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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21111449 | 2011 | Cell line : - Source : Cancer Hospital of Fudan University (Shanghai, China). Sample Type : CRC tumor and adjacent normal tissues No. of Sample : 64 fresh stage II and III CRC tissues, 36 with recurrence and 28 without Stage : TNM Stage II,III | Immunohistochemistry,Quantitative real-time polymerase chain reaction and Western blotting,Multivariate analysis | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008] | Chromosome | 9 |
| Location | 9q21.3-q22 |
| Start | 89559277 |
| End | 89562104 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2828 |
| OMIM ID | 139185 |
| HGNC ID | HGNC:4165 |
| Unigene ID | Hs.65029 |
| Ensembl ID | ENSG00000180447 |
| PharmGKB ID | PA28578 |
Protein Information
| Protein ID | NP_002039.2 |
|---|---|
| Protein Name | growth arrest-specific 1 |
| Molecular Wt. (Da) | 32002 |
| Protein Sequence | Download Select all |
| Length | 345 |
| Uniprot ID | P41220 |
| Ensembl Protein ID | ENSP00000235382 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6469 | SHH | 2838 | NP_000184.1 | in vitro;in vivo | 11572986 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hedgehog signaling pathway | hsa04340 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02351 | 48-141 | GDNF |
| cl19746 | 48-141 | GDNF superfamily |
| smart00907 | 48-143 | GDNF |
Ontology Information
| HPRD ID | 3943 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.