Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FUT4 | 2526 | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) | 11 | FUC-TIV |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26427914 | 2015 | Cell line : 12 CRC-derived cell lines Source : ATCC Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry,real time RT-PCR ,Reagents, transcript induction and kinase assays | Up-regulation | - | Cancer-related CD15/FUT4 overexpression participates in cetuximab or bevacizumab mechanisms of resistance in mCRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Fucosyltransferases" |
| Description | The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009] | Chromosome | 11 |
| Location | 11q21 |
| Start | 94277017 |
| End | 94283064 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6048 |
| OMIM ID | 104230 |
| HGNC ID | HGNC:4015 |
| Unigene ID | Hs.390420 |
| Ensembl ID | ENSG00000196371 |
| PharmGKB ID | PA28431 |
Protein Information
| Protein ID | NP_002024.1 |
|---|---|
| Protein Name | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) |
| Molecular Wt. (Da) | 58953 |
| Protein Sequence | Download Select all |
| Length | 530 |
| Uniprot ID | P98179 |
| Ensembl Protein ID | ENSP00000365946 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | hsa00601 |
| Metabolic pathways | hsa01100 |
| Other types of O-glycan biosynthesis | hsa00514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00852 | 154-528 | Glyco_transf_10 |
| cl02988 | 154-528 | Glyco_transf_10 superfamily |
Ontology Information
| HPRD ID | 3982 |
|---|---|
| Molecular Class | Enzyme: Fucosyltransferase |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.