Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GALNT12 | 79695 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)  | 9 | CRCS1; GalNAc-T12  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19617566    | 2009 | Cell line : - Source : ATCC Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry, western Blotting. | Mutation | - | The 8 GALNT12 mutations are evidence that this gene may have a role in colorectal cancers. These data also provides evidence that mutations of GALNT12 may be detected in the normal tissues of individuals who develop cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Glycosyltransferase family 2 domain containing |
| Description | This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]   | Chromosome | 9 |
| Location | 9q22.33 |
| Start | 98807699   |
| End | 98850081   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 42383   |
| OMIM ID | 610290    |
| HGNC ID | HGNC:19877    |
| Unigene ID | Hs.47099     |
| Ensembl ID | ENSG00000119514    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_024642.4 |
|---|---|
| Exon | join(1..371,15558..15727,19054..19243,24074..24259, 27551..27668,29274..29450,32304..32435,36398..36511, 38279..38425,41254..42383)   | mRNA Sequence |    Download   Select all |
| Length | 2752   |
CDS Information
| Location | join(1..371,15558..15727,19054..19243,24074..24259, 27551..27668,29274..29450,32304..32435,36398..36511, 38279..38425,41254..41394) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS6737.1 |    
Protein Information
| Protein ID | NP_078918.3 |
|---|---|
| Protein Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) |
| Molecular Wt. (Da) | 66808 |
| Protein Sequence |    Download   Select all |
| Length | 581   |
| Uniprot ID | Q12778 |    
| Ensembl Protein ID | ENSP00000368880   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 2.4.1.41 |    
|---|---|
| Name | polypeptide N-acetylgalactosaminyltransferase protein-UDP acetylgalactosaminyltransferase UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase glycoprotein acetylgalactosaminyltransferase polypeptide-N-acetylgalactosamine transferase UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase ppGalNAc-T |
| Class | Transferases; Glycosyltransferases; Hexosyltransferases |
| Sysname | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase   |
| Substrate | UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203]; polypeptide   |
| Product | UDP [CPD:C00015]; N-acetyl-alpha-D-galactosaminyl-polypeptide   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4582 |    MUC1 |    1152 |    P15941 |    in vitro |    12135769    |
| 4583 |    MUC2 |    11828 |    NP_002448.2 |    in vitro |    12135769    |
| 4589 |    MUC7 |    11759 |    NP_689504.2 |    in vitro |    12135769    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways |    hsa01100 |    
| Mucin type O-Glycan biosynthesis |    hsa00512 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02510 | 139-433  | pp-GalNAc-T |
| cl11394 | 139-433  | Glyco_tranf_GTA_type superfamily |
| cd00161 | 447-576  | RICIN |
| cl22458 | 447-576  | RICIN superfamily |
| pfam00535 | 139-322  | Glycos_transf_2 |
| cd00761 | 140-254  | Glyco_tranf_GTA_type |
| cd02525 | 139-357  | Succinoglycan_BP_ExoA |
| cd04179 | 140-270  | DPM_DPG-synthase_like |
| cd04186 | 140-363  | GT_2_like_c |
| cd04184 | 136-229  | GT2_RfbC_Mx_like |
| cd04192 | 140-281  | GT_2_like_e |
| cd06423 | 140-254  | CESA_like |
| cd04188 | 140-254  | DPG_synthase |
| cd06442 | 140-253  | DPM1_like |
| cd04187 | 140-229  | DPM1_like_bac |
| cd02522 | 139-351  | GT_2_like_a |
| cd06439 | 131-228  | CESA_like_1 |
| cd06434 | 138-230  | GT2_HAS |
| pfam02709 | 305-365  | Glyco_transf_7C |
| pfam00652 | 445-574  | Ricin_B_lectin |
| COG0463 | 134-429  | WcaA |
| smart00458 | 453-577  | RICIN |
| TIGR03965 | 170-363  | mycofact_glyco |
| COG1215 | 113-361  | BcsA |
| pfam13641 | 136-367  | Glyco_tranf_2_3 |
| pfam10111 | 139-345  | Glyco_tranf_2_2 |
| TIGR04283 | 139-249  | glyco_like_mftF |
| PRK10073 | 136-228  | PRK10073 |
Ontology Information
| HPRD ID | 1297 |    
|---|---|
| Molecular Class | Enzyme: Galactosyltransferase |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

