CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24280874	2014	Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 93 Stage : -	Methylation specific PCR	Hypermethylation	-	FOXE1 and SYNE1 hypermethylation markers demonstrated significantly increased expression in neoplastic tissue. Promoter methylation analysis of these genes might be a useful marker of neoplasia in long-standing IBD.

Gene Details

Chromosome 9 - NC_000009.12 (97853255..97856715)
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Gene Type	protein coding
Gene Family	Forkhead boxes
Description	This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.
Chromosome	9
Location	9q22
Start	97853255
End	97856715
Strand	+
Gene Sequence	>gi\|568815589:97853255-97856715 Homo sapiens chromosome 9, GRCh38.p2 Primary Assembly CTCGCCAGCGGTCCGCAGGGCTGGAGACCCACGCCGTGGAGAGGACCAGCCTCAGGTCGCCCCGCCTGGG CCCGCGCCCCGACCTCGCTGCCCCCGCCTCGCCTCTCTGCCCGTGGCGCTTACGGCCACCTTGGCCTCGG GGGCAGGGCATGGGCGGCCCCCGCCAGATCGCCCAGCGCCAGTACTAACTGCCCTCGCTCTGGCCTTCGA GCCCGAAGCCTCTTCTGCGCGCACAACCTAGGCAGTAATCCTAAACTAGCGGGCACCACAGACCAGCTGC AGCCACCCCAACCCAGGGATCACTTCCGGACCCCTCGACCGCCCGGCACCAGCGCGCAAGGGACCCTTCA GCCGGAGACCAGAGTCCAGTCCCGGTCACGAGGCCACCGCCGCTGCCCGCCTCGAGAAGCACCACGCGGG CTGAGCCGTCGGCTAGCGGGTCACTCCCGAGCCTCTGTCTGCACCGCGCCAGCCCCAGACCACGGACGCT GAGCCTCCAGCGCGTGCCAGCCTGGGCCGCTGGGCTCTCGGGGCCAGCCCGCGACGATCCCCTGAGCTCT CCGCAGAAGGGCCGAGCGTCCGTTCCGGGGACGCCAGGCCCGCCCCCGCCCCCCGACAGCCGCGGGGATC CAGAGCCCGGGGGTGCGGGACGCCCGCGCCATGACTGCCGAGAGCGGGCCGCCGCCGCCGCAGCCGGAGG TGCTGGCTACCGTGAAGGAAGAGCGCGGCGAGACGGCAGCAGGGGCCGGGGTCCCAGGGGAGGCCACGGG CCGCGGGGCGGGCGGGCGGCGCCGCAAGCGCCCCCTGCAGCGCGGGAAGCCGCCCTACAGCTACATCGCG CTCATCGCCATGGCCATCGCGCACGCGCCCGAGCGCCGCCTCACGCTGGGCGGCATCTACAAGTTCATCA CCGAGCGCTTCCCCTTCTACCGCGACAACCCCAAAAAGTGGCAGAACAGCATCCGCCACAACCTCACACT CAACGACTGCTTCCTCAAGATCCCGCGCGAGGCCGGCCGCCCGGGTAAGGGCAACTACTGGGCGCTTGAC CCCAACGCGGAGGACATGTTCGAGAGCGGCAGCTTCCTGCGCCGCCGCAAGCGCTTCAAGCGCTCGGACC TCTCCACCTACCCGGCTTACATGCACGACGCGGCGGCTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCCGC CGCCGCCATCTTCCCAGGCGCGGTGCCCGCCGCGCGCCCCCCCTACCCGGGCGCCGTCTATGCAGGCTAC GCGCCGCCGTCGCTGGCCGCGCCGCCTCCAGTCTACTACCCCGCGGCGTCGCCCGGCCCTTGCCGCGTCT TCGGCCTGGTTCCTGAGCGGCCGCTCAGCCCAGAGCTGGGGCCCGCACCGTCGGGGCCCGGCGGCTCTTG CGCCTTTGCCTCCGCCGGCGCCCCCGCTACCACCACCGGCTACCAGCCCGCAGGCTGCACCGGGGCCCGG CCGGCCAACCCCTCCGCCTATGCGGCTGCCTACGCGGGCCCCGACGGCGCGTACCCGCAGGGCGCCGGCA GTGCGATCTTTGCCGCTGCTGGCCGCCTGGCGGGACCCGCTTCGCCCCCAGCGGGCGGCAGCAGTGGCGG CGTGGAGACCACGGTGGACTTCTACGGGCGCACGTCGCCCGGCCAGTTCGGAGCGCTGGGAGCCTGCTAC AACCCTGGCGGGCAGCTCGGAGGGGCCAGTGCAGGCGCCTACCATGCTCGCCATGCTGCCGCTTATCCCG GTGGGATAGATCGGTTCGTGTCCGCCATGTGAGCCAGCGTAGGGACGAAAACTCATAGACACATCGGCTG TTCACACGTTCCCCGCAATCTGAGAACGAACAGGAATGGAGAGAGGACTCAACTGGGACCCACGTGGAAA AGACCGAGCAGGCCACAGAGGCTCGGTCTCCCCGCGCACAGCGTAGGCACCCGGTGTACTCTGTAAACGG GAGGAGGTGGGGCGAGGCAGCCAGAGCCCTTGGACTGGCACAGGGACCCTCGATGGAGCGAAGCCCTCAA ACGGGATGCTTTCTGGTATTCTATCGGGGAGGGTCCTTGGCGGTAACCAGAGGGCAGCGTAGTGTCAACA CCAGAGACCAGGATCCAAATTGTGGGGAATCAGTTTCAGCCTTCCATGTGCTGCCGGAACTCGGGCCTTT TTACGCGGTTCGTCCTCTAGTGCCTTTAACTGCGTTACTACAATAAAAGGCTGCGGCAGCGCCTTTCTTC TTAAAGTGAGGAGGACAAATTTGCAAAAGAAATAGGCTTTTCTTCTTTTTTAAATTGGAGAAATCTCTGC TCTGGTTGACCTGGGCTGGTTTTCCCTGTCTCTGAGAACTTGAGACCTAGCTCCGAGTTGAACTGTGCGT CAGCACTCCAGTCCCATCACCTGAACCTTCAGTCTCCCCCATCTGTTACACTAGAGGGCTGCAGGACTCT ATCCACCGCCCCCGGGTTATCATTCAGGGCCCCATCATCTTGGATGCTGCCCTGCGTATTTGGCAGCAAT GGTGGGCCACCCAGGGCCTCTGAGTAGCCACCCAAAGCCTAGCCGCTGTTCTAGGGAACGGAAAAGAGTT CATGGCCAAGCGTCTAACCTAAAGTCCCAGGATTGGCTCCAGGCAGCAATTATATCATAACTTATTGAAC TTTTGAGCAGGACGTGCTGGTAATTTCATGGCTGTTACTGCCCAGTCATAAATCTGCTTTTCCATTATAA GGCAGAGAGAAGTACATTCGTTCATTTGTCCACTGTTTCTTGTCATCACGCAGCCCTGGACCCAAAGGGT GAACTAAAGTTTAAGGAGATGAGAGGATTCAAGGAGCCCGTTGGTGACGCCTTTCAGTAGCTGGGGAGGG CTCTTCCATCCCCAGCACCCCCTGCTACACCTCAGCAGCCTCCCCCATGCAAAAAGGAAAGAGAAAAATT AAGTTAGGGCAGTCAGTAAAGTGAGCTTTAGAAAGAAACTGGAATTTTAACTTCATTTTGTATCTTGCTT AAGTAGCAGGCTCACTAAAATTAGAGAAAGTCCAATAACTCTCCCCCTTTCCCTTGAGAAATCTTTAAGT TTCGATTCTGGAGCAAAAACTTTCAGCATTAAATATTTCAGAGGCTCCATTCACAGCTTTCAGATAAACT GGAGTGTTCAGATGGACTGTTTTAATAAAAATCTTTGAGCAAGTGAGTTATGGCAAGAGAAACTCAGCCT CTTTCTGTATAAACTTAACAGGGAAGGGCTGGGGTGTGAAAAAGAAGATTGTATGAAAACCATTGGTAAT TTTTATTTTTTATTTTTGGGACTGCACTATCCTGTTCACGAAGACATGTGAACTTGGTTCAGTCCAAATG GGGATTTGTATAAACCAGTGCTCTCCATTAGAAATATGGTGCAAGCCACATATGTAATTTTAAATATTCT AGTAGCCACATTAATAAAGTAAAAAGAAACA Download Select all
Length	3461
OMIM ID	602617
HGNC ID	HGNC:3806
Unigene ID	Hs.159234
Ensembl ID	ENSG00000178919
PharmGKB ID	-

mRNA Information

mRNA ID	NM_004473.3
Exon	1..3461
mRNA Sequence	>2304 CTCGCCAGCGGTCCGCAGGGCTGGAGACCCACGCCGTGGAGAGGACCAGCCTCAGGTCGCCCCG CCTGGGCCCGCGCCCCGACCTCGCTGCCCCCGCCTCGCCTCTCTGCCCGTGGCGCTTACGGCCA CCTTGGCCTCGGGGGCAGGGCATGGGCGGCCCCCGCCAGATCGCCCAGCGCCAGTACTAACTGC CCTCGCTCTGGCCTTCGAGCCCGAAGCCTCTTCTGCGCGCACAACCTAGGCAGTAATCCTAAAC TAGCGGGCACCACAGACCAGCTGCAGCCACCCCAACCCAGGGATCACTTCCGGACCCCTCGACC GCCCGGCACCAGCGCGCAAGGGACCCTTCAGCCGGAGACCAGAGTCCAGTCCCGGTCACGAGGC CACCGCCGCTGCCCGCCTCGAGAAGCACCACGCGGGCTGAGCCGTCGGCTAGCGGGTCACTCCC GAGCCTCTGTCTGCACCGCGCCAGCCCCAGACCACGGACGCTGAGCCTCCAGCGCGTGCCAGCC TGGGCCGCTGGGCTCTCGGGGCCAGCCCGCGACGATCCCCTGAGCTCTCCGCAGAAGGGCCGAG CGTCCGTTCCGGGGACGCCAGGCCCGCCCCCGCCCCCCGACAGCCGCGGGGATCCAGAGCCCGG GGGTGCGGGACGCCCGCGCCATGACTGCCGAGAGCGGGCCGCCGCCGCCGCAGCCGGAGGTGCT GGCTACCGTGAAGGAAGAGCGCGGCGAGACGGCAGCAGGGGCCGGGGTCCCAGGGGAGGCCACG GGCCGCGGGGCGGGCGGGCGGCGCCGCAAGCGCCCCCTGCAGCGCGGGAAGCCGCCCTACAGCT ACATCGCGCTCATCGCCATGGCCATCGCGCACGCGCCCGAGCGCCGCCTCACGCTGGGCGGCAT CTACAAGTTCATCACCGAGCGCTTCCCCTTCTACCGCGACAACCCCAAAAAGTGGCAGAACAGC ATCCGCCACAACCTCACACTCAACGACTGCTTCCTCAAGATCCCGCGCGAGGCCGGCCGCCCGG GTAAGGGCAACTACTGGGCGCTTGACCCCAACGCGGAGGACATGTTCGAGAGCGGCAGCTTCCT GCGCCGCCGCAAGCGCTTCAAGCGCTCGGACCTCTCCACCTACCCGGCTTACATGCACGACGCG GCGGCTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCATCTTCCCAGGCGCGGTGC CCGCCGCGCGCCCCCCCTACCCGGGCGCCGTCTATGCAGGCTACGCGCCGCCGTCGCTGGCCGC GCCGCCTCCAGTCTACTACCCCGCGGCGTCGCCCGGCCCTTGCCGCGTCTTCGGCCTGGTTCCT GAGCGGCCGCTCAGCCCAGAGCTGGGGCCCGCACCGTCGGGGCCCGGCGGCTCTTGCGCCTTTG CCTCCGCCGGCGCCCCCGCTACCACCACCGGCTACCAGCCCGCAGGCTGCACCGGGGCCCGGCC GGCCAACCCCTCCGCCTATGCGGCTGCCTACGCGGGCCCCGACGGCGCGTACCCGCAGGGCGCC GGCAGTGCGATCTTTGCCGCTGCTGGCCGCCTGGCGGGACCCGCTTCGCCCCCAGCGGGCGGCA GCAGTGGCGGCGTGGAGACCACGGTGGACTTCTACGGGCGCACGTCGCCCGGCCAGTTCGGAGC GCTGGGAGCCTGCTACAACCCTGGCGGGCAGCTCGGAGGGGCCAGTGCAGGCGCCTACCATGCT CGCCATGCTGCCGCTTATCCCGGTGGGATAGATCGGTTCGTGTCCGCCATGTGAGCCAGCGTAG GGACGAAAACTCATAGACACATCGGCTGTTCACACGTTCCCCGCAATCTGAGAACGAACAGGAA TGGAGAGAGGACTCAACTGGGACCCACGTGGAAAAGACCGAGCAGGCCACAGAGGCTCGGTCTC CCCGCGCACAGCGTAGGCACCCGGTGTACTCTGTAAACGGGAGGAGGTGGGGCGAGGCAGCCAG AGCCCTTGGACTGGCACAGGGACCCTCGATGGAGCGAAGCCCTCAAACGGGATGCTTTCTGGTA TTCTATCGGGGAGGGTCCTTGGCGGTAACCAGAGGGCAGCGTAGTGTCAACACCAGAGACCAGG ATCCAAATTGTGGGGAATCAGTTTCAGCCTTCCATGTGCTGCCGGAACTCGGGCCTTTTTACGC GGTTCGTCCTCTAGTGCCTTTAACTGCGTTACTACAATAAAAGGCTGCGGCAGCGCCTTTCTTC TTAAAGTGAGGAGGACAAATTTGCAAAAGAAATAGGCTTTTCTTCTTTTTTAAATTGGAGAAAT CTCTGCTCTGGTTGACCTGGGCTGGTTTTCCCTGTCTCTGAGAACTTGAGACCTAGCTCCGAGT TGAACTGTGCGTCAGCACTCCAGTCCCATCACCTGAACCTTCAGTCTCCCCCATCTGTTACACT AGAGGGCTGCAGGACTCTATCCACCGCCCCCGGGTTATCATTCAGGGCCCCATCATCTTGGATG CTGCCCTGCGTATTTGGCAGCAATGGTGGGCCACCCAGGGCCTCTGAGTAGCCACCCAAAGCCT AGCCGCTGTTCTAGGGAACGGAAAAGAGTTCATGGCCAAGCGTCTAACCTAAAGTCCCAGGATT GGCTCCAGGCAGCAATTATATCATAACTTATTGAACTTTTGAGCAGGACGTGCTGGTAATTTCA TGGCTGTTACTGCCCAGTCATAAATCTGCTTTTCCATTATAAGGCAGAGAGAAGTACATTCGTT CATTTGTCCACTGTTTCTTGTCATCACGCAGCCCTGGACCCAAAGGGTGAACTAAAGTTTAAGG AGATGAGAGGATTCAAGGAGCCCGTTGGTGACGCCTTTCAGTAGCTGGGGAGGGCTCTTCCATC CCCAGCACCCCCTGCTACACCTCAGCAGCCTCCCCCATGCAAAAAGGAAAGAGAAAAATTAAGT TAGGGCAGTCAGTAAAGTGAGCTTTAGAAAGAAACTGGAATTTTAACTTCATTTTGTATCTTGC TTAAGTAGCAGGCTCACTAAAATTAGAGAAAGTCCAATAACTCTCCCCCTTTCCCTTGAGAAAT CTTTAAGTTTCGATTCTGGAGCAAAAACTTTCAGCATTAAATATTTCAGAGGCTCCATTCACAG CTTTCAGATAAACTGGAGTGTTCAGATGGACTGTTTTAATAAAAATCTTTGAGCAAGTGAGTTA TGGCAAGAGAAACTCAGCCTCTTTCTGTATAAACTTAACAGGGAAGGGCTGGGGTGTGAAAAAG AAGATTGTATGAAAACCATTGGTAATTTTTATTTTTTATTTTTGGGACTGCACTATCCTGTTCA CGAAGACATGTGAACTTGGTTCAGTCCAAATGGGGATTTGTATAAACCAGTGCTCTCCATTAGA AATATGGTGCAAGCCACATATGTAATTTTAAATATTCTAGTAGCCACATTAATAAAGTAAAAAG AAACAAAAAAAAAAAAA Download Select all
Length	3473

CDS Information

Location	661..1782
CDS Sequence	>lcl\|NM_004473.3_cds_NP_004464.2_1 [gene=FOXE1] [protein=forkhead box protein E1] [protein_id=NP_004464.2] [location=661..1782] ATGACTGCCGAGAGCGGGCCGCCGCCGCCGCAGCCGGAGGTGCTGGCTACCGTGAAGGAAGAGCGCGGCG AGACGGCAGCAGGGGCCGGGGTCCCAGGGGAGGCCACGGGCCGCGGGGCGGGCGGGCGGCGCCGCAAGCG CCCCCTGCAGCGCGGGAAGCCGCCCTACAGCTACATCGCGCTCATCGCCATGGCCATCGCGCACGCGCCC GAGCGCCGCCTCACGCTGGGCGGCATCTACAAGTTCATCACCGAGCGCTTCCCCTTCTACCGCGACAACC CCAAAAAGTGGCAGAACAGCATCCGCCACAACCTCACACTCAACGACTGCTTCCTCAAGATCCCGCGCGA GGCCGGCCGCCCGGGTAAGGGCAACTACTGGGCGCTTGACCCCAACGCGGAGGACATGTTCGAGAGCGGC AGCTTCCTGCGCCGCCGCAAGCGCTTCAAGCGCTCGGACCTCTCCACCTACCCGGCTTACATGCACGACG CGGCGGCTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCATCTTCCCAGGCGCGGTGCCCGC CGCGCGCCCCCCCTACCCGGGCGCCGTCTATGCAGGCTACGCGCCGCCGTCGCTGGCCGCGCCGCCTCCA GTCTACTACCCCGCGGCGTCGCCCGGCCCTTGCCGCGTCTTCGGCCTGGTTCCTGAGCGGCCGCTCAGCC CAGAGCTGGGGCCCGCACCGTCGGGGCCCGGCGGCTCTTGCGCCTTTGCCTCCGCCGGCGCCCCCGCTAC CACCACCGGCTACCAGCCCGCAGGCTGCACCGGGGCCCGGCCGGCCAACCCCTCCGCCTATGCGGCTGCC TACGCGGGCCCCGACGGCGCGTACCCGCAGGGCGCCGGCAGTGCGATCTTTGCCGCTGCTGGCCGCCTGG CGGGACCCGCTTCGCCCCCAGCGGGCGGCAGCAGTGGCGGCGTGGAGACCACGGTGGACTTCTACGGGCG CACGTCGCCCGGCCAGTTCGGAGCGCTGGGAGCCTGCTACAACCCTGGCGGGCAGCTCGGAGGGGCCAGT GCAGGCGCCTACCATGCTCGCCATGCTGCCGCTTATCCCGGTGGGATAGATCGGTTCGTGTCCGCCATGT GA Download Select all
CCDS ID	CCDS35078.1

Protein Information

Protein ID	NP_004464.2
Protein Name	forkhead box E1 (thyroid transcription factor 2)
Molecular Wt. (Da)	37945
Protein Sequence	>2304 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAM AIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWA LDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPY PGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPA TTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVET TVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM Download Select all
Length	373
Uniprot ID	P08236
Ensembl Protein ID	ENSP00000302728

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
T	Phosphorylation	36

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
5331	PLCB3	2577	NP_000923.1	in vitro	10748198

Pathway Information

No matching records could be found.

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00059	53-130	FH
cl00061	53-130	FH superfamily
smart00339	53-141	FH
pfam00250	53-141	Fork_head
COG5025	12-139	COG5025
COG5025	53-140	COG5025
PRK07003	182-318	PRK07003
PHA03247	188-311	PHA03247

Ontology Information

HPRD ID	823
Molecular Class	Transcription factor
Molecular Function	DNA binding (GO:0003677)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report

CoReCG

Search results:

General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO