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General Information

• Evidence
• Gene
• mRNA
• CDS
• Protein
• PTM
• Enzyme
• PPi
• Pathway
• Structural
• Domain
• Ontology
• SNP
• Drug
• External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
25991585	2015	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Up-regulation	-	MiR-409-3p expression was significantly downregulated in CRC tissue and GAB1, NR4A2 and LMO4 were directly regulated by this miRNA.

Gene Details

NC_000004.11 (144257680..144395718)
View Larger Image   

Gene Type	protein coding
Gene Family	Pleckstrin homology (PH) domain containing
Description	The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	4
Location	4q31.1
Start	144257680
End	144395718
Strand	+
Gene Sequence	Download   Select all
Length	138039
OMIM ID	604439
HGNC ID	HGNC:4066
Unigene ID	Hs.80720
Ensembl ID	ENSG00000109458
PharmGKB ID	PA28477

mRNA Information

mRNA ID	XM_005262881.3
Exon	join(1..499,78716..79010,96730..96955,97327..97407, 101238..101839,103041..103126,103318..103621, 120919..121008,122624..122717,123603..123726, 129342..129464,132270..136538)
mRNA Sequence	Download   Select all
Length	6793

CDS Information

   

Location	428..2683
CDS Sequence	Download   Select all
CCDS ID	CCDS3759.1

Protein Information

      

Protein ID	XP_005262938.1
Protein Name	GRB2-associated binding protein 1
Molecular Wt. (Da)	82863
Protein Sequence	Download   Select all
Length	751
Uniprot ID	Q04864
Ensembl Protein ID	ENSP00000295025

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	259
S	Phosphorylation	266
Y	Phosphorylation	373
Y	Phosphorylation	259
S	Phosphorylation	266
Y	Dephosphorylation	589
Y	Dephosphorylation	627
Y	Dephosphorylation	659
Y	Dephosphorylation	657
Y	Dephosphorylation	689
Y	Phosphorylation	285
Y	Phosphorylation	307
Y	Phosphorylation	406
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	589
Y	Phosphorylation	627
Y	Phosphorylation	659
Y	Phosphorylation	285
Y	Phosphorylation	307
Y	Phosphorylation	406
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	619
Y	Phosphorylation	657
Y	Phosphorylation	689
Y	Phosphorylation	589
Y	Phosphorylation	242
Y	Phosphorylation	285
Y	Phosphorylation	373
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	627
Y	Phosphorylation	659
Y	Phosphorylation	242
Y	Phosphorylation	285
Y	Phosphorylation	373
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	619
Y	Phosphorylation	657
Y	Phosphorylation	689
Y	Phosphorylation	285
Y	Phosphorylation	307
Y	Phosphorylation	373
Y	Phosphorylation	406
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	589
Y	Phosphorylation	627
Y	Phosphorylation	659
Y	Phosphorylation	285
Y	Phosphorylation	307
Y	Phosphorylation	373
Y	Phosphorylation	406
Y	Phosphorylation	447
Y	Phosphorylation	472
Y	Phosphorylation	619
Y	Phosphorylation	657
Y	Phosphorylation	689
T	Phosphorylation	312
T	Phosphorylation	312
S	Phosphorylation	381
S	Phosphorylation	381
S	Phosphorylation	454
S	Phosphorylation	454
T	Phosphorylation	476
T	Phosphorylation	476
S	Phosphorylation	581
S	Phosphorylation	581
S	Phosphorylation	597
S	Phosphorylation	597
T	Phosphorylation	312
T	Phosphorylation	312
S	Phosphorylation	381
S	Phosphorylation	381
S	Phosphorylation	454
S	Phosphorylation	454
T	Phosphorylation	476
T	Phosphorylation	476
S	Phosphorylation	551
S	Phosphorylation	551
S	Phosphorylation	567
S	Phosphorylation	567
S	Phosphorylation	547
Y	Phosphorylation	317
Y	Phosphorylation	317
S	Phosphorylation	355
S	Phosphorylation	355
Y	Phosphorylation	405
Y	Phosphorylation	405
Y	Phosphorylation	658
Y	Phosphorylation	688
S	Phosphorylation	634
S	Phosphorylation	664
S	Phosphorylation	637
S	Phosphorylation	667

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                  

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
708	C1QBP	3168	NP_001203.1	in vitro;in vivo	10747014
1398	CRK	1267	NP_058431.2	in vitro	12138161
1399	CRKL	3596	NP_005198.1	yeast 2-hybrid	1   075   386   910   871   280
2885	GRB2	150	NP_002077.1	yeast 2-hybrid	113   140   421   196   037   000   000   000
3635	INPP5D	9033	NP_001017915.1	in vivo	11402314
4215	MAP3K3	3965	NP_976226.1	in vitro;in vivo	12065326
5295	PIK3R1	1381	NP_852664.1	in vitro	1   194   058   116   638   570
5335	PLCG1	1398	NP_002651.2	in vivo	8596638
5336	PLCG2	2570	AAH11772.1	in vivo	11507676
5979	RET	1266	NP_066124.1	in vivo	11360177
6464	SHC1	2780	NP_001123512.1	in vitro	12808090
6654	SOS1	1681	NP_005624.2	in vitro	11707404
7462	LAT2	9304	NP_071323.1	in vitro;in vivo	12486104
10818	FRS2	6372	NP_006645.3	in vitro;in vivo	11353842

Pathway Information

                                          

Pathway Name	Pathway ID
Bacterial invasion of epithelial cells	hsa05100
ErbB signaling pathway	hsa04012
Neurotrophin signaling pathway	hsa04722
Phospholipase D signaling pathway	hsa04072
Proteoglycans in cancer	hsa05205
Ras signaling pathway	hsa04014
Renal cell carcinoma	hsa05211

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd01266	3-125	PH_Gab1_Gab2
cl17171	3-125	PH-like superfamily
cd13324	6-117	PH_Gab-like
cd13385	1-122	PH_Gab3
cd13384	5-117	PH_Gab2_2
pfam00169	6-115	PH
smart00233	6-115	PH
cd13255	1-114	PH_TAAP2-like
cd13298	5-108	PH1_PH_fungal
cd10573	26-111	PH_DAPP1
cd13296	9-108	PH2_MyoX
cd00821	8-111	PH
cd13282	9-114	PH1_PLEKHH1_PLEKHH2
cd13271	2-115	PH2_TAPP1_2
cd13253	9-109	PH1_ARAP
cd01257	4-107	PH_IRS
cd13276	9-111	PH_AtPH1
cd13250	10-111	PH_ACAP
cd13248	2-109	PH_PEPP1_2_3
cd13263	5-111	PH_RhoGap25-like
cd13267	1-114	PH_DOCK-D
cd01260	4-111	PH_CNK_mammalian-like
pfam15413	10-111	PH_11
cd01251	10-111	PH2_ADAP
cd13316	8-111	PH_Boi
cd13215	4-111	PH-GRAM1_AGT26
cd13378	4-111	PH_RhoGAP2
cd13256	9-111	PH3_ARAP
cd01265	9-108	PH_TBC1D2A
cd01238	9-119	PH_Btk
cd13297	3-124	PH3_MyoX-like
cd13260	19-115	PH_RASA1
cd01235	26-111	PH_Sbf1_hMTMR5
cd13299	6-108	PH2_PH_fungal
cd13308	1-111	PH_3BP2
cd13301	10-111	PH1_Pleckstrin_2
cd13302	3-111	PH2_Pleckstrin_2
cd14673	5-111	PH_PHLDB1_2
cd13326	8-108	PH_CNK_insect-like
cd13288	10-111	PH_Ses
cd13279	6-111	PH_Cla4_Ste20
cd13283	24-111	PH_GPBP
cd13266	6-111	PH_Skap_family
cd01252	9-111	PH_GRP1-like
cd01244	11-119	PH_GAP1-like
cd01236	6-107	PH_RIP
cd13251	9-108	PH_ASAP
cd01263	25-109	PH_anillin
cd13261	26-118	PH_RasGRF1_2
cd13287	7-108	PH_ORP3_ORP6_ORP7
cd13278	25-120	PH_Bud4
cd13379	5-111	PH_RhoGap24
cd13273	4-111	PH_SWAP-70
pfam14593	27-114	PH_3
cd13292	16-111	PH_Osh1p_Osh2p_yeast
cd13252	10-107	PH1_ADAP
cd13265	6-108	PH_evt
cd13294	26-108	PH_ORP_plant
pfam15409	10-114	PH_8
cd13254	42-108	PH2_ARAP
PHA03307	214-570	PHA03307

Ontology Information

   

HPRD ID	1241
Molecular Class	Adapter molecule
Molecular Function	Transcription factor activity (GO:0003700)
Biological Process	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)

SNP Information

View SNP Geneview Report   

Drug Information

No matching records could be found.

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO