989-1149 | STKc_obscurin_rpt1 |
| cd05738 | 678-746 | Ig2_RPTP_IIa_LAR_like |
| cd14054 | 1006-1144 | STKc_BMPR2_AMHR2 |
| cd06657 | 997-1152 | STKc_PAK4 |
| cd05632 | 997-1144 | STKc_GRK5 |
| cd14208 | 1000-1154 | PTK_Jak3_rpt1 |
| cd07864 | 997-1094 | STKc_CDK12 |
| cd14173 | 1006-1102 | STKc_Mnk2 |
| cd05584 | 831-1144 | STKc_p70S6K |
| cd05618 | 1002-1144 | STKc_aPKC_iota |
| cd14076 | 829-1100 | STKc_Kin4 |
| cd14136 | 1005-1091 | STKc_SRPK |
| cd05614 | 827-1152 | STKc_MSK2_N |
| cd14037 | 1005-1092 | STKc_NAK_like |
| cd05585 | 1002-1190 | STKc_YPK1_like |
| cd13991 | 997-1160 | STKc_NIK |
| cd05594 | 1002-1144 | STKc_PKB_alpha |
| cd14039 | 1006-1091 | STKc_IKK_alpha |
| cd14070 | 1002-1100 | STKc_HUNK |
| cd06615 | 1003-1150 | PKc_MEK |
| cd14094 | 1002-1125 | STKc_CASK |
| cd05874 | 680-743 | Ig6_NrCAM |
| cd07880 | 997-1119 | STKc_p38gamma |
| cd05729 | 670-748 | Ig2_FGFR_like |
| cd14175 | 1004-1144 | STKc_RSK1_C |
| cd14195 | 991-1102 | STKc_DAPK3 |
| cd14177 | 1004-1100 | STKc_RSK4_C |
| cd14161 | 824-1102 | STKc_NUAK2 |
| cd07842 | 834-1095 | STKc_CDK8_like |
| cd05604 | 831-1144 | STKc_SGK3 |
| cd05633 | 1002-1144 | STKc_GRK3 |
| cd14662 | 997-1138 | STKc_SnRK2 |
| cd05612 | 1002-1107 | STKc_PRKX_like |
| cd14086 | 1005-1152 | STKc_CaMKII |
| cd14077 | 1001-1090 | STKc_Kin1_2 |
| cd14193 | 994-1102 | STKc_MLCK4 |
| cd14073 | 826-1090 | STKc_NUAK |
| cd05725 | 679-748 | Ig3_Robo |
| cd14110 | 1002-1094 | STKc_obscurin_rpt2 |
| cd05731 | 679-749 | Ig3_L1-CAM_like |
| cd14018 | 1005-1145 | STKc_PINK1 |
| cd14178 | 1006-1116 | STKc_RSK3_C |
| cd14098 | 1005-1149 | STKc_Rad53_Cds1 |
| cd14108 | 983-1102 | STKc_SPEG_rpt1 |
| cd13989 | 1006-1092 | STKc_IKK |
| cd14026 | 1004-1147 | STKc_RIP2 |
| cd05743 | 676-740 | Ig_Perlecan_D2_like |
| cd14183 | 825-1108 | STKc_DCKL1 |
| cd14198 | 992-1109 | STKc_DRAK2 |
| cd13990 | 985-1092 | STKc_TLK |
| cd14179 | 1019-1100 | STKc_MSK1_C |
| cd05583 | 991-1100 | STKc_MSK_N |
| cd05745 | 679-748 | Ig3_Peroxidasin |
| cd14167 | 988-1100 | STKc_CaMKI_alpha |
| cd05588 | 1002-1108 | STKc_aPKC |
| cd05733 | 679-743 | Ig6_L1-CAM_like |
| cd05744 | 680-748 | Ig_Myotilin_C_like |
| cd14191 | 994-1102 | STKc_MLCK1 |
| cd14082 | 1005-1098 | STKc_PKD |
| cd05867 | 680-748 | Ig4_L1-CAM_like |
| cd06651 | 971-1094 | STKc_MEKK3 |
| cd05851 | 677-749 | Ig3_Contactin-1 |
| cd14180 | 1012-1117 | STKc_MSK2_C |
| cd14176 | 1004-1152 | STKc_RSK2_C |
| cd05586 | 1002-1100 | STKc_Sck1_like |
| cd14097 | 1006-1152 | STKc_STK33 |
| cd07837 | 993-1159 | STKc_CdkB_plant |
| cd05876 | 679-749 | Ig3_L1-CAM |
| cd13986 | 1008-1159 | STKc_16 |
| cd14114 | 994-1107 | STKc_Twitchin_like |
| cd14075 | 1005-1090 | STKc_NIM1 |
| cd07876 | 1004-1092 | STKc_JNK2 |
| cd14142 | 1020-1144 | STKc_ACVR1_ALK1 |
| cd08216 | 997-1160 | PK_STRAD |
| cd07875 | 971-1102 | STKc_JNK1 |
| cd14109 | 995-1116 | PK_Unc-89_rpt1 |
| cd06646 | 1005-1095 | STKc_MAP4K5 |
| pfam13927 | 660-735 | Ig_3 |
| cd05593 | 1002-1199 | STKc_PKB_gamma |
| pfam00047 | 675-733 | ig |
| cd14133 | 1005-1102 | PKc_DYRK_like |
| cd14185 | 1008-1133 | STKc_DCKL3 |
| cd14117 | 821-1100 | STKc_Aurora-B_like |
| cd14174 | 1006-1102 | STKc_Mnk1 |
| cd14144 | 1020-1144 | STKc_BMPR1 |
| cd13977 | 1001-1090 | STKc_PDIK1L |
| cd14166 | 1005-1127 | STKc_CaMKI_gamma |
| cd05748 | 354-427 | Ig_Titin_like |
| cd05599 | 1019-1111 | STKc_NDR_like |
| cd05893 | 680-748 | Ig_Palladin_C |
| cd05591 | 1002-1115 | STKc_nPKC_epsilon |
| cd14092 | 1005-1100 | STKc_MSK_C |
| cd14019 | 982-1144 | STKc_Cdc7 |
| cd14005 | 1004-1152 | STKc_PIM |
| cd07879 | 997-1094 | STKc_p38delta |
| cd05857 | 670-748 | Ig2_FGFR |
| cd05868 | 679-748 | Ig4_NrCAM |
| cd05859 | 333-426 | Ig4_PDGFR-alpha |
| cd05573 | 1018-1100 | STKc_ROCK_NDR_like |
| cd14184 | 825-1100 | STKc_DCKL2 |
| cd05609 | 1002-1109 | STKc_MAST |
| cd14113 | 994-1100 | STKc_Trio_C |
| cd14112 | 1005-1152 | STKc_Unc-89_rpt2 |
| cd14089 | 1005-1128 | STKc_MAPKAPK |
| cd13982 | 976-1145 | STKc_IRE1 |
| cd14096 | 997-1099 | STKc_RCK1-like |
| cd14210 | 998-1102 | PKc_DYRK |
| cd14170 | 1006-1151 | STKc_MAPKAPK2 |
| cd05734 | 679-748 | Ig7_DSCAM |
| cd14095 | 995-1108 | STKc_DCKL |
| cd05730 | 335-404 | Ig3_NCAM-1_like |
| cd05748 | 686-748 | Ig_Titin_like |
| cd05724 | 360-403 | Ig2_Robo |
| cd00096 | 354-404 | Ig |
| cd00096 | 248-325 | Ig |
| pfam00047 | 570-638 | ig |
| cd05729 | 352-426 | Ig2_FGFR_like |
| cd05742 | 570-640 | Ig1_VEGFR_like |
| cd05862 | 570-655 | Ig1_VEGFR |
| cd05736 | 359-404 | Ig2_Follistatin_like |
| pfam00047 | 363-404 | ig |
| cd04969 | 358-424 | Ig5_Contactin_like |
| cd05893 | 354-405 | Ig_Palladin_C |
| pfam13895 | 142-222 | Ig_2 |
| cl11960 | 142-222 | Ig superfamily |
| cd05859 | 688-749 | Ig4_PDGFR-alpha |
| pfam13895 | 568-645 | Ig_2 |
| cd05867 | 354-426 | Ig4_L1-CAM_like |
| cd05744 | 354-405 | Ig_Myotilin_C_like |
| cd05731 | 362-403 | Ig3_L1-CAM_like |
| pfam07714 | 827-1154 | Pkinase_Tyr |
| pfam07679 | 661-748 | I-set |
| smart00410 | 237-328 | IG_like |
| smart00408 | 569-640 | IGc2 |
| smart00410 | 143-219 | IG_like |
| smart00219 | 827-1154 | TyrKc |
| smart00221 | 827-1154 | STYKc |
| smart00220 | 828-1152 | S_TKc |
| pfam00069 | 827-1152 | Pkinase |
| COG0515 | 828-1217 | SPS1 |
| smart00410 | 668-748 | IG_like |
| smart00409 | 668-748 | IG |
| smart00408 | 676-738 | IGc2 |
| PTZ00283 | 1005-1145 | PTZ00283 |
| PHA03209 | 993-1101 | PHA03209 |
| PLN00034 | 1003-1152 | PLN00034 |
| PTZ00267 | 1004-1165 | PTZ00267 |
| PLN00009 | 1001-1111 | PLN00009 |
| PTZ00036 | 1002-1125 | PTZ00036 |
| PTZ00024 | 1005-1102 | PTZ00024 |
| PTZ00263 | 816-1100 | PTZ00263 |
| pfam07679 | 354-426 | I-set |
| smart00409 | 568-640 | IG |
| smart00410 | 568-640 | IG_like |
| smart00409 | 237-328 | IG |
| PHA03212 | 991-1152 | PHA03212 |
| smart00408 | 354-404 | IGc2 |
| PHA03207 | 991-1092 | PHA03207 |
| PHA02988 | 980-1154 | PHA02988 |
| smart00409 | 354-424 | IG |
| smart00410 | 354-424 | IG_like |
| PTZ00426 | 1002-1100 | PTZ00426 |
| pfam07679 | 568-640 | I-set |
| smart00409 | 143-219 | IG |
| pfam07679 | 234-313 | I-set |
| smart00408 | 245-315 | IGc2 |
Ontology Information
| HPRD ID | 3111 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P17948 | DB00398 | Sorafenib | SmallMoleculeDrug |
| P17948 | DB01268 | Sunitinib | SmallMoleculeDrug |
| P17948 | DB06589 | Pazopanib | SmallMoleculeDrug |
| P17948 | DB06626 | Axitinib | SmallMoleculeDrug |
| P17948 | DB08896 | Regorafenib | SmallMoleculeDrug |
| P17948 | DB09078 | Lenvatinib | SmallMoleculeDrug |
| P17948 | DB09079 | Nintedanib | SmallMoleculeDrug |