Search results:


General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GABRA1 2554 gamma-aminobutyric acid (GABA) A receptor, alpha 1  5EJM5 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22038115   2012Cell line : -

Source : -

Sample Type : CRC tumor and adjacent normal tissues

No. of Sample : 134

Stage : -

PyrosequencingMethylation-GABRA1 and LAMA2, may have roles in colorectal tumorigenesis and could be potential biomarkers for the screening and the detection of colorectal cancer in clinical practice.


Gene Details



NC_000005.9 (161274197..161326965)

View Larger Image
   
Gene Type protein coding
Gene Family GABA receptors, "Ligand-gated ion channels / GABA(A) receptors"
Description This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5q34
Start 161274197  
End 161326965  
Strand +  
Gene Sequence

   Download   Select all

Length 52769  
OMIM ID 137160   
HGNC ID HGNC:4075   
Unigene ID Hs.175934   
Ensembl ID ENSG00000022355   
PharmGKB ID PA28489   

mRNA Information


mRNA ID NM_000806.5
Exon join(1..221,1001..1232,3606..3694,6968..7080,18531..18598, 25927..26147,28370..28452,35368..35511,43708..43860, 48476..48678,49921..52769)  
mRNA Sequence

   Download   Select all

Length 4376  



CDS Information


   
Location469..1839
CDS Sequence

   Download   Select all

CCDS ID CCDS4357.1



Protein Information


      
Protein ID NP_000797.2
Protein Namegamma-aminobutyric acid (GABA) A receptor, alpha 1
Molecular Wt. (Da)0
Protein Sequence

   Download   Select all

Length 456  
Uniprot IDQ04206
Ensembl Protein ID ENSP00000311508  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1815DRD4541NP_000788.2in vitro10050966   
5530PPP3CA234NP_000935.1in vitro12574411   


Pathway Information


                                    
Pathway Name Pathway ID
GABAergic synapse hsa04727
Morphine addiction hsa05032
Neuroactive ligand-receptor interaction hsa04080
Nicotine addiction hsa05033
Retrograde endocannabinoid signaling hsa04723
Taste transduction hsa04742


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam0293143-250  Neur_chan_LBD
cl0378843-250  Neur_chan_LBD superfamily
pfam02932257-439  Neur_chan_memb
cl08379257-439  Neur_chan_memb superfamily
TIGR0086014-442  LIC


Ontology Information


   
HPRD ID6886
Molecular ClassExtracellular ligand gated channel
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P14867DB00186LorazepamSmallMoleculeDrug
P14867DB00189EthchlorvynolSmallMoleculeDrug
P14867DB00228EnfluraneSmallMoleculeDrug
P14867DB00231TemazepamSmallMoleculeDrug
P14867DB00231TemazepamSmallMoleculeDrug
P14867DB00237ButabarbitalSmallMoleculeDrug
P14867DB00241ButalbitalSmallMoleculeDrug
P14867DB00241ButalbitalSmallMoleculeDrug
P14867DB00273TopiramateSmallMoleculeDrug
P14867DB00273TopiramateSmallMoleculeDrug
P14867DB00292EtomidateSmallMoleculeDrug
P14867DB00292EtomidateSmallMoleculeDrug
P14867DB00306TalbutalSmallMoleculeDrug
P14867DB00306TalbutalSmallMoleculeDrug
P14867DB00312PentobarbitalSmallMoleculeDrug
P14867DB00312PentobarbitalSmallMoleculeDrug
P14867DB00334OlanzapineSmallMoleculeDrug
P14867DB00349ClobazamSmallMoleculeDrug
P14867DB00371MeprobamateSmallMoleculeDrug
P14867DB00371MeprobamateSmallMoleculeDrug
P14867DB00402EszopicloneSmallMoleculeDrug
P14867DB00402EszopicloneSmallMoleculeDrug
P14867DB00404AlprazolamSmallMoleculeDrug
P14867DB00418SecobarbitalSmallMoleculeDrug
P14867DB00425ZolpidemSmallMoleculeDrug
P14867DB00474MethohexitalSmallMoleculeDrug
P14867DB00475ChlordiazepoxideSmallMoleculeDrug
P14867DB00543AmoxapineSmallMoleculeDrug
P14867DB00543AmoxapineSmallMoleculeDrug
P14867DB00546AdinazolamSmallMoleculeDrug
P14867DB00599ThiopentalSmallMoleculeDrug
P14867DB00628ClorazepateSmallMoleculeDrug
P14867DB00659AcamprosateSmallMoleculeDrug
P14867DB00683MidazolamSmallMoleculeDrug
P14867DB00690FlurazepamSmallMoleculeDrug
P14867DB00753IsofluraneSmallMoleculeDrug
P14867DB00753IsofluraneSmallMoleculeDrug
P14867DB00794PrimidoneSmallMoleculeDrug
P14867DB00794PrimidoneSmallMoleculeDrug
P14867DB00801HalazepamSmallMoleculeDrug
P14867DB00801HalazepamSmallMoleculeDrug
P14867DB00818PropofolSmallMoleculeDrug
P14867DB00829DiazepamSmallMoleculeDrug
P14867DB00829DiazepamSmallMoleculeDrug
P14867DB00837ProgabideSmallMoleculeDrug
P14867DB00842OxazepamSmallMoleculeDrug
P14867DB00842OxazepamSmallMoleculeDrug
P14867DB00849MethylphenobarbitalSmallMoleculeDrug
P14867DB00897TriazolamSmallMoleculeDrug
P14867DB00897TriazolamSmallMoleculeDrug
P14867DB00898EthanolSmallMoleculeDrug
P14867DB00962ZaleplonSmallMoleculeDrug
P14867DB01028MethoxyfluraneSmallMoleculeDrug
P14867DB01028MethoxyfluraneSmallMoleculeDrug
P14867DB01049Ergoloid mesylateSmallMoleculeDrug
P14867DB01068ClonazepamSmallMoleculeDrug
P14867DB01107MethyprylonSmallMoleculeDrug
P14867DB01107MethyprylonSmallMoleculeDrug
P14867DB01154ThiamylalSmallMoleculeDrug
P14867DB01159HalothaneSmallMoleculeDrug
P14867DB01159HalothaneSmallMoleculeDrug
P14867DB01174PhenobarbitalSmallMoleculeDrug
P14867DB01189DesfluraneSmallMoleculeDrug
P14867DB01198ZopicloneSmallMoleculeDrug
P14867DB01205FlumazenilSmallMoleculeDrug
P14867DB01205FlumazenilSmallMoleculeDrug
P14867DB01215EstazolamSmallMoleculeDrug
P14867DB01215EstazolamSmallMoleculeDrug
P14867DB01236SevofluraneSmallMoleculeDrug
P14867DB01236SevofluraneSmallMoleculeDrug
P14867DB01346Quinidine barbiturateSmallMoleculeDrug
P14867DB01351AmobarbitalSmallMoleculeDrug
P14867DB01352AprobarbitalSmallMoleculeDrug
P14867DB01353ButethalSmallMoleculeDrug
P14867DB01354HeptabarbitalSmallMoleculeDrug
P14867DB01355HexobarbitalSmallMoleculeDrug
P14867DB01381Ginkgo bilobaSmallMoleculeDrug
P14867DB01437GlutethimideSmallMoleculeDrug
P14867DB01437GlutethimideSmallMoleculeDrug
P14867DB01558BromazepamSmallMoleculeDrug
P14867DB01559ClotiazepamSmallMoleculeDrug
P14867DB01567FludiazepamSmallMoleculeDrug
P14867DB01587KetazolamSmallMoleculeDrug
P14867DB01588PrazepamSmallMoleculeDrug
P14867DB01588PrazepamSmallMoleculeDrug
P14867DB01589QuazepamSmallMoleculeDrug
P14867DB01589QuazepamSmallMoleculeDrug
P14867DB01594CinolazepamSmallMoleculeDrug
P14867DB01595NitrazepamSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO