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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FXYD3 | 5349 | FXYD domain containing ion transport regulator 3 | 19 | MAT8; PLML |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Down-regulation | - | - |
| 19289258 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | - |
| 19955746 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 185 CRC patient sample and 106 adjascent normal tissue Stage : - | Immunohistochemistry | Up-regulation | - | The FXYD3 was associated with certain biological variables and may be involved in the development of the relative earlier stages of colorectal cancers. |
| 22612312 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Plaque-spot serological assay | Up-regulation | - | FXYD3 along with 13 other genes are consider as a panel of genes which can acts as potential cancer biomarkers.
|
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008] | Chromosome | 19 |
| Location | 19q13.12 |
| Start | 35115816 |
| End | 35124324 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 8509 |
| OMIM ID | 604996 |
| HGNC ID | HGNC:4027 |
| Unigene ID | Hs.301350 |
| Ensembl ID | ENSG00000089356 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011527032.1 |
|---|---|
| Exon | join(1..144,449..544,1442..1563,3353..3436,3548..3601, 5263..5295,5407..5430,6950..7139,7456..7493,7626..8509) | mRNA Sequence | Download Select all |
| Length | 1588 |
CDS Information
| Location | join(1491..1563,3353..3436,3548..3601,5263..5295, 5407..5430,6950..7139,7456..7493,7626..7642) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001129479.1 |
|---|---|
| Protein Name | FXYD domain containing ion transport regulator 3 |
| Molecular Wt. (Da) | 15023 |
| Protein Sequence | Download Select all |
| Length | 144 |
| Uniprot ID | P16870 |
| Ensembl Protein ID | ENSP00000386104 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 26135 | SERBP1 | 9570 | AAH26916.1 | yeast 2-hybrid | 16169070 |
| 54850 | FBXL12 | 12363 | NP_060173.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02038 | 24-73 | ATP1G1_PLM_MAT8 |
| cl03413 | 24-73 | ATP1G1_PLM_MAT8 superfamily |
Ontology Information
| HPRD ID | 7633 |
|---|---|
| Molecular Class | Ion channel |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.