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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22859720 | 2012 | Cell line : HCT116, LS174T, RKO, HT29, SW620 and LoVo, LS174T Source : ATCC, University of Southern California. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Microarray analysis,Q-PCR analysis,Western blotting,Annexin V/Propidium Iodide analysis | Up-regulation | - | The G-protein-coupled receptor galanin receptor 1 (GalR1) was identified as a novel regulator of drug resistance. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Galanin receptors |
| Description | The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008] | Chromosome | 18 |
| Location | 18q23 |
| Start | 74962008 |
| End | 74982098 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 20091 |
| OMIM ID | 600377 |
| HGNC ID | HGNC:4132 |
| Unigene ID | Hs.272191 |
| Ensembl ID | ENSG00000166573 |
| PharmGKB ID | PA28545 |
mRNA Information
| mRNA ID | NM_001480.3 |
|---|---|
| Exon | join(1..1163,6107..6172,18534..20091) | mRNA Sequence | Download Select all |
| Length | 2787 |
Protein Information
| Protein ID | NP_001471.2 |
|---|---|
| Protein Name | galanin receptor 1 |
| Molecular Wt. (Da) | 38822 |
| Protein Sequence | Download Select all |
| Length | 349 |
| Uniprot ID | P40938 |
| Ensembl Protein ID | ENSP00000369411 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 51083 | GAL | 658 | NP_057057.2 | in vitro;in vivo | 861 719 998 086 677 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 57-303 | 7tm_1 |
| PHA03087 | 33-336 | PHA03087 |
| PHA02638 | 38-336 | PHA02638 |
| PHA02834 | 33-318 | PHA02834 |
Ontology Information
| HPRD ID | 22 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.