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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GDNF | 2668 | glial cell derived neurotrophic factor | 5 | ATF1, ATF2, HFB1-GDNF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
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- PPi
- Pathway
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- Domain
- Ontology
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- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17708263 | 2007 | Cell line : 4 human colorectal cancer cell lines Source : - Sample Type : - No. of Sample : - Stage : - | Flow cytometry and ELISA | Up-regulation | - | In colorectal cancer, the enhancement of integrin expression by signaling through the GDNF receptor strongly influences adhesion to and invasion of ECM proteins. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010] | Chromosome | 5 |
| Location | 5p13.1-p12 |
| Start | 37812779 |
| End | 37839782 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 27004 |
| OMIM ID | 600837 |
| HGNC ID | HGNC:4232 |
| Unigene ID | Hs.248114 |
| Ensembl ID | ENSG00000168621 |
| PharmGKB ID | PA28644 |
mRNA Information
| mRNA ID | NM_000514.3 |
|---|---|
| Exon | join(1..174,4859..5035,23546..27004) | mRNA Sequence | Download Select all |
| Length | 3810 |
Protein Information
| Protein ID | NP_000505.1 |
|---|---|
| Protein Name | glial cell derived neurotrophic factor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 211 |
| Uniprot ID | Q9HCK4 |
| Ensembl Protein ID | ENSP00000417164 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00019 | 115-211 | TGF_beta |
| cl02510 | 115-211 | TGF_beta superfamily |
Ontology Information
| HPRD ID | 3414 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.