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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11786918 | 2002 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Northern blotting | Up-regulation | - | Up-regulation of FZD10 mRNA in several types of human cells might lead to carcinogenesis through activation of the beta-catenin - TCF signaling pathway synergistically with some class of WNTs. |
| 19134005 | 2009 | Cell line : - Source : Sample Type : CRC tumor No. of Sample : 104 Stage : - | Immunostaining | Up-regulation | - | FZD10 has a distinct role from other FZDs in canonical Wnt signal transduction.Frequencies of FZD10-immunopositive cells in tumor tissues were significantly higher in CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors, "CD molecules" |
| Description | This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008] | Chromosome | 12 |
| Location | 12q24.33 |
| Start | 130647004 |
| End | 130650285 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3282 |
| OMIM ID | 606147 |
| HGNC ID | HGNC:4039 |
| Unigene ID | Hs.31664 |
| Ensembl ID | - |
| PharmGKB ID | PA28456 |
Protein Information
| Protein ID | NP_009128.1 |
|---|---|
| Protein Name | frizzled class receptor 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 581 |
| Uniprot ID | Q9NQ94 |
| Ensembl Protein ID | ENSP00000282641 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07462 | 30-156 | CRD_FZ10 |
| cl02447 | 30-156 | CRD_FZ superfamily |
| pfam01534 | 217-535 | Frizzled |
| cl21587 | 217-535 | 7tm_2 superfamily |
| cd07463 | 30-155 | CRD_FZ9 |
| cd07457 | 32-152 | CRD_FZ9_like |
| cd07448 | 31-152 | CRD_FZ4 |
| cd07456 | 33-152 | CRD_FZ5_like |
| smart00063 | 34-150 | FRI |
| cd07458 | 32-152 | CRD_FZ1_like |
| cd07461 | 34-149 | CRD_FZ8 |
| pfam01392 | 34-148 | Fz |
| cd07460 | 34-149 | CRD_FZ5 |
| cd07066 | 33-151 | CRD_FZ |
| cd07465 | 32-138 | CRD_FZ1 |
| cd07466 | 32-138 | CRD_FZ7 |
| cd07464 | 32-138 | CRD_FZ2 |
| cd07442 | 34-138 | CRD_SFRP4 |
| cd07446 | 34-156 | CRD_SFRP2 |
| cd07449 | 34-143 | CRD_FZ3 |
| cd07454 | 32-153 | CRD_LIN_17 |
| cd07441 | 34-138 | CRD_SFRP3 |
| cd07444 | 36-148 | CRD_SFRP5 |
| cd07888 | 33-148 | CRD_corin_2 |
| cd07453 | 36-160 | CRD_crescent |
| cd07452 | 33-142 | CRD_sizzled |
| cd07450 | 34-142 | CRD_FZ6 |
| cd07443 | 36-152 | CRD_SFRP1 |
| cd07455 | 32-142 | CRD_Collagen_XVIII |
| cd07445 | 30-144 | CRD_corin_1 |
| cd07447 | 33-134 | CRD_Carboxypeptidase_Z |
| cd07451 | 58-144 | CRD_SMO |
Ontology Information
| HPRD ID | 16310 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.