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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12147710 | 2002 | Cell line : HT29,Colo205 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 20 Stage : - | In situ RNA hybridisation,immunoperoxidase based antibody staining | Up-regulation | - | Expression of Fz1/2 receptors may be involved in processes associated with tumour invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors |
| Description | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008] | Chromosome | 7 |
| Location | 7q21 |
| Start | 90893783 |
| End | 90898132 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4350 |
| OMIM ID | 603408 |
| HGNC ID | HGNC:4038 |
| Unigene ID | Hs.94234 |
| Ensembl ID | ENSG00000157240 |
| PharmGKB ID | PA28455 |
Protein Information
| Protein ID | NP_003496.1 |
|---|---|
| Protein Name | frizzled class receptor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 647 |
| Uniprot ID | Q86YL7 |
| Ensembl Protein ID | ENSP00000294489 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1742 | DLG4 | 4199 | NP_001356.1 | in vivo;yeast 2-hybrid | 12067714 |
| 7473 | WNT3 | 1318 | NP_110380.1 | in vivo | 10557084 |
| 7474 | WNT5A | 1293 | NP_003383.2 | in vivo | 10557084 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07465 | 112-238 | CRD_FZ1 |
| cl02447 | 112-238 | CRD_FZ superfamily |
| pfam01534 | 309-640 | Frizzled |
| cl21587 | 309-640 | 7tm_2 superfamily |
| cd07458 | 114-232 | CRD_FZ1_like |
| cd07466 | 112-234 | CRD_FZ7 |
| cd07464 | 112-238 | CRD_FZ2 |
| cd07456 | 116-231 | CRD_FZ5_like |
| smart00063 | 116-229 | FRI |
| cd07461 | 116-234 | CRD_FZ8 |
| cd07460 | 116-234 | CRD_FZ5 |
| pfam01392 | 116-228 | Fz |
| cd07066 | 116-229 | CRD_FZ |
| cd07457 | 114-228 | CRD_FZ9_like |
| cd07462 | 114-219 | CRD_FZ10 |
| cd07448 | 116-220 | CRD_FZ4 |
| cd07463 | 116-219 | CRD_FZ9 |
| cd07449 | 116-219 | CRD_FZ3 |
| cd07441 | 116-228 | CRD_SFRP3 |
| cd07442 | 116-228 | CRD_SFRP4 |
| cd07446 | 116-238 | CRD_SFRP2 |
| cd07450 | 116-219 | CRD_FZ6 |
| cd07444 | 118-228 | CRD_SFRP5 |
| cd07888 | 116-223 | CRD_corin_2 |
| cd07453 | 118-238 | CRD_crescent |
| cd07454 | 114-228 | CRD_LIN_17 |
| cd07443 | 118-234 | CRD_SFRP1 |
| cd07452 | 118-219 | CRD_sizzled |
| cd07447 | 116-218 | CRD_Carboxypeptidase_Z |
| cd07445 | 114-218 | CRD_corin_1 |
| cd07455 | 118-204 | CRD_Collagen_XVIII |
| cd07451 | 116-217 | CRD_SMO |
Ontology Information
| HPRD ID | 16306 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.