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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FUT2 | 2524 | fucosyltransferase 2 (secretor status included) | 19 | sej, Se2, SEC2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24941225 | 2014 | Cell line : - Source : Department of Anal and Colorectal Surgery, 1st Affiliated Hospital of Guangxi Medical University. Sample Type : CRC Tumor No. of Sample : 194 Stage : - | Genotyping | Up-regulation | - | The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fucosyltransferases |
| Description | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19q13.33 |
| Start | 49199228 |
| End | 49209191 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 9964 |
| OMIM ID | 182100 |
| HGNC ID | HGNC:4013 |
| Unigene ID | Hs.579928 |
| Ensembl ID | ENSG00000176920 |
| PharmGKB ID | PA28429 |
mRNA Information
| mRNA ID | NM_000511.5 |
|---|---|
| Exon | join(1..119,6985..9964) | mRNA Sequence | Download Select all |
| Length | 3099 |
Protein Information
| Protein ID | NP_000502.4 |
|---|---|
| Protein Name | fucosyltransferase 2 (secretor status included) |
| Molecular Wt. (Da) | 38886 |
| Protein Sequence | Download Select all |
| Length | 343 |
| Uniprot ID | Q13972 |
| Ensembl Protein ID | ENSP00000378228 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosphingolipid biosynthesis - globo series | hsa00603 |
| Glycosphingolipid biosynthesis - lacto and neolacto series | hsa00601 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11301 | 69-322 | Fut1_Fut2_like |
| cl16914 | 69-322 | O-FucT_like superfamily |
| pfam01531 | 21-334 | Glyco_transf_11 |
| cd11296 | 160-298 | O-FucT_like |
| cd11548 | 106-298 | NodZ_like |
Ontology Information
| HPRD ID | 2964 |
|---|---|
| Molecular Class | Enzyme: Fucosyltransferase |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.