Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GATA5 | 140628 | GATA binding protein 5 | 20 | bB379O24.1, GATAS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25759530 | 2015 | Cell line : - Source : Li Huili Hospital (Ningbo, China). Sample Type : CRC tumor and normal tissue No. of Sample : 57 CRC, 30 adenomas, 47 control Stage : - | Sodium bisulfite conversion,methylation-specific PCR | Methylation | - | A combination of GATA5 and SFRP2 methylation could be promising as a marker for the detection and diagnosis of CRC and adenomas.Hypermethylated GATA5 was detected in plasma in 61.4% (35/57) of CRC cases, 43.33% (13/30) of adenoma cases, and 21.28% (10/47) of control cases. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008] | Chromosome | 20 |
| Location | 20q13.33 |
| Start | 61038553 |
| End | 61051026 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 12474 |
| OMIM ID | 611496 |
| HGNC ID | HGNC:15802 |
| Unigene ID | Hs.352250 |
| Ensembl ID | ENSG00000130700 |
| PharmGKB ID | PA28588 |
Protein Information
| Protein ID | NP_536721.1 |
|---|---|
| Protein Name | GATA binding protein 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 397 |
| Uniprot ID | Q8NHS0 |
| Ensembl Protein ID | ENSP00000316053 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6927 | HNF1A | 800 | NP_000536.5 | in vitro;in vivo | 1 201 106 014 715 520 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 188-232 | ZnF_GATA |
| cl00158 | 188-232 | ZnF_GATA superfamily |
| cd00202 | 253-293 | ZnF_GATA |
| cl00158 | 253-293 | ZnF_GATA superfamily |
| pfam00320 | 189-223 | GATA |
| pfam00320 | 251-277 | GATA |
| pfam05349 | 1-172 | GATA-N |
| smart00401 | 184-229 | ZnF_GATA |
| smart00401 | 251-287 | ZnF_GATA |
| COG5641 | 181-237 | GAT1 |
| COG5641 | 191-297 | GAT1 |
Ontology Information
| HPRD ID | 12345 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.