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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25772759 | 2015 | Cell line : - Source : Department of Pathology in the College of Medicine at the Catholic University of Korea. Sample Type : - No. of Sample : - Stage : - | miRNA-specific qRT-PCR, real time RT-PCR,Western blotting,Luciferase reporter assay,Immunohistochemistry | Up-regulation | - | FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers.Expression of FZD6 in patients with CRC and found it to be increased in tumors, as compared to paired adjacent non-tumor tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors |
| Description | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011] | Chromosome | 8 |
| Location | 8q22.3-q23 |
| Start | 104310661 |
| End | 104345094 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 34434 |
| OMIM ID | 603409 |
| HGNC ID | HGNC:4044 |
| Unigene ID | Hs.591863 |
| Ensembl ID | ENSG00000164930 |
| PharmGKB ID | PA28461 |
mRNA Information
| mRNA ID | ?NM_001164615.1 |
|---|---|
| Exon | join(1..138,1524..1852,20158..20354,26049..27066, 29836..29984,31223..31633,32909..34434) | mRNA Sequence | Download Select all |
| Length | 3779 |
Protein Information
| Protein ID | NP_001158087.1 |
|---|---|
| Protein Name | frizzled class receptor 6 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 706 |
| Uniprot ID | Q8WTW4 |
| Ensembl Protein ID | ENSP00000232501 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 606 |
| T | Phosphorylation | 607 |
| S | Phosphorylation | 653 |
| S | Phosphorylation | 656 |
| T | Phosphorylation | 659 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 54361 | WNT4 | 4601 | NP_110388.2 | in vivo | 15265686 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07450 | 20-146 | CRD_FZ6 |
| cl02447 | 20-146 | CRD_FZ superfamily |
| pfam01534 | 188-513 | Frizzled |
| cl21587 | 188-513 | 7tm_2 superfamily |
| cd07449 | 20-138 | CRD_FZ3 |
| smart00063 | 24-132 | FRI |
| cd07066 | 23-126 | CRD_FZ |
| pfam01392 | 24-126 | Fz |
| cd07458 | 24-125 | CRD_FZ1_like |
| cd07457 | 24-126 | CRD_FZ9_like |
| cd07466 | 24-124 | CRD_FZ7 |
| cd07464 | 24-126 | CRD_FZ2 |
| cd07456 | 24-126 | CRD_FZ5_like |
| cd07460 | 24-141 | CRD_FZ5 |
| cd07461 | 23-126 | CRD_FZ8 |
| cd07465 | 24-126 | CRD_FZ1 |
| cd07462 | 24-126 | CRD_FZ10 |
| cd07448 | 23-125 | CRD_FZ4 |
| cd07463 | 24-140 | CRD_FZ9 |
| cd07454 | 24-126 | CRD_LIN_17 |
| cd07441 | 23-136 | CRD_SFRP3 |
| cd07888 | 24-131 | CRD_corin_2 |
| cd07442 | 24-136 | CRD_SFRP4 |
| cd07446 | 23-126 | CRD_SFRP2 |
| cd07453 | 29-126 | CRD_crescent |
| cd07443 | 32-125 | CRD_SFRP1 |
| cd07444 | 26-137 | CRD_SFRP5 |
| cd07447 | 23-125 | CRD_Carboxypeptidase_Z |
| cd07452 | 27-125 | CRD_sizzled |
| cd07445 | 23-142 | CRD_corin_1 |
| cd07451 | 23-124 | CRD_SMO |
| cd07455 | 26-126 | CRD_Collagen_XVIII |
| pfam00002 | 205-431 | 7tm_2 |
Ontology Information
| HPRD ID | 9191 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.