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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24887481 | 2014 | Cell line : HT55, HT29 Source : - Sample Type : - No. of Sample : - Stage : - | Flow cytometry,Real time RT-PCR and Western blotting Gene Knockdown and transfection. | Down-regulation | - | Inhibition of GATA6 significantly increased the effect of irradiation on HT55 and HT29 cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012] | Chromosome | 18 |
| Location | 18q11-q12 |
| Start | 19749404 |
| End | 19782491 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33088 |
| OMIM ID | 601656 |
| HGNC ID | HGNC:4174 |
| Unigene ID | Hs.514746 |
| Ensembl ID | ENSG00000141448 |
| PharmGKB ID | PA28589 |
mRNA Information
| mRNA ID | NM_005257.5 |
|---|---|
| Exon | join(1..246,1672..2843,7519..7685,12017..12142, 13321..13408,13504..13607,31220..33092) | mRNA Sequence | Download Select all |
| Length | 3785 |
Protein Information
| Protein ID | NP_005248.2 |
|---|---|
| Protein Name | GATA binding protein 6 |
| Molecular Wt. (Da) | 59902 |
| Protein Sequence | Download Select all |
| Length | 595 |
| Uniprot ID | Q9Y6N7 |
| Ensembl Protein ID | ENSP00000420321 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 266 |
| S | Phosphorylation | 268 |
| T | Phosphorylation | 534 |
| S | Phosphorylation | 436 |
| S | Phosphorylation | 437 |
| T | Phosphorylation | 530 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1397 | CRIP2 | 3113 | NP_001303.1 | in vitro;in vivo | 12530967 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vivo | 10851229 |
| 3087 | HHEX | 6829 | NP_002720.1 | yeast 2-hybrid | 15016828 |
| 5469 | MED1 | 5055 | NP_004765.2 | in vitro | 11724781 |
| 7080 | NKX2-1 | 2798 | NP_001073136.1 | in vitro;yeast 2-hybrid | 11733512 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 443-494 | ZnF_GATA |
| cl00158 | 443-494 | ZnF_GATA superfamily |
| cd00202 | 389-434 | ZnF_GATA |
| cl00158 | 389-434 | ZnF_GATA superfamily |
| pfam00320 | 444-478 | GATA |
| pfam00320 | 390-423 | GATA |
| pfam05349 | 147-381 | GATA-N |
| smart00401 | 441-488 | ZnF_GATA |
| smart00401 | 388-435 | ZnF_GATA |
| COG5641 | 443-533 | GAT1 |
| COG5641 | 364-528 | GAT1 |
| COG5641 | 373-591 | GAT1 |
Ontology Information
| HPRD ID | 11895 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.