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General Information
- Evidence
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23324568 | 2013 | Cell line : - Source : Leiden University Medical Center (Leiden, The Netherlands) or at the Rijnland Hospital (Leiderdorp, The Netherlands). Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Oligonucleotide microarrays | Methylation | - | Repression of FOXD3 gene expression in tumors could be related to its promoter hypermethylation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] | Chromosome | 1 |
| Location | 1p31.3 |
| Start | 63788730 |
| End | 63790797 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2068 |
| OMIM ID | 611539 |
| HGNC ID | HGNC:3804 |
| Unigene ID | Hs.546573 |
| Ensembl ID | ENSG00000187140 |
| PharmGKB ID | PA28221 |
Protein Information
| Protein ID | NP_036315.1 |
|---|---|
| Protein Name | forkhead box D3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 478 |
| Uniprot ID | Q6J9G0 |
| Ensembl Protein ID | ENSP00000075503 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 213 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5460 | POU5F1 | 1252 | NP_002692.2 | in vitro | 11891324 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 141-218 | FH |
| cl00061 | 141-218 | FH superfamily |
| pfam00250 | 141-229 | Fork_head |
| smart00339 | 141-229 | FH |
| COG5025 | 133-227 | COG5025 |
| COG5025 | 135-225 | COG5025 |
Ontology Information
| HPRD ID | 5838 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.