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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GAS5 | 60674 | growth arrest-specific 5 (non-protein coding) | 1 | SNHG2, NCRNA00030 |
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25326054 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 66 Stage : - | Real-time PCR | Down-regulation | - | GAS5, as a growth regulator, may serve as a candidate prognostic biomarker in human colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Long non-coding RNAs, "-" |
| Description | This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015] | Chromosome | 1 |
| Location | 1q25.1 |
| Start | 173833039 |
| End | 173837125 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4087 |
| OMIM ID | 608280 |
| HGNC ID | HGNC:16355 |
| Unigene ID | - |
| Ensembl ID | ENSG00000234741 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | growth arrest-specific 5 (non-protein coding) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | |
| Ensembl Protein ID |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
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PPi Information
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No matching records from HPRD source could be found.
Pathway Information
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Structure Information
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Domain Information
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Drug Information
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