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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18592008 | 2008 | Cell line : HCT 116 Source : - Sample Type : - No. of Sample : - Stage : - | real-time PCR, TOPflash assay,Western blotting, MTS and matrigel assays | Up-regulation | - | FZD7-siRNA was shown to significantly decrease cell viability and in vitro invasion activity after transfection into HCT-116 cells. |
| 22182510 | 2012 | Cell line : HCT 116 Source : - Sample Type : - No. of Sample : - Stage : STAGE II,III,IV. | - | Up-regulation | - | Fzd7 is the Wnt receptor most commonly upregulated in a variety of cancers including colorectal cancer, hepatocellular carcinoma and triple negative breast cancer.Targeted inhibition of Fzd7 represents a rational and promising new approach for cancer therapy. |
| 0 | 0 | Cell line : HT 29, HCT 116 Source : - Sample Type : - No. of Sample : - Stage : Stage II, III, IV | RNA interference, Luciferase reporter assay,Crystal violet stain,Cell-cycle assay,Western blotting, RhoA activation assay,real time RT-PCR,Cell Invasion Assay | Up-regulation | - | FZD7 may be involved in enhancement of survival, invasion and metastatic capabilities of colon cancer cells through non-canonical Wnt signalling pathways as well as the canonical pathway. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class F : Frizzled receptors |
| Description | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] | Chromosome | 2 |
| Location | 2q33 |
| Start | 202899310 |
| End | 202903160 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3851 |
| OMIM ID | 603410 |
| HGNC ID | HGNC:4045 |
| Unigene ID | Hs.173859 |
| Ensembl ID | ENSG00000155760 |
| PharmGKB ID | PA28462 |
Protein Information
| Protein ID | NP_003498.1 |
|---|---|
| Protein Name | frizzled class receptor 7 |
| Molecular Wt. (Da) | 68508 |
| Protein Sequence | Download Select all |
| Length | 574 |
| Uniprot ID | O00425 |
| Ensembl Protein ID | ENSP00000258729 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 29979 | UBQLN1 | 5440 | NP_038466.2 | yeast 2-hybrid | 16189514 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
| 260425 | MAGI3 | 11290 | NP_001136254.1 | yeast 2-hybrid | 15195140 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal cell carcinoma | hsa05217 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Melanogenesis | hsa04916 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07466 | 45-169 | CRD_FZ7 |
| cl02447 | 45-169 | CRD_FZ superfamily |
| pfam01534 | 243-564 | Frizzled |
| cl21587 | 243-564 | 7tm_2 superfamily |
| cd07458 | 47-165 | CRD_FZ1_like |
| cd07464 | 45-167 | CRD_FZ2 |
| cd07465 | 45-167 | CRD_FZ1 |
| cd07456 | 49-164 | CRD_FZ5_like |
| smart00063 | 49-162 | FRI |
| cd07461 | 49-167 | CRD_FZ8 |
| cd07460 | 49-167 | CRD_FZ5 |
| pfam01392 | 49-161 | Fz |
| cd07066 | 49-162 | CRD_FZ |
| cd07457 | 47-152 | CRD_FZ9_like |
| cd07448 | 49-162 | CRD_FZ4 |
| cd07462 | 47-152 | CRD_FZ10 |
| cd07463 | 49-152 | CRD_FZ9 |
| cd07441 | 49-161 | CRD_SFRP3 |
| cd07442 | 49-161 | CRD_SFRP4 |
| cd07449 | 49-152 | CRD_FZ3 |
| cd07450 | 49-152 | CRD_FZ6 |
| cd07446 | 49-167 | CRD_SFRP2 |
| cd07888 | 49-156 | CRD_corin_2 |
| cd07444 | 51-153 | CRD_SFRP5 |
| cd07453 | 51-167 | CRD_crescent |
| cd07443 | 51-167 | CRD_SFRP1 |
| cd07454 | 47-154 | CRD_LIN_17 |
| cd07452 | 51-152 | CRD_sizzled |
| cd07447 | 49-151 | CRD_Carboxypeptidase_Z |
| cd07455 | 51-137 | CRD_Collagen_XVIII |
| cd07445 | 49-151 | CRD_corin_1 |
| cd07451 | 49-150 | CRD_SMO |
Ontology Information
| HPRD ID | 5484 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.