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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24255701 | 2013 | Cell line : - Source : Anatomical Pathology and Cytology Laboratory, Department of Pathology, Queen Elizabeth Hospital, HKSAR. Sample Type : CRC tumor and normal tissue No. of Sample : 875 Stage : Duke stage A-D | Immunocytochemistry | Unknown | - | Frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors |
| Description | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010] | Chromosome | 8 |
| Location | 8p21 |
| Start | 28351722 |
| End | 28431785 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 80064 |
| OMIM ID | 606143 |
| HGNC ID | HGNC:4041 |
| Unigene ID | Hs.40735 |
| Ensembl ID | ENSG00000104290 |
| PharmGKB ID | PA28458 |
mRNA Information
| mRNA ID | ?NM_017412.3 |
|---|---|
| Exon | join(1..139,5729..5774,8466..8998,26434..26630, 32943..33960,57399..57547,61534..61767,68594..80064) | mRNA Sequence | Download Select all |
| Length | 13804 |
Protein Information
| Protein ID | NP_059108.1 |
|---|---|
| Protein Name | frizzled class receptor 3 |
| Molecular Wt. (Da) | 53160 |
| Protein Sequence | Download Select all |
| Length | 666 |
| Uniprot ID | O15397 |
| Ensembl Protein ID | ENSP00000256079 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 10755 | GIPC1 | 5462 | NP_005707.1 | in vivo | 12011974 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07449 | 24-150 | CRD_FZ3 |
| cl02447 | 24-150 | CRD_FZ superfamily |
| pfam01534 | 192-517 | Frizzled |
| cl21587 | 192-517 | 7tm_2 superfamily |
| smart00063 | 28-136 | FRI |
| cd07450 | 24-138 | CRD_FZ6 |
| pfam01392 | 28-136 | Fz |
| cd07458 | 27-131 | CRD_FZ1_like |
| cd07066 | 28-135 | CRD_FZ |
| cd07456 | 28-136 | CRD_FZ5_like |
| cd07461 | 27-144 | CRD_FZ8 |
| cd07448 | 27-131 | CRD_FZ4 |
| cd07460 | 28-144 | CRD_FZ5 |
| cd07462 | 28-136 | CRD_FZ10 |
| cd07466 | 28-131 | CRD_FZ7 |
| cd07464 | 28-131 | CRD_FZ2 |
| cd07465 | 28-131 | CRD_FZ1 |
| cd07463 | 28-136 | CRD_FZ9 |
| cd07457 | 27-136 | CRD_FZ9_like |
| cd07442 | 28-134 | CRD_SFRP4 |
| cd07441 | 27-134 | CRD_SFRP3 |
| cd07888 | 28-132 | CRD_corin_2 |
| cd07446 | 27-131 | CRD_SFRP2 |
| cd07444 | 30-131 | CRD_SFRP5 |
| cd07454 | 28-131 | CRD_LIN_17 |
| cd07453 | 30-131 | CRD_crescent |
| cd07443 | 30-131 | CRD_SFRP1 |
| cd07452 | 30-139 | CRD_sizzled |
| cd07447 | 28-130 | CRD_Carboxypeptidase_Z |
| cd07445 | 27-135 | CRD_corin_1 |
| cd07451 | 27-140 | CRD_SMO |
| cd07455 | 30-141 | CRD_Collagen_XVIII |
| pfam00002 | 204-433 | 7tm_2 |
Ontology Information
| HPRD ID | 5935 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Peroxidase activity (GO:0004601) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.