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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GDF15 | 9518 | growth differentiation factor 15 | 19 | PLAB, MIC-1, PDF, MIC1, NAG-1, PTGFB |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24565956 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ELISA | Up-regulation | - | There is an association between higher levels of circulating MIC-1 (GDF15) and CRC. The novel plasma inflammatory biomarker macrophage inhibitory cytokine-1 (MIC-1, GDF15) may have a direct mechanistic role in colorectal carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[ | Chromosome | 19 |
| Location | 19p13.11 |
| Start | 18386158 |
| End | 18389176 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3019 |
| OMIM ID | 605312 |
| HGNC ID | HGNC:30142 |
| Unigene ID | Hs.616962 |
| Ensembl ID | ENSG00000130513 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004864.2 |
|---|---|
| Exon | join(1..309,2129..3019) | mRNA Sequence | Download Select all |
| Length | 1220 |
CDS Information
| Location | join(33..309,2129..2778) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12376.1 |
Protein Information
| Protein ID | NP_004855.2 |
|---|---|
| Protein Name | growth differentiation factor 15 |
| Molecular Wt. (Da) | 12515 |
| Protein Sequence | Download Select all |
| Length | 308 |
| Uniprot ID | P06213 |
| Ensembl Protein ID | ENSP00000303830 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 196 |
| C | Disulfide Bridge | 203;211 |
| N | Glycosylation | 70 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00204 | 211-308 | TGFB |
| cl02510 | 211-308 | TGF_beta superfamily |
| pfam00019 | 211-308 | TGF_beta |
| PHA02913 | 222-307 | PHA02913 |
| PRK10929 | 23-147 | PRK10929 |
Ontology Information
| HPRD ID | 2843 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.