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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22569260 | 2012 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Dual luciferase reporter assay,real time RT-PCR, PCR, Western blotting, Immunocytochemistry,Acidic phosphatase assay,Flow cytometry | Down-regulation | - | miR-223 regulates FOXO1 expression and cell proliferation. |
| 25369914 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCT, MTT assay, colony formation assay, cell cycle analysis. | Down-regulation | - | miR-96 contributed to CRC cell growth and that TP53INP1, FOXO1 and FOXO3a were direct targets of miR-96, suggesting that miR-96 may have the potential to be used in the development of miRNA?based therapies for CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] | Chromosome | 13 |
| Location | 13q14.1 |
| Start | 41129801 |
| End | 41240734 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 110934 |
| OMIM ID | 136533 |
| HGNC ID | HGNC:3819 |
| Unigene ID | Hs.370666 |
| Ensembl ID | ENSG00000150907 |
| PharmGKB ID | PA28237 |
mRNA Information
| mRNA ID | NM_002015.3 |
|---|---|
| Exon | join(64..1078,105801..107152,107627..110997) | mRNA Sequence | Download Select all |
| Length | 5738 |
Protein Information
| Protein ID | NP_002006.2 |
|---|---|
| Protein Name | forkhead box O1 |
| Molecular Wt. (Da) | 69531 |
| Protein Sequence | Download Select all |
| Length | 655 |
| Uniprot ID | P11233 |
| Ensembl Protein ID | ENSP00000005257 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 24 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 319 |
| S | Phosphorylation | 256 |
| S | Phosphorylation | 325 |
| S | Phosphorylation | 322 |
| S | Phosphorylation | 329 |
| S | Phosphorylation | 505;- |
| S | Phosphorylation | 509;- |
| S | Phosphorylation | 287 |
| S | Phosphorylation | 432 |
| S | Phosphorylation | 470 |
| T | Phosphorylation | 478 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro;in vivo;yeast 2-hybrid | 1 143 544 511 353 770 |
| 5914 | RARA | 6769 | NP_000955.1 | in vitro;in vivo | 11353774 |
| 7068 | THRB | 7521 | NP_000452.2 | in vitro;in vivo | 11353774 |
| 23411 | SIRT1 | 8381 | NP_036370.2 | in vivo | 15692560 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| AMPK signaling pathway | hsa04152 |
| FoxO signaling pathway | hsa04068 |
| Glucagon signaling pathway | hsa04922 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Thyroid hormone signaling pathway | hsa04919 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 160-240 | FH |
| cl00061 | 160-240 | FH superfamily |
| smart00339 | 160-242 | FH |
| pfam00250 | 164-269 | Fork_head |
| COG5025 | 152-267 | COG5025 |
| COG5025 | 163-226 | COG5025 |
Ontology Information
| HPRD ID | 1550 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.