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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FUT8 | 2530 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 14 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25174450 | 2014 | Cell line : - Source : Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University (China) Sample Type : CRC Tumor No. of Sample : ?65 Stage : - | real time RT-PCR, Western blotting, immunofluorescence, and inhibited cell proliferation, migration, and invasion assay | Up-regulation | - | miR-198 was shown to target the 3'UTR of FUT8 directly to downregulate FUT8 expression at both mRNA and protein levels. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fucosyltransferases |
| Description | This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] | Chromosome | 14 |
| Location | 14q24.3 |
| Start | 65877310 |
| End | 66210839 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 333530 |
| OMIM ID | 602589 |
| HGNC ID | HGNC:4019 |
| Unigene ID | Hs.597649 |
| Ensembl ID | ENSG00000033170 |
| PharmGKB ID | PA28435 |
mRNA Information
| mRNA ID | NM_178155.2 |
|---|---|
| Exon | join(1..1402,45030..45127,150746..151175,205387..205502, 205620..205782,218901..219015,258652..258889, 311184..311430,313556..313732,322640..322790, 331502..333530) | mRNA Sequence | Download Select all |
| Length | 5179 |
Protein Information
| Protein ID | NP_835368.1 |
|---|---|
| Protein Name | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) |
| Molecular Wt. (Da) | 66385 |
| Protein Sequence | Download Select all |
| Length | 575 |
| Uniprot ID | Q9BWF3 |
| Ensembl Protein ID | ENSP00000309166 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosaminoglycan biosynthesis - keratan sulfate | hsa00533 |
| Metabolic pathways | hsa01100 |
| N-Glycan biosynthesis | hsa00510 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd11300 | 174-499 | Fut8_like |
| cl16914 | 174-499 | O-FucT_like superfamily |
| cd11792 | 506-560 | SH3_Fut8 |
| cl17036 | 506-560 | SH3 superfamily |
| cd11296 | 325-473 | O-FucT_like |
| pfam14604 | 509-559 | SH3_9 |
| cd11548 | 329-475 | NodZ_like |
| smart00326 | 508-559 | SH3 |
| cd11784 | 508-558 | SH3_SH3RF2_3 |
| cd00174 | 508-555 | SH3 |
| pfam00018 | 508-555 | SH3_1 |
| cd11783 | 508-554 | SH3_SH3RF_3 |
| cd11823 | 509-560 | SH3_Nostrin |
| cd11925 | 508-554 | SH3_SH3RF3_3 |
| cd11791 | 509-554 | SH3_UBASH3 |
| cd12055 | 509-560 | SH3_CIN85_2 |
| cd11836 | 509-554 | SH3_Intersectin_1 |
| cd11832 | 508-556 | SH3_Shank |
| cd11777 | 509-559 | SH3_CIP4_Bzz1_like |
| cd11801 | 509-560 | SH3_JIP1_like |
| cd11793 | 508-560 | SH3_ephexin1_like |
| cd11916 | 509-559 | SH3_Sorbs1_3 |
| cd11926 | 508-554 | SH3_SH3RF1_3 |
| pfam02050 | 41-151 | FliJ |
| cl21477 | 41-151 | FliJ superfamily |
| cd11785 | 509-555 | SH3_SH3RF_C |
| cd11886 | 508-554 | SH3_BOI |
| cd11819 | 508-555 | SH3_Cortactin_like |
| cd11827 | 509-555 | SH3_MyoIe_If_like |
| cd11918 | 509-554 | SH3_Vinexin_3 |
| cd11772 | 509-560 | SH3_OSTF1 |
| cd11301 | 342-468 | Fut1_Fut2_like |
| cd11780 | 509-554 | SH3_Sorbs_3 |
| cd11917 | 509-559 | SH3_Sorbs2_3 |
| cd11877 | 509-560 | SH3_PIX |
| cd11779 | 509-556 | SH3_Irsp53_BAIAP2L |
| cd11874 | 509-560 | SH3_CD2AP-like_2 |
| COG0013 | 50-152 | AlaS |
| PRK03918 | 40-142 | PRK03918 |
Ontology Information
| HPRD ID | 7036 |
|---|---|
| Molecular Class | Enzyme: Fucosyltransferase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.