Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FUT3 | 2525 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) | 19 | CD174 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22276141 | 2012 | Cell line : - Source : UAB Hospital Sample Type : CRC tumor and normal tissues No. of Sample : 303 Stage III CRC Stage : TNM Stage III. | Microarray for expression profiling,p53 mutational analysis,Microsatellite instability analysis,qNPA, qRT-PCR, and IHC platforms. | Up-regulation | - | 35 up-regulated genes, TRIM29, FUT3, IQGAP3, and SLC6A8 were confirmed. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Blood group antigens", "Fucosyltransferases" |
| Description | The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 19 |
| Location | 19p13.3 |
| Start | 5842899 |
| End | 5851485 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8587 |
| OMIM ID | 111100 |
| HGNC ID | HGNC:4014 |
| Unigene ID | Hs.169238 |
| Ensembl ID | ENSG00000171124 |
| PharmGKB ID | PA28430 |
mRNA Information
| mRNA ID | NM_001097641.1 |
|---|---|
| Exon | join(1..85,6624..8587) | mRNA Sequence | Download Select all |
| Length | 2066 |
Protein Information
| Protein ID | NP_001091110.1 |
|---|---|
| Protein Name | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
| Molecular Wt. (Da) | 41986 |
| Protein Sequence | Download Select all |
| Length | 361 |
| Uniprot ID | Q7Z6E9 |
| Ensembl Protein ID | ENSP00000317872 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Disulfide Bridge | 81;338 |
| C | Disulfide Bridge | 91;341 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | hsa00601 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00852 | 14-360 | Glyco_transf_10 |
| cl02988 | 14-360 | Glyco_transf_10 superfamily |
Ontology Information
| HPRD ID | 2067 |
|---|---|
| Molecular Class | Enzyme: Fucosyltransferase |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.