Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GGH | 8836 | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 8 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18414409 | 2008 | Cell line : - Source : Colorectal Unit of the Royal Adelaide Hospital in Australia were used. Sample Type : CRC tumor and normal tissue No. of Sample : 114 Stage : - | real time RT-PCR,Methylation analysis, immunohistochemistry | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008] | Chromosome | 8 |
| Location | 8q12.3 |
| Start | 63927638 |
| End | 63951610 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 23973 |
| OMIM ID | 601509 |
| HGNC ID | HGNC:4248 |
| Unigene ID | Hs.78619 |
| Ensembl ID | ENSG00000137563 |
| PharmGKB ID | PA432 |
Protein Information
| Protein ID | NP_003869.1 |
|---|---|
| Protein Name | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 318 |
| Uniprot ID | Q9Y3F4 |
| Ensembl Protein ID | ENSP00000025399 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 307;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Folate biosynthesis | hsa00790 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01747 | 36-306 | GATase1_Glutamyl_Hydrolase |
| cl00020 | 36-306 | GAT_1 superfamily |
| cd01653 | 47-162 | GATase1 |
| cd03128 | 47-137 | GAT_1 |
| cd01745 | 36-251 | GATase1_2 |
| PRK06895 | 171-246 | PRK06895 |
| PRK05670 | 173-246 | PRK05670 |
| pfam07722 | 34-246 | Peptidase_C26 |
| COG2071 | 31-281 | PuuD |
| pfam00117 | 61-249 | GATase |
| COG0512 | 61-246 | PabA |
| PRK12838 | 128-249 | PRK12838 |
Ontology Information
| HPRD ID | 5541 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Receptor binding (GO:0005102) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q92820 | DB00158 | Folic Acid | SmallMoleculeDrug |
| Q92820 | DB00563 | Methotrexate | SmallMoleculeDrug |