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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GAB2 9846 GRB2-associated binding protein 2  11KIAA0571 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26045784   2015Cell line : -

Source : Department of gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : TNM Stage I-IV

real time RT-PCR,Western blotting,ImmunohistochemistryUp-regulation-Gab2 expression may play an important role in the progression of CRC, and underscored that Gab2 has the potential value as a prognostic predictor for CRC patients.


Gene Details



NC_000019.9 (10596796..10614054, complement)

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Gene Type protein coding
Gene Family Pleckstrin homology (PH) domain containing
Description This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11q13.4-q1
Start 10596796  
End 10614054  
Strand -  
Gene Sequence

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Length 17259  
OMIM ID 606203   
HGNC ID HGNC:14458   
Unigene ID Hs.429434   
Ensembl ID ENSG00000033327   
PharmGKB ID PA28478   

mRNA Information


mRNA ID ?NM_012296.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS8259.1



Protein Information


      
Protein IDNP_036428.1
Protein NameGRB2-associated binding protein 2
Molecular Wt. (Da)0
Protein Sequence

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Length 676  
Uniprot IDQ9HBE1
Ensembl Protein ID ENSP00000215919  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation266
YPhosphorylation266
YDephosphorylation643
YDephosphorylation643
YDephosphorylation643
YDephosphorylation643
YPhosphorylation614
YPhosphorylation614
SPhosphorylation623
SPhosphorylation623
SPhosphorylation623
SPhosphorylation159
SPhosphorylation159
SPhosphorylation543
SPhosphorylation543
SPhosphorylation404
SPhosphorylation404
TPhosphorylation385
TPhosphorylation385
SPhosphorylation140
SPhosphorylation140
SPhosphorylation148
SPhosphorylation148
YPhosphorylation643
YPhosphorylation643
YPhosphorylation324
YPhosphorylation324
SPhosphorylation623

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                  
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
919CD2471729NP_932170.1in vivo11572860   
1399CRKL3596NP_005198.1in vitro;in vivo11334882   
2057EPOR587NP_000112.1in vivo10455108   
2120ETV615976NP_001978.1in vitro;in vivo15143164   
2885GRB2150NP_002077.1in vitro;in vivo118   823   611   006   865   000   000   000   
3635INPP5D9033NP_001017915.1in vivo11402314   
4067LYN1301NP_002341.1in vivo11971018   
5295PIK3R11381NP_852664.1in vitro;in vivo1   006   865   116   219   540   
5336PLCG22570AAH11772.1in vitro;in vivo12135708   
6464SHC12780NP_001123512.1in vitro;in vivo10704825   
6714SRC1819NP_005408.1in vitro10391903   
6850SYK2514NP_003168.2in vitro11895767   
9402GRAP25156NP_004801.1in vitro;in vivo1   199   751   012   176   360   
27040LAT3832NP_001014989.2in vivo11572860   


Pathway Information


                                          
Pathway Name Pathway ID
Chronic myeloid leukemia hsa05220
Fc epsilon RI signaling pathway hsa04664
Fc gamma R-mediated phagocytosis hsa04666
Osteoclast differentiation hsa04380
Phospholipase D signaling pathway hsa04072
Ras signaling pathway hsa04014
Sphingolipid signaling pathway hsa04071


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd012664-126  PH_Gab1_Gab2
cl171714-126  PH-like superfamily
cd133247-118  PH_Gab-like
cd133855-125  PH_Gab3
cd133846-118  PH_Gab2_2
pfam001697-116  PH
cd132557-115  PH_TAAP2-like
smart002337-116  PH
cd132987-112  PH1_PH_fungal
cd1057327-109  PH_DAPP1
cd1329611-115  PH2_MyoX
cd1328226-121  PH1_PLEKHH1_PLEKHH2
cd0082111-112  PH
cd1325311-111  PH1_ARAP
cd132482-112  PH_PEPP1_2_3
cd132717-116  PH2_TAPP1_2
cd1325011-112  PH_ACAP
cd133085-112  PH_3BP2
cd132672-115  PH_DOCK-D
cd012516-112  PH2_ADAP
cd012575-112  PH_IRS
cd132636-112  PH_RhoGap25-like
cd012603-112  PH_CNK_mammalian-like
cd0126526-110  PH_TBC1D2A
cd1327611-112  PH_AtPH1
cd0123527-112  PH_Sbf1_hMTMR5
cd1326127-123  PH_RasGRF1_2
cd0123827-119  PH_Btk
cd132889-112  PH_Ses
pfam1541311-112  PH_11
cd132155-112  PH-GRAM1_AGT26
cd133785-112  PH_RhoGAP2
cd132972-112  PH3_MyoX-like
cd133269-112  PH_CNK_insect-like
cd146738-112  PH_PHLDB1_2
cd133796-112  PH_RhoGap24
cd1325113-109  PH_ASAP
cd1326611-112  PH_Skap_family
cd132997-112  PH2_PH_fungal
cd1330127-112  PH1_Pleckstrin_2
cd0124412-120  PH_GAP1-like
cd133024-112  PH2_Pleckstrin_2
cd1325611-112  PH3_ARAP
cd132735-112  PH_SWAP-70
cd0125211-112  PH_GRP1-like
cd133169-112  PH_Boi
cd132797-112  PH_Cla4_Ste20
cd0123326-112  PH_KIFIA_KIFIB
cd1329427-112  PH_ORP_plant
cd0125427-112  PH_PLD
cd1326010-116  PH_RASA1
cd0121821-114  PH_Phafin2-like
cd1330911-114  PH_SKIP
cd1327511-125  PH_M-RIP
cd1467627-115  PH_DOK1,2,3
cd1337020-125  PH_GAP1m_mammal-like
cd1325210-112  PH1_ADAP
cd0125912-109  PH_APBB1IP
cd1327826-119  PH_Bud4
cd0125310-112  PH_ARHGAP21-like
cd012367-113  PH_RIP
cd1323626-112  PH2_FGD1-4
cd1329220-112  PH_Osh1p_Osh2p_yeast
cd132898-110  PH_Osh3p_yeast
PTZ00232553-639  PTZ00232
cl11954553-639  PTZ00232 superfamily


Ontology Information


   
HPRD ID9236
Molecular ClassAdapter molecule
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO