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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23095641 | 2012 | Cell line : HT-29, HCT-116 ,HCT 15 Source : ATCC Sample Type : - No. of Sample : - Stage : - | MTS assay,Cell cycle analysis | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] | Chromosome | 20 |
| Location | 20q11.2 |
| Start | 35879489 |
| End | 35887534 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 8046 |
| OMIM ID | 139190 |
| HGNC ID | HGNC:4265 |
| Unigene ID | Hs.37023 |
| Ensembl ID | ENSG00000118702 |
| PharmGKB ID | PA28675 |
mRNA Information
| mRNA ID | XM_011528788.1 |
|---|---|
| Exon | join(1..136,4971..5072,5381..5485,7550..7669,10651..10814) | mRNA Sequence | Download Select all |
| Length | 627 |
Protein Information
| Protein ID | XP_011527090.1 |
|---|---|
| Protein Name | growth hormone releasing hormone |
| Molecular Wt. (Da) | 12229 |
| Protein Sequence | Download Select all |
| Length | 107 |
| Uniprot ID | P35398 |
| Ensembl Protein ID | ENSP00000261523 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2692 | GHRHR | 748 | NP_000814.2 | in vivo | 1333056 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00123 | 32-59 | Hormone_2 |
| cl23492 | 32-59 | Hormone_2 superfamily |
| smart00070 | 32-58 | GLUCA |
| cl23044 | 32-58 | GLUCA superfamily |
Ontology Information
| HPRD ID | 1565 |
|---|---|
| Molecular Class | Peptide hormone |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.